CY1106898T1 - Χρηση d-σερινης ή d-αλανινης για την αντιμετωπιση της σχιζοφρενειας - Google Patents

Χρηση d-σερινης ή d-αλανινης για την αντιμετωπιση της σχιζοφρενειας

Info

Publication number
CY1106898T1
CY1106898T1 CY20071101253T CY071101253T CY1106898T1 CY 1106898 T1 CY1106898 T1 CY 1106898T1 CY 20071101253 T CY20071101253 T CY 20071101253T CY 071101253 T CY071101253 T CY 071101253T CY 1106898 T1 CY1106898 T1 CY 1106898T1
Authority
CY
Cyprus
Prior art keywords
modified form
schizophrenia
alanine
serine
treatment
Prior art date
Application number
CY20071101253T
Other languages
English (en)
Inventor
Guochuan Tsai
Joseph Coyle
Original Assignee
The General Hospital Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The General Hospital Corporation filed Critical The General Hospital Corporation
Publication of CY1106898T1 publication Critical patent/CY1106898T1/el

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/315—Zinc compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Η εφεύρεση παρέχει μεθόδους για αντιμετώπιση νευροψυχιατρικών διαταραχών όπως σχιζοφρένεια, Νόσος του ΑΙzheimer, αυτισμός, κατάθλιψη, καλοήθης μνημονική διαταραχή, διαταραχές μάθησης στην παιδική ηλικία, κλειστή κρανιακή κάκωση, και διαταραχή ελλειμματικής προσοχής. Οι μέθοδοι συνεπάγονται τη χορήγηση σε έναν ασθενή διαγνωσμένο ότι έχει μια νευροψυχιατρική διαταραχή μιας φαρμακευτικής σύνθεσης η οποία περιέχει (i) μια θεραπευτικώς αποτελεσματική ποσότητα D-αλανίνης (ή μιας τροποποιημένης μορφής αυτής), εφόσον η σύνθεση είναι ουσιαστικά απαλλαγμένη από D-κυκλοσερίνη, και/ή (ii) D-σερίνης (ή μιας τροποποιημένης μορφής αυτής), και/ή (iii) 105 έως 500 mg D-κυκλοσερίνης (ή μιας τροποποιημένης μορφής αυτής), και/ή (iv) Ν-μεθυλογλυκίνης (ή μιας τροποποιημένης μορφής αυτής).
CY20071101253T 1998-04-14 2007-10-02 Χρηση d-σερινης ή d-αλανινης για την αντιμετωπιση της σχιζοφρενειας CY1106898T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8164598P 1998-04-14 1998-04-14
EP99917453A EP1073432B1 (en) 1998-04-14 1999-04-14 Use of d-serine or d-alanine for treating schizophrenia

Publications (1)

Publication Number Publication Date
CY1106898T1 true CY1106898T1 (el) 2012-09-26

Family

ID=22165468

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20071101253T CY1106898T1 (el) 1998-04-14 2007-10-02 Χρηση d-σερινης ή d-αλανινης για την αντιμετωπιση της σχιζοφρενειας

Country Status (17)

Country Link
US (5) US6228875B1 (el)
EP (3) EP2338482A3 (el)
JP (1) JP2002511409A (el)
AT (1) ATE369848T1 (el)
AU (1) AU765603C (el)
CA (2) CA2601132C (el)
CY (1) CY1106898T1 (el)
DE (2) DE1073432T1 (el)
DK (1) DK1073432T3 (el)
ES (1) ES2164040T3 (el)
HK (1) HK1036583A1 (el)
HU (1) HUP0101627A3 (el)
IL (1) IL139008A0 (el)
NZ (1) NZ508160A (el)
PT (1) PT1073432E (el)
RU (1) RU2219924C2 (el)
WO (1) WO1999052519A2 (el)

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JP2002511409A (ja) 2002-04-16
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CA2328197A1 (en) 1999-10-21
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CA2601132C (en) 2011-11-08
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