DE60104686D1 - Applikator mit auf einer schleiffende oberfläche überzogene substanz zum auftragen auf haut - Google Patents
Applikator mit auf einer schleiffende oberfläche überzogene substanz zum auftragen auf hautInfo
- Publication number
- DE60104686D1 DE60104686D1 DE60104686T DE60104686T DE60104686D1 DE 60104686 D1 DE60104686 D1 DE 60104686D1 DE 60104686 T DE60104686 T DE 60104686T DE 60104686 T DE60104686 T DE 60104686T DE 60104686 D1 DE60104686 D1 DE 60104686D1
- Authority
- DE
- Germany
- Prior art keywords
- skin
- application
- applicator
- grinding surface
- delivery
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
- A61B17/205—Vaccinating by means of needles or other puncturing devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0061—Methods for using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/576,643 US6595947B1 (en) | 2000-05-22 | 2000-05-22 | Topical delivery of vaccines |
US576643 | 2000-05-22 | ||
PCT/US2001/016121 WO2001089622A1 (en) | 2000-05-22 | 2001-05-18 | Applicator having abrading surface coated with substance to be applied to skin |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60104686D1 true DE60104686D1 (de) | 2004-09-09 |
DE60104686T2 DE60104686T2 (de) | 2005-08-11 |
Family
ID=24305324
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60104686T Expired - Lifetime DE60104686T2 (de) | 2000-05-22 | 2001-05-18 | Applikator mit auf einer schleiffende oberfläche überzogene substanz zum auftragen auf haut |
Country Status (12)
Country | Link |
---|---|
US (3) | US6595947B1 (de) |
EP (1) | EP1289599B1 (de) |
JP (1) | JP4801309B2 (de) |
CN (1) | CN100394995C (de) |
AT (1) | ATE272423T1 (de) |
AU (2) | AU6175701A (de) |
BR (1) | BR0111345B1 (de) |
CA (1) | CA2410561C (de) |
DE (1) | DE60104686T2 (de) |
ES (1) | ES2222376T3 (de) |
MX (1) | MXPA02011557A (de) |
WO (1) | WO2001089622A1 (de) |
Families Citing this family (76)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002064193A2 (en) * | 2000-12-14 | 2002-08-22 | Georgia Tech Research Corporation | Microneedle devices and production thereof |
US6743215B2 (en) * | 2001-04-06 | 2004-06-01 | Mattioli Engineering Ltd. | Method and apparatus for skin absorption enhancement and cellulite reduction |
AU2002367977B2 (en) * | 2001-08-13 | 2008-06-19 | University Of Rochester | Transcutaneous immunization against papillomavirus with papillomavirus virus-like particles |
FR2828648A1 (fr) * | 2001-08-16 | 2003-02-21 | Adam Bouaziz | Constitution d'un vaccin extractible a partir d'un insert immunogene. |
US20040120964A1 (en) * | 2001-10-29 | 2004-06-24 | Mikszta John A. | Needleless vaccination using chimeric yellow fever vaccine-vectored vaccines against heterologous flaviviruses |
US6908453B2 (en) * | 2002-01-15 | 2005-06-21 | 3M Innovative Properties Company | Microneedle devices and methods of manufacture |
AU2003251831B2 (en) | 2002-07-19 | 2009-06-11 | 3M Innovative Properties Company | Microneedle devices and microneedle delivery apparatus |
TW200409657A (en) * | 2002-08-08 | 2004-06-16 | Alza Corp | Transdermal vaccine delivery device having coated microprotrusions |
US7166086B2 (en) * | 2002-08-29 | 2007-01-23 | Becton, Dickinson And Company | Substance delivery via a rotating microabrading surface |
WO2004024211A2 (en) * | 2002-09-12 | 2004-03-25 | Children's Hospital Medical Center | Method and device for painless injection of medication |
