AU2001234467A1 - Versatile hydrophilic dyes - Google Patents
Versatile hydrophilic dyesInfo
- Publication number
- AU2001234467A1 AU2001234467A1 AU2001234467A AU3446701A AU2001234467A1 AU 2001234467 A1 AU2001234467 A1 AU 2001234467A1 AU 2001234467 A AU2001234467 A AU 2001234467A AU 3446701 A AU3446701 A AU 3446701A AU 2001234467 A1 AU2001234467 A1 AU 2001234467A1
- Authority
- AU
- Australia
- Prior art keywords
- och
- conh
- nhco
- group
- independently selected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000975 dye Substances 0.000 title abstract description 87
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims abstract description 18
- 238000003384 imaging method Methods 0.000 claims abstract description 17
- 238000002560 therapeutic procedure Methods 0.000 claims abstract description 15
- 150000001875 compounds Chemical class 0.000 claims abstract description 14
- 238000001514 detection method Methods 0.000 claims abstract description 12
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 claims abstract 2
- 239000000203 mixture Substances 0.000 claims description 47
- 238000000034 method Methods 0.000 claims description 45
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 44
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 28
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 25
- 239000003795 chemical substances by application Substances 0.000 claims description 22
- 229910052739 hydrogen Inorganic materials 0.000 claims description 18
- 230000000975 bioactive effect Effects 0.000 claims description 17
- 239000001257 hydrogen Substances 0.000 claims description 17
- 239000008280 blood Substances 0.000 claims description 16
- 210000004369 blood Anatomy 0.000 claims description 16
- 150000001720 carbohydrates Chemical class 0.000 claims description 15
- 229920001542 oligosaccharide Polymers 0.000 claims description 15
- 150000002482 oligosaccharides Chemical class 0.000 claims description 15
- DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical compound NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 claims description 14
- 102000002068 Glycopeptides Human genes 0.000 claims description 14
- 108010015899 Glycopeptides Proteins 0.000 claims description 14
- 125000003545 alkoxy group Chemical group 0.000 claims description 14
- 125000004103 aminoalkyl group Chemical group 0.000 claims description 14
- 125000002837 carbocyclic group Chemical group 0.000 claims description 14
- 239000002738 chelating agent Substances 0.000 claims description 14
- 150000004696 coordination complex Chemical class 0.000 claims description 14
- 229940079593 drug Drugs 0.000 claims description 14
- 239000003814 drug Substances 0.000 claims description 14
- 125000000623 heterocyclic group Chemical group 0.000 claims description 14
- 229910052751 metal Inorganic materials 0.000 claims description 14
- 239000002184 metal Substances 0.000 claims description 14
- 150000002772 monosaccharides Chemical class 0.000 claims description 14
- 229910052757 nitrogen Inorganic materials 0.000 claims description 14
- 229910052760 oxygen Inorganic materials 0.000 claims description 14
- 239000001301 oxygen Substances 0.000 claims description 14
- 230000002285 radioactive effect Effects 0.000 claims description 14
- 229910052717 sulfur Inorganic materials 0.000 claims description 14
- 125000000217 alkyl group Chemical group 0.000 claims description 13
- 125000004434 sulfur atom Chemical group 0.000 claims description 13
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims description 11
- CFODQUSMSYDHBS-UHFFFAOYSA-N octreotate Chemical group O=C1NC(CC=2C=CC=CC=2)C(=O)NC(CC=2[C]3C=CC=CC3=NC=2)C(=O)NC(CCCCN)C(=O)NC(C(C)O)C(=O)NC(C(=O)NC(C(O)C)C(O)=O)CSSCC1NC(=O)C(N)CC1=CC=CC=C1 CFODQUSMSYDHBS-UHFFFAOYSA-N 0.000 claims description 11
- 102000004169 proteins and genes Human genes 0.000 claims description 10
- 108090000623 proteins and genes Proteins 0.000 claims description 10
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 7
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 7
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 7
- 229910052736 halogen Inorganic materials 0.000 claims description 7
- 150000002367 halogens Chemical class 0.000 claims description 7
- 229940088597 hormone Drugs 0.000 claims description 7
- 239000005556 hormone Substances 0.000 claims description 7
- 230000003278 mimic effect Effects 0.000 claims description 7
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 7
- 239000000816 peptidomimetic Substances 0.000 claims description 7
- 238000010521 absorption reaction Methods 0.000 claims description 6
- 238000001727 in vivo Methods 0.000 claims description 6
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- 230000003287 optical effect Effects 0.000 claims description 5
- 238000010791 quenching Methods 0.000 claims description 4
- 230000000171 quenching effect Effects 0.000 claims description 4
- 238000000338 in vitro Methods 0.000 claims description 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 3
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- 208000003788 Neoplasm Micrometastasis Diseases 0.000 claims description 2
- 238000001839 endoscopy Methods 0.000 claims description 2
- 238000002428 photodynamic therapy Methods 0.000 claims description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 238000002405 diagnostic procedure Methods 0.000 claims 4
- 125000004008 6 membered carbocyclic group Chemical group 0.000 claims 3
- VZGJNCHEUPMLPM-DGKZTOLNSA-N C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](N)CCC(N)=O)C(C)C)C1=CN=CN1 Chemical group C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](N)CCC(N)=O)C(C)C)C1=CN=CN1 VZGJNCHEUPMLPM-DGKZTOLNSA-N 0.000 claims 3
- 108010062050 bombesin (7-14) Proteins 0.000 claims 3
- 229930182830 galactose Natural products 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 238000000149 argon plasma sintering Methods 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 208000007536 Thrombosis Diseases 0.000 claims 1
- 238000002835 absorbance Methods 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 238000003325 tomography Methods 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 abstract description 42
- 230000005856 abnormality Effects 0.000 abstract description 4
- 239000000863 peptide conjugate Substances 0.000 abstract description 4
- 210000004881 tumor cell Anatomy 0.000 abstract description 4
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract description 2
- 238000002059 diagnostic imaging Methods 0.000 abstract 2
- 230000001419 dependent effect Effects 0.000 abstract 1
- 230000002349 favourable effect Effects 0.000 abstract 1
- 239000012216 imaging agent Substances 0.000 abstract 1
- NFHFRUOZVGFOOS-UHFFFAOYSA-N palladium;triphenylphosphane Chemical compound [Pd].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 NFHFRUOZVGFOOS-UHFFFAOYSA-N 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 49
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 32
- 241000700159 Rattus Species 0.000 description 29
- QGKMIGUHVLGJBR-UHFFFAOYSA-M (4z)-1-(3-methylbutyl)-4-[[1-(3-methylbutyl)quinolin-1-ium-4-yl]methylidene]quinoline;iodide Chemical group [I-].C12=CC=CC=C2N(CCC(C)C)C=CC1=CC1=CC=[N+](CCC(C)C)C2=CC=CC=C12 QGKMIGUHVLGJBR-UHFFFAOYSA-M 0.000 description 26
- 239000000243 solution Substances 0.000 description 25
- 239000000562 conjugate Substances 0.000 description 23
