DE60010657T2 - Laborvorrichtung mit verschlusskappe und küvetten für kristallzüchtung mittels dampfdiffusionsverfahren - Google Patents
Laborvorrichtung mit verschlusskappe und küvetten für kristallzüchtung mittels dampfdiffusionsverfahren Download PDFInfo
- Publication number
- DE60010657T2 DE60010657T2 DE60010657T DE60010657T DE60010657T2 DE 60010657 T2 DE60010657 T2 DE 60010657T2 DE 60010657 T DE60010657 T DE 60010657T DE 60010657 T DE60010657 T DE 60010657T DE 60010657 T2 DE60010657 T2 DE 60010657T2
- Authority
- DE
- Germany
- Prior art keywords
- cap
- trough
- tray
- locking
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000009792 diffusion process Methods 0.000 title claims abstract description 9
- 238000004326 stimulated echo acquisition mode for imaging Methods 0.000 title 1
- 239000013078 crystal Substances 0.000 claims abstract description 26
- 238000000034 method Methods 0.000 claims abstract description 24
- 238000011049 filling Methods 0.000 claims abstract description 5
- 229920002521 macromolecule Polymers 0.000 claims description 18
- 239000000463 material Substances 0.000 claims description 12
- 238000001556 precipitation Methods 0.000 claims description 11
- 230000001376 precipitating effect Effects 0.000 claims description 7
- 238000007789 sealing Methods 0.000 claims description 7
- 239000003795 chemical substances by application Substances 0.000 claims description 6
- 229920001893 acrylonitrile styrene Polymers 0.000 claims description 4
- -1 Polypropylene Polymers 0.000 claims description 3
- 239000004743 Polypropylene Substances 0.000 claims description 3
- 239000004793 Polystyrene Substances 0.000 claims description 3
- 229920001155 polypropylene Polymers 0.000 claims description 3
- 229920002223 polystyrene Polymers 0.000 claims description 3
- 239000004721 Polyphenylene oxide Substances 0.000 claims description 2
- 239000013536 elastomeric material Substances 0.000 claims description 2
- 229920006287 phenoxy resin Polymers 0.000 claims description 2
- 239000013034 phenoxy resin Substances 0.000 claims description 2
- 229920000058 polyacrylate Polymers 0.000 claims description 2
- 229920000515 polycarbonate Polymers 0.000 claims description 2
- 239000004417 polycarbonate Substances 0.000 claims description 2
- 229920000193 polymethacrylate Polymers 0.000 claims description 2
- 229920006380 polyphenylene oxide Polymers 0.000 claims description 2
- SCUZVMOVTVSBLE-UHFFFAOYSA-N prop-2-enenitrile;styrene Chemical compound C=CC#N.C=CC1=CC=CC=C1 SCUZVMOVTVSBLE-UHFFFAOYSA-N 0.000 claims description 2
- 230000002093 peripheral effect Effects 0.000 claims 3
- 230000003993 interaction Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 238000002425 crystallisation Methods 0.000 abstract description 13
- 230000008025 crystallization Effects 0.000 abstract description 12
- 108090000623 proteins and genes Proteins 0.000 abstract description 7
- 102000004169 proteins and genes Human genes 0.000 abstract description 7
- 239000000243 solution Substances 0.000 description 24
- 238000002474 experimental method Methods 0.000 description 9
- 238000010276 construction Methods 0.000 description 7
- 239000011521 glass Substances 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 239000004519 grease Substances 0.000 description 4
- 238000012216 screening Methods 0.000 description 4
- 230000008901 benefit Effects 0.000 description 3
- 238000011109 contamination Methods 0.000 description 3
- 239000006059 cover glass Substances 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 239000011324 bead Substances 0.000 description 2
- 238000002050 diffraction method Methods 0.000 description 2
- 239000013013 elastic material Substances 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 238000007654 immersion Methods 0.000 description 2
- 239000012460 protein solution Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 238000012800 visualization Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 101001017516 Drosophila melanogaster Muscle segmentation homeobox Proteins 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 238000011067 equilibration Methods 0.000 description 1
- 238000012835 hanging drop method Methods 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920005606 polypropylene copolymer Polymers 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000000565 sealant Substances 0.000 description 1
- 239000003566 sealing material Substances 0.000 description 1
- 238000005475 siliconizing Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000012815 thermoplastic material Substances 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
- 239000012780 transparent material Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/06—Crystallising dishes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5082—Test tubes per se
- B01L3/50825—Closing or opening means, corks, bungs
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
- B01L3/50853—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates with covers or lids
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
- C30B29/54—Organic compounds
- C30B29/58—Macromolecular compounds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0689—Sealing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
- B01L2300/041—Connecting closures to device or container
- B01L2300/042—Caps; Plugs
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Metallurgy (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Analytical Chemistry (AREA)
- Organic Chemistry (AREA)
- Sampling And Sample Adjustment (AREA)
- Closures For Containers (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Control And Other Processes For Unpacking Of Materials (AREA)
- Devices For Use In Laboratory Experiments (AREA)
- Peptides Or Proteins (AREA)
- Special Wing (AREA)
- Fire-Extinguishing Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2261326 | 1999-02-09 | ||
| CA002261326A CA2261326A1 (en) | 1999-02-09 | 1999-02-09 | Laboratory cap and well for hanging-drop crystallization methods |
| PCT/CA2000/000119 WO2000047323A1 (en) | 1999-02-09 | 2000-02-09 | Laboratory cap and well for hanging-drop crystallization methods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60010657D1 DE60010657D1 (de) | 2004-06-17 |
| DE60010657T2 true DE60010657T2 (de) | 2005-02-10 |
Family
ID=4163275
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60010657T Expired - Lifetime DE60010657T2 (de) | 1999-02-09 | 2000-02-09 | Laborvorrichtung mit verschlusskappe und küvetten für kristallzüchtung mittels dampfdiffusionsverfahren |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7316805B1 (enExample) |
| EP (1) | EP1148946B1 (enExample) |
| JP (1) | JP4753107B2 (enExample) |
| KR (1) | KR20020013837A (enExample) |
| AT (1) | ATE266474T1 (enExample) |
| AU (1) | AU773384C (enExample) |
| CA (1) | CA2261326A1 (enExample) |
| DE (1) | DE60010657T2 (enExample) |
| DK (1) | DK1148946T3 (enExample) |
| IL (1) | IL144752A (enExample) |
| WO (1) | WO2000047323A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6797461B2 (en) | 2000-10-27 | 2004-09-28 | Promega Corporation | Tryptase substrates and assay for tryptase activity using same |
| JP3905399B2 (ja) | 2002-02-25 | 2007-04-18 | プロテインウエーブ株式会社 | 生体高分子の結晶生成装置 |
| US20030235519A1 (en) * | 2002-06-24 | 2003-12-25 | Corning Incorporated | Protein crystallography hanging drop lid that individually covers each of the wells in a microplate |
| US7112241B2 (en) | 2002-12-31 | 2006-09-26 | Corning Incorporated | Protein crystallography hanging drop multiwell plate |
| ES2300738T3 (es) | 2003-01-17 | 2008-06-16 | Nextal Biotechnologie Inc. | Placas de cristalizacion precargadas y procedimientos para preparacion y uso de las mismas. |
| CN100448503C (zh) * | 2003-01-17 | 2009-01-07 | 纳克斯泰尔生物技术公司 | 预填充的结晶板及其制备和应用方法 |
| JP2008506616A (ja) * | 2004-07-16 | 2008-03-06 | ネクスタル バイオテクノロジー インコーポレイテッド | 基質の結晶条件を最適化するための方法および装置 |
| CA2680274C (en) * | 2007-03-09 | 2015-10-27 | Nexus Biosystems, Inc. | Device and method for removing a peelable seal |
| WO2012098212A1 (en) * | 2011-01-20 | 2012-07-26 | 4Titude Limited | Microplate and multiwell strip with double rimmmed wells |
| JP5972866B2 (ja) | 2011-03-31 | 2016-08-17 | クニミネ工業株式会社 | タンパク質結晶化条件探索剤及びタンパク質結晶化条件探索方法 |
| US9381524B2 (en) | 2011-11-08 | 2016-07-05 | Becton, Dickinson And Company | System and method for automated sample preparation |
| US9075039B2 (en) | 2011-11-08 | 2015-07-07 | Becton, Dickinson And Company | Container and cap for a biological specimen |
| US9180461B2 (en) * | 2012-10-22 | 2015-11-10 | Qiagen Gaithersburg, Inc. | Condensation-reducing incubation cover |
| DE102013011534B4 (de) * | 2013-07-10 | 2015-09-03 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Kultivierungsgefäß und Verfahren zur Kultivierung biologischer Zellen in hängenden Tropfen |
| JP6957493B2 (ja) | 2016-03-02 | 2021-11-02 | ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company | 自動化システムにおけるねじ蓋容器にアクセスするためのパッケージング及び装置 |
| GB201705870D0 (en) * | 2017-04-11 | 2017-05-24 | 4Titude Ltd | Improved sealing mat |
| FR3083785B1 (fr) * | 2018-07-10 | 2020-06-19 | Technoflex | Dispositif de maintien pour recipients comportant un tuyau de remplissage et utilisation dudit dispositif |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2366886A (en) | 1942-11-20 | 1945-01-09 | American Tag Company | Capsule handling apparatus |
| US3107204A (en) | 1961-01-23 | 1963-10-15 | Dalde Reagents Inc | Microbiological testing method and structure therefor |
| US3297184A (en) * | 1963-11-05 | 1967-01-10 | B D Lab Inc | Cap for culture tubes |
| US3537956A (en) | 1967-06-26 | 1970-11-03 | Joseph R Falcone | Petrie dish |
| US3597326A (en) | 1968-07-26 | 1971-08-03 | John Liner | Multi-dish laboratory unit |
| US3649464A (en) | 1969-12-05 | 1972-03-14 | Microbiological Ass Inc | Assay and culture tray |
| US3692498A (en) | 1970-10-12 | 1972-09-19 | Lab Aids Inc | Chemical testing apparatus |
| US3745091A (en) | 1970-11-18 | 1973-07-10 | Miles Lab | Biological reaction chamber apparatus |
| US3729382A (en) | 1970-12-09 | 1973-04-24 | Becton Dickinson Co | Microorganism sampling dish |
| US3907505A (en) | 1973-05-30 | 1975-09-23 | Miles Lab | Selectively detachable apparatus |
| US3860136A (en) * | 1974-01-30 | 1975-01-14 | Child Resistant Packaging Inc | Child-resistant enclosure for hazardous materials |
| US4038149A (en) * | 1975-12-31 | 1977-07-26 | Linbro Scientific, Inc. | Laboratory trays with lockable covers |
| US4154795A (en) | 1976-07-23 | 1979-05-15 | Dynatech Holdings Limited | Microtest plates |
| US4495289A (en) | 1981-03-17 | 1985-01-22 | Data Packaging Corporation | Tissue culture cluster dish |
| US4599314A (en) * | 1983-06-14 | 1986-07-08 | Hsc Research Development Corporation | Multiple vessel specimen tray with lid for releasably adhering vessel covers |
| DE3402276C1 (de) * | 1984-01-24 | 1985-02-21 | Eppendorf Gerätebau Netheler + Hinz GmbH, 2000 Hamburg | Reaktionsgefaess aus Kunststoff fuer kleine Fluessigkeitsmengen |
| FR2604917B1 (fr) | 1986-10-09 | 1989-01-27 | Aerospatiale | Procede, cellule et dispositif de cristallogenese, notamment par vaisseau spatial |
| US4829006A (en) * | 1988-02-01 | 1989-05-09 | Difco Laboratories | Centrifugation vial and cluster tray |
| JPH04124082A (ja) | 1990-09-14 | 1992-04-24 | Agency Of Ind Science & Technol | 結晶形成方法 |
| KR100236506B1 (ko) * | 1990-11-29 | 2000-01-15 | 퍼킨-엘머시터스인스트루먼츠 | 폴리머라제 연쇄 반응 수행 장치 |
| EP0607262A1 (en) * | 1991-10-09 | 1994-07-27 | Schering Corporation | Crystal forming device and automated crystallization system |
| US5221410A (en) * | 1991-10-09 | 1993-06-22 | Schering Corporation | Crystal forming device |
| US5342581A (en) * | 1993-04-19 | 1994-08-30 | Sanadi Ashok R | Apparatus for preventing cross-contamination of multi-well test plates |
| DE4412286A1 (de) * | 1994-04-09 | 1995-10-12 | Boehringer Mannheim Gmbh | System zur kontaminationsfreien Bearbeitung von Reaktionsabläufen |
| US5419278A (en) * | 1994-05-25 | 1995-05-30 | Carter; Daniel C. | Vapor equilibration tray for growing protein crystals |
| US6074614A (en) * | 1995-06-07 | 2000-06-13 | Molecular Devices Corporation | Multi-assay plate cover for elimination of meniscus |
| US6027694A (en) * | 1996-10-17 | 2000-02-22 | Texperts, Inc. | Spillproof microplate assembly |
-
1999
- 1999-02-09 CA CA002261326A patent/CA2261326A1/en not_active Abandoned
-
2000
- 2000-02-09 EP EP00903455A patent/EP1148946B1/en not_active Expired - Lifetime
- 2000-02-09 KR KR1020017010078A patent/KR20020013837A/ko not_active Withdrawn
- 2000-02-09 DE DE60010657T patent/DE60010657T2/de not_active Expired - Lifetime
- 2000-02-09 AU AU25291/00A patent/AU773384C/en not_active Expired
- 2000-02-09 AT AT00903455T patent/ATE266474T1/de not_active IP Right Cessation
- 2000-02-09 DK DK00903455T patent/DK1148946T3/da active
- 2000-02-09 WO PCT/CA2000/000119 patent/WO2000047323A1/en not_active Ceased
- 2000-02-09 JP JP2000598269A patent/JP4753107B2/ja not_active Expired - Lifetime
- 2000-02-09 IL IL14475200A patent/IL144752A/xx not_active IP Right Cessation
- 2000-09-02 US US09/913,088 patent/US7316805B1/en not_active Expired - Lifetime
-
2007
- 2007-04-05 US US11/784,157 patent/US20070184551A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| IL144752A (en) | 2005-03-20 |
| KR20020013837A (ko) | 2002-02-21 |
| US20070184551A1 (en) | 2007-08-09 |
| EP1148946A1 (en) | 2001-10-31 |
| DK1148946T3 (da) | 2004-08-09 |
| DE60010657D1 (de) | 2004-06-17 |
| ATE266474T1 (de) | 2004-05-15 |
| JP4753107B2 (ja) | 2011-08-24 |
| CA2261326A1 (en) | 2000-08-09 |
| AU2529100A (en) | 2000-08-29 |
| JP2002536255A (ja) | 2002-10-29 |
| US7316805B1 (en) | 2008-01-08 |
| IL144752A0 (en) | 2002-06-30 |
| EP1148946B1 (en) | 2004-05-12 |
| AU773384B2 (en) | 2004-05-27 |
| WO2000047323A1 (en) | 2000-08-17 |
| AU773384C (en) | 2004-12-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8328 | Change in the person/name/address of the agent |
Representative=s name: CBDL PATENTANWAELTE, 47051 DUISBURG |
|
| 8364 | No opposition during term of opposition |