ATE337331T1 - Pyrrolidincarbonylamin-enthaltende cyclische peptid-disulfide als antagonists von vcam-vla4 - Google Patents
Pyrrolidincarbonylamin-enthaltende cyclische peptid-disulfide als antagonists von vcam-vla4Info
- Publication number
- ATE337331T1 ATE337331T1 AT00929365T AT00929365T ATE337331T1 AT E337331 T1 ATE337331 T1 AT E337331T1 AT 00929365 T AT00929365 T AT 00929365T AT 00929365 T AT00929365 T AT 00929365T AT E337331 T1 ATE337331 T1 AT E337331T1
- Authority
- AT
- Austria
- Prior art keywords
- carbonylamin
- vla4
- vcam
- pyrrolidine
- antagonists
- Prior art date
Links
- 108010069514 Cyclic Peptides Proteins 0.000 title 1
- 102000001189 Cyclic Peptides Human genes 0.000 title 1
- PMKLYGZZDNUKSR-UHFFFAOYSA-N N=C=O.C1CNCC1 Chemical compound N=C=O.C1CNCC1 PMKLYGZZDNUKSR-UHFFFAOYSA-N 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 150000002019 disulfides Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/18—Fluorenes; Hydrogenated fluorenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Crystallography & Structural Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13021599P | 1999-04-20 | 1999-04-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE337331T1 true ATE337331T1 (de) | 2006-09-15 |
Family
ID=22443611
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00929365T ATE337331T1 (de) | 1999-04-20 | 2000-04-17 | Pyrrolidincarbonylamin-enthaltende cyclische peptid-disulfide als antagonists von vcam-vla4 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6265572B1 (de) |
| EP (1) | EP1171452B1 (de) |
| JP (1) | JP2002542256A (de) |
| KR (1) | KR100636481B1 (de) |
| CN (1) | CN1167710C (de) |
| AR (1) | AR023546A1 (de) |
| AT (1) | ATE337331T1 (de) |
| AU (1) | AU769294B2 (de) |
| BR (1) | BR0009838A (de) |
| CA (1) | CA2370259A1 (de) |
| DE (1) | DE60030266T2 (de) |
| ES (1) | ES2269141T3 (de) |
| TR (1) | TR200103004T2 (de) |
| WO (1) | WO2000063234A2 (de) |
| ZA (1) | ZA200108018B (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6939855B2 (en) * | 1997-07-31 | 2005-09-06 | Elan Pharmaceuticals, Inc. | Anti-inflammatory compositions and method |
| WO2006090208A1 (en) * | 2005-02-28 | 2006-08-31 | Medichem S.A. | Process and methods for the preparation of gabapentin and its intermediates |
| WO2008103378A2 (en) | 2007-02-20 | 2008-08-28 | Merrimack Pharmaceuticals, Inc. | Methods of treating multiple sclerosis by administration of alpha-fetoprotein in combination with an integrin antagonist |
| NZ589086A (en) | 2008-04-11 | 2012-09-28 | Merrimack Pharmaceuticals Inc | Human serum albumin (HSA) linkers and conjugates thereof |
| US8927694B2 (en) | 2008-11-18 | 2015-01-06 | Merrimack Pharmaceuticals, Inc. | Human serum albumin linkers and conjugates thereof |
| WO2013057092A1 (en) | 2011-10-17 | 2013-04-25 | Westfaelische Wilhelms-Universitaet Muenster | Methods of risk assessment of pml and related apparatus |
| WO2014036520A1 (en) | 2012-08-30 | 2014-03-06 | Merrimack Pharmaceuticals, Inc. | Combination therapies comprising anti-erbb3 agents |