US20070154494A1 (en) * | 2003-02-13 | 2007-07-05 | Becton Dickinson And Company | Anthrax vaccines and delivery methods |
US8961477B2 (en) * | 2003-08-25 | 2015-02-24 | 3M Innovative Properties Company | Delivery of immune response modifier compounds |
US20050095283A1 (en) * | 2003-09-16 | 2005-05-05 | Aphios Corporation | Compositions and methods for topically treating diseases |
BRPI0416132A (pt) * | 2003-10-31 | 2007-01-02 | Alza Corp | sistema e método para liberação de vacina transdérmica |
CA2552385C (en) * | 2003-12-29 | 2013-07-23 | 3M Innovative Properties Company | Medical devices and kits including same |
US7896841B2 (en) * | 2004-02-17 | 2011-03-01 | Children's Hospital Medical Center | Injection device for administering a vaccine |
WO2005082596A1 (en) * | 2004-02-23 | 2005-09-09 | 3M Innovative Properties Company | Method of molding for microneedle arrays |
CA2562932A1 (en) * | 2004-04-01 | 2005-10-27 | Alza Corporation | Apparatus and method for transdermal delivery of influenza vaccine |
MXPA06011971A (es) * | 2004-04-13 | 2007-04-16 | Johnson & Johnson | Aparato y metodo para suministro transdermico de multiples vacunas. |
ES2650188T3 (es) * | 2004-06-10 | 2018-01-17 | 3M Innovative Properties Company | Dispositivo y kit de aplicación de parches |
US20070292445A1 (en) * | 2004-07-06 | 2007-12-20 | Transpharma Medical Ltd. | Delivery system for transdermal immunization |
US7316665B2 (en) * | 2004-08-25 | 2008-01-08 | Becton, Dickinson And Company | Method and device for the delivery of a substance including a covering |
AU2005306426B2 (en) * | 2004-11-18 | 2011-04-28 | 3M Innovative Properties Company | Masking method for coating a microneedle array |
JP5015787B2 (ja) | 2004-11-18 | 2012-08-29 | スリーエム イノベイティブ プロパティズ カンパニー | マイクロニードルアレイの接触コーティング法 |
US8057842B2 (en) | 2004-11-18 | 2011-11-15 | 3M Innovative Properties Company | Method of contact coating a microneedle array |
WO2006055802A1 (en) | 2004-11-18 | 2006-05-26 | 3M Innovative Properties Company | Microneedle array applicator and retainer |
WO2006055795A1 (en) | 2004-11-18 | 2006-05-26 | 3M Innovative Properties Company | Low-profile microneedle array applicator |
WO2006062974A2 (en) | 2004-12-07 | 2006-06-15 | 3M Innovative Properties Company | Method of molding a microneedle |
WO2006108185A1 (en) | 2005-04-07 | 2006-10-12 | 3M Innovative Properties Company | System and method for tool feedback sensing |
US20060253079A1 (en) * | 2005-04-25 | 2006-11-09 | Mcdonough Justin | Stratum corneum piercing device |
US20070270738A1 (en) * | 2005-04-25 | 2007-11-22 | Wu Jeffrey M | Method of treating ACNE with stratum corneum piercing patch |
US20080009802A1 (en) * | 2005-04-25 | 2008-01-10 | Danilo Lambino | Method of treating acne with stratum corneum piercing device |
WO2007002523A2 (en) | 2005-06-24 | 2007-01-04 | 3M Innovative Properties Company | Collapsible patch with microneedle array |
AU2006261898B2 (en) * | 2005-06-27 | 2011-11-03 | 3M Innovative Properties Company | Microneedle array applicator device |
EP1896115B2 (de) * | 2005-06-27 | 2020-01-22 | 3M Innovative Properties Company | Mikronadelkartuschenanordnung |
US20070009542A1 (en) * | 2005-07-05 | 2007-01-11 | Galit Levin | Method and device for transdermal immunization |
CN101912288A (zh) * | 2005-09-02 | 2010-12-15 | 因特赛尔美国公司 | 经皮递送疫苗和透皮递送药物的装置及其应用 |
