DE60026350T2 - Diaryl piperidyl-pyrrol-derivate als antiprotozoenmittel - Google Patents

Diaryl piperidyl-pyrrol-derivate als antiprotozoenmittel Download PDF

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Publication number
DE60026350T2
DE60026350T2 DE60026350T DE60026350T DE60026350T2 DE 60026350 T2 DE60026350 T2 DE 60026350T2 DE 60026350 T DE60026350 T DE 60026350T DE 60026350 T DE60026350 T DE 60026350T DE 60026350 T2 DE60026350 T2 DE 60026350T2
Authority
DE
Germany
Prior art keywords
alkyl
methyl
optionally substituted
cycloalkyl
pyridyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60026350T
Other languages
German (de)
English (en)
Other versions
DE60026350D1 (de
Inventor
Tesfaye Rahway BIFTU
D. Danqing Rahway FENG
Gui-Bai Rahway LIANG
M. Mitree Rahway PONPIPOM
Xiaoxia Rahway QIAN
H. Michael Rahway FISHER
J. Matthew Rahway WYVRATT
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE60026350D1 publication Critical patent/DE60026350D1/de
Publication of DE60026350T2 publication Critical patent/DE60026350T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/116—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
    • A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
DE60026350T 1999-11-12 2000-11-09 Diaryl piperidyl-pyrrol-derivate als antiprotozoenmittel Expired - Lifetime DE60026350T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16514299P 1999-11-12 1999-11-12
US165142P 1999-11-12
PCT/US2000/030747 WO2001034149A1 (en) 1999-11-12 2000-11-09 Diaryl piperidyl pyrrole derivatives as antiprotozoal agents

Publications (2)

Publication Number Publication Date
DE60026350D1 DE60026350D1 (de) 2006-04-27
DE60026350T2 true DE60026350T2 (de) 2006-11-09

Family

ID=22597609

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60026350T Expired - Lifetime DE60026350T2 (de) 1999-11-12 2000-11-09 Diaryl piperidyl-pyrrol-derivate als antiprotozoenmittel

Country Status (11)

Country Link
US (2) US6291480B1 (https=)
EP (1) EP1278520B1 (https=)
JP (1) JP4722360B2 (https=)
AT (1) ATE318600T1 (https=)
AU (1) AU781552B2 (https=)
CA (1) CA2390100C (https=)
DE (1) DE60026350T2 (https=)
ES (1) ES2257336T3 (https=)
NZ (1) NZ518718A (https=)
WO (1) WO2001034149A1 (https=)
ZA (1) ZA200203685B (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001034150A1 (en) * 1999-11-12 2001-05-17 Merck & Co., Inc. Aliphatic amine substituted piperidyl diaryl pyrrole derivatives as antiprotozoal agents
GB0112348D0 (en) 2001-05-19 2001-07-11 Smithkline Beecham Plc Compounds
EP1414948B1 (en) * 2001-07-10 2009-09-16 Biogen Idec Inc. Inhibition of apoptosis process and improvement of cell performance
US7375105B2 (en) 2001-09-05 2008-05-20 Smithkline Beecham P.L.C. Pyridine substituted furan derivatives as Raf kinase inhibitors
EP1632488A1 (en) * 2003-06-11 2006-03-08 Sankyo Company, Limited Cyclic tertiary amine compound
WO2007056457A2 (en) 2005-11-09 2007-05-18 Combinatorx, Incorporated Methods, compositions, and kits for the treatment of medical conditions
WO2014121342A1 (en) * 2013-02-08 2014-08-14 Luoda Pharma Pty Limited Methods of treating topical microbial infections
RU2659205C1 (ru) * 2017-06-01 2018-06-28 Федеральное государственное бюджетное научное учреждение "Прикаспийский зональный научно-исследовательский ветеринарный институт" Способ профилактики кокцидиоза цыплят-бройлеров при выращивании их на мясо
BE1028700B1 (nl) * 2020-10-13 2022-05-16 Poulpharm Bvba Werkwijze voor het testen van de efficiëntie van anti-parasitaire (coccidiose) middelen bij pluimvee en konijnen
WO2025085377A1 (en) * 2023-10-16 2025-04-24 Zoetis Services Llc Use of zoalene in livestock
WO2025171002A1 (en) * 2024-02-05 2025-08-14 Elanco Us Inc. Multi-layered granule therapeutics

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4153703A (en) * 1977-06-30 1979-05-08 Uniroyal, Inc. Method of controlling insects and acarids with certain aryl-substituted thiazoles
WO1996017841A1 (en) * 1994-12-06 1996-06-13 Nippon Soda Co., Ltd. Pyridylpyrrole compounds, process for production, and agrohorticultural bactericide
US5792778A (en) * 1995-08-10 1998-08-11 Merck & Co., Inc. 2-substituted aryl pyrroles, compositions containing such compounds and methods of use
WO1997005877A1 (en) * 1995-08-10 1997-02-20 Merck & Co., Inc. 2-substituted aryl pyrroles, compositions containing such compounds and methods of use
AU7529096A (en) * 1995-10-31 1997-05-22 Merck & Co., Inc. Substituted aryl pyrroles, compositions containing such compounds and methods of use
JPH09194477A (ja) * 1996-01-18 1997-07-29 Nippon Soda Co Ltd 新規なピリジルピロール化合物、製法および農園芸用殺菌剤
WO1997048725A1 (en) * 1996-06-21 1997-12-24 Peptech Limited Novel peptides for prevention and treatment of infection
WO2000001688A1 (en) * 1998-07-02 2000-01-13 Sankyo Company, Limited Five-membered heteroaryl compounds
JP2000080094A (ja) * 1998-07-02 2000-03-21 Sankyo Co Ltd ５員ヘテロアリ―ル化合物
WO2000066124A1 (fr) * 1999-04-28 2000-11-09 Sankyo Company, Limited Agents preventifs ou inhibiteurs destines a une hepatopathie
JP2001010957A (ja) * 1999-04-28 2001-01-16 Sankyo Co Ltd 肝障害の予防または抑制剤

Also Published As

Publication number Publication date
JP4722360B2 (ja) 2011-07-13
EP1278520A1 (en) 2003-01-29
JP2003527336A (ja) 2003-09-16
US6291480B1 (en) 2001-09-18
AU781552B2 (en) 2005-05-26
CA2390100C (en) 2010-01-05
ATE318600T1 (de) 2006-03-15
CA2390100A1 (en) 2001-05-17
NZ518718A (en) 2004-03-26
ZA200203685B (en) 2003-06-05
EP1278520B1 (en) 2006-03-01
US6384052B1 (en) 2002-05-07
DE60026350D1 (de) 2006-04-27
AU1590401A (en) 2001-06-06
WO2001034149A1 (en) 2001-05-17
ES2257336T3 (es) 2006-08-01
EP1278520A4 (en) 2003-05-02

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8327 Change in the person/name/address of the patent owner

Owner name: MERCK & CO., INC., RAHWAY, N.J., US

8327 Change in the person/name/address of the patent owner

Owner name: MERCK SHARP & DOHME CORP., NEW JERSEY, N.J., US

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