- MOFVSTNWEDAEEK-UHFFFAOYSA-M indocyanine green Chemical compound [Na+].[O-]S(=O)(=O)CCCCN1C2=CC=C3C=CC=CC3=C2C(C)(C)C1=CC=CC=CC=CC1=[N+](CCCCS([O-])(=O)=O)C2=CC=C(C=CC=C3)C3=C2C1(C)C MOFVSTNWEDAEEK-UHFFFAOYSA-M 0.000 description 23
- 229960004657 indocyanine green Drugs 0.000 description 23
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 21
- 230000015572 biosynthetic process Effects 0.000 description 20
- 239000007924 injection Substances 0.000 description 20
- 238000002347 injection Methods 0.000 description 20
- 239000007787 solid Substances 0.000 description 20
- 238000003786 synthesis reaction Methods 0.000 description 20
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 18
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 18
- 150000001413 amino acids Chemical class 0.000 description 15
- 241001465754 Metazoa Species 0.000 description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
- 238000006243 chemical reaction Methods 0.000 description 12
- 235000001014 amino acid Nutrition 0.000 description 10
- 210000000056 organ Anatomy 0.000 description 10
- 102000005962 receptors Human genes 0.000 description 10
- 108020003175 receptors Proteins 0.000 description 10
- 210000001519 tissue Anatomy 0.000 description 10
- RFFLAFLAYFXFSW-UHFFFAOYSA-N 1,2-dichlorobenzene Chemical compound ClC1=CC=CC=C1Cl RFFLAFLAYFXFSW-UHFFFAOYSA-N 0.000 description 9
- 208000006336 acinar cell carcinoma Diseases 0.000 description 8
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 8
- -1 succinimidyl esters Chemical class 0.000 description 8
- 239000007943 implant Substances 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- 235000018102 proteins Nutrition 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 6
- 210000004185 liver Anatomy 0.000 description 6
- 230000037361 pathway Effects 0.000 description 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 5
- 238000013459 approach Methods 0.000 description 5
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- 239000000543 intermediate Substances 0.000 description 5
- 102000004196 processed proteins & peptides Human genes 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- 125000003088 (fluoren-9-ylmethoxy)carbonyl group Chemical group 0.000 description 4
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 4
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 4
- AFCARXCZXQIEQB-UHFFFAOYSA-N N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CCNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 AFCARXCZXQIEQB-UHFFFAOYSA-N 0.000 description 4
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- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 description 3
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- JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 description 2
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
- A61K41/0033—Sonodynamic cancer therapy with sonochemically active agents or sonosensitizers, having their cytotoxic effects enhanced through application of ultrasounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0056—Peptides, proteins, polyamino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Luminescent Compositions (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/484,321 | 2000-01-18 | ||
| US09/484,321 US6183726B1 (en) | 2000-01-18 | 2000-01-18 | Versatile hydrophilic dyes |
| US09/757,333 US6939532B2 (en) | 2000-01-18 | 2001-01-09 | Versatile hydrophilic dyes |
| US09/757,333 | 2001-01-09 | ||
| PCT/US2001/001471 WO2001052746A1 (en) | 2000-01-18 | 2001-01-17 | Versatile hydrophilic dyes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2001234467A1 true AU2001234467A1 (en) | 2001-07-31 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2001234467A Abandoned AU2001234467A1 (en) | 2000-01-18 | 2001-01-17 | Versatile hydrophilic dyes |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6939532B2 (de) |
