CN1328376C - 血管内皮细胞生长因子变体及其应用 - Google Patents

血管内皮细胞生长因子变体及其应用 Download PDF

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Publication number
CN1328376C
CN1328376C CNB008081018A CN00808101A CN1328376C CN 1328376 C CN1328376 C CN 1328376C CN B008081018 A CNB008081018 A CN B008081018A CN 00808101 A CN00808101 A CN 00808101A CN 1328376 C CN1328376 C CN 1328376C
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China
Prior art keywords
vegf
amino acid
flt
variants
variant polypeptide
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Expired - Lifetime
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CNB008081018A
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English (en)
Chinese (zh)
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CN1352684A (zh
Inventor
布赖恩·坎宁安
亚伯拉罕·德沃斯
李冰
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Genentech Inc
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Genentech Inc
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Publication of CN1352684A publication Critical patent/CN1352684A/zh
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Publication of CN1328376C publication Critical patent/CN1328376C/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/009—Sachets, pouches characterised by the material or function of the envelope
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CNB008081018A 1999-04-16 2000-04-10 血管内皮细胞生长因子变体及其应用 Expired - Lifetime CN1328376C (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12978899P 1999-04-16 1999-04-16
US60/129,788 1999-04-16
US18423500P 2000-02-23 2000-02-23
US60/184,235 2000-02-23
PCT/US2000/009483 WO2000063380A1 (en) 1999-04-16 2000-04-10 Vascular endothelial cell growth factor variants and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN 200710104285 Division CN101070343A (zh) 1999-04-16 2000-04-10 血管内皮细胞生长因子变体及其应用

Publications (2)

Publication Number Publication Date
CN1352684A CN1352684A (zh) 2002-06-05
CN1328376C true CN1328376C (zh) 2007-07-25

Family

ID=26827914

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB008081018A Expired - Lifetime CN1328376C (zh) 1999-04-16 2000-04-10 血管内皮细胞生长因子变体及其应用

Country Status (15)

Country Link
US (1) US20060063203A1 (enExample)
EP (2) EP1655368B1 (enExample)
JP (1) JP2002541849A (enExample)
KR (1) KR100634926B1 (enExample)
CN (1) CN1328376C (enExample)
AT (2) ATE420177T1 (enExample)
AU (1) AU771042B2 (enExample)
CA (1) CA2370246C (enExample)
DE (2) DE60028565T2 (enExample)
ES (2) ES2320367T3 (enExample)
HU (1) HU228898B1 (enExample)
IL (2) IL145675A0 (enExample)
MX (1) MXPA01010469A (enExample)
NZ (1) NZ514488A (enExample)
WO (1) WO2000063380A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6020473A (en) * 1995-08-25 2000-02-01 Genentech, Inc. Nucleic acids encoding variants of vascular endothelial cell growth factor
CA2385665A1 (en) * 1999-11-02 2001-05-10 Genentech, Inc. Modulation of enos activity and therapeutic uses thereof
US7078382B1 (en) 1999-11-02 2006-07-18 Genentech, Inc. Modulation of eNOS activity and therapeutic uses thereof
US20050123925A1 (en) 2002-11-15 2005-06-09 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
WO2003084574A1 (en) 2002-03-01 2003-10-16 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
US20050100963A1 (en) 2002-03-01 2005-05-12 Dyax Corporation KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7211240B2 (en) * 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
ES2506142T3 (es) * 2002-03-01 2014-10-13 Dyax Corp. Péptidos de unión a KDR y a VEGF/KDR y su uso en diagnóstico
EP2430923A1 (en) 2002-06-05 2012-03-21 Genentech, Inc. Compositions and methods for liver growth and liver protection
US7696320B2 (en) 2004-08-24 2010-04-13 Domantis Limited Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor
EP2526960A1 (en) 2003-03-12 2012-11-28 Genentech, Inc. Use of BV8 and/or EG-VEGF to promote hematopoiesis
WO2006014729A2 (en) 2004-07-20 2006-02-09 Genentech, Inc. Inhibitors of angiopoietin-like 4 protein, combinations, and their use
LT1781698T (lt) 2004-07-20 2016-09-26 Genentech, Inc. Į angiopoetiną panašaus baltymo 4 kompozicijos ir panaudojimo būdai
CN102614134B (zh) 2005-03-25 2016-09-07 瑞泽恩制药公司 Vegf拮抗剂制剂
WO2007109183A2 (en) * 2006-03-20 2007-09-27 Novartis Ag Mutations and polymorphisms of fms-related tyrosine kinase 1
RU2432155C3 (ru) 2006-06-16 2017-11-17 Ридженерон Фармасьютикалз, Инк. Составы антагониста vegf, подходящие для интравитреального введения

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997008313A1 (en) * 1995-08-25 1997-03-06 Genentech, Inc. Variants of vascular endothelial cell growth factor, their uses, and processes for their production
CN1145636A (zh) * 1994-03-08 1997-03-19 人体基因组科学有限公司 血管内皮生长因子2
CN1185159A (zh) * 1995-06-06 1998-06-17 人体基因组科学有限公司 人血管内皮生长因子3

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US169292A (en) * 1875-10-26 Improvement in butter-packages
US6750044B1 (en) * 1996-10-17 2004-06-15 Genentech, Inc. Variants of vascular endothelial cell growth factor having antagonistic properties, nucleic acids encoding the same and host cells comprising those nucleic acids

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1145636A (zh) * 1994-03-08 1997-03-19 人体基因组科学有限公司 血管内皮生长因子2
CN1185159A (zh) * 1995-06-06 1998-06-17 人体基因组科学有限公司 人血管内皮生长因子3
WO1997008313A1 (en) * 1995-08-25 1997-03-06 Genentech, Inc. Variants of vascular endothelial cell growth factor, their uses, and processes for their production

Also Published As

Publication number Publication date
EP1655368A1 (en) 2006-05-10
ATE420177T1 (de) 2009-01-15
WO2000063380A1 (en) 2000-10-26
DE60028565D1 (de) 2006-07-20
EP1171594A1 (en) 2002-01-16
KR20020008151A (ko) 2002-01-29
ES2320367T3 (es) 2009-05-21
EP1171594B1 (en) 2006-06-07
IL145675A0 (en) 2002-06-30
HK1093218A1 (en) 2007-02-23
CA2370246A1 (en) 2000-10-26
AU771042B2 (en) 2004-03-11
CN1352684A (zh) 2002-06-05
NZ514488A (en) 2004-01-30
JP2002541849A (ja) 2002-12-10
EP1655368B1 (en) 2009-01-07
KR100634926B1 (ko) 2006-10-17
ES2265931T3 (es) 2007-03-01
IL145675A (en) 2010-11-30
HU228898B1 (en) 2013-06-28
AU4222000A (en) 2000-11-02
DE60041367D1 (de) 2009-02-26
US20060063203A1 (en) 2006-03-23
DE60028565T2 (de) 2007-06-06
ATE329024T1 (de) 2006-06-15
MXPA01010469A (es) 2002-07-30
HUP0200827A3 (en) 2004-11-29
HUP0200827A2 (en) 2002-06-29
CA2370246C (en) 2017-03-21

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Granted publication date: 20070725