| PL3873900T3 (pl) | 2018-10-30 | 2025-06-02 | Gilead Sciences, Inc. | Imidazo[1,2-a]pirydynowe pochodne jako inhibitory integryny alpha4beta7 do leczenia chorób zapalnych |
| EP3873897B1 (de) | 2018-10-30 | 2024-08-14 | Gilead Sciences, Inc. | N-benzoyl-phenylalanin-derivate als alpha4beta7 integrin-inhibitoren zur behandlung von entzündlichen erkrankungen |
| LT3873884T (lt) | 2018-10-30 | 2025-03-10 | Gilead Sciences, Inc. | 3-(chinolin-8-il)-1,4-dihidropirido[3,4-d]pirimidin-2,4-diono dariniai kaip alfa4beta7 integrino inhibitoriai, skirti uždegiminių ligų gydymui |
| KR102659859B1 (ko) | 2018-10-30 | 2024-04-25 | 길리애드 사이언시즈, 인코포레이티드 | 알파4β7 인테그린의 억제를 위한 화합물 |
| EP4013499A1 (de) | 2019-08-14 | 2022-06-22 | Gilead Sciences, Inc. | Verbindungen zur inhibierung von alpha-4-beta-7-integrin |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5192746A (en) | 1990-07-09 | 1993-03-09 | Tanabe Seiyaku Co., Ltd. | Cyclic cell adhesion modulation compounds |
-
2000
- 2000-04-14 US US09/548,992 patent/US6265572B1/en not_active Expired - Fee Related
- 2000-04-17 JP JP2000612324A patent/JP2002542256A/ja active Pending
- 2000-04-17 CA CA002370259A patent/CA2370259A1/en not_active Abandoned
- 2000-04-17 CN CNB008064601A patent/CN1167710C/zh not_active Expired - Fee Related
- 2000-04-17 AU AU47482/00A patent/AU769294B2/en not_active Ceased
- 2000-04-17 ES ES00929365T patent/ES2269141T3/es not_active Expired - Lifetime
- 2000-04-17 TR TR2001/03004T patent/TR200103004T2/xx unknown
- 2000-04-17 AT AT00929365T patent/ATE337331T1/de not_active IP Right Cessation
- 2000-04-17 BR BR0009838-8A patent/BR0009838A/pt not_active IP Right Cessation
- 2000-04-17 EP EP00929365A patent/EP1171452B1/de not_active Expired - Lifetime
- 2000-04-17 DE DE60030266T patent/DE60030266T2/de not_active Expired - Fee Related
- 2000-04-17 KR KR1020017013304A patent/KR100636481B1/ko not_active Expired - Fee Related
- 2000-04-17 WO PCT/EP2000/003459 patent/WO2000063234A2/en not_active Ceased
- 2000-04-19 AR ARP000101825A patent/AR023546A1/es active IP Right Grant
-
2001
- 2001-09-28 ZA ZA200108018A patent/ZA200108018B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1347419A (zh) | 2002-05-01 |
| DE60030266T2 (de) | 2007-07-19 |
| JP2002542256A (ja) | 2002-12-10 |
| ES2269141T3 (es) | 2007-04-01 |
| CA2370259A1 (en) | 2000-10-26 |
| CN1167710C (zh) | 2004-09-22 |
| DE60030266D1 (de) | 2006-10-05 |
| BR0009838A (pt) | 2002-01-08 |
| EP1171452B1 (de) | 2006-08-23 |
| TR200103004T2 (tr) | 2002-01-21 |
| ZA200108018B (en) | 2003-03-26 |
| WO2000063234A3 (en) | 2001-01-18 |
| US6265572B1 (en) | 2001-07-24 |
| WO2000063234A2 (en) | 2000-10-26 |
| EP1171452A2 (de) | 2002-01-16 |
| KR20010108517A (ko) | 2001-12-07 |
| AU769294B2 (en) | 2004-01-22 |
| AR023546A1 (es) | 2002-09-04 |
| AU4748200A (en) | 2000-11-02 |
| KR100636481B1 (ko) | 2006-10-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1171452 Country of ref document: EP |
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| REN | Ceased due to non-payment of the annual fee |