DE60042522D1 - Cyanin- oder indocyaninefarbstoffe biokonjugate für biomedische anwendungen - Google Patents

Cyanin- oder indocyaninefarbstoffe biokonjugate für biomedische anwendungen

Info

Publication number
DE60042522D1
DE60042522D1 DE60042522T DE60042522T DE60042522D1 DE 60042522 D1 DE60042522 D1 DE 60042522D1 DE 60042522 T DE60042522 T DE 60042522T DE 60042522 T DE60042522 T DE 60042522T DE 60042522 D1 DE60042522 D1 DE 60042522D1
Authority
DE
Germany
Prior art keywords
therapy
imaging
detection
dye
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60042522T
Other languages
English (en)
Inventor
Samuel Achilefu
Richard Bradley Dorshow
Joseph Edward Bugaj
Raghavan Rajagopalan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Application granted granted Critical
Publication of DE60042522D1 publication Critical patent/DE60042522D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60042522T 1999-05-20 2000-04-26 Cyanin- oder indocyaninefarbstoffe biokonjugate für biomedische anwendungen Expired - Lifetime DE60042522D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13506099P 1999-05-20 1999-05-20
US09/325,769 US6217848B1 (en) 1999-05-20 1999-06-04 Cyanine and indocyanine dye bioconjugates for biomedical applications
PCT/US2000/011060 WO2000071162A2 (en) 1999-05-20 2000-04-26 Cyanine and indocyanine dye bioconjugates for biomedical applications

Publications (1)

Publication Number Publication Date
DE60042522D1 true DE60042522D1 (de) 2009-08-20

Family

ID=26832945

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60042522T Expired - Lifetime DE60042522D1 (de) 1999-05-20 2000-04-26 Cyanin- oder indocyaninefarbstoffe biokonjugate für biomedische anwendungen

Country Status (11)

Country Link
US (1) US6217848B1 (de)
EP (2) EP1178830B1 (de)
JP (1) JP2003500367A (de)
AT (1) ATE435662T1 (de)
AU (1) AU4488800A (de)
CA (1) CA2373475C (de)
DE (1) DE60042522D1 (de)
DK (1) DK1178830T3 (de)
ES (1) ES2329542T3 (de)
PT (1) PT1178830E (de)
WO (1) WO2000071162A2 (de)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6630570B1 (en) * 1999-04-09 2003-10-07 Insitut für Diagnostikforschung GmbH Short-chain peptide-dye conjugates as contrast media for optical diagnosis
US7175953B2 (en) * 1999-04-09 2007-02-13 Institute Fuer Diagnostik Forschung Short-warp peptide-dye conjugate as contrast agent for optical diagnostic
US20050182434A1 (en) * 2000-08-11 2005-08-18 National Research Council Of Canada Method and apparatus for performing intra-operative angiography
US7230088B2 (en) * 2001-07-03 2007-06-12 Mallinckrodt, Inc. Compounds for dual photodiagnosis and therapy
US7351807B2 (en) * 2000-01-18 2008-04-01 Mallinckrodt Inc. Cyanine-sulfenates for dual phototherapy
US20030017164A1 (en) * 2001-07-03 2003-01-23 Mallinckrodt Inc. Dye-azide compounds for dual phototherapy
US7790144B2 (en) * 2000-01-18 2010-09-07 Mallinckrodt Inc. Receptor-avid exogenous optical contrast and therapeutic agents
US6180085B1 (en) * 2000-01-18 2001-01-30 Mallinckrodt Inc. Dyes
US6190641B1 (en) * 2000-01-18 2001-02-20 Mallinckrodt Inc. Indocyanine dyes
US6673334B1 (en) * 2000-10-16 2004-01-06 Mallinkcrodt, Inc. Light sensitive compounds for instant determination of organ function
US7556797B2 (en) * 2000-10-16 2009-07-07 Mallinckrodt Inc. Minimally invasive physiological function monitoring agents
US6838074B2 (en) 2001-08-08 2005-01-04 Bristol-Myers Squibb Company Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent
US20030105300A1 (en) * 2001-10-17 2003-06-05 Mallinckrodt Inc. Tumor targeted photodiagnostic-phototherapeutic agents
IL148921A0 (en) * 2002-03-26 2002-09-12 Peptor Ltd Photo active backbone cyclized somatostatin analogs for optical imaging and photodynamic therapy
US20040022731A1 (en) * 2002-04-26 2004-02-05 Alexei Bogdanov In vivo imaging of apoptosis
US6658143B2 (en) * 2002-04-29 2003-12-02 Amersham Biosciences Corp. Ray-based image analysis for biological specimens
US7580185B2 (en) 2002-08-28 2009-08-25 Carl Zeiss Surgical Gmbh Microscopy system, microscopy method and a method of treating an aneurysm
US7303741B2 (en) * 2002-09-23 2007-12-04 General Electric Company Systems and methods for high-resolution in vivo imaging of biochemical activity in a living organism
US7226577B2 (en) 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
DE10302787A1 (de) * 2003-01-24 2004-08-12 Schering Ag Hydrophile, Thiol-reaktive Cyaninfarbstoffe und deren Konjugate mit Biomolekülen für die Fluoreszenzdiagnostik
WO2004080483A1 (en) * 2003-03-10 2004-09-23 Mpa Technologies, Inc. Targeted agents for both photodiagnosis and photodynamic therapy
WO2005000218A2 (en) * 2003-05-31 2005-01-06 Washington University Macrocyclic cyanine and indocyanine bioconjugates provide improved biomedical applications
NO20035681D0 (no) * 2003-12-18 2003-12-18 Amersham Health As Optisk avbildning av lungekreft
NO20035683D0 (no) * 2003-12-18 2003-12-18 Amersham Health As Optisk avbildning av prostatakreft
NO20035682D0 (no) * 2003-12-18 2003-12-18 Amersham Health As Optisk avbildning av ösofagkreft og Barretts ösofag
DE102004022628A1 (de) * 2004-05-07 2005-12-15 Sensient Imaging Technologies Gmbh FRET-Bioassay
US20050272967A1 (en) * 2004-05-18 2005-12-08 Siemens Aktiengesellschaft Biomolecular contrast agents with multiple signal variance for therapy planning and control in radiation therapy with proton or ion beams
US7585492B2 (en) * 2004-05-18 2009-09-08 Siemens Aktiengesellschaft Biomolecular contrast agents for therapy success and dose monitoring in radiation therapy with proton or ion beams
US20050259779A1 (en) * 2004-05-18 2005-11-24 Siemens Aktiengesellschaft Biomolecular contrast agents for therapy optimization in radiation therapy with proton or ion beams
US20060239916A1 (en) * 2005-01-07 2006-10-26 Kai Licha Use of cyanine dyes for the diagnosis of proliferative diseases
US20070122344A1 (en) 2005-09-02 2007-05-31 University Of Rochester Medical Center Office Of Technology Transfer Intraoperative determination of nerve location
US20080161744A1 (en) 2006-09-07 2008-07-03 University Of Rochester Medical Center Pre-And Intra-Operative Localization of Penile Sentinel Nodes
GB0714202D0 (en) * 2007-07-20 2007-08-29 Ge Healthcare Bio Sciences Ab Isoelectric point markers
US8406860B2 (en) 2008-01-25 2013-03-26 Novadaq Technologies Inc. Method for evaluating blush in myocardial tissue
US20090214436A1 (en) 2008-02-18 2009-08-27 Washington University Dichromic fluorescent compounds
EP2100621A1 (de) 2008-03-10 2009-09-16 mivenion GmbH Polyether-Polyol-Dendron-Konjugate mit Effektormolekülen für biologisches Targeting
US10219742B2 (en) 2008-04-14 2019-03-05 Novadaq Technologies ULC Locating and analyzing perforator flaps for plastic and reconstructive surgery
ES2671710T3 (es) 2008-05-02 2018-06-08 Novadaq Technologies ULC Métodos para la producción y uso de eritrocitos cargados con sustancias para la observación y el tratamiento de la hemodinámica microvascular
US9433700B2 (en) 2009-04-27 2016-09-06 Medibeacon Inc. Tissue sealant compositions, vascular closure devices, and uses thereof
US10492671B2 (en) 2009-05-08 2019-12-03 Novadaq Technologies ULC Near infra red fluorescence imaging for visualization of blood vessels during endoscopic harvest
CN102573925B (zh) 2009-10-05 2015-08-05 佳能株式会社 光声成像用造影剂和使用所述光声成像用造影剂的光声成像方法
WO2012054749A1 (en) 2010-10-20 2012-04-26 Li-Cor, Inc. Cyanine dyes and their conjugates
EP2686385B1 (de) 2011-03-15 2019-01-16 Ramot at Tel Aviv University, Ltd. Aktivierbare fluorogene verbindungen und ihre verwendung als nahinfrarotsonden
ES2627026T3 (es) * 2011-09-05 2017-07-26 Hiroshi Maeda Sonda molecular fluorescente de tipo polímero
EP3553075A1 (de) 2012-01-23 2019-10-16 Washington University Brillenbildgebungssysteme und -verfahren
US10278585B2 (en) 2012-06-21 2019-05-07 Novadaq Technologies ULC Quantification and analysis of angiography and perfusion
EP2912464B1 (de) * 2012-10-24 2017-04-26 Becton Dickinson and Company Hydroxamatsubstituierte azaindolincyanin-farbstoffe und biokonjugate daraus
KR101440109B1 (ko) 2013-01-29 2014-09-12 부경대학교 산학협력단 위장관암의 림프절 전이 검출용 광음향 단층촬영 시스템
WO2016049756A1 (en) 2014-09-29 2016-04-07 Novadaq Technologies Inc. Imaging a target fluorophore in a biological material in the presence of autofluorescence
CN107427247B (zh) 2014-10-09 2021-06-04 史赛克欧洲运营有限公司 使用荧光介导的光电容积描记法的组织中的绝对血液流动的定量
US10806804B2 (en) * 2015-05-06 2020-10-20 Washington University Compounds having RD targeting motifs and methods of use thereof
WO2018145193A1 (en) 2017-02-10 2018-08-16 Novadaq Technologies ULC Open-field handheld fluorescence imaging systems and methods
EP4072598A4 (de) 2019-12-13 2024-02-21 Washington University St Louis Nahinfrarot-fluoreszierende farbstoffe, formulierungen und zugehörige verfahren
WO2023227601A1 (en) 2022-05-23 2023-11-30 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Near-infrared fluorescent heptamethine dye conjugates with favorable bleaching properties