WO2007061781A1 (en) * | 2005-11-18 | 2007-05-31 | 3M Innovative Properties Company | Coatable compositions, coatings derived therefrom and microarrays having such coatings |
US20080262416A1 (en) * | 2005-11-18 | 2008-10-23 | Duan Daniel C | Microneedle Arrays and Methods of Preparing Same |
EP1962942A1 (de) * | 2005-12-21 | 2008-09-03 | 3M Innovative Properties Company | Mikronadelvorrichtungen |
US9339641B2 (en) | 2006-01-17 | 2016-05-17 | Emkinetics, Inc. | Method and apparatus for transdermal stimulation over the palmar and plantar surfaces |
US9610459B2 (en) | 2009-07-24 | 2017-04-04 | Emkinetics, Inc. | Cooling systems and methods for conductive coils |
WO2007124411A1 (en) * | 2006-04-20 | 2007-11-01 | 3M Innovative Properties Company | Device for applying a microneedle array |
US11224742B2 (en) | 2006-10-02 | 2022-01-18 | Emkinetics, Inc. | Methods and devices for performing electrical stimulation to treat various conditions |
WO2008042902A2 (en) | 2006-10-02 | 2008-04-10 | Emkinetics, Inc. | Method and apparatus for magnetic induction therapy |
US10786669B2 (en) | 2006-10-02 | 2020-09-29 | Emkinetics, Inc. | Method and apparatus for transdermal stimulation over the palmar and plantar surfaces |
US9005102B2 (en) | 2006-10-02 | 2015-04-14 | Emkinetics, Inc. | Method and apparatus for electrical stimulation therapy |
US20090054333A1 (en) * | 2006-10-17 | 2009-02-26 | Antonio Giordano | Peptide inhibitors of cyclin-dependent kinase activity and uses thereof |
US20080214987A1 (en) * | 2006-12-22 | 2008-09-04 | Nanomed Devices, Inc. | Microdevice And Method For Transdermal Delivery And Sampling Of Active Substances |
KR20100105829A (ko) | 2007-07-17 | 2010-09-30 | 히스톨로직스 엘엘씨 | 마찰성 경-상피 조직의 분리 및 수집 장치 및 면역 반응을 유도 및/또는 증강시키는 방법 |
US8795197B2 (en) * | 2007-07-17 | 2014-08-05 | Histologics, LLC | Frictional trans-epithelial tissue disruption collection apparatus and method of inducing an immune response |
EP2200666B1 (de) * | 2007-10-09 | 2014-12-03 | Syneron Medical Ltd. | Magnetische pflasterkopplung |
AU2008332738B2 (en) | 2007-12-05 | 2013-08-15 | Syneron Medical Ltd. | A disposable electromagnetic energy applicator and method of using it |
CN101938951B (zh) | 2008-01-17 | 2013-06-12 | 赛诺龙医疗公司 | 用于个人使用的毛发去除装置及使用该装置的方法 |
WO2009093230A2 (en) | 2008-01-24 | 2009-07-30 | Syneron Medical Ltd. | A device, apparatus, and method of adipose tissue treatment |
MX2011002987A (es) | 2008-09-21 | 2011-07-20 | Syneron Medical Ltd | Un metodo y aparato para el tratamiento personal de la piel. |
US8691502B2 (en) | 2008-10-31 | 2014-04-08 | Tremrx, Inc. | T-cell vaccination with viral vectors via mechanical epidermal disruption |
US8606366B2 (en) | 2009-02-18 | 2013-12-10 | Syneron Medical Ltd. | Skin treatment apparatus for personal use and method for using same |
US8834423B2 (en) | 2009-10-23 | 2014-09-16 | University of Pittsburgh—of the Commonwealth System of Higher Education | Dissolvable microneedle arrays for transdermal delivery to human skin |
AU2010313487A1 (en) | 2009-10-26 | 2012-05-24 | Emkinetics, Inc. | Method and apparatus for electromagnetic stimulation of nerve, muscle, and body tissues |
US9044213B1 (en) | 2010-03-26 | 2015-06-02 | Histologics, LLC | Frictional tissue sampling and collection method and device |
GB201007207D0 (en) | 2010-04-29 | 2010-06-16 | Univ Cork | Method |
US8588884B2 (en) | 2010-05-28 | 2013-11-19 | Emkinetics, Inc. | Microneedle electrode |
