DE60031953D1 - Replizierbarer proben-array - Google Patents
Replizierbarer proben-arrayInfo
- Publication number
- DE60031953D1 DE60031953D1 DE60031953T DE60031953T DE60031953D1 DE 60031953 D1 DE60031953 D1 DE 60031953D1 DE 60031953 T DE60031953 T DE 60031953T DE 60031953 T DE60031953 T DE 60031953T DE 60031953 D1 DE60031953 D1 DE 60031953D1
- Authority
- DE
- Germany
- Prior art keywords
- array
- address
- ligand
- binding
- replicable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/005—Beads
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00527—Sheets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00585—Parallel processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00596—Solid-phase processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00623—Immobilisation or binding
- B01J2219/00626—Covalent
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00632—Introduction of reactive groups to the surface
- B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00646—Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports
- B01J2219/00648—Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports by the use of solid beads
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00659—Two-dimensional arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00722—Nucleotides
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
- Y10S436/809—Multifield plates or multicontainer arrays
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/84—Manufacture, treatment, or detection of nanostructure
- Y10S977/849—Manufacture, treatment, or detection of nanostructure with scanning probe
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Mechanical Treatment Of Semiconductor (AREA)
- Holo Graphy (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/240,466 US6514768B1 (en) | 1999-01-29 | 1999-01-29 | Replicable probe array |
PCT/US2000/001944 WO2000044939A1 (en) | 1999-01-29 | 2000-01-27 | Replicable probe array |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60031953D1 true DE60031953D1 (de) | 2007-01-04 |
Family
ID=22906652
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60031953T Expired - Lifetime DE60031953D1 (de) | 1999-01-29 | 2000-01-27 | Replizierbarer proben-array |
Country Status (9)
Country | Link |
---|---|
US (2) | US6514768B1 (de) |
EP (1) | EP1147222B1 (de) |
JP (1) | JP2002535013A (de) |
AT (1) | ATE346166T1 (de) |
AU (1) | AU776309B2 (de) |
CA (1) | CA2361163A1 (de) |
DE (1) | DE60031953D1 (de) |
MX (1) | MXPA01007638A (de) |
WO (1) | WO2000044939A1 (de) |
Families Citing this family (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6287850B1 (en) * | 1995-06-07 | 2001-09-11 | Affymetrix, Inc. | Bioarray chip reaction apparatus and its manufacture |
US6703228B1 (en) * | 1998-09-25 | 2004-03-09 | Massachusetts Institute Of Technology | Methods and products related to genotyping and DNA analysis |
US7510841B2 (en) * | 1998-12-28 | 2009-03-31 | Illumina, Inc. | Methods of making and using composite arrays for the detection of a plurality of target analytes |
US6514768B1 (en) * | 1999-01-29 | 2003-02-04 | Surmodics, Inc. | Replicable probe array |
US6958225B2 (en) | 1999-10-27 | 2005-10-25 | Affymetrix, Inc. | Complexity management of genomic DNA |
CA2389769A1 (en) * | 1999-11-02 | 2001-05-10 | Celine Hu | Molecular microarrays and methods for production and use thereof |
SE0002700D0 (sv) * | 2000-07-18 | 2000-07-18 | Karolinska Innovations Ab | Method of preparing nucleic acid microchips |
DE10035451C2 (de) * | 2000-07-19 | 2002-12-05 | November Ag Molekulare Medizin | Verfahren und Vorrichtung zur Identifizierung einer Polymersequenz |