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5745457A (en) * 1980-09-02 1982-03-15 Fuji Photo Film Co Ltd Microimmunological measuring method
JP3147992B2 (ja) * 1992-05-29 2001-03-19 イビデン株式会社 免疫測定用標識試薬
JP3354975B2 (ja) * 1992-10-06 2002-12-09 イビデン株式会社 蛍光標識試薬および蛍光免疫測定法
US5453505A (en) 1994-06-30 1995-09-26 Biometric Imaging, Inc. N-heteroaromatic ion and iminium ion substituted cyanine dyes for use as fluorescence labels
DE4445065A1 (de) 1994-12-07 1996-06-13 Diagnostikforschung Inst Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung
US5962424A (en) * 1995-02-21 1999-10-05 Arch Development Corporation Methods and compositions for targeting selectins
DE19602295C2 (de) * 1996-01-23 2003-08-14 Deutsches Krebsforsch Verwendung eines Konjugats aus einer zur Fluoreszenz-fähigen Verbindung, Cyanurchlorid oder einem Derivat davon als Linker und einem Protein
WO1997033620A2 (de) * 1996-03-15 1997-09-18 Pulsion Verw. Gmbh & Co. Medical Systems Kg Verbindungen zur behandlung von tumoren
DE19649971A1 (de) 1996-11-19 1998-05-28 Diagnostikforschung Inst Optische Diagnostika zur Diagnostik neurodegenerativer Krankheiten mittels Nahinfrarot-Strahlung (NIR-Strahlung)
AU7221398A (en) 1997-04-29 1998-11-24 Nycomed Imaging As Method of demarcating tissue
EP0979107A1 (de) 1997-04-29 2000-02-16 Nycomed Imaging As Lichtbilderzeugungskontrastmitteln
AU766290B2 (en) * 1998-04-03 2003-10-16 Mallinckrodt, Inc. Non-covalent bioconjugates useful for diagnosis and therapy
AU2412800A (en) * 1999-01-15 2000-08-01 Light Sciences Corporation Noninvasive vascular therapy
WO2000041725A2 (en) * 1999-01-15 2000-07-20 Light Sciences Corporation Therapeutic compositions for metabolic bone disorders or bone metastases
US6602274B1 (en) * 1999-01-15 2003-08-05 Light Sciences Corporation Targeted transcutaneous cancer therapy

Also Published As

Publication number Publication date
ATE435662T1 (de) 2009-07-15
AU4488800A (en) 2000-12-12
ES2329542T3 (es) 2009-11-27
WO2000071162A2 (en) 2000-11-30
EP1178830B1 (de) 2009-07-08
CA2373475A1 (en) 2000-11-30
US6217848B1 (en) 2001-04-17
JP2003500367A (ja) 2003-01-07
EP2058007A3 (de) 2009-05-27
EP2058007A2 (de) 2009-05-13
WO2000071162A3 (en) 2001-07-05
DK1178830T3 (da) 2009-10-12
PT1178830E (pt) 2009-09-02
EP1178830A2 (de) 2002-02-13
CA2373475C (en) 2012-10-23

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