MX370579B (es) | 2012-05-01 | 2019-12-17 | Univ Pittsburgh Commonwealth Sys Higher Education | Arreglos de microagujas cargadas en la punta para insercion transdermica. |
US10201332B1 (en) | 2012-12-03 | 2019-02-12 | Healoe Llc | Device and method of orienting a biopsy device on epithelial tissue |
US20140297784A1 (en) * | 2013-03-29 | 2014-10-02 | Lucy Ma Zhao | Cross Platform Application Transactions |
KR20220100078A (ko) * | 2014-01-31 | 2022-07-14 | 팩터 바이오사이언스 인크. | 핵산 제조 및 송달을 위한 방법 및 산물 |
US11241505B2 (en) | 2015-02-13 | 2022-02-08 | Factor Bioscience Inc. | Nucleic acid products and methods of administration thereof |
US10441768B2 (en) | 2015-03-18 | 2019-10-15 | University of Pittsburgh—of the Commonwealth System of Higher Education | Bioactive components conjugated to substrates of microneedle arrays |
US11684763B2 (en) | 2015-10-16 | 2023-06-27 | University of Pittsburgh—of the Commonwealth System of Higher Education | Multi-component bio-active drug delivery and controlled release to the skin by microneedle array devices |
WO2017120322A1 (en) | 2016-01-05 | 2017-07-13 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Skin microenvironment targeted delivery for promoting immune and other responses |
US11013466B2 (en) | 2016-01-28 | 2021-05-25 | Healoe, Llc | Device and method to control and manipulate a catheter |
CA3033788A1 (en) | 2016-08-17 | 2018-02-22 | Factor Bioscience Inc. | Nucleic acid products and methods of administration thereof |
IL269610B2 (en) | 2017-03-27 | 2023-11-01 | Novoxel Ltd | System, device and method for delivering intradermal solution |
DE102017126501A1 (de) | 2017-11-10 | 2019-05-16 | Lts Lohmann Therapie-Systeme Ag | Mikronadelsystem zur Applikation eines Hepatitis-Impfstoffes |
US10501404B1 (en) | 2019-07-30 | 2019-12-10 | Factor Bioscience Inc. | Cationic lipids and transfection methods |
Family Cites Families (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3289670A (en) * | 1964-03-09 | 1966-12-06 | Milo Bundy Corp | Device for abrading and applying biologicals to the skin of a patient |
US3351059A (en) * | 1964-06-02 | 1967-11-07 | Norman Lettvin | Single stable dose vaccinator |
US3556080A (en) * | 1968-04-08 | 1971-01-19 | Lincoln Lab Inc | Skin allergy testing device |
US3964482A (en) | 1971-05-17 | 1976-06-22 | Alza Corporation | Drug delivery device |
US4270548A (en) * | 1979-09-05 | 1981-06-02 | Aller-Screen, Inc. | Allergy testing method |
US4483348A (en) | 1982-03-25 | 1984-11-20 | Nathan Sher | Skin testing device |
GB2125280B (en) | 1982-08-18 | 1986-01-02 | Hyman Goldberg | Surgical scrubbing device |
US4568343A (en) * | 1984-10-09 | 1986-02-04 | Alza Corporation | Skin permeation enhancer compositions |
US4746515A (en) * | 1987-02-26 | 1988-05-24 | Alza Corporation | Skin permeation enhancer compositions using glycerol monolaurate |
AU614092B2 (en) | 1987-09-11 | 1991-08-22 | Paul Max Grinwald | Improved method and apparatus for enhanced drug permeation of skin |
CA2008262A1 (en) * | 1989-01-30 | 1990-07-30 | John A. Gilly | Clinical applicator |
EP0429842B1 (de) * | 1989-10-27 | 1996-08-28 | Korea Research Institute Of Chemical Technology | Vorrichtung zur transdermalen Applikation von Protein- oder Peptid-Medikamenten |
SU1724181A1 (ru) | 1990-03-22 | 1992-04-07 | Ивано-Франковский Государственный Медицинский Институт | Устройство дл камерно-скарификационного тестировани кожи |
TW279133B (de) * | 1990-12-13 | 1996-06-21 | Elan Med Tech | |
DE4117900A1 (de) | 1991-05-31 | 1992-12-03 | Spantec Werkzeugtechnik Gmbh | Walzenstirnfraeser |
US5620896A (en) * | 1992-03-23 | 1997-04-15 | University Of Massachusetts Medical Center | DNA vaccines against rotavirus infections |
US5273528A (en) * | 1992-07-10 | 1993-12-28 | Skeen Mikell L | Livestock inoculator |
DE4307869C2 (de) * | 1993-03-12 | 1996-04-04 | Microparts Gmbh | Mikrostrukturkörper und Verfahren zu deren Herstellung |
US5679647A (en) | 1993-08-26 | 1997-10-21 | The Regents Of The University Of California | Methods and devices for immunizing a host against tumor-associated antigens through administration of naked polynucleotides which encode tumor-associated antigenic peptides |
US5885211A (en) * | 1993-11-15 | 1999-03-23 | Spectrix, Inc. | Microporation of human skin for monitoring the concentration of an analyte |
US5380337A (en) * | 1994-01-24 | 1995-01-10 | Romaine; Richard A. | Mesh-type skin biopsy appliance |
US5660680A (en) | 1994-03-07 | 1997-08-26 | The Regents Of The University Of California | Method for fabrication of high vertical aspect ratio thin film structures |
FR2720003B1 (fr) * | 1994-05-23 | 1998-06-26 | Samsung Electro Mech | Dispositif servant à inciser la peau pour une médication transcutanée. |
CA2149836C (en) | 1994-05-23 | 1999-07-06 | Sang Bae Choi | Perforating device for dermal administration |
US5591139A (en) * | 1994-06-06 | 1997-01-07 | The Regents Of The University Of California | IC-processed microneedles |
WO1996007369A1 (en) | 1994-09-05 | 1996-03-14 | Cyanamid Websters Pty. Limited | Scratch vaccine applicator and/or method of applying a vaccine |
AU5740496A (en) | 1995-05-22 | 1996-12-11 | General Hospital Corporation, The | Micromechanical device and method for enhancing delivery of compounds through the skin |
WO1996037256A1 (en) * | 1995-05-22 | 1996-11-28 | Silicon Microdevices, Inc. | Micromechanical patch for enhancing the delivery of compounds through the skin |
JPH0910307A (ja) * | 1995-06-30 | 1997-01-14 | Pentel Kk | 注射器用ホルダ− |
US5958589A (en) | 1995-07-07 | 1999-09-28 | The United States Of America As Represented By The Secretary Of Agriculture | Starch-based microcellular foams |
DE19525607A1 (de) | 1995-07-14 | 1997-01-16 | Boehringer Ingelheim Kg | Transcorneales Arzneimittelfreigabesystem |
US5658515A (en) * | 1995-09-25 | 1997-08-19 | Lee; Abraham P. | Polymer micromold and fabrication process |
GB9520209D0 (en) | 1995-09-25 | 1995-12-06 | Cawley R | Skin cleaning apparatus |
US6032060A (en) * | 1996-01-25 | 2000-02-29 | 3M Innovative Properties Company | Method for conditioning skin and an electrode by passing electrical energy |
AUPN814496A0 (en) * | 1996-02-19 | 1996-03-14 | Monash University | Dermal penetration enhancer |
AU3399197A (en) | 1996-06-18 | 1998-01-07 | Alza Corporation | Device for enhancing transdermal agent delivery or sampling |
US5919364A (en) * | 1996-06-24 | 1999-07-06 | Regents Of The University Of California | Microfabricated filter and shell constructed with a permeable membrane |
DK0921840T3 (da) | 1996-07-03 | 2003-09-22 | Altea Therapeutics Corp | Multipel mekanisk mikroperforering af hud eller slimhinde |
EP0934093B1 (de) | 1996-09-17 | 2003-01-15 | Deka Products Limited Partnership | System zur medikamentenabgabe durch transport |
US5910306A (en) * | 1996-11-14 | 1999-06-08 | The United States Of America As Represented By The Secretary Of The Army | Transdermal delivery system for antigen |
US5980898A (en) | 1996-11-14 | 1999-11-09 | The United States Of America As Represented By The U.S. Army Medical Research & Material Command | Adjuvant for transcutaneous immunization |
EP1009520A4 (de) | 1997-01-24 | 2003-05-14 | Univ California | Gerät und verfahren zum planaren laminaren mischen |
US5928207A (en) | 1997-06-30 | 1999-07-27 | The Regents Of The University Of California | Microneedle with isotropically etched tip, and method of fabricating such a device |
US5931794A (en) | 1997-10-21 | 1999-08-03 | Pitesky; Isadore | Allergy testing apparatus |
IL122016A (en) * | 1997-10-22 | 2001-09-13 | Tav Tech Ltd | Apparatus for dermal abrasion |
WO1999029364A1 (en) * | 1997-12-11 | 1999-06-17 | Alza Corporation | Device for enhancing transdermal agent flux |
ATE365050T1 (de) | 1998-02-25 | 2007-07-15 | Us Gov Sec Army | Verwendung von hautpenetrationsförderern und für die zerstörung der oberen hautschichten geeigneten mitteln zur erhöhung der transkutanen immunantwort |
US5970998A (en) | 1998-02-27 | 1999-10-26 | The Regents Of The University Of California | Microfabricated cantilever ratchet valve, and method for using same |
US6173202B1 (en) | 1998-03-06 | 2001-01-09 | Spectrx, Inc. | Method and apparatus for enhancing flux rates of a fluid in a microporated biological tissue |
US6106751A (en) | 1998-03-18 | 2000-08-22 | The Regents Of The University Of California | Method for fabricating needles via conformal deposition in two-piece molds |
US6503231B1 (en) | 1998-06-10 | 2003-01-07 | Georgia Tech Research Corporation | Microneedle device for transport of molecules across tissue |
US6312612B1 (en) | 1999-06-09 | 2001-11-06 | The Procter & Gamble Company | Apparatus and method for manufacturing an intracutaneous microneedle array |
US6256533B1 (en) | 1999-06-09 | 2001-07-03 | The Procter & Gamble Company | Apparatus and method for using an intracutaneous microneedle array |
US6623457B1 (en) * | 1999-09-22 | 2003-09-23 | Becton, Dickinson And Company | Method and apparatus for the transdermal administration of a substance |
US6835184B1 (en) * | 1999-09-24 | 2004-12-28 | Becton, Dickinson And Company | Method and device for abrading skin |
US6331266B1 (en) * | 1999-09-29 | 2001-12-18 | Becton Dickinson And Company | Process of making a molded device |
US6494865B1 (en) * | 1999-10-14 | 2002-12-17 | Becton Dickinson And Company | Intradermal delivery device including a needle assembly |
WO2001041864A1 (en) * | 1999-12-10 | 2001-06-14 | Alza Corporation | Skin treatment apparatus for sustained transdermal drug delivery |
-
2000
- 2000-05-22 US US09/576,643 patent/US6595947B1/en not_active Expired - Lifetime
-
2001
- 2001-05-18 CA CA002410561A patent/CA2410561C/en not_active Expired - Lifetime
- 2001-05-18 AT AT01935686T patent/ATE272423T1/de not_active IP Right Cessation
- 2001-05-18 AU AU6175701A patent/AU6175701A/xx active Pending
- 2001-05-18 CN CNB018099157A patent/CN100394995C/zh not_active Expired - Fee Related
- 2001-05-18 MX MXPA02011557A patent/MXPA02011557A/es active IP Right Grant
- 2001-05-18 JP JP2001585860A patent/JP4801309B2/ja not_active Expired - Fee Related
- 2001-05-18 WO PCT/US2001/016121 patent/WO2001089622A1/en active IP Right Grant
- 2001-05-18 BR BRPI0111345-3A patent/BR0111345B1/pt not_active IP Right Cessation
- 2001-05-18 DE DE60104686T patent/DE60104686T2/de not_active Expired - Lifetime
- 2001-05-18 EP EP01935686A patent/EP1289599B1/de not_active Expired - Lifetime
- 2001-05-18 ES ES01935686T patent/ES2222376T3/es not_active Expired - Lifetime
- 2001-05-18 AU AU2001261757A patent/AU2001261757B2/en not_active Ceased
-
2003
- 2003-05-13 US US10/436,757 patent/US20030191085A1/en not_active Abandoned
-
2007
- 2007-09-07 US US11/851,956 patent/US7731968B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2410561A1 (en) | 2001-11-29 |
US6595947B1 (en) | 2003-07-22 |
AU6175701A (en) | 2001-12-03 |
ATE272423T1 (de) | 2004-08-15 |
BR0111345A (pt) | 2004-02-03 |
ES2222376T3 (es) | 2005-02-01 |
MXPA02011557A (es) | 2004-09-06 |
CN100394995C (zh) | 2008-06-18 |
JP4801309B2 (ja) | 2011-10-26 |
DE60104686T2 (de) | 2005-08-11 |
US7731968B2 (en) | 2010-06-08 |
WO2001089622A1 (en) | 2001-11-29 |
CA2410561C (en) | 2009-05-12 |
US20030191085A1 (en) | 2003-10-09 |
BR0111345B1 (pt) | 2010-10-05 |
EP1289599B1 (de) | 2004-08-04 |
US20080009785A1 (en) | 2008-01-10 |
EP1289599A1 (de) | 2003-03-12 |
CN1430526A (zh) | 2003-07-16 |
AU2001261757B2 (en) | 2004-04-01 |
JP2003534065A (ja) | 2003-11-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE60104686D1 (de) | Applikator mit auf einer schleiffende oberfläche überzogene substanz zum auftragen auf haut | |
EP1159441B8 (de) | Verabreichung von nukleinsäuren und proteinen an zellen | |
MX344216B (es) | Productos geneticos expresados de forma diferencial en tumores y su uso. | |
BR9808646A (pt) | Sequenciador de gene e processos | |
HUP0002095A2 (hu) | Vegyületek prosztatarák immunterápiás kezelésére és alkalmazásuk | |
WO2005046709A3 (en) | Tgf - beta binding and supported peptides | |
WO2003011898A3 (fr) | Peptides synthetiques ou naturels liant la proteine phosphatase 2a, methode d'identification et utilisations | |
WO2001048209A3 (en) | Genes identified as required for proliferation of e. coli | |
WO2020070678A3 (en) | Antibodies specific for human and cynomolgus apoc3 and methods of use thereof | |
ATE521702T1 (de) | Krebsantigene und deren nutzung | |
WO2005026205A3 (de) | Differentiell in tumoren exprimierte genprodukte und deren verwendung | |
AU2002368411A1 (en) | Method for immobilizing biologic molecules on solid surfaces | |
WO2004017992A3 (en) | Ptk7 protein involvement in carcinoma | |
DK0990703T3 (da) | Nyt polypeptid, DNA, som koder herfor, samt anvendelse heraf | |
WO2002026929A3 (en) | Kini-3 motor protein and methods for its use | |
WO2002000719A3 (en) | Human and mouse g-protein couipled receptors | |
FI962044A (fi) | DNA-sekvenssejä, jotka koodittavat sian haiman karboksipeptidaasi-B:tä | |
WO2004047758A3 (en) | Methods of therapy and diagnosis using targeting of cells that express p2y10 | |
WO2001096593A3 (en) | Novel motor proteins and methods for their use | |
AU2003302901A1 (en) | Human recombinant endooligopeptidase a (heopa) | |
NO20014691D0 (no) | Sete-spesifikke, isotop-merkede proteiner, aminosyrer samt biokjemiske prekursorer for slike | |
ATE528392T1 (de) | Neues protein und dessen dns | |
AU2003295435A1 (en) | Biological carriers for the delivery of proteins or peptides | |
WO2002079479A3 (en) | Motor proteins and methods for their use | |
EP1427825B8 (de) | Menschliche alpha2-delta4-calciumkanal-untereinheit codierende cdna |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |