AU771042B2 - Vascular endothelial cell growth factor variants and uses thereof - Google Patents

Vascular endothelial cell growth factor variants and uses thereof Download PDF

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Publication number
AU771042B2
AU771042B2 AU42220/00A AU4222000A AU771042B2 AU 771042 B2 AU771042 B2 AU 771042B2 AU 42220/00 A AU42220/00 A AU 42220/00A AU 4222000 A AU4222000 A AU 4222000A AU 771042 B2 AU771042 B2 AU 771042B2
Authority
AU
Australia
Prior art keywords
vegf
amino acid
variant
vegf variant
flt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU42220/00A
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English (en)
Other versions
AU4222000A (en
Inventor
Devos Abraham
Brian Cunningham
Bing Li
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of AU4222000A publication Critical patent/AU4222000A/en
Application granted granted Critical
Publication of AU771042B2 publication Critical patent/AU771042B2/en
Priority to AU2004202596A priority Critical patent/AU2004202596B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/009Sachets, pouches characterised by the material or function of the envelope
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU42220/00A 1999-04-16 2000-04-10 Vascular endothelial cell growth factor variants and uses thereof Expired AU771042B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2004202596A AU2004202596B2 (en) 1999-04-16 2004-06-11 Vascular endothelial cell growth factor variants and uses thereof

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12978899P 1999-04-16 1999-04-16
US60/129788 1999-04-16
US18423500P 2000-02-23 2000-02-23
US60/184235 2000-02-23
PCT/US2000/009483 WO2000063380A1 (en) 1999-04-16 2000-04-10 Vascular endothelial cell growth factor variants and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2004202596A Division AU2004202596B2 (en) 1999-04-16 2004-06-11 Vascular endothelial cell growth factor variants and uses thereof

Publications (2)

Publication Number Publication Date
AU4222000A AU4222000A (en) 2000-11-02
AU771042B2 true AU771042B2 (en) 2004-03-11

Family

ID=26827914

Family Applications (1)

Application Number Title Priority Date Filing Date
AU42220/00A Expired AU771042B2 (en) 1999-04-16 2000-04-10 Vascular endothelial cell growth factor variants and uses thereof

Country Status (15)

Country Link
US (1) US20060063203A1 (enExample)
EP (2) EP1655368B1 (enExample)
JP (1) JP2002541849A (enExample)
KR (1) KR100634926B1 (enExample)
CN (1) CN1328376C (enExample)
AT (2) ATE420177T1 (enExample)
AU (1) AU771042B2 (enExample)
CA (1) CA2370246C (enExample)
DE (2) DE60028565T2 (enExample)
ES (2) ES2320367T3 (enExample)
HU (1) HU228898B1 (enExample)
IL (2) IL145675A0 (enExample)
MX (1) MXPA01010469A (enExample)
NZ (1) NZ514488A (enExample)
WO (1) WO2000063380A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6020473A (en) * 1995-08-25 2000-02-01 Genentech, Inc. Nucleic acids encoding variants of vascular endothelial cell growth factor
CA2385665A1 (en) * 1999-11-02 2001-05-10 Genentech, Inc. Modulation of enos activity and therapeutic uses thereof
US7078382B1 (en) 1999-11-02 2006-07-18 Genentech, Inc. Modulation of eNOS activity and therapeutic uses thereof
US20050123925A1 (en) 2002-11-15 2005-06-09 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
WO2003084574A1 (en) 2002-03-01 2003-10-16 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
US20050100963A1 (en) 2002-03-01 2005-05-12 Dyax Corporation KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7211240B2 (en) * 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
ES2506142T3 (es) * 2002-03-01 2014-10-13 Dyax Corp. Péptidos de unión a KDR y a VEGF/KDR y su uso en diagnóstico
EP2430923A1 (en) 2002-06-05 2012-03-21 Genentech, Inc. Compositions and methods for liver growth and liver protection
US7696320B2 (en) 2004-08-24 2010-04-13 Domantis Limited Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor
EP2526960A1 (en) 2003-03-12 2012-11-28 Genentech, Inc. Use of BV8 and/or EG-VEGF to promote hematopoiesis
WO2006014729A2 (en) 2004-07-20 2006-02-09 Genentech, Inc. Inhibitors of angiopoietin-like 4 protein, combinations, and their use
LT1781698T (lt) 2004-07-20 2016-09-26 Genentech, Inc. Į angiopoetiną panašaus baltymo 4 kompozicijos ir panaudojimo būdai
CN102614134B (zh) 2005-03-25 2016-09-07 瑞泽恩制药公司 Vegf拮抗剂制剂
WO2007109183A2 (en) * 2006-03-20 2007-09-27 Novartis Ag Mutations and polymorphisms of fms-related tyrosine kinase 1
RU2432155C3 (ru) 2006-06-16 2017-11-17 Ридженерон Фармасьютикалз, Инк. Составы антагониста vegf, подходящие для интравитреального введения

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997008313A1 (en) * 1995-08-25 1997-03-06 Genentech, Inc. Variants of vascular endothelial cell growth factor, their uses, and processes for their production

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US169292A (en) * 1875-10-26 Improvement in butter-packages
DK0751992T3 (da) * 1994-03-08 2006-03-06 Human Genome Sciences Inc Karendotelvækstfaktor 2
CN1185159A (zh) * 1995-06-06 1998-06-17 人体基因组科学有限公司 人血管内皮生长因子3
US6750044B1 (en) * 1996-10-17 2004-06-15 Genentech, Inc. Variants of vascular endothelial cell growth factor having antagonistic properties, nucleic acids encoding the same and host cells comprising those nucleic acids

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997008313A1 (en) * 1995-08-25 1997-03-06 Genentech, Inc. Variants of vascular endothelial cell growth factor, their uses, and processes for their production

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KEYTS ET AL. (1996) J. BIOL. CHEM. 271:5638-5646 *

Also Published As

Publication number Publication date
EP1655368A1 (en) 2006-05-10
ATE420177T1 (de) 2009-01-15
WO2000063380A1 (en) 2000-10-26
DE60028565D1 (de) 2006-07-20
EP1171594A1 (en) 2002-01-16
KR20020008151A (ko) 2002-01-29
ES2320367T3 (es) 2009-05-21
EP1171594B1 (en) 2006-06-07
IL145675A0 (en) 2002-06-30
HK1093218A1 (en) 2007-02-23
CA2370246A1 (en) 2000-10-26
CN1352684A (zh) 2002-06-05
NZ514488A (en) 2004-01-30
JP2002541849A (ja) 2002-12-10
EP1655368B1 (en) 2009-01-07
KR100634926B1 (ko) 2006-10-17
ES2265931T3 (es) 2007-03-01
IL145675A (en) 2010-11-30
HU228898B1 (en) 2013-06-28
AU4222000A (en) 2000-11-02
DE60041367D1 (de) 2009-02-26
US20060063203A1 (en) 2006-03-23
DE60028565T2 (de) 2007-06-06
ATE329024T1 (de) 2006-06-15
MXPA01010469A (es) 2002-07-30
HUP0200827A3 (en) 2004-11-29
HUP0200827A2 (en) 2002-06-29
CN1328376C (zh) 2007-07-25
CA2370246C (en) 2017-03-21

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired