DE60030429D1 - Neuronale, die exozytose hemmende peptide und diese enthaltende kosmetische und pharmazeutische zusammensetzungen - Google Patents
Neuronale, die exozytose hemmende peptide und diese enthaltende kosmetische und pharmazeutische zusammensetzungenInfo
- Publication number
- DE60030429D1 DE60030429D1 DE60030429T DE60030429T DE60030429D1 DE 60030429 D1 DE60030429 D1 DE 60030429D1 DE 60030429 T DE60030429 T DE 60030429T DE 60030429 T DE60030429 T DE 60030429T DE 60030429 D1 DE60030429 D1 DE 60030429D1
- Authority
- DE
- Germany
- Prior art keywords
- cosmetic
- pharmaceutical compositions
- exocytosis
- neuronals
- compositions containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 239000002537 cosmetic Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 102000004183 Synaptosomal-Associated Protein 25 Human genes 0.000 abstract 2
- 108010057722 Synaptosomal-Associated Protein 25 Proteins 0.000 abstract 2
- 230000028023 exocytosis Effects 0.000 abstract 2
- 230000001537 neural effect Effects 0.000 abstract 2
- 230000001575 pathological effect Effects 0.000 abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 230000004075 alteration Effects 0.000 abstract 1
- 235000001014 amino acid Nutrition 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 230000001815 facial effect Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 230000037303 wrinkles Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009900844A ES2160485B1 (es) | 1999-04-23 | 1999-04-23 | Peptidos inhibidores de la exocitosis neuronal, composiciones cosmeticas y farmaceuticas que los contienen. |
ES9900844 | 1999-04-23 | ||
PCT/ES2000/000058 WO2000064932A1 (es) | 1999-04-23 | 2000-02-18 | Peptitos inhibidores de la exocitosis neuronal, composiciones cosmeticas y farmaceuticas que los contienen |
EP00905076A EP1180524B2 (de) | 1999-04-23 | 2000-02-18 | Neuronale, die exozytose hemmende peptide und diese enthaltende kosmetische und pharmazeutische zusammensetzungen |
Publications (3)
Publication Number | Publication Date |
---|---|
DE60030429D1 true DE60030429D1 (de) | 2006-10-12 |
DE60030429T2 DE60030429T2 (de) | 2007-10-31 |
DE60030429T3 DE60030429T3 (de) | 2012-01-12 |
Family
ID=8308129
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60030429T Expired - Lifetime DE60030429T3 (de) | 1999-04-23 | 2000-02-18 | Neuronale, die exozytose hemmende peptide und diese enthaltende kosmetische und pharmazeutische zusammensetzungen |
Country Status (12)
Country | Link |
---|---|
US (2) | US7015192B1 (de) |
EP (1) | EP1180524B2 (de) |
JP (2) | JP4363556B2 (de) |
AT (1) | ATE338062T1 (de) |
AU (1) | AU2672900A (de) |
BR (2) | BRPI0011152B8 (de) |
CA (1) | CA2370289C (de) |
DE (1) | DE60030429T3 (de) |
DK (1) | DK1180524T4 (de) |
ES (1) | ES2160485B1 (de) |
PT (1) | PT1180524E (de) |
WO (1) | WO2000064932A1 (de) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2160485B1 (es) * | 1999-04-23 | 2002-05-16 | Lipotec Sa | Peptidos inhibidores de la exocitosis neuronal, composiciones cosmeticas y farmaceuticas que los contienen. |
US7807780B2 (en) | 2000-07-21 | 2010-10-05 | Revance Therapeutics, Inc. | Multi-component biological transport systems |
US7332567B2 (en) * | 2001-08-28 | 2008-02-19 | Allergan, Inc. | Fret protease assays for clostridial toxins |
FR2846885B1 (fr) * | 2002-11-13 | 2004-12-24 | Oreal | Utilisation d'une association de composants a effet synergique inhibiteur de canaux calciques pour prevenir ou traiter les ridules |
