DE60045217D1 - Iminocyclitol-inhibitoren von hexoaminidase und glycosidase - Google Patents
Iminocyclitol-inhibitoren von hexoaminidase und glycosidaseInfo
- Publication number
- DE60045217D1 DE60045217D1 DE60045217T DE60045217T DE60045217D1 DE 60045217 D1 DE60045217 D1 DE 60045217D1 DE 60045217 T DE60045217 T DE 60045217T DE 60045217 T DE60045217 T DE 60045217T DE 60045217 D1 DE60045217 D1 DE 60045217D1
- Authority
- DE
- Germany
- Prior art keywords
- iminocyclitol
- hexoaminidase
- glycosidase
- inhibitors
- hexoaminidases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000005744 Glycoside Hydrolases Human genes 0.000 title abstract 2
- 108010031186 Glycoside Hydrolases Proteins 0.000 title abstract 2
- NJOZFAFEQVQFJI-KVTDHHQDSA-N (2r,3r,4r,5r)-2-(aminomethyl)-5-(hydroxymethyl)pyrrolidine-3,4-diol Chemical compound NC[C@H]1N[C@H](CO)[C@@H](O)[C@@H]1O NJOZFAFEQVQFJI-KVTDHHQDSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13354999P | 1999-05-11 | 1999-05-11 | |
| PCT/US2000/013048 WO2000068194A1 (en) | 1999-05-11 | 2000-05-11 | Iminocyclitol inhibitors of hexoaminidase and glycosidase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60045217D1 true DE60045217D1 (de) | 2010-12-23 |
Family
ID=22459157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60045217T Expired - Lifetime DE60045217D1 (de) | 1999-05-11 | 2000-05-11 | Iminocyclitol-inhibitoren von hexoaminidase und glycosidase |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1181274B1 (enExample) |
| JP (1) | JP2002544191A (enExample) |
| AT (1) | ATE487697T1 (enExample) |
| AU (1) | AU779347B2 (enExample) |
| CA (1) | CA2373183C (enExample) |
| DE (1) | DE60045217D1 (enExample) |
| WO (1) | WO2000068194A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4363183B2 (ja) * | 2001-06-08 | 2009-11-11 | 三菱化学株式会社 | アザ糖化合物 |
| CA2553866A1 (en) * | 2004-01-20 | 2005-08-11 | Optimer Pharmaceuticals, Inc. | Treatment of degenerative cartilage conditions in a mammal with glycosi dase inhibitors |
| CA2661582C (en) | 2006-08-31 | 2015-09-29 | Simon Fraser University | Selective glycosidase inhibitors and uses thereof |
| LT2655388T (lt) | 2010-12-23 | 2016-11-10 | Alectos Therapeutics Inc. | Selektyvieji glikozidazės inhibitoriai ir jų panaudojimas |
| US9718854B2 (en) | 2011-03-31 | 2017-08-01 | Alectos Therapeutics Inc. | Selective glycosidase inhibitors and uses thereof |
| US9701693B2 (en) | 2011-06-27 | 2017-07-11 | Alectos Therapeutics Inc. | Selective glycosidase inhibitors and uses thereof |
| WO2014032188A1 (en) | 2012-08-31 | 2014-03-06 | Alectos Therapeutics Inc. | Glycosidase inhibitors and uses thereof |
| US9670195B2 (en) | 2012-08-31 | 2017-06-06 | Alectos Therapeutics Inc. | Glycosidase inhibitors and uses thereof |
| AU2013337570B2 (en) | 2012-10-31 | 2018-01-18 | Alectos Therapeutics Inc. | Glycosidase inhibitors and uses thereof |
| MX2016010365A (es) * | 2014-02-12 | 2016-11-30 | Amicus Therapeutics Inc | Derivados de azucares que comprenden restos que contienen azufre, metodos para prepararlos y metodos para emplearlos en el tratamiento de mps iiic. |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5250703A (en) * | 1992-09-29 | 1993-10-05 | Monsanto Company | Pyrrolidin-3,4-diol derivatives of heptitols and preparation thereof |
| US5451679A (en) * | 1994-03-08 | 1995-09-19 | G. D. Searle & Co. | 2-chloro and 2-bromo derivatives of 1,5-iminosugars |
-
2000
- 2000-05-11 AT AT00930662T patent/ATE487697T1/de not_active IP Right Cessation
- 2000-05-11 EP EP00930662A patent/EP1181274B1/en not_active Expired - Lifetime
- 2000-05-11 AU AU48444/00A patent/AU779347B2/en not_active Ceased
- 2000-05-11 DE DE60045217T patent/DE60045217D1/de not_active Expired - Lifetime
- 2000-05-11 JP JP2000617175A patent/JP2002544191A/ja active Pending
- 2000-05-11 CA CA002373183A patent/CA2373183C/en not_active Expired - Fee Related
- 2000-05-11 WO PCT/US2000/013048 patent/WO2000068194A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU4844400A (en) | 2000-11-21 |
| ATE487697T1 (de) | 2010-11-15 |
| JP2002544191A (ja) | 2002-12-24 |
| CA2373183A1 (en) | 2000-11-16 |
| EP1181274A1 (en) | 2002-02-27 |
| EP1181274A4 (en) | 2005-08-17 |
| EP1181274B1 (en) | 2010-11-10 |
| AU779347B2 (en) | 2005-01-20 |
| WO2000068194A1 (en) | 2000-11-16 |
| CA2373183C (en) | 2009-12-08 |
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