DE60014043D1 - Flouride von 4-substituierten piperidin-derivaten - Google Patents

Flouride von 4-substituierten piperidin-derivaten

Info

Publication number
DE60014043D1
DE60014043D1 DE60014043T DE60014043T DE60014043D1 DE 60014043 D1 DE60014043 D1 DE 60014043D1 DE 60014043 T DE60014043 T DE 60014043T DE 60014043 T DE60014043 T DE 60014043T DE 60014043 D1 DE60014043 D1 DE 60014043D1
Authority
DE
Germany
Prior art keywords
substituted piperidine
flouride
piperidine derivatives
hydrates
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60014043T
Other languages
English (en)
Other versions
DE60014043T2 (de
Inventor
Yoichi Iimura
Takashi Kosasa
Yoshiharu Yamanishi
Hachiro Sugimoto
Yoshio Takeuchi
Tetsuo Shibata
Emiko Suzuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai R&D Management Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Application granted granted Critical
Publication of DE60014043D1 publication Critical patent/DE60014043D1/de
Publication of DE60014043T2 publication Critical patent/DE60014043T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE60014043T 1999-03-03 2000-03-02 Flouride von 4-substituierten piperidin-derivaten Expired - Lifetime DE60014043T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP5575599 1999-03-03
JP5575599 1999-03-03
PCT/JP2000/001232 WO2000051985A1 (fr) 1999-03-03 2000-03-02 Fluorures de derives de piperidine substitues en position 4

Publications (2)

Publication Number Publication Date
DE60014043D1 true DE60014043D1 (de) 2004-10-28
DE60014043T2 DE60014043T2 (de) 2005-09-29

Family

ID=13007671

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60014043T Expired - Lifetime DE60014043T2 (de) 1999-03-03 2000-03-02 Flouride von 4-substituierten piperidin-derivaten

Country Status (7)

Country Link
US (1) US6677330B1 (de)
EP (1) EP1157989B1 (de)
KR (1) KR100694682B1 (de)
AT (1) ATE277011T1 (de)
AU (1) AU2825600A (de)
DE (1) DE60014043T2 (de)
WO (1) WO2000051985A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1209151E (pt) * 1999-09-01 2007-05-31 Eisai R&D Man Co Ltd Derivados piperidina 4-substituídos.
WO2001098271A1 (fr) 2000-06-21 2001-12-27 Eisai Co., Ltd. Compose piperidine 4-substitue
AU2001267899A1 (en) * 2000-07-03 2002-01-14 Eisai Co. Ltd. Pharmaceutical compositions for controlling intraocular pressure
EP1316549A4 (de) * 2000-09-01 2005-01-12 Eisai Co Ltd 1-benzyl-4-[(5,6-dimethoxy-2-fluor-1-indanon)-2-yl] methylpiperidin
MXPA04006344A (es) 2001-12-28 2005-03-31 Takeda Pharmaceutical Preventivos/remedios para la perturbacion de miccion.
JPWO2003061658A1 (ja) * 2002-01-22 2005-05-19 エーザイ株式会社 インダノン誘導体を含有するシグマ受容体結合剤
RU2478619C2 (ru) 2006-12-11 2013-04-10 Ривайва Фармасьютикалс, Инк. Композиции, синтез и способы применения ингибиторов холинэстеразы на основе инданона
KR101454362B1 (ko) 2008-03-24 2014-10-23 아이큐어 주식회사 도네페질을 유효성분으로 함유하는 치매 치료용경피흡수제제
US9145372B2 (en) 2010-11-15 2015-09-29 Agenebio, Inc. Pyridazine derivatives, compositions and methods for treating cognitive impairment
US9249098B2 (en) * 2012-07-10 2016-02-02 Xueheng Cheng Derivatives of donepezil
CN103787954B (zh) 2012-10-26 2016-01-20 中国科学院上海药物研究所 一类氟取代的环状胺类化合物及其制备方法、药物组合物和用途
CA3123897C (en) 2013-12-20 2024-02-06 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
CA2990004C (en) 2015-06-19 2024-04-23 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
KR101714575B1 (ko) * 2015-10-15 2017-03-09 국방과학연구소 피리디니움 옥심 유도체 또는 이의 약학적으로 허용가능한 염, 및 이를 유효성분으로 포함하는 약학적 조성물
US11505555B2 (en) 2016-12-19 2022-11-22 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US20180170941A1 (en) 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
JP2021528427A (ja) 2018-06-19 2021-10-21 エージンバイオ， インコーポレイテッド 認知障害を処置するためのベンゾジアゼピン誘導体、組成物および方法
WO2024039886A1 (en) 2022-08-19 2024-02-22 Agenebio, Inc. Benzazepine derivatives, compositions, and methods for treating cognitive impairment

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK623586A (da) * 1985-12-27 1987-06-28 Eisai Co Ltd Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne
FI95572C (fi) 1987-06-22 1996-02-26 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
JP3075566B2 (ja) 1990-05-15 2000-08-14 エーザイ株式会社 光学活性インダノン誘導体
TW197435B (de) 1990-11-22 1993-01-01 Takeda Pharm Industry Co Ltd
EP0535496A1 (de) * 1991-09-25 1993-04-07 Hoechst-Roussel Pharmaceuticals Incorporated (1-Indanon-2-yl)Methylpiperidine, Zwischenprodukte und Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
JPH07133274A (ja) * 1993-11-09 1995-05-23 Sankyo Co Ltd ピロール誘導体
WO1997046526A1 (en) * 1996-06-07 1997-12-11 Eisai Co., Ltd. Stable polymorphs of donepezil (1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine) hydrochloride and process for production
US6277866B1 (en) * 1999-03-03 2001-08-21 Eisai Co., Ltd. 1-benzyl-4[(5,6-dimethoxy-2-fluoro-1-indanon)-2-yl]methylpiperidine
DE10104415A1 (de) 2001-02-01 2002-08-29 Heidelberger Druckmasch Ag Verfahren und Vorrichtung zur Handhabung einer zu belichtenden Belichtungsfläche, insbesondere einer Druckplatte
US6696802B1 (en) 2002-08-22 2004-02-24 Fusion Uv Systems Inc. Radio frequency driven ultra-violet lamp
DE602004003743T2 (de) 2003-06-02 2007-10-04 Fujikura Ltd. Faserlaser und Verfahren zu dessen Betrieb

Also Published As

Publication number Publication date
ATE277011T1 (de) 2004-10-15
DE60014043T2 (de) 2005-09-29
AU2825600A (en) 2000-09-21
KR20010102440A (ko) 2001-11-15
EP1157989B1 (de) 2004-09-22
EP1157989A4 (de) 2002-05-29
WO2000051985A1 (fr) 2000-09-08
KR100694682B1 (ko) 2007-03-13
US6677330B1 (en) 2004-01-13
EP1157989A1 (de) 2001-11-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: EISAI R&D MANAGEMENT CO., LTD., TOKYO, JP