DE60011005D1 - Mit bioaktiven Mitteln beladene Polymeren - Google Patents

Mit bioaktiven Mitteln beladene Polymeren

Info

Publication number
DE60011005D1
DE60011005D1 DE60011005T DE60011005T DE60011005D1 DE 60011005 D1 DE60011005 D1 DE 60011005D1 DE 60011005 T DE60011005 T DE 60011005T DE 60011005 T DE60011005 T DE 60011005T DE 60011005 D1 DE60011005 D1 DE 60011005D1
Authority
DE
Germany
Prior art keywords
bioactive agent
implant
solvent
bioactive agents
bioactive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60011005T
Other languages
English (en)
Inventor
Jeroen Mattijs Bezemer
Jan Feijen
Blitterswijk Clemens Anton Van
Dirk Wybe Grijpma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chienna BV
Original Assignee
Chienna BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chienna BV filed Critical Chienna BV
Application granted granted Critical
Publication of DE60011005D1 publication Critical patent/DE60011005D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C07K17/04—Peptides being immobilised on, or in, an organic carrier entrapped within the carrier, e.g. gel, hollow fibre
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y10S530/815—Carrier is a synthetic polymer
    • Y10S530/817—Entrapped within the carrier, e.g. gel, hollow fibre

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Peptides Or Proteins (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Artificial Filaments (AREA)
  • Spinning Methods And Devices For Manufacturing Artificial Fibers (AREA)
DE60011005T 1999-09-30 2000-09-28 Mit bioaktiven Mitteln beladene Polymeren Expired - Lifetime DE60011005D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99203195 1999-09-30

Publications (1)

Publication Number Publication Date
DE60011005D1 true DE60011005D1 (de) 2004-07-01

Family

ID=8240692

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60011005T Expired - Lifetime DE60011005D1 (de) 1999-09-30 2000-09-28 Mit bioaktiven Mitteln beladene Polymeren

Country Status (6)

Country Link
US (2) US6685957B1 (de)
JP (1) JP2001181924A (de)
AT (1) ATE267842T1 (de)
AU (1) AU6132700A (de)
CA (1) CA2321321A1 (de)
DE (1) DE60011005D1 (de)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6132700A (en) * 1999-09-30 2001-04-05 Chienna B.V. Polymers loaded with bioactive agents
EP1247537A1 (de) * 2001-04-04 2002-10-09 Isotis B.V. Beschichtung für medizinische Vorrichtungen
US20080075750A1 (en) * 2001-05-11 2008-03-27 The Nemours Foundation Methods for producing three-dimensional tissue-engineered cardiac constructs and uses regarding same
US7737185B2 (en) * 2001-07-09 2010-06-15 Repros Therapeutics Inc. Methods and compositions with trans-clomiphene
ES2312593T3 (es) * 2001-07-09 2009-03-01 Repros Therapeutics Inc. Procedimientos y materiales para el tratamiento de la deficiencia de testosterona en hombres.
US7629388B2 (en) * 2001-11-20 2009-12-08 William Marsh Rice University Synthesis and characterization of biodegradable cationic poly(propylene fumarate-co-ethylene glycol) copolymer hydrogels modified with agmatine for enhanced cell adhesion
US6926919B1 (en) * 2003-02-26 2005-08-09 Advanced Cardiovascular Systems, Inc. Method for fabricating a coating for a medical device
US8585771B2 (en) 2004-02-26 2013-11-19 Endosphere, Inc. Methods and devices to curb appetite and/or to reduce food intake
US8147561B2 (en) * 2004-02-26 2012-04-03 Endosphere, Inc. Methods and devices to curb appetite and/or reduce food intake
US7931693B2 (en) * 2004-02-26 2011-04-26 Endosphere, Inc. Method and apparatus for reducing obesity
WO2006002399A2 (en) * 2004-06-24 2006-01-05 Surmodics, Inc. Biodegradable implantable medical devices, methods and systems
US20060024350A1 (en) * 2004-06-24 2006-02-02 Varner Signe E Biodegradable ocular devices, methods and systems
MX2007000050A (es) * 2004-07-14 2007-07-10 Repros Therapeutics Inc Trans-clomifeno para el tratamiento de hipertrofia de prostata benigna, cancer de prostata, hipogonadismo, trigliceridos elevados y colesterol elevado.
US7351423B2 (en) 2004-09-01 2008-04-01 Depuy Spine, Inc. Musculo-skeletal implant having a bioactive gradient
WO2007001448A2 (en) 2004-11-04 2007-01-04 Massachusetts Institute Of Technology Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals
US20060148066A1 (en) * 2005-01-05 2006-07-06 Senecal Kris J Electrospun nanofibrous membrane assembly for use in capturing chemical and/or biological analytes
RU2404757C2 (ru) * 2005-02-04 2010-11-27 Репрос Терапьютикс Инк. Способы и материалы с транс-кломифеном для лечения мужского бесплодия
US20080274183A1 (en) * 2005-02-04 2008-11-06 Phillip Michael Cook Thermoplastic articles containing a medicament
US10328032B2 (en) 2005-03-04 2019-06-25 Biosurfaces, Inc. Nanofibrous materials as drug, protein, or genetic release vehicles
TWI283717B (en) * 2005-03-09 2007-07-11 Taiwan Textile Res Inst Method of fabricating nano-silver fibers
CA3071412A1 (en) * 2005-03-22 2006-09-28 Allergan Pharmaceuticals International Limited Dosing regimes for trans-clomiphene
US20060240108A1 (en) * 2005-04-26 2006-10-26 Bernard Bobby L Cellulosic films incorporating a pharmaceutically acceptable plasticizer with enhanced wettability
FR2891746B1 (fr) * 2005-10-11 2008-01-11 Centre Nat Rech Scient Matrice poreuse biocompatible et biodegradable notamment utile pour la construction cellulaire
US9267937B2 (en) 2005-12-15 2016-02-23 Massachusetts Institute Of Technology System for screening particles
CA2648099C (en) 2006-03-31 2012-05-29 The Brigham And Women's Hospital, Inc System for targeted delivery of therapeutic agents
CN101495065B (zh) 2006-04-25 2014-07-23 泰里福来克斯医学公司 磷酸钙聚合物复合材料及其制备方法
US9060835B2 (en) * 2006-05-26 2015-06-23 Endosphere, Inc. Conformationally-stabilized intraluminal device for medical applications
WO2007150030A2 (en) * 2006-06-23 2007-12-27 Massachusetts Institute Of Technology Microfluidic synthesis of organic nanoparticles
WO2008019142A2 (en) * 2006-08-04 2008-02-14 Massachusetts Institute Of Technology Oligonucleotide systems for targeted intracellular delivery
WO2008098165A2 (en) 2007-02-09 2008-08-14 Massachusetts Institute Of Technology Oscillating cell culture bioreactor
EP2144600A4 (de) * 2007-04-04 2011-03-16 Massachusetts Inst Technology Poly (aminsäure)-zielmoleküle
US20110137227A1 (en) * 2007-07-16 2011-06-09 Mckinley James T Methods and devices for delivering or delaying lipids within a duodenum
HUE034775T2 (hu) * 2007-09-28 2018-02-28 Pfizer Rákos sejt célzása nanorészecskék alkalmazásával
EP2620157A3 (de) 2007-10-12 2013-10-16 Massachusetts Institute of Technology Impfstoffnanotechnologie
MX2010004195A (es) 2007-10-16 2010-06-02 Repros Therapeutics Inc Trans-clomifeno para el sindrome metabolico.
JP2012501965A (ja) 2008-06-16 2012-01-26 バインド バイオサイエンシズ インコーポレイテッド 薬剤を装填したポリマーナノ粒子及びその製造方法と使用方法
EA020753B1 (ru) * 2008-06-16 2015-01-30 Бинд Терапьютикс, Инк. Терапевтические полимерные наночастицы, содержащие алкалоиды vinca, и их применение
US8613951B2 (en) 2008-06-16 2013-12-24 Bind Therapeutics, Inc. Therapeutic polymeric nanoparticles with mTor inhibitors and methods of making and using same
US8591905B2 (en) 2008-10-12 2013-11-26 The Brigham And Women's Hospital, Inc. Nicotine immunonanotherapeutics
US8277812B2 (en) 2008-10-12 2012-10-02 Massachusetts Institute Of Technology Immunonanotherapeutics that provide IgG humoral response without T-cell antigen
US8563041B2 (en) * 2008-12-12 2013-10-22 Bind Therapeutics, Inc. Therapeutic particles suitable for parenteral administration and methods of making and using same
JP2012512175A (ja) * 2008-12-15 2012-05-31 バインド バイオサイエンシズ インコーポレイテッド 治療薬を徐放するための長時間循環性ナノ粒子
US8815971B2 (en) * 2008-12-22 2014-08-26 ATRP Solutions, Inc. Control over controlled radical polymerization processes
US8822610B2 (en) 2008-12-22 2014-09-02 ATRP Solutions, Inc. Control over controlled radical polymerization processes
US20100291182A1 (en) * 2009-01-21 2010-11-18 Arsenal Medical, Inc. Drug-Loaded Fibers
US8173750B2 (en) * 2009-04-23 2012-05-08 ATRP Solutions, Inc. Star macromolecules for personal and home care
WO2010123574A1 (en) 2009-04-23 2010-10-28 Atrp Solutions Inc Star macromolecules for personal and home care
US9783628B2 (en) 2009-04-23 2017-10-10 ATRP Solutions, Inc. Dual-mechanism thickening agents for hydraulic fracturing fluids
US10420862B2 (en) 2009-08-24 2019-09-24 Aresenal AAA, LLC. In-situ forming foams for treatment of aneurysms
US9044580B2 (en) 2009-08-24 2015-06-02 Arsenal Medical, Inc. In-situ forming foams with outer layer
US20110202016A1 (en) * 2009-08-24 2011-08-18 Arsenal Medical, Inc. Systems and methods relating to polymer foams
US9173817B2 (en) 2009-08-24 2015-11-03 Arsenal Medical, Inc. In situ forming hemostatic foam implants
US9504698B2 (en) * 2009-10-29 2016-11-29 Warsaw Orthopedic, Inc. Flowable composition that sets to a substantially non-flowable state
EA036522B1 (ru) 2009-12-11 2020-11-19 Пфайзер Инк. Фармацевтическая композиция, пригодная для лиофилизации, содержащая множество терапевтических частиц
EA201290499A1 (ru) 2009-12-15 2013-01-30 Байнд Байосайенсиз, Инк. Композиции терапевтических полимерных наночастиц с высокой температурой стеклования и высокомолекулярными сополимерами
CN102970987A (zh) 2010-07-02 2013-03-13 宝洁公司 通过施用包含长丝的个人保健制品来递送保健活性物质的方法
US9587064B2 (en) 2010-12-08 2017-03-07 ATRP Solutions, Inc. Salt-tolerant star macromolecules
US9194058B2 (en) 2011-01-31 2015-11-24 Arsenal Medical, Inc. Electrospinning process for manufacture of multi-layered structures
US8968626B2 (en) 2011-01-31 2015-03-03 Arsenal Medical, Inc. Electrospinning process for manufacture of multi-layered structures
US9034240B2 (en) 2011-01-31 2015-05-19 Arsenal Medical, Inc. Electrospinning process for fiber manufacture
WO2012118236A1 (ja) * 2011-03-03 2012-09-07 帝人株式会社 繊維成形体
WO2013019733A2 (en) * 2011-07-29 2013-02-07 Brown University Methods, compositions and kits for therapeutic treatment with wet spun microstructures
UA113291C2 (xx) 2011-08-04 2017-01-10 Метаболіти транскломіфену і їх застосування
US9370482B1 (en) 2011-09-09 2016-06-21 Harrison Yu Method of incorporating additives to shaped porous monocomponent biopolymer fibers during fiber orienting step
US8993831B2 (en) 2011-11-01 2015-03-31 Arsenal Medical, Inc. Foam and delivery system for treatment of postpartum hemorrhage
US9238011B2 (en) 2012-04-23 2016-01-19 Brown University Compositions, methods and kits for therapeutic treatment with wet spun microstructures
CA2882832C (en) 2012-08-30 2021-08-24 ATRP Solutions, Inc. Dual mechanism thickening agents for hydraulic fracturing fluids
JP6356678B2 (ja) 2012-09-17 2018-07-11 ファイザー・インク 治療用ナノ粒子を製造する方法
CA2889770A1 (en) 2012-11-02 2014-05-08 Repros Therapeutics Inc. Trans-clomiphene for use in cancer therapy
CN105263978B (zh) 2013-02-04 2018-04-17 Atrp解决方案公司 耐盐星形大分子
KR20140141857A (ko) * 2013-05-31 2014-12-11 한국생명공학연구원 패실로마이세스 속 균주를 이용한 생물 농약 제조방법
AP2016009494A0 (en) 2014-03-14 2016-10-31 Pfizer Therapeutic nanoparticles comprising a therapeutic agent and methods of making and using same
US10336848B2 (en) 2014-07-03 2019-07-02 Pilot Polymer Technologies, Inc. Surfactant-compatible star macromolecules
CN106702525B (zh) * 2015-07-22 2019-01-18 远东新世纪股份有限公司 用于产制纤维的材料及由其所制得的纤维
WO2017143199A1 (en) * 2016-02-18 2017-08-24 Biosurfaces, Inc. Nanofibrous materials as drug, protein, or genetic release vehicles
US20210330868A1 (en) * 2018-09-06 2021-10-28 Bio-On S.P.A. Membrane to re-establish continuity of injured biological tissues

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4576817A (en) * 1984-06-07 1986-03-18 Laclede Professional Products, Inc. Enzymatic bandages and pads
US5096585A (en) * 1991-01-28 1992-03-17 W. R. Grace & Co.-Conn. Process for preparing protein non-adsorptive microporous polysulfone membranes
US5151227A (en) * 1991-03-18 1992-09-29 W. R. Grace & Co.-Conn. Process for continuous spinning of hollow-fiber membranes using a solvent mixture as a precipitation medium
US5288502A (en) * 1991-10-16 1994-02-22 The University Of Texas System Preparation and uses of multi-phase microspheres
US5855610A (en) * 1995-05-19 1999-01-05 Children's Medical Center Corporation Engineering of strong, pliable tissues
US5874029A (en) * 1996-10-09 1999-02-23 The University Of Kansas Methods for particle micronization and nanonization by recrystallization from organic solutions sprayed into a compressed antisolvent
US5980948A (en) 1996-08-16 1999-11-09 Osteotech, Inc. Polyetherester copolymers as drug delivery matrices
US6162537A (en) * 1996-11-12 2000-12-19 Solutia Inc. Implantable fibers and medical articles
EP0891783B1 (de) 1997-07-16 2002-06-12 IsoTis N.V. Vorrichtung zur Knochenbehandlung bestehend aus abbaubarem thermoplastischen Copolyester und kultivierten Zellen
AU6132700A (en) * 1999-09-30 2001-04-05 Chienna B.V. Polymers loaded with bioactive agents

Also Published As

Publication number Publication date
AU6132700A (en) 2001-04-05
ATE267842T1 (de) 2004-06-15
CA2321321A1 (en) 2001-03-30
US6685957B1 (en) 2004-02-03
US20040086544A1 (en) 2004-05-06
JP2001181924A (ja) 2001-07-03

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Legal Events

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8332 No legal effect for de