DE60030266T2 - Pyrrolidincarbonylamin-enthaltende cyclische peptid-disulfide als antagonisten von vcam-vla4 - Google Patents
Pyrrolidincarbonylamin-enthaltende cyclische peptid-disulfide als antagonisten von vcam-vla4 Download PDFInfo
- Publication number
- DE60030266T2 DE60030266T2 DE60030266T DE60030266T DE60030266T2 DE 60030266 T2 DE60030266 T2 DE 60030266T2 DE 60030266 T DE60030266 T DE 60030266T DE 60030266 T DE60030266 T DE 60030266T DE 60030266 T2 DE60030266 T2 DE 60030266T2
- Authority
- DE
- Germany
- Prior art keywords
- amino
- compound
- pharmaceutically acceptable
- acceptable salt
- carbonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 CCNC(C(CSSC[C@@](C(O)=O)NC(C(*)(*)C(C)(C)C*)=O)NC([C@]1N(*)CC[C@]1c(cc1)ccc1O)=O)=O Chemical compound CCNC(C(CSSC[C@@](C(O)=O)NC(C(*)(*)C(C)(C)C*)=O)NC([C@]1N(*)CC[C@]1c(cc1)ccc1O)=O)=O 0.000 description 5
- HBOXOJWEPUNMGT-KLAILNCOSA-N CC(C)C(C(OC)=NC1[C@H](CCO)c(cc2)ccc2OC)N=C1OC Chemical compound CC(C)C(C(OC)=NC1[C@H](CCO)c(cc2)ccc2OC)N=C1OC HBOXOJWEPUNMGT-KLAILNCOSA-N 0.000 description 1
- PPSJPFYHODTYRC-WWDZGPRUSA-N CC(C)C(C(OC)=NC1[C@H](CCO[SH-](C)(=O)=O)c(cc2)ccc2OC)N=C1OC Chemical compound CC(C)C(C(OC)=NC1[C@H](CCO[SH-](C)(=O)=O)c(cc2)ccc2OC)N=C1OC PPSJPFYHODTYRC-WWDZGPRUSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/18—Fluorenes; Hydrogenated fluorenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13021599P | 1999-04-20 | 1999-04-20 | |
| US130215P | 1999-04-20 | ||
| PCT/EP2000/003459 WO2000063234A2 (en) | 1999-04-20 | 2000-04-17 | Pyrrolidincarbonylamino cyclic disulfides as vcam-vla4 antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60030266D1 DE60030266D1 (de) | 2006-10-05 |
| DE60030266T2 true DE60030266T2 (de) | 2007-07-19 |
Family
ID=22443611
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60030266T Expired - Fee Related DE60030266T2 (de) | 1999-04-20 | 2000-04-17 | Pyrrolidincarbonylamin-enthaltende cyclische peptid-disulfide als antagonisten von vcam-vla4 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6265572B1 (https=) |
| EP (1) | EP1171452B1 (https=) |
| JP (1) | JP2002542256A (https=) |
| KR (1) | KR100636481B1 (https=) |
| CN (1) | CN1167710C (https=) |
| AR (1) | AR023546A1 (https=) |
| AT (1) | ATE337331T1 (https=) |
| AU (1) | AU769294B2 (https=) |
| BR (1) | BR0009838A (https=) |
| CA (1) | CA2370259A1 (https=) |
| DE (1) | DE60030266T2 (https=) |
| ES (1) | ES2269141T3 (https=) |
| TR (1) | TR200103004T2 (https=) |
| WO (1) | WO2000063234A2 (https=) |
| ZA (1) | ZA200108018B (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6939855B2 (en) | 1997-07-31 | 2005-09-06 | Elan Pharmaceuticals, Inc. | Anti-inflammatory compositions and method |
| CA2598816A1 (en) * | 2005-02-28 | 2006-08-31 | Medichem S.A. | Process and methods for the preparation of gabapentin and its intermediates |
| WO2008103378A2 (en) | 2007-02-20 | 2008-08-28 | Merrimack Pharmaceuticals, Inc. | Methods of treating multiple sclerosis by administration of alpha-fetoprotein in combination with an integrin antagonist |
| MX2010011145A (es) | 2008-04-11 | 2011-04-11 | Merrimack Pharmaceuticals Inc | Enlazadores de la albumina de suero humana y conjugados de la misma. |
| WO2010059315A1 (en) | 2008-11-18 | 2010-05-27 | Merrimack Pharmaceuticals, Inc. | Human serum albumin linkers and conjugates thereof |
| MX2014004025A (es) | 2011-10-17 | 2014-08-01 | Univ Muenster Wilhelms | Metodos de valoracion de riesgo de lmp y aparatos relacionados. |
| WO2014036520A1 (en) | 2012-08-30 | 2014-03-06 | Merrimack Pharmaceuticals, Inc. | Combination therapies comprising anti-erbb3 agents |
| FI3873884T3 (fi) | 2018-10-30 | 2025-02-24 | Gilead Sciences Inc | 3-(kinolin-8-yyli)-1,4-dihydropyrido[3,4-d]pyrimidiini-2,4-dionijohdannaisia alfa-4-beta-7-integriinin estäjinä tulehdussairauksien hoidossa |
| JP7189368B2 (ja) | 2018-10-30 | 2022-12-13 | ギリアード サイエンシーズ， インコーポレイテッド | アルファ４ベータ７インテグリンの阻害のための化合物 |
| ES3013256T3 (en) | 2018-10-30 | 2025-04-11 | Gilead Sciences Inc | Imidazo[1,2-a]pyridine derivatives as alpha4beta7 integrin inhibitors for the treatment of inflammatory diseases |
| EP3873605B1 (en) | 2018-10-30 | 2024-10-23 | Gilead Sciences, Inc. | Compounds for inhibition of alpha4beta7 integrin |
| WO2021030438A1 (en) | 2019-08-14 | 2021-02-18 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5192746A (en) | 1990-07-09 | 1993-03-09 | Tanabe Seiyaku Co., Ltd. | Cyclic cell adhesion modulation compounds |
-
2000
- 2000-04-14 US US09/548,992 patent/US6265572B1/en not_active Expired - Fee Related
- 2000-04-17 CA CA002370259A patent/CA2370259A1/en not_active Abandoned
- 2000-04-17 ES ES00929365T patent/ES2269141T3/es not_active Expired - Lifetime
- 2000-04-17 CN CNB008064601A patent/CN1167710C/zh not_active Expired - Fee Related
- 2000-04-17 KR KR1020017013304A patent/KR100636481B1/ko not_active Expired - Fee Related
- 2000-04-17 DE DE60030266T patent/DE60030266T2/de not_active Expired - Fee Related
- 2000-04-17 WO PCT/EP2000/003459 patent/WO2000063234A2/en not_active Ceased
- 2000-04-17 JP JP2000612324A patent/JP2002542256A/ja active Pending
- 2000-04-17 TR TR2001/03004T patent/TR200103004T2/xx unknown
- 2000-04-17 BR BR0009838-8A patent/BR0009838A/pt not_active IP Right Cessation
- 2000-04-17 AT AT00929365T patent/ATE337331T1/de not_active IP Right Cessation
- 2000-04-17 EP EP00929365A patent/EP1171452B1/en not_active Expired - Lifetime
- 2000-04-17 AU AU47482/00A patent/AU769294B2/en not_active Ceased
- 2000-04-19 AR ARP000101825A patent/AR023546A1/es active IP Right Grant
-
2001
- 2001-09-28 ZA ZA200108018A patent/ZA200108018B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2370259A1 (en) | 2000-10-26 |
| AR023546A1 (es) | 2002-09-04 |
| JP2002542256A (ja) | 2002-12-10 |
| KR20010108517A (ko) | 2001-12-07 |
| BR0009838A (pt) | 2002-01-08 |
| US6265572B1 (en) | 2001-07-24 |
| TR200103004T2 (tr) | 2002-01-21 |
| DE60030266D1 (de) | 2006-10-05 |
| EP1171452A2 (en) | 2002-01-16 |
| CN1167710C (zh) | 2004-09-22 |
| WO2000063234A2 (en) | 2000-10-26 |
| ES2269141T3 (es) | 2007-04-01 |
| EP1171452B1 (en) | 2006-08-23 |
| ATE337331T1 (de) | 2006-09-15 |
| ZA200108018B (en) | 2003-03-26 |
| KR100636481B1 (ko) | 2006-10-18 |
| AU769294B2 (en) | 2004-01-22 |
| WO2000063234A3 (en) | 2001-01-18 |
| CN1347419A (zh) | 2002-05-01 |
| AU4748200A (en) | 2000-11-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |