DE60010028T2 - Chlorin- und Bakteriochlorin-aminophenylDTPA Konjugate als MR Kontrastmittel und Radiopharmazeutika - Google Patents

Chlorin- und Bakteriochlorin-aminophenylDTPA Konjugate als MR Kontrastmittel und Radiopharmazeutika Download PDF

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Publication number
DE60010028T2
DE60010028T2 DE60010028T DE60010028T DE60010028T2 DE 60010028 T2 DE60010028 T2 DE 60010028T2 DE 60010028 T DE60010028 T DE 60010028T DE 60010028 T DE60010028 T DE 60010028T DE 60010028 T2 DE60010028 T2 DE 60010028T2
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DE
Germany
Prior art keywords
dtpa
compound
aminophenyl
reacting
compound according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60010028T
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German (de)
English (en)
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DE60010028D1 (de
Inventor
Ravindra K. Pandey
Zachary Grossman
Peter Kanter
Thomas J. Dougherty
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Health Research Inc
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Health Research Inc
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Publication of DE60010028D1 publication Critical patent/DE60010028D1/de
Publication of DE60010028T2 publication Critical patent/DE60010028T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0485—Porphyrins, texaphyrins wherein the nitrogen atoms forming the central ring system complex the radioactive metal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
DE60010028T 1999-12-23 2000-12-20 Chlorin- und Bakteriochlorin-aminophenylDTPA Konjugate als MR Kontrastmittel und Radiopharmazeutika Expired - Lifetime DE60010028T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US17196199P 1999-12-23 1999-12-23
US171961P 1999-12-23
US09/739,155 US6534040B2 (en) 1999-12-23 2000-12-18 Chlorin and bacteriochlorin-based aminophenyl DTPA and N2S2 conjugates for MR contrast media and radiopharmaceuticals
US739155 2000-12-18

Publications (2)

Publication Number Publication Date
DE60010028D1 DE60010028D1 (de) 2004-05-27
DE60010028T2 true DE60010028T2 (de) 2005-04-28

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
DE60010028T Expired - Lifetime DE60010028T2 (de) 1999-12-23 2000-12-20 Chlorin- und Bakteriochlorin-aminophenylDTPA Konjugate als MR Kontrastmittel und Radiopharmazeutika

Country Status (8)

Country Link
US (1) US6534040B2 (US20010046983A1-20011129-C00007.png)
EP (1) EP1110963B1 (US20010046983A1-20011129-C00007.png)
JP (1) JP4885354B2 (US20010046983A1-20011129-C00007.png)
AT (1) ATE264862T1 (US20010046983A1-20011129-C00007.png)
AU (1) AU779361B2 (US20010046983A1-20011129-C00007.png)
CA (1) CA2329320C (US20010046983A1-20011129-C00007.png)
DE (1) DE60010028T2 (US20010046983A1-20011129-C00007.png)
DK (1) DK1110963T3 (US20010046983A1-20011129-C00007.png)

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USRE38994E1 (en) 1988-07-20 2006-02-28 Health Research, Inc. Pyropheophorbides conjugates and their use in photodynamic therapy
US6454789B1 (en) * 1999-01-15 2002-09-24 Light Science Corporation Patient portable device for photodynamic therapy
US6602274B1 (en) * 1999-01-15 2003-08-05 Light Sciences Corporation Targeted transcutaneous cancer therapy
WO2000041726A2 (en) 1999-01-15 2000-07-20 Light Sciences Corporation Noninvasive vascular therapy
JP2002534483A (ja) * 1999-01-15 2002-10-15 ライト サイエンシーズ コーポレイション 代謝性骨障害または骨転移のための治療的組成物
US20030114434A1 (en) * 1999-08-31 2003-06-19 James Chen Extended duration light activated cancer therapy
US7897140B2 (en) * 1999-12-23 2011-03-01 Health Research, Inc. Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents
US7078014B2 (en) * 1999-12-23 2006-07-18 Health Research, Inc. Method for using chlorin and bacteriochlorin-based aminophenyl DTPA and N2S2 conjugates for MR contrast media and radiopharmaceuticals
US7097826B2 (en) * 1999-12-23 2006-08-29 Health Research, Inc. Chlorin and bacteriochlorin-based difunctional aminophenyl DTPA and N2S2 conjugates for MR contrast media and radiopharmaceuticals
US6