DE60041814D1 - Verafhren zum messen von physiologischen funktionen mit einem farbstoff wie fluorescein-polyacrylsäure - Google Patents

Verafhren zum messen von physiologischen funktionen mit einem farbstoff wie fluorescein-polyacrylsäure

Info

Publication number
DE60041814D1
DE60041814D1 DE60041814T DE60041814T DE60041814D1 DE 60041814 D1 DE60041814 D1 DE 60041814D1 DE 60041814 T DE60041814 T DE 60041814T DE 60041814 T DE60041814 T DE 60041814T DE 60041814 D1 DE60041814 D1 DE 60041814D1
Authority
DE
Germany
Prior art keywords
fluorescein
dye
polyacrylic acid
physiological functions
measuring physiological
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60041814T
Other languages
English (en)
Inventor
Richard Bradley Dorshow
Samuel Achilefu
Raghavan Rajagopalan
Joseph Edward Bugaj
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Application granted granted Critical
Publication of DE60041814D1 publication Critical patent/DE60041814D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A61K49/0034—Indocyanine green, i.e. ICG, cardiogreen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
    • A61K49/0043—Fluorescein, used in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0054—Macromolecular compounds, i.e. oligomers, polymers, dendrimers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE60041814T 1999-02-26 2000-01-20 Verafhren zum messen von physiologischen funktionen mit einem farbstoff wie fluorescein-polyacrylsäure Expired - Lifetime DE60041814D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/258,148 US6228344B1 (en) 1997-03-13 1999-02-26 Method of measuring physiological function
PCT/US2000/001322 WO2000050093A1 (en) 1999-02-26 2000-01-20 Method of measuring physiological function

Publications (1)

Publication Number Publication Date
DE60041814D1 true DE60041814D1 (de) 2009-04-30

Family

ID=22979287

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60041814T Expired - Lifetime DE60041814D1 (de) 1999-02-26 2000-01-20 Verafhren zum messen von physiologischen funktionen mit einem farbstoff wie fluorescein-polyacrylsäure

Country Status (8)

Country Link
US (1) US6228344B1 (de)
EP (3) EP1642597A3 (de)
JP (1) JP2002537363A (de)
AT (1) ATE425768T1 (de)
CA (1) CA2360421A1 (de)
DE (1) DE60041814D1 (de)
ES (1) ES2324198T3 (de)
WO (1) WO2000050093A1 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6669951B2 (en) 1999-08-24 2003-12-30 Cellgate, Inc. Compositions and methods for enhancing drug delivery across and into epithelial tissues
MXPA02001857A (es) * 1999-08-24 2003-07-14 Cellgate Inc Composiciones y metodos para incrementar la entrega de drogas a traves y dentro de tejidos epiteliales.
US7229961B2 (en) 1999-08-24 2007-06-12 Cellgate, Inc. Compositions and methods for enhancing drug delivery across and into ocular tissues
DE10028603C1 (de) * 2000-06-09 2001-12-13 Texas Instruments Deutschland Schaltungsanordnung zur Erzeugung eines Ausgangs-Phasensignals mit einer bezüglich einer Referenzphase beliebig veränderlichen Phasenverschiebung
US6656451B1 (en) * 2000-10-16 2003-12-02 Mallinckrodt, Inc. Indole compounds as novel dyes for organ function monitoring
US6733744B1 (en) * 2000-10-16 2004-05-11 Mallinckrodt Inc. Indole compounds as minimally invasive physiological function monitoring agents
US7556797B2 (en) * 2000-10-16 2009-07-07 Mallinckrodt Inc. Minimally invasive physiological function monitoring agents
US6716413B1 (en) * 2000-10-16 2004-04-06 Mallinckrodt, Inc. Indole compounds as tissue-specific exogenous optical agents
US6673334B1 (en) * 2000-10-16 2004-01-06 Mallinkcrodt, Inc. Light sensitive compounds for instant determination of organ function
US8337444B2 (en) * 2001-05-22 2012-12-25 Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern California Measurement of cardiac output and blood volume by non-invasive detection of indicator dilution for hemodialysis
US7474906B2 (en) * 2001-05-22 2009-01-06 Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern California Method for dye injection for the transcutaneous measurement of cardiac output
US6757554B2 (en) * 2001-05-22 2004-06-29 Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern California Measurement of cardiac output and blood volume by non-invasive detection of indicator dilution
US20080027298A1 (en) * 2001-05-22 2008-01-31 Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern Californ System for Repetitive Measurements of Cardiac Output in Freely Moving Individuals
US7226577B2 (en) 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
CN101203248A (zh) * 2005-06-21 2008-06-18 马林克罗特公司 光学成像造影剂
EP1981401A4 (de) 2006-01-20 2010-07-21 Alfred E Mann Inst Biomed Eng Messung von herzminutenvolumen und blutvolumen durch nichtinvasive erfassung von indikatorverdünnung
WO2007106142A2 (en) 2006-02-24 2007-09-20 Mallinckrodt Inc. Process for using optical agents
AU2007249226A1 (en) * 2006-05-12 2007-11-22 Board Of Regents, The University Of Texas System Imaging agents and methods
US20080249400A1 (en) * 2006-10-06 2008-10-09 University Of Rochester Medical Center Intraoperative Imaging Of Hepatobiliary Structures
WO2008063559A2 (en) * 2006-11-21 2008-05-29 Mallinckrodt Inc. Methods for using optical agents
DE102007007738A1 (de) * 2007-02-09 2008-08-14 Südzucker AG Mannheim/Ochsenfurt Farbmarkierte Oligo- oder Polysaccharide
US20100268090A1 (en) * 2007-11-06 2010-10-21 Rubinstein Eduardo H Measurement of hematocrit and cardiac output from optical transmission and reflection changes
EP2350206A2 (de) * 2008-09-29 2011-08-03 Mallinckrodt Inc. Dithienpyrrolfarbstoffe für bildgebung und therapie
EP2350205A2 (de) * 2008-09-29 2011-08-03 Mallinckrodt Inc. Dithienofuranfarbstoffe für bildgebung und therapie
WO2010037067A1 (en) * 2008-09-29 2010-04-01 Mallinckrodt Inc. Fused ring thiophene dyes for imaging and therapy
WO2010129258A2 (en) 2009-04-27 2010-11-11 Mallinckrodt Inc. Tissue sealant compositions, vascular closure devices, and uses thereof
WO2010132515A1 (en) 2009-05-12 2010-11-18 Mallinckrodt Inc. Compounds containing acyclic n-n bonds for phototherapy
US9186349B2 (en) 2009-05-12 2015-11-17 Mallinckrodt Llc Diaza heterocyclic compounds for phototherapy
EP2437772B1 (de) 2009-06-05 2017-12-06 13Therapeutics, Inc. Immunregulierende peptide und verwendungsverfahren dafür
WO2011031955A2 (en) 2009-09-11 2011-03-17 Mallinckrodt Inc. Optical monitoring of leukemia
WO2011060113A1 (en) 2009-11-11 2011-05-19 Mallinckrodt Inc. Sulfenamide compounds for phototherapy
WO2011084571A2 (en) 2009-12-16 2011-07-14 Mallinckrodt Inc. Azide derivatives for phototherapy
US8580748B2 (en) 2011-04-06 2013-11-12 13Therapeutics, Inc. Peptides for the treatment of hearing
TWI507674B (zh) * 2014-07-09 2015-11-11 Univ Nat Taiwan 以螢光物質檢測器官代謝功能之系統及方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL84356A (en) 1986-11-05 1991-08-16 Sumitomo Electric Industries Liver function testing apparatus
US4848349A (en) 1987-04-29 1989-07-18 Sherman Igor A Substance and method for measuring hepatic blood flow
KR910002651B1 (ko) 1987-11-13 1991-04-27 스미또모 덴끼 고교 가부시끼가이샤 간 기능 검사 장치
JPH01129838A (ja) 1987-11-13 1989-05-23 Sumitomo Electric Ind Ltd 肝機能検査装置
JPH02309929A (ja) 1989-05-24 1990-12-25 Sumitomo Electric Ind Ltd 肝機能検査装置
US5301673A (en) 1991-11-18 1994-04-12 Massachusetts General Hospital Ambulatory clearance function monitor
US5458128A (en) 1994-06-17 1995-10-17 Polanyi; Michael Method and apparatus for noninvasively measuring concentration of a dye in arterial blood
DE4445065A1 (de) 1994-12-07 1996-06-13 Diagnostikforschung Inst Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung
GB9517043D0 (en) 1995-08-19 1995-10-25 Univ Birmingham The use of bile acid derivatives
US5928625A (en) * 1997-03-13 1999-07-27 Mallinckrodt Inc. Method of measuring physiological function
EP1189645B1 (de) * 1998-04-03 2009-09-02 Mallinckrodt Inc. Nichtkovalente biokonjugate für diagnose und therapie

Also Published As

Publication number Publication date
EP1642597A2 (de) 2006-04-05
EP1854489A1 (de) 2007-11-14
WO2000050093A1 (en) 2000-08-31
JP2002537363A (ja) 2002-11-05
EP1154802A1 (de) 2001-11-21
EP1154802B1 (de) 2009-03-18
ATE425768T1 (de) 2009-04-15
EP1642597A3 (de) 2006-10-25
US6228344B1 (en) 2001-05-08
CA2360421A1 (en) 2000-08-31
ES2324198T3 (es) 2009-08-03

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