| EP (1) | EP1250095B1 (de) |
| JP (1) | JP2003535041A (de) |
| AT (1) | ATE279147T1 (de) |
| AU (1) | AU2001234467A1 (de) |
| DE (1) | DE60106389T8 (de) |
| ES (1) | ES2231445T3 (de) |
| WO (1) | WO2001052746A1 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US7790144B2 (en) * | 2000-01-18 | 2010-09-07 | Mallinckrodt Inc. | Receptor-avid exogenous optical contrast and therapeutic agents |
| US6180086B1 (en) * | 2000-01-18 | 2001-01-30 | Mallinckrodt Inc. | Hydrophilic cyanine dyes |
| US6939532B2 (en) * | 2000-01-18 | 2005-09-06 | Mallinckrodt, Inc. | Versatile hydrophilic dyes |
| US20030105299A1 (en) * | 2001-10-17 | 2003-06-05 | Mallinckrodt Inc. | Carbocyanine dyes for tandem, photodiagnostic and therapeutic applications |
| US6761878B2 (en) * | 2001-10-17 | 2004-07-13 | Mallinckrodt, Inc. | Pathological tissue detection and treatment employing targeted benzoindole optical agents |
| US20030105300A1 (en) * | 2001-10-17 | 2003-06-05 | Mallinckrodt Inc. | Tumor targeted photodiagnostic-phototherapeutic agents |
| US20030152577A1 (en) * | 2002-02-07 | 2003-08-14 | Mallinckrodt Inc. | Dye-bioconjugates for simultaneous optical diagnostic and therapeutic applications |
| US7226577B2 (en) | 2003-01-13 | 2007-06-05 | Bracco Imaging, S. P. A. | Gastrin releasing peptide compounds |
| WO2004080483A1 (en) * | 2003-03-10 | 2004-09-23 | Mpa Technologies, Inc. | Targeted agents for both photodiagnosis and photodynamic therapy |
| US20100022449A1 (en) * | 2006-03-09 | 2010-01-28 | Mallinckrodt Inc. | Receptor-avid exogenous optical contrast and therapeutic agents |
| US20100040547A1 (en) * | 2006-08-03 | 2010-02-18 | Frangioni John V | Dyes and precursors and conjugates thereof |
| EP2100621A1 (de) * | 2008-03-10 | 2009-09-16 | mivenion GmbH | Polyether-Polyol-Dendron-Konjugate mit Effektormolekülen für biologisches Targeting |
| US9433700B2 (en) | 2009-04-27 | 2016-09-06 | Medibeacon Inc. | Tissue sealant compositions, vascular closure devices, and uses thereof |
| PT2530093T (pt) | 2010-01-28 | 2018-12-28 | Univ Nagoya Nat Univ Corp | Composto de indocianina, método de síntese do mesmo, método de purificação do mesmo, composição de diagnóstico utilizando o composto de indocianina, e dispositivo para medição da cinética in vivo e dispositivo para visualização da circulação utilizando a composição de diagnóstico |
| US10053447B2 (en) | 2010-12-21 | 2018-08-21 | Pierce Biotechnology, Inc | Fluorescent compounds |
| US8889884B1 (en) | 2011-07-14 | 2014-11-18 | Pierce Biotechnology, Inc. | Phosphine derivatives of fluorescent compounds |
| US9249307B2 (en) | 2011-08-16 | 2016-02-02 | Pierce Biotechnology, Inc. | Benzocyanine compounds |
| US9751868B2 (en) | 2012-02-28 | 2017-09-05 | Pierce Biotechnology, Inc. | Benzocyanine compounds |
| EP2804860B1 (de) | 2012-03-02 | 2016-06-15 | Pierce Biotechnology, Inc. | Indol-derivate als markierungsfarbstoff für biomoleküle |
| EP2850078B1 (de) | 2012-08-28 | 2018-04-25 | Pierce Biotechnology, Inc. | Benzopyryliumverbindungen |
| EP3044196A4 (de) * | 2013-09-11 | 2017-05-24 | Equip, LLC | Auf einzel-peg basierende farbstoffe |
| US9862682B2 (en) | 2016-01-08 | 2018-01-09 | BroadPharm | Functionalized pegylated cyanine compounds, pharmaceutical compositions, and methods of use thereof |
Family Cites Families (24)
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| JPS59192595A (ja) | 1983-04-16 | 1984-10-31 | Tdk Corp | 光記録媒体 |
| JPH0729496B2 (ja) | 1986-03-07 | 1995-04-05 | 三菱レイヨン株式会社 | 光情報記録媒体 |
| US6406713B1 (en) | 1987-03-05 | 2002-06-18 | The Liposome Company, Inc. | Methods of preparing low-toxicity drug-lipid complexes |
| JP3023726B2 (ja) | 1991-04-16 | 2000-03-21 | コニカ株式会社 | ハロゲン化銀写真感光材料 |
| US5453505A (en) | 1994-06-30 | 1995-09-26 | Biometric Imaging, Inc. | N-heteroaromatic ion and iminium ion substituted cyanine dyes for use as fluorescence labels |
| DE4445065A1 (de) | 1994-12-07 | 1996-06-13 | Diagnostikforschung Inst | Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung |
| US5732104A (en) | 1994-12-14 | 1998-03-24 | Motorola, Inc. | Signalling techniques and device for high speed data transmission over voiceband channels |
| US5709845A (en) | 1996-05-13 | 1998-01-20 | Rajagopalan; Raghavan | Tricyclic functional dyes for contrast enhancement in optical imaging |
| US5672333A (en) | 1996-05-13 | 1997-09-30 | Mallinckrodt Medical, Inc. | Delta1,6 bicyclo 4,4,0! functional dyes for contrast enhancement in optical imaging |
| US5723104A (en) | 1996-05-13 | 1998-03-03 | Fung; Ella Y. | Monocyclic functional dyes for contrast enhancement in optical imaging |
| DE19649971A1 (de) | 1996-11-19 | 1998-05-28 | Diagnostikforschung Inst | Optische Diagnostika zur Diagnostik neurodegenerativer Krankheiten mittels Nahinfrarot-Strahlung (NIR-Strahlung) |
| AUPO598797A0 (en) | 1997-04-04 | 1997-05-01 | Decor Corporation Pty Ltd, The | Mops |
| GB9707133D0 (en) | 1997-04-08 | 1997-05-28 | Identalink Corp | Identity systems |
| ES2244169T3 (es) | 1998-02-09 | 2005-12-01 | Bracco International B.V. | Suministro direccionado de medios biologicamente activos. |
| US6190641B1 (en) | 2000-01-18 | 2001-02-20 | Mallinckrodt Inc. | Indocyanine dyes |
| US6180085B1 (en) | 2000-01-18 | 2001-01-30 | Mallinckrodt Inc. | Dyes |
| US6180087B1 (en) | 2000-01-18 | 2001-01-30 | Mallinckrodt Inc. | Tunable indocyanine dyes for biomedical applications |
| US6180086B1 (en) | 2000-01-18 | 2001-01-30 | Mallinckrodt Inc. | Hydrophilic cyanine dyes |
| US6395257B1 (en) | 2000-01-18 | 2002-05-28 | Mallinckrodt Inc. | Dendrimer precursor dyes for imaging |
| US6183726B1 (en) * | 2000-01-18 | 2001-02-06 | Mallinckrodt Inc. | Versatile hydrophilic dyes |
| US6939532B2 (en) | 2000-01-18 | 2005-09-06 | Mallinckrodt, Inc. | Versatile hydrophilic dyes |
| US6733744B1 (en) * | 2000-10-16 | 2004-05-11 | Mallinckrodt Inc. | Indole compounds as minimally invasive physiological function monitoring agents |
| US6485704B1 (en) | 2001-05-04 | 2002-11-26 | Mallinckrodt Inc. | Azo compound for type I pototherapy |
| US20030105299A1 (en) | 2001-10-17 | 2003-06-05 | Mallinckrodt Inc. | Carbocyanine dyes for tandem, photodiagnostic and therapeutic applications |
-
2001
- 2001-01-09 US US09/757,333 patent/US6939532B2/en not_active Expired - Fee Related
- 2001-01-17 JP JP2001552801A patent/JP2003535041A/ja active Pending
- 2001-01-17 AT AT01906573T patent/ATE279147T1/de not_active IP Right Cessation
- 2001-01-17 DE DE60106389T patent/DE60106389T8/de active Active
- 2001-01-17 WO PCT/US2001/001471 patent/WO2001052746A1/en active IP Right Grant
- 2001-01-17 ES ES01906573T patent/ES2231445T3/es not_active Expired - Lifetime
- 2001-01-17 EP EP01906573A patent/EP1250095B1/de not_active Expired - Lifetime
- 2001-01-17 AU AU2001234467A patent/AU2001234467A1/en not_active Abandoned
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2005
- 2005-05-10 US US11/126,137 patent/US7566444B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7566444B2 (en) | 2009-07-28 |
| WO2001052746A1 (en) | 2001-07-26 |
| US20030165432A1 (en) | 2003-09-04 |
| US6939532B2 (en) | 2005-09-06 |
| DE60106389T2 (de) | 2006-03-09 |
| DE60106389D1 (de) | 2004-11-18 |
| ES2231445T3 (es) | 2005-05-16 |
| EP1250095B1 (de) | 2004-10-13 |
| WO2001052746A9 (en) | 2002-10-31 |
| EP1250095A1 (de) | 2002-10-23 |
| US20050201939A1 (en) | 2005-09-15 |
| EP1250095A4 (de) | 2003-05-07 |
| DE60106389T8 (de) | 2006-06-08 |
| JP2003535041A (ja) | 2003-11-25 |
| ATE279147T1 (de) | 2004-10-15 |
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