US7071167B2 (en) | 2002-11-13 | 2006-07-04 | L'oreal | Use of a combination of components with an inhibitory synergistic effect on calcium channels to prevent or treat wrinkles and fine lines |
JP2004323400A (ja) * | 2003-04-23 | 2004-11-18 | Mikimoto Pharmaceut Co Ltd | 皮膚外用剤 |
US9211248B2 (en) | 2004-03-03 | 2015-12-15 | Revance Therapeutics, Inc. | Compositions and methods for topical application and transdermal delivery of botulinum toxins |
AU2005251676B2 (en) | 2004-03-03 | 2011-09-29 | Revance Therapeutics, Inc. | Compositions and methods for topical diagnostic and therapeutic transport |
SG10201803560WA (en) | 2004-03-03 | 2018-06-28 | Revance Therapeutics Inc | Compositions And Methods For Topical Application And Transdermal Delivery Of Botulinum Toxins |
US20060073208A1 (en) | 2004-10-01 | 2006-04-06 | Allergan, Inc. | Cosmetic neurotoxin compositions and methods |
BRPI0517917B1 (pt) * | 2004-11-02 | 2020-11-10 | Dsm Ip Assets B.V. | compostos, sais de adição de ácido, método para preparar os compostos, uso de compostos, composição topicamente aplicável, e, método para o tratamento de rugas de expressão e/ou relacionadas com a idade em pele humana |
AU2006218431B2 (en) | 2005-03-03 | 2012-12-06 | Revance Therapeutics, Inc. | Compositions and methods for topical application and transdermal delivery of botulinum toxins |
EP1856139B1 (de) * | 2005-03-03 | 2011-04-27 | Revance Therapeutics, Inc. | Zusammensetzungen und methoden zur topischen anwendung und zur transdermalen verabreichung eines oligopeptids |
ES2259928B1 (es) * | 2005-04-08 | 2007-11-01 | Lipotec, S.A. | Composicion cosmetica o dermofarmaceutica que comprende peptidos derivados de encefalinas para reducir y/o eliminar arrugas faciales. |
BRPI0618753A2 (pt) | 2005-11-17 | 2011-09-13 | Revance Therapeutics Inc | composição para liberação transdérmica de toxina botulìnica e método de administração |
EP1976869A2 (de) * | 2005-12-23 | 2008-10-08 | Partnership&Corp. Technology Transfer | Synthetische peptide zur verwendung als inhibitoren der neurotransmittersekretion und als induktoren der muskelrelaxation |
ES2322882B1 (es) * | 2006-10-25 | 2010-04-22 | Lipotec Sa | Peptidos inhibidores de la exocitosis neuronal. |
EP1992332A1 (de) * | 2007-05-08 | 2008-11-19 | Tupperware Products S.A. | Kosmetische Anti-Aging-Hautpflegezusammensetzungen |
ES2356883B1 (es) * | 2008-07-24 | 2012-02-22 | Bcn Peptides, S.A. | Composición para el tratamiento del dolor y/o la inflamación. |
ES2527022T3 (es) | 2009-07-24 | 2015-01-19 | Lipotec, S.A. | Compuestos inhibidores de la contracción muscular |
US20130078295A1 (en) * | 2010-06-09 | 2013-03-28 | Lipotec S.A. | Skin antiaging treatment |
US20110305735A1 (en) * | 2010-06-09 | 2011-12-15 | Lipotec, S.A. | Skin antiaging treatment |
ES2385683B1 (es) * | 2010-10-18 | 2013-10-07 | Bcn Peptides, S.A. | Composiciones para el tratamiento del dolor y/o la inflamación. |
EP2802337B2 (de) * | 2011-11-07 | 2021-01-20 | Feng Tian | Peptidverbindungen als hemmer einer neurotransmittersekretion |
ES2424294B1 (es) | 2012-03-22 | 2014-07-21 | Lipotec, S.A. | Exopolisacárido para el tratamiento y/o cuidado de la piel, mucosas, cabello y/o uñas |
US10149812B2 (en) | 2012-04-13 | 2018-12-11 | Activen | Cosmetic composition comprising a muconopeptide |
EP2649983A1 (de) | 2012-04-13 | 2013-10-16 | Lipotec, S.A. | Verbindungen zur Hemmung neuronaler Exozytose (II) |
KR102113994B1 (ko) | 2012-04-13 | 2020-05-25 | 루브리졸 어드밴스드 머티어리얼스, 인코포레이티드 | 신경세포 세포외배출(ii)을 억제하는 화합물 |
EP2649984A1 (de) | 2012-04-13 | 2013-10-16 | Lipotec, S.A. | Verbindungen zur Hemmung neuronaler Exozytose |
EP2649985A1 (de) | 2012-04-13 | 2013-10-16 | Lipotec, S.A. | Verbindungen zur Hemmung neuronaler Exozytose (III) |
CN104334155B (zh) | 2012-04-13 | 2017-06-16 | 艾克迪文 | 包含μ芋螺肽的化妆品组合物 |
JP2016535770A (ja) | 2013-11-01 | 2016-11-17 | スフェリウム バイオメッド エス.エル. | 治療用及び美容用物質を経皮送達するための封入体 |
TWI728957B (zh) | 2014-10-31 | 2021-06-01 | 美商盧伯利索先進材料有限公司 | 用於傳送活性劑至皮膚表面的熱塑性聚胺基甲酸酯膜及其用途和形成方法 |
CN104478991B (zh) * | 2014-12-10 | 2018-06-19 | 深圳市维琪医药研发有限公司 | 一种新型多肽化合物及其制备方法和其医药应用 |
CN104829691B (zh) * | 2015-05-19 | 2018-11-02 | 山西锦波生物医药股份有限公司 | 除皱短肽及其制备方法 |
CN108473652A (zh) | 2015-11-05 | 2018-08-31 | 路博润先进材料公司 | 可热成型的双网络水凝胶组合物 |
JP7296642B2 (ja) | 2018-02-27 | 2023-06-23 | リポトゥルー,エセ.エレ. | 化粧料および医薬に使用するためのペプチドおよび組成物 |
EP3807293A1 (de) | 2018-06-13 | 2021-04-21 | Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A. | Peptide mit hemmender wirkung auf neuronale exozytose |
US20230190616A1 (en) | 2018-08-10 | 2023-06-22 | Lubrizol Advanced Materials, Inc. | Compounds useful for the treatment and/or care of the skin, hair, nails and/or mucous membranes |
MA53932A (fr) | 2018-10-16 | 2021-08-25 | Glo Pharma Inc | Compositions de conotoxine servant d'antagonistes peptidiques des récepteurs nicotiniques de l'acétylcholine et méthodes associées |
MX2020014330A (es) | 2018-12-26 | 2021-03-09 | Caregen Co Ltd | Composicion para relajacion muscular. |
EP4144337A1 (de) | 2021-09-02 | 2023-03-08 | Guangzhou Jiyan Cosmetics Technology Co. Ltd. | Kosmetische zusammensetzung aus vitis vinifera |
EP4230638A1 (de) | 2022-02-16 | 2023-08-23 | Lipotrue, S.L. | Peptide und zusammensetzungen zur verwendung in kosmetika |
WO2023161264A1 (en) | 2022-02-23 | 2023-08-31 | Prospera Biotech, S.L. | Compositions for treating hyperhidrosis |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997034620A1 (en) * | 1996-03-18 | 1997-09-25 | The Regents Of The University Of California | Peptide inhibitors of neurotransmitter secretion by neuronal cells |
ES2160485B1 (es) * | 1999-04-23 | 2002-05-16 | Lipotec Sa | Peptidos inhibidores de la exocitosis neuronal, composiciones cosmeticas y farmaceuticas que los contienen. |
-
1999
- 1999-04-23 ES ES009900844A patent/ES2160485B1/es not_active Expired - Fee Related
-
2000
- 2000-02-18 EP EP00905076A patent/EP1180524B2/de not_active Expired - Lifetime
- 2000-02-18 CA CA2370289A patent/CA2370289C/en not_active Expired - Lifetime
- 2000-02-18 AT AT00905076T patent/ATE338062T1/de active
- 2000-02-18 DK DK00905076.6T patent/DK1180524T4/da active
- 2000-02-18 BR BRPI0011152A patent/BRPI0011152B8/pt unknown
- 2000-02-18 US US10/030,485 patent/US7015192B1/en not_active Expired - Lifetime
- 2000-02-18 WO PCT/ES2000/000058 patent/WO2000064932A1/es active IP Right Grant
- 2000-02-18 BR BR0011152-0A patent/BR0011152A/pt not_active IP Right Cessation
- 2000-02-18 DE DE60030429T patent/DE60030429T3/de not_active Expired - Lifetime
- 2000-02-18 PT PT00905076T patent/PT1180524E/pt unknown
- 2000-02-18 AU AU26729/00A patent/AU2672900A/en not_active Abandoned
- 2000-02-18 JP JP2000614281A patent/JP4363556B2/ja not_active Expired - Lifetime
-
2006
- 2006-01-09 US US11/327,952 patent/US7473679B2/en not_active Expired - Fee Related
-
2009
- 2009-06-17 JP JP2009144480A patent/JP4892037B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US20060276392A1 (en) | 2006-12-07 |
ES2160485B1 (es) | 2002-05-16 |
CA2370289A1 (en) | 2000-11-02 |
DK1180524T3 (da) | 2006-12-11 |
JP2009221223A (ja) | 2009-10-01 |
CA2370289C (en) | 2011-04-19 |
WO2000064932A1 (es) | 2000-11-02 |
PT1180524E (pt) | 2007-01-31 |
JP2002542777A (ja) | 2002-12-17 |
DK1180524T4 (da) | 2010-10-25 |
EP1180524B2 (de) | 2010-07-07 |
US7473679B2 (en) | 2009-01-06 |
ATE338062T1 (de) | 2006-09-15 |
BRPI0011152B8 (pt) | 2022-05-10 |
BR0011152A (pt) | 2002-02-19 |
JP4892037B2 (ja) | 2012-03-07 |
JP4363556B2 (ja) | 2009-11-11 |
ES2160485A1 (es) | 2001-11-01 |
DE60030429T2 (de) | 2007-10-31 |
EP1180524B1 (de) | 2006-08-30 |
DE60030429T3 (de) | 2012-01-12 |
AU2672900A (en) | 2000-11-10 |
EP1180524A1 (de) | 2002-02-20 |
BRPI0011152B1 (pt) | 2018-03-13 |
US7015192B1 (en) | 2006-03-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE60030429D1 (de) | Neuronale, die exozytose hemmende peptide und diese enthaltende kosmetische und pharmazeutische zusammensetzungen | |
ES2176285T3 (es) | Amidas y esteres de peptidos inhibidoras del cancer de seres humanos. | |
ATE338771T1 (de) | Antagonisten des intestinotrophen glp-2 peptides | |
ATE280826T1 (de) | Cc-chemokinzeptor c-c ckr-5, dessen derivate und verwendungen | |
CY1106898T1 (el) | Χρηση d-σερινης ή d-αλανινης για την αντιμετωπιση της σχιζοφρενειας | |
YU46097A (sh) | Nova klasa estara i njihove farmaceutske smeše | |
LV10720A (lv) | Peptidi un farmaceitiska kompozicija uz to bazes | |
CY1109981T1 (el) | Αναλογα του gaba για την προληψη και αγωγη γαστρεντερικης βλαβης | |
DK0794961T3 (da) | LHRH-antagonistpeptider | |
FI962557A (fi) | PLA2-inhibiittoreiden käyttö Alzheimerin taudin hoidossa | |
TR200103469T2 (tr) | Amiloidojenik hastalığının önlenmesi ve tedavisi | |
DE69532996D1 (de) | Peptidanaloge des menschlichen basischen myelinproteins | |
ATE396205T1 (de) | Die verwendung von peptiden von il-2 und peptid- derivaten als therapeutische wirkstoffe | |
NO20001869L (no) | FremgangsmÕte for behandling av Alzheimers sykdom | |
DK2380583T3 (da) | Små peptider til behandling af Alzheimers sygdom og andre beta-amyloidprotein-fibrillogeneseforstyrrelser | |
WO2002074956A3 (en) | Dopaminergic neuronal survival-promoting factors and uses thereof | |
TR200000455T2 (tr) | Alzheimer hastalığının tedavisinde fankinonun kullanılması. | |
ATE3416T1 (de) | Pharmakologisch aktive peptide und diese enthaltende arzneimittel. | |
DE69503724D1 (de) | L-Carnitin-Salz, dieses enthaltende kosmetische und pharmazeutische Zusammensetzungen zur Behandlung von Dermatosen | |
ATE233812T1 (de) | Peptide mit pronociceptiveigenschaften | |
ATE345809T1 (de) | Arzneimittelzusammensetzung enthaltend tcf-ii | |
PT655244E (pt) | Composicao a base de acidos aminados para o tratamento de infeccoes | |
TR199501328A2 (tr) | Alzheimer peptidi. | |
ATE31418T1 (de) | Arzneimittel, welche tripeptide enthalten. | |
DE59108261D1 (de) | Peptide des HIV-gag Proteins, ihre Herstellung und Verwendung |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8327 | Change in the person/name/address of the patent owner |
Owner name: LIPOTEC, S.A., GAVA, BARCELONA, ES |
|
8363 | Opposition against the patent | ||
8366 | Restricted maintained after opposition proceedings | ||
8332 | No legal effect for de | ||
R074 | Re-establishment allowed |
Ref document number: 1180524 Country of ref document: EP |
|
R074 | Re-establishment allowed |
Ref document number: 1180524 Country of ref document: EP |