DE60042896D1 - Zusammensetzungen und verfahren zur behandlung von amyloidosis mit sulphonatderivaten - Google Patents

Zusammensetzungen und verfahren zur behandlung von amyloidosis mit sulphonatderivaten

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Publication number
DE60042896D1
DE60042896D1 DE60042896T DE60042896T DE60042896D1 DE 60042896 D1 DE60042896 D1 DE 60042896D1 DE 60042896 T DE60042896 T DE 60042896T DE 60042896 T DE60042896 T DE 60042896T DE 60042896 D1 DE60042896 D1 DE 60042896D1
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DE
Germany
Prior art keywords
group
hydrogen atom
independently
therapeutic compound
amyloid aggregation
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Expired - Lifetime
Application number
DE60042896T
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German (de)
English (en)
Inventor
Heather Gordon
Walter Szarek
Donald Weaver
Xianqi Kong
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BHI LP
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Bellus Health International Ltd
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Publication of DE60042896D1 publication Critical patent/DE60042896D1/de
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
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