CA2417903A1 (en) * | 2000-08-02 | 2002-02-07 | Surmodics, Inc. | Replicable probe array |
EP1202062B1 (de) * | 2000-10-31 | 2007-02-28 | Micronas GmbH | Gemusterte Polymeroberflächen geeignet für Biokonjugationen und Verfahren zu ihrer Herstellung |
US7297553B2 (en) * | 2002-05-28 | 2007-11-20 | Nanosphere, Inc. | Method for attachment of silylated molecules to glass surfaces |
AU2002322458A1 (en) * | 2001-07-13 | 2003-01-29 | Nanosphere, Inc. | Method for immobilizing molecules onto surfaces |
US6444318B1 (en) | 2001-07-17 | 2002-09-03 | Surmodics, Inc. | Self assembling monolayer compositions |
EP1461605A4 (de) * | 2001-10-02 | 2009-10-21 | Univ Northwestern | Protein- und peptid-nanoarrays |
US7348055B2 (en) | 2001-12-21 | 2008-03-25 | Surmodics, Inc. | Reagent and method for providing coatings on surfaces |
US7211382B2 (en) * | 2002-04-09 | 2007-05-01 | Orchid Cellmark Inc. | Primer extension using modified nucleotides |
US20030232379A1 (en) * | 2002-06-14 | 2003-12-18 | Amorese Douglas A. | Methods of performing array based assays and compositions for practicing the same |
WO2004031366A2 (en) * | 2002-10-02 | 2004-04-15 | New Light Industries, Ltd | Manufacturing method and readout system for biopolymer arrays |
US20040115336A1 (en) * | 2002-12-12 | 2004-06-17 | Industrial Technology Research Institute | Method of fabricating a grating-based optical biosensor |
CA2897376A1 (en) * | 2003-02-26 | 2004-09-10 | Radoje T. Drmanac | Modular system and probes for dna analysis |
US20090036327A1 (en) * | 2003-07-08 | 2009-02-05 | Trex Enterprises Corp. | Method for chemical treatment of porous silicon surface |
WO2005037338A1 (en) * | 2003-10-14 | 2005-04-28 | Cook Incorporated | Hydrophilic coated medical device |
US7862849B2 (en) * | 2003-10-17 | 2011-01-04 | Massachusetts Institute Of Technology | Nanocontact printing |
US20050119589A1 (en) * | 2003-11-14 | 2005-06-02 | Tung Hsiaoho E. | Rapid sample collection and analysis device and methods of use |
US20050136414A1 (en) * | 2003-12-23 | 2005-06-23 | Kevin Gunderson | Methods and compositions for making locus-specific arrays |
EP1763589A1 (de) * | 2004-06-30 | 2007-03-21 | RiNA Netzwerk RNA-Technologien GmbH | Biochip-pausen |
EP1623996A1 (de) * | 2004-08-06 | 2006-02-08 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Verbessertes Verfahren zur Auswahl eines Proteins von einer Bibliothek |
US7406391B2 (en) * | 2004-09-20 | 2008-07-29 | Affymetrix, Inc. | System, method, and computer product for detection instrument calibration |
JP2008514950A (ja) * | 2004-10-01 | 2008-05-08 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | サンプル中の素子のラベリングを検出するための方法及び装置 |
JP4954196B2 (ja) * | 2005-04-12 | 2012-06-13 | マサチューセッツ インスティテュート オブ テクノロジー | ナノコンタクト・プリント |
EP3257949A1 (de) | 2005-06-15 | 2017-12-20 | Complete Genomics Inc. | Nukleinsäureanalyse durch zufällige mischungen von nichtüberlappenden fragmenten |
US20090264299A1 (en) * | 2006-02-24 | 2009-10-22 | Complete Genomics, Inc. | High throughput genome sequencing on DNA arrays |
US8535616B2 (en) * | 2005-08-02 | 2013-09-17 | Moxtek, Inc. | Sub-wavelength metallic apertures as light enhancement devices |
US9012207B2 (en) * | 2005-08-02 | 2015-04-21 | University Of Utah Research Foundation | Biosensors including metallic nanocavities |
US7960104B2 (en) * | 2005-10-07 | 2011-06-14 | Callida Genomics, Inc. | Self-assembled single molecule arrays and uses thereof |
EP1957989B1 (de) * | 2005-11-30 | 2014-09-03 | Alere Switzerland GmbH | Vorrichtung zum nachweis des vorhandenseins oder der menge eines analyten in einer flüssigkeitsprobe und verfahren dazu |
US20070148677A1 (en) * | 2005-12-02 | 2007-06-28 | Chagovetz Alexander M | Methods and systems for acquiring real-time quantitative melt data |
US20070168197A1 (en) * | 2006-01-18 | 2007-07-19 | Nokia Corporation | Audio coding |
CA2643700A1 (en) * | 2006-02-24 | 2007-11-22 | Callida Genomics, Inc. | High throughput genome sequencing on dna arrays |
AU2007280929B2 (en) * | 2006-07-26 | 2012-03-22 | Abbott Rapid Diagnostics International Unlimited Company | Analysis device for biological sample |
US8927465B2 (en) | 2006-08-03 | 2015-01-06 | National University University of Singapore | Microarray system and a process for producing microarrays |
US7910302B2 (en) * | 2006-10-27 | 2011-03-22 | Complete Genomics, Inc. | Efficient arrays of amplified polynucleotides |
US20080221832A1 (en) * | 2006-11-09 | 2008-09-11 | Complete Genomics, Inc. | Methods for computing positional base probabilities using experminentals base value distributions |
WO2008070375A2 (en) | 2006-11-09 | 2008-06-12 | Complete Genomics, Inc. | Selection of dna adaptor orientation |
US20090042735A1 (en) * | 2007-03-05 | 2009-02-12 | Blair Steven M | Methods and Compositions Related to Nucleic Acid Detection |
JP2010537168A (ja) * | 2007-08-13 | 2010-12-02 | ユニバーシティ・オブ・ユタ・リサーチ・ファウンデイション | ハイスループット検出に適したマイクロアレイを製造する方法 |
US9388457B2 (en) | 2007-09-14 | 2016-07-12 | Affymetrix, Inc. | Locus specific amplification using array probes |
ITBO20070627A1 (it) * | 2007-09-14 | 2009-03-15 | Twof Inc | Metodo per la preparazione di dna microarray con sonde ad alta densita' lineare |
WO2009052214A2 (en) * | 2007-10-15 | 2009-04-23 | Complete Genomics, Inc. | Sequence analysis using decorated nucleic acids |
US20090263872A1 (en) * | 2008-01-23 | 2009-10-22 | Complete Genomics Inc. | Methods and compositions for preventing bias in amplification and sequencing reactions |
US8298768B2 (en) | 2007-11-29 | 2012-10-30 | Complete Genomics, Inc. | Efficient shotgun sequencing methods |
US8617811B2 (en) | 2008-01-28 | 2013-12-31 | Complete Genomics, Inc. | Methods and compositions for efficient base calling in sequencing reactions |
US8415099B2 (en) | 2007-11-05 | 2013-04-09 | Complete Genomics, Inc. | Efficient base determination in sequencing reactions |
US7897344B2 (en) * | 2007-11-06 | 2011-03-01 | Complete Genomics, Inc. | Methods and oligonucleotide designs for insertion of multiple adaptors into library constructs |
US8518640B2 (en) * | 2007-10-29 | 2013-08-27 | Complete Genomics, Inc. | Nucleic acid sequencing and process |
WO2009061840A1 (en) * | 2007-11-05 | 2009-05-14 | Complete Genomics, Inc. | Methods and oligonucleotide designs for insertion of multiple adaptors employing selective methylation |
US8592150B2 (en) | 2007-12-05 | 2013-11-26 | Complete Genomics, Inc. | Methods and compositions for long fragment read sequencing |
US9074244B2 (en) | 2008-03-11 | 2015-07-07 | Affymetrix, Inc. | Array-based translocation and rearrangement assays |
WO2009134612A2 (en) | 2008-04-11 | 2009-11-05 | University Of Utah Research Foundation | Methods and compositions related to quantitative array based methylation analysis |
WO2009132028A1 (en) * | 2008-04-21 | 2009-10-29 | Complete Genomics, Inc. | Array structures for nucleic acid detection |
US8568659B2 (en) * | 2008-09-11 | 2013-10-29 | Mabgen, Llc | Fiber optic device |
US8374818B2 (en) * | 2008-12-19 | 2013-02-12 | Affymetrix, Inc. | System, method and apparatus for calibrating inspection tools |
DE102009012169B3 (de) * | 2009-03-06 | 2010-11-04 | Albert-Ludwigs-Universität Freiburg | Vorrichtung und Verfahren zum Herstellen eines Replikats oder eines Derivats aus einem Array von Molekülen und Anwendungen derselben |
US9767342B2 (en) | 2009-05-22 | 2017-09-19 | Affymetrix, Inc. | Methods and devices for reading microarrays |
US9524369B2 (en) | 2009-06-15 | 2016-12-20 | Complete Genomics, Inc. | Processing and analysis of complex nucleic acid sequence data |
WO2011038158A2 (en) * | 2009-09-23 | 2011-03-31 | Life Technologies Corporation | Methods, compositions, systems and apparatus for molecular array fabrication |
CN102200536B (zh) | 2010-03-25 | 2015-05-27 | 艾博生物医药(杭州)有限公司 | 测试液体样本中被分析物的检测装置 |
CA2804861C (en) | 2010-07-09 | 2018-01-02 | The Governors Of The University Of Alberta | Solid gel amplification method and apparatus for genotyping and pathogen detection |
CA2809729C (en) * | 2010-08-30 | 2019-01-29 | The Governors Of The University Of Alberta | Setting of multiple priming oligonucleotides for solid gel amplification in hydrogels |
EP2718465B1 (de) * | 2011-06-09 | 2022-04-13 | Illumina, Inc. | Verfahren zur vorbereitung eines analyt-arrays |
JP2012029694A (ja) * | 2011-09-29 | 2012-02-16 | Massachusetts Inst Of Technology | ナノコンタクト・プリント |
DE102011054101A1 (de) | 2011-09-30 | 2013-04-04 | Albert-Ludwigs-Universität Freiburg | Verfahren zur räumlichen Anordnung von Probenfragmenten zur Amplifikation und Immobilisierung für weitere Derivatisierungen |
EP4155397A1 (de) * | 2016-02-10 | 2023-03-29 | The Regents of The University of Michigan | Nachweis von nukleinsäuren |
Family Cites Families (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5512329A (en) | 1982-09-29 | 1996-04-30 | Bsi Corporation | Substrate surface preparation |
US5002582A (en) | 1982-09-29 | 1991-03-26 | Bio-Metric Systems, Inc. | Preparation of polymeric surfaces via covalently attaching polymers |
US4722906A (en) | 1982-09-29 | 1988-02-02 | Bio-Metric Systems, Inc. | Binding reagents and methods |
US5217492A (en) | 1982-09-29 | 1993-06-08 | Bio-Metric Systems, Inc. | Biomolecule attachment to hydrophobic surfaces |
US4979959A (en) | 1986-10-17 | 1990-12-25 | Bio-Metric Systems, Inc. | Biocompatible coating for solid surfaces |
US5700637A (en) | 1988-05-03 | 1997-12-23 | Isis Innovation Limited | Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays |
US5744101A (en) | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
EP0562025B1 (de) | 1990-12-06 | 2001-02-07 | Affymetrix, Inc. (a Delaware Corporation) | Verbindungen und ihre Verwendung in einer binären Synthesestrategie |
US6017696A (en) | 1993-11-01 | 2000-01-25 | Nanogen, Inc. | Methods for electronic stringency control for molecular biological analysis and diagnostics |
ES2145044T3 (es) | 1992-02-13 | 2000-07-01 | Surmodics Inc | Inmovilizacion de especies quimicas en matrices reticuladas. |
DE69333650T2 (de) | 1992-02-19 | 2006-01-12 | The Public Health Research Institute Of The City Of New York, Inc. | Neue anordnungn von oligonukleotiden und ihr nutzen zum sortieren, isolieren, sequenzieren und manipulieren von nukleinsäuren |
US5795714A (en) | 1992-11-06 | 1998-08-18 | Trustees Of Boston University | Method for replicating an array of nucleic acid probes |
US5414075A (en) | 1992-11-06 | 1995-05-09 | Bsi Corporation | Restrained multifunctional reagent for surface modification |
US5837832A (en) | 1993-06-25 | 1998-11-17 | Affymetrix, Inc. | Arrays of nucleic acid probes on biological chips |
US5587293A (en) * | 1994-01-06 | 1996-12-24 | Terrapin Technologies, Inc. | Method to identify binding partners |
US5556752A (en) | 1994-10-24 | 1996-09-17 | Affymetrix, Inc. | Surface-bound, unimolecular, double-stranded DNA |
CA2222136C (en) | 1995-05-26 | 2005-04-05 | Bsi Corporation | Method and implantable article for promoting endothelialization |
US5783502A (en) | 1995-06-07 | 1998-07-21 | Bsi Corporation | Virus inactivating coatings |
AU6752496A (en) | 1995-07-28 | 1997-03-05 | Ely Michael Rabani | Pattern formation, replication, fabrication and devices thereby |
US5714360A (en) | 1995-11-03 | 1998-02-03 | Bsi Corporation | Photoactivatable water soluble cross-linking agents containing an onium group |
US5837196A (en) * | 1996-01-26 | 1998-11-17 | The Regents Of The University Of California | High density array fabrication and readout method for a fiber optic biosensor |
EP0920440B1 (de) * | 1996-02-09 | 2012-08-22 | Cornell Research Foundation, Inc. | Detektion von unterschieden in der sequenz von nukleinsäuren mittels der ligasedetektionsreaktion und adressierbaren anordnungen |
US5896917A (en) | 1996-02-22 | 1999-04-27 | Lemont Aircraft Corporation | Active heat sink structure with flow augmenting rings and method for removing heat |
US5942555A (en) | 1996-03-21 | 1999-08-24 | Surmodics, Inc. | Photoactivatable chain transfer agents and semi-telechelic photoactivatable polymers prepared therefrom |
WO1997046313A1 (en) | 1996-06-07 | 1997-12-11 | Eos Biotechnology, Inc. | Immobilised linear oligonucleotide arrays |
JP3377215B2 (ja) | 1996-09-06 | 2003-02-17 | インターナショナル・ビジネス・マシーンズ・コーポレーション | 化学的に定義されたボディを配向析出する方法 |
US6124092A (en) | 1996-10-04 | 2000-09-26 | The Perkin-Elmer Corporation | Multiplex polynucleotide capture methods and compositions |
US5900481A (en) | 1996-11-06 | 1999-05-04 | Sequenom, Inc. | Bead linkers for immobilizing nucleic acids to solid supports |
CA2267070A1 (en) | 1996-11-06 | 1998-05-14 | Sequenom, Inc. | Compositions and methods for immobilizing nucleic acids to solid supports |
US6121027A (en) * | 1997-08-15 | 2000-09-19 | Surmodics, Inc. | Polybifunctional reagent having a polymeric backbone and photoreactive moieties and bioactive groups |
JP2002529715A (ja) | 1998-11-06 | 2002-09-10 | ソレックサ リミテッド | 分子アレイを複製する方法 |
US20030148360A1 (en) * | 1999-01-29 | 2003-08-07 | Surmodics, Inc. | Replicable probe array |
US6514768B1 (en) * | 1999-01-29 | 2003-02-04 | Surmodics, Inc. | Replicable probe array |
-
1999
- 1999-01-29 US US09/240,466 patent/US6514768B1/en not_active Expired - Fee Related
-
2000
- 2000-01-27 WO PCT/US2000/001944 patent/WO2000044939A1/en active IP Right Grant
- 2000-01-27 DE DE60031953T patent/DE60031953D1/de not_active Expired - Lifetime
- 2000-01-27 MX MXPA01007638A patent/MXPA01007638A/es unknown
- 2000-01-27 CA CA002361163A patent/CA2361163A1/en not_active Abandoned
- 2000-01-27 EP EP00905741A patent/EP1147222B1/de not_active Expired - Lifetime
- 2000-01-27 AU AU27378/00A patent/AU776309B2/en not_active Ceased
- 2000-01-27 JP JP2000596179A patent/JP2002535013A/ja active Pending
- 2000-01-27 AT AT00905741T patent/ATE346166T1/de not_active IP Right Cessation
-
2003
- 2003-02-03 US US10/357,679 patent/US20030170914A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2000044939A1 (en) | 2000-08-03 |
AU2737800A (en) | 2000-08-18 |
ATE346166T1 (de) | 2006-12-15 |
US6514768B1 (en) | 2003-02-04 |
EP1147222B1 (de) | 2006-11-22 |
CA2361163A1 (en) | 2000-08-03 |
EP1147222A1 (de) | 2001-10-24 |
US20030170914A1 (en) | 2003-09-11 |
JP2002535013A (ja) | 2002-10-22 |
MXPA01007638A (es) | 2002-03-14 |
AU776309B2 (en) | 2004-09-02 |
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