ATE487697T1 - Iminocyclitol-inhibitoren von hexoaminidase und glycosidase - Google Patents

Iminocyclitol-inhibitoren von hexoaminidase und glycosidase

Info

Publication number
ATE487697T1
ATE487697T1 AT00930662T AT00930662T ATE487697T1 AT E487697 T1 ATE487697 T1 AT E487697T1 AT 00930662 T AT00930662 T AT 00930662T AT 00930662 T AT00930662 T AT 00930662T AT E487697 T1 ATE487697 T1 AT E487697T1
Authority
AT
Austria
Prior art keywords
iminocyclitol
hexoaminidase
glycosidase
inhibitors
hexoaminidases
Prior art date
Application number
AT00930662T
Other languages
German (de)
English (en)
Inventor
Chi-Huey Wong
Jungie Liu
Original Assignee
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Inst filed Critical Scripps Research Inst
Application granted granted Critical
Publication of ATE487697T1 publication Critical patent/ATE487697T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT00930662T 1999-05-11 2000-05-11 Iminocyclitol-inhibitoren von hexoaminidase und glycosidase ATE487697T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13354999P 1999-05-11 1999-05-11
PCT/US2000/013048 WO2000068194A1 (en) 1999-05-11 2000-05-11 Iminocyclitol inhibitors of hexoaminidase and glycosidase

Publications (1)

Publication Number Publication Date
ATE487697T1 true ATE487697T1 (de) 2010-11-15

Family

ID=22459157

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00930662T ATE487697T1 (de) 1999-05-11 2000-05-11 Iminocyclitol-inhibitoren von hexoaminidase und glycosidase

Country Status (7)

Country Link
EP (1) EP1181274B1 (enExample)
JP (1) JP2002544191A (enExample)
AT (1) ATE487697T1 (enExample)
AU (1) AU779347B2 (enExample)
CA (1) CA2373183C (enExample)
DE (1) DE60045217D1 (enExample)
WO (1) WO2000068194A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003008379A1 (en) * 2001-06-08 2003-01-30 Mitsubishi Chemical Corporation Azasugar compounds
JP2007518814A (ja) * 2004-01-20 2007-07-12 ザ・スクリップス・リサーチ・インスティテュート グリコシダーゼ阻害剤によるほ乳類での変性軟骨症の治療
EP2057171A4 (en) 2006-08-31 2010-04-21 Univ Fraser Simon SELECTIVE GLYCOSIDASE INHIBITORS AND APPLICATIONS THEREOF
BR112013016179A2 (pt) 2010-12-23 2018-07-10 Alectos Therapeutics Inc inibidores seletivos da glicosidase e usos dos mesmos.
US9718854B2 (en) 2011-03-31 2017-08-01 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
WO2013000086A1 (en) 2011-06-27 2013-01-03 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
EP2890675A4 (en) * 2012-08-31 2016-01-13 Alectos Therapeutics Inc GLYCOSIDASE INHIBITORS AND USES THEREOF
EP2890676B1 (en) 2012-08-31 2018-12-05 Alectos Therapeutics Inc. Glycosidase inhibitors and uses thereof
EP2914604A4 (en) 2012-10-31 2016-07-20 Alectos Therapeutics Inc GLYCOSIDASE INHIBITORS AND USES THEREOF
CA2939380A1 (en) * 2014-02-12 2015-08-20 Amicus Therapeutics, Inc. Sugar derivatives comprising sulfur-containing moieties and methods of making same and methods of using the same for the treatment of mps iiic

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5250703A (en) * 1992-09-29 1993-10-05 Monsanto Company Pyrrolidin-3,4-diol derivatives of heptitols and preparation thereof
US5451679A (en) * 1994-03-08 1995-09-19 G. D. Searle & Co. 2-chloro and 2-bromo derivatives of 1,5-iminosugars

Also Published As

Publication number Publication date
CA2373183A1 (en) 2000-11-16
DE60045217D1 (de) 2010-12-23
CA2373183C (en) 2009-12-08
EP1181274B1 (en) 2010-11-10
JP2002544191A (ja) 2002-12-24
AU4844400A (en) 2000-11-21
EP1181274A4 (en) 2005-08-17
WO2000068194A1 (en) 2000-11-16
AU779347B2 (en) 2005-01-20
EP1181274A1 (en) 2002-02-27

Similar Documents

Publication Publication Date Title
DE60020100D1 (de) Dimerverbindungen und als inhibitoren der neuramidinase
DK1194425T3 (da) Substituerede benzimidazoler
BR9708735A (pt) Derivados de uréia como inibidores da enzina impdh
DE59709342D1 (de) Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten
DE59710411D1 (de) Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten
NO20014535D0 (no) Inhibitorer av IMPDH-enzym
EE200900039A (et) KinasoliiniÁderivaadidÁangiogeneesiÁinhibiitoritenaÁjaÁvahehendid
DE60030574D1 (de) Fünfgliedrige derivate von heterozyklen und ihre verwendung als monoaminoxidase-inhibitoren
UY26082A1 (es) Derivados de 1,4-diazabiciclo [3.2.2] nonan-4-carboxilato y -carboxamidas, su preparacion y su aplicacion en terapeutica
ES2106965T3 (es) Nuevas 4-aza-5alfa-androstan-3-onas 7beta-sustituidas como inhibidores de 5alfa-reductasa.
DE69940115D1 (de) Heterocyclische inhibitoren von p38
NZ335981A (en) Ketobenzamides as calpain inhibitors
ATE258437T1 (de) Chinolone und deren therapeutische verwendung
ATE405266T1 (de) Monozyklische oder bizyklische carbozyklen und heterozyklen als hemmer von factor xa
EE200000706A (et) Bitsüklilised pürimidiinid ja bitsüklilised 3,4-dihüdropürimidiinid kui rakkude proliferatsiooni inhibiitorid
FI942423A7 (fi) Sakkariinijohdannisia proteolyyttisen entsyymin inhibiittoreina
FI925787A7 (fi) Proeteolyyttisten entsyymien sakkariinijohdannaisinhibiittoreita
DE60045217D1 (de) Iminocyclitol-inhibitoren von hexoaminidase und glycosidase
ATE275400T1 (de) Verwendung von melatonin zur behandlung der androgenetischen und diffusen alopezie vom weiblichen typ
ATE258930T1 (de) Dihydrobenzifurane
FI925947A7 (fi) Uusia heterosyklisiä 2-sakkarinyylimetyylikarboksylaatteja, jotka ovatkäyttökelpoisia proteolyyttisten entsyymien inhibiittoreina, niitä sisältäviä koostumuksia ja niiden käyttö
ATE292109T1 (de) Substituierte benzamide als inhibitoren von rhinovirus 3c protease
ATE250074T1 (de) 2,3-o-isoproylidene derivativen von monosacchariden und verwendung als zell-adhäsion- inhibitoren
PT736009E (pt) N-oxidos de 4-arilpiperazinas e 4-arilpiperidinas como farmacos antipsicoticos
FI962236L (fi) Heterosykliset bentseenisulfonyyli-imiinijohdannaiset IL-1:n toiminnan inhibiittoreina

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties