DE60028565T2 - Vaskuläre endothelzellen wachstumsfaktor (vegf) varianten und dessen verwendungen - Google Patents
Vaskuläre endothelzellen wachstumsfaktor (vegf) varianten und dessen verwendungen Download PDFInfo
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- DE60028565T2 DE60028565T2 DE60028565T DE60028565T DE60028565T2 DE 60028565 T2 DE60028565 T2 DE 60028565T2 DE 60028565 T DE60028565 T DE 60028565T DE 60028565 T DE60028565 T DE 60028565T DE 60028565 T2 DE60028565 T2 DE 60028565T2
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- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 238000012453 sprague-dawley rat model Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000011146 sterile filtration Methods 0.000 description 1
- 210000001562 sternum Anatomy 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- MNQYNQBOVCBZIQ-JQOFMKNESA-A sucralfate Chemical compound O[Al](O)OS(=O)(=O)O[C@@H]1[C@@H](OS(=O)(=O)O[Al](O)O)[C@H](OS(=O)(=O)O[Al](O)O)[C@@H](COS(=O)(=O)O[Al](O)O)O[C@H]1O[C@@]1(COS(=O)(=O)O[Al](O)O)[C@@H](OS(=O)(=O)O[Al](O)O)[C@H](OS(=O)(=O)O[Al](O)O)[C@@H](OS(=O)(=O)O[Al](O)O)O1 MNQYNQBOVCBZIQ-JQOFMKNESA-A 0.000 description 1
- 229960004291 sucralfate Drugs 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000008838 symmetric binding Effects 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 230000008467 tissue growth Effects 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 239000012049 topical pharmaceutical composition Substances 0.000 description 1
- 229960001479 tosylchloramide sodium Drugs 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
- 230000005030 transcription termination Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 108091008578 transmembrane receptors Proteins 0.000 description 1
- 102000027257 transmembrane receptors Human genes 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 108010003137 tyrosyltyrosine Proteins 0.000 description 1
- 210000003606 umbilical vein Anatomy 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 108010073969 valyllysine Proteins 0.000 description 1
- 230000006711 vascular endothelial growth factor production Effects 0.000 description 1
- 231100000216 vascular lesion Toxicity 0.000 description 1
- 230000008728 vascular permeability Effects 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
- 239000012130 whole-cell lysate Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 229920001221 xylan Polymers 0.000 description 1
- 150000004823 xylans Chemical class 0.000 description 1
- BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 1
- 229960001600 xylazine Drugs 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/009—Sachets, pouches characterised by the material or function of the envelope
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12978899P | 1999-04-16 | 1999-04-16 | |
| US129788P | 1999-04-16 | ||
| US18423500P | 2000-02-23 | 2000-02-23 | |
| US184235P | 2000-02-23 | ||
| PCT/US2000/009483 WO2000063380A1 (en) | 1999-04-16 | 2000-04-10 | Vascular endothelial cell growth factor variants and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60028565D1 DE60028565D1 (de) | 2006-07-20 |
| DE60028565T2 true DE60028565T2 (de) | 2007-06-06 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60028565T Expired - Lifetime DE60028565T2 (de) | 1999-04-16 | 2000-04-10 | Vaskuläre endothelzellen wachstumsfaktor (vegf) varianten und dessen verwendungen |
| DE60041367T Expired - Lifetime DE60041367D1 (de) | 1999-04-16 | 2000-04-10 | Vaskuläre Endothelzellen Wachstumsfaktor (VEGF) Varianten und dessen Verwendungen |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60041367T Expired - Lifetime DE60041367D1 (de) | 1999-04-16 | 2000-04-10 | Vaskuläre Endothelzellen Wachstumsfaktor (VEGF) Varianten und dessen Verwendungen |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20060063203A1 (enExample) |
| EP (2) | EP1655368B1 (enExample) |
| JP (1) | JP2002541849A (enExample) |
| KR (1) | KR100634926B1 (enExample) |
| CN (1) | CN1328376C (enExample) |
| AT (2) | ATE420177T1 (enExample) |
| AU (1) | AU771042B2 (enExample) |
| CA (1) | CA2370246C (enExample) |
| DE (2) | DE60028565T2 (enExample) |
| ES (2) | ES2320367T3 (enExample) |
| HU (1) | HU228898B1 (enExample) |
| IL (2) | IL145675A0 (enExample) |
| MX (1) | MXPA01010469A (enExample) |
| NZ (1) | NZ514488A (enExample) |
| WO (1) | WO2000063380A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6020473A (en) * | 1995-08-25 | 2000-02-01 | Genentech, Inc. | Nucleic acids encoding variants of vascular endothelial cell growth factor |
| CA2385665A1 (en) * | 1999-11-02 | 2001-05-10 | Genentech, Inc. | Modulation of enos activity and therapeutic uses thereof |
| US7078382B1 (en) | 1999-11-02 | 2006-07-18 | Genentech, Inc. | Modulation of eNOS activity and therapeutic uses thereof |
| US20050123925A1 (en) | 2002-11-15 | 2005-06-09 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
| US7261876B2 (en) | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
| WO2003084574A1 (en) | 2002-03-01 | 2003-10-16 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
| US20050100963A1 (en) | 2002-03-01 | 2005-05-12 | Dyax Corporation | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
| US7211240B2 (en) * | 2002-03-01 | 2007-05-01 | Bracco International B.V. | Multivalent constructs for therapeutic and diagnostic applications |
| US8623822B2 (en) | 2002-03-01 | 2014-01-07 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
| US7794693B2 (en) | 2002-03-01 | 2010-09-14 | Bracco International B.V. | Targeting vector-phospholipid conjugates |
| ES2506142T3 (es) * | 2002-03-01 | 2014-10-13 | Dyax Corp. | Péptidos de unión a KDR y a VEGF/KDR y su uso en diagnóstico |
| EP2430923A1 (en) | 2002-06-05 | 2012-03-21 | Genentech, Inc. | Compositions and methods for liver growth and liver protection |
| US7696320B2 (en) | 2004-08-24 | 2010-04-13 | Domantis Limited | Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor |
| EP2526960A1 (en) | 2003-03-12 | 2012-11-28 | Genentech, Inc. | Use of BV8 and/or EG-VEGF to promote hematopoiesis |
| WO2006014729A2 (en) | 2004-07-20 | 2006-02-09 | Genentech, Inc. | Inhibitors of angiopoietin-like 4 protein, combinations, and their use |
| LT1781698T (lt) | 2004-07-20 | 2016-09-26 | Genentech, Inc. | Į angiopoetiną panašaus baltymo 4 kompozicijos ir panaudojimo būdai |
| CN102614134B (zh) | 2005-03-25 | 2016-09-07 | 瑞泽恩制药公司 | Vegf拮抗剂制剂 |
| WO2007109183A2 (en) * | 2006-03-20 | 2007-09-27 | Novartis Ag | Mutations and polymorphisms of fms-related tyrosine kinase 1 |
| RU2432155C3 (ru) | 2006-06-16 | 2017-11-17 | Ридженерон Фармасьютикалз, Инк. | Составы антагониста vegf, подходящие для интравитреального введения |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US169292A (en) * | 1875-10-26 | Improvement in butter-packages | ||
| DK0751992T3 (da) * | 1994-03-08 | 2006-03-06 | Human Genome Sciences Inc | Karendotelvækstfaktor 2 |
| CN1185159A (zh) * | 1995-06-06 | 1998-06-17 | 人体基因组科学有限公司 | 人血管内皮生长因子3 |
| US6020473A (en) * | 1995-08-25 | 2000-02-01 | Genentech, Inc. | Nucleic acids encoding variants of vascular endothelial cell growth factor |
| US6750044B1 (en) * | 1996-10-17 | 2004-06-15 | Genentech, Inc. | Variants of vascular endothelial cell growth factor having antagonistic properties, nucleic acids encoding the same and host cells comprising those nucleic acids |
-
2000
- 2000-04-10 NZ NZ514488A patent/NZ514488A/xx not_active IP Right Cessation
- 2000-04-10 CN CNB008081018A patent/CN1328376C/zh not_active Expired - Lifetime
- 2000-04-10 ES ES06000875T patent/ES2320367T3/es not_active Expired - Lifetime
- 2000-04-10 IL IL14567500A patent/IL145675A0/xx unknown
- 2000-04-10 CA CA2370246A patent/CA2370246C/en not_active Expired - Lifetime
- 2000-04-10 AT AT06000875T patent/ATE420177T1/de active
- 2000-04-10 AU AU42220/00A patent/AU771042B2/en not_active Expired
- 2000-04-10 EP EP06000875A patent/EP1655368B1/en not_active Expired - Lifetime
- 2000-04-10 AT AT00921966T patent/ATE329024T1/de active
- 2000-04-10 HU HU0200827A patent/HU228898B1/hu unknown
- 2000-04-10 KR KR1020017013112A patent/KR100634926B1/ko not_active Expired - Lifetime
- 2000-04-10 MX MXPA01010469A patent/MXPA01010469A/es active IP Right Grant
- 2000-04-10 ES ES00921966T patent/ES2265931T3/es not_active Expired - Lifetime
- 2000-04-10 WO PCT/US2000/009483 patent/WO2000063380A1/en not_active Ceased
- 2000-04-10 DE DE60028565T patent/DE60028565T2/de not_active Expired - Lifetime
- 2000-04-10 EP EP00921966A patent/EP1171594B1/en not_active Expired - Lifetime
- 2000-04-10 JP JP2000612459A patent/JP2002541849A/ja active Pending
- 2000-04-10 DE DE60041367T patent/DE60041367D1/de not_active Expired - Lifetime
-
2001
- 2001-09-25 IL IL145675A patent/IL145675A/en not_active IP Right Cessation
-
2005
- 2005-08-16 US US11/204,554 patent/US20060063203A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1655368A1 (en) | 2006-05-10 |
| ATE420177T1 (de) | 2009-01-15 |
| WO2000063380A1 (en) | 2000-10-26 |
| DE60028565D1 (de) | 2006-07-20 |
| EP1171594A1 (en) | 2002-01-16 |
| KR20020008151A (ko) | 2002-01-29 |
| ES2320367T3 (es) | 2009-05-21 |
| EP1171594B1 (en) | 2006-06-07 |
| IL145675A0 (en) | 2002-06-30 |
| HK1093218A1 (en) | 2007-02-23 |
| CA2370246A1 (en) | 2000-10-26 |
| AU771042B2 (en) | 2004-03-11 |
| CN1352684A (zh) | 2002-06-05 |
| NZ514488A (en) | 2004-01-30 |
| JP2002541849A (ja) | 2002-12-10 |
| EP1655368B1 (en) | 2009-01-07 |
| KR100634926B1 (ko) | 2006-10-17 |
| ES2265931T3 (es) | 2007-03-01 |
| IL145675A (en) | 2010-11-30 |
| HU228898B1 (en) | 2013-06-28 |
| AU4222000A (en) | 2000-11-02 |
| DE60041367D1 (de) | 2009-02-26 |
| US20060063203A1 (en) | 2006-03-23 |
| ATE329024T1 (de) | 2006-06-15 |
| MXPA01010469A (es) | 2002-07-30 |
| HUP0200827A3 (en) | 2004-11-29 |
| HUP0200827A2 (en) | 2002-06-29 |
| CN1328376C (zh) | 2007-07-25 |
| CA2370246C (en) | 2017-03-21 |
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| 8364 | No opposition during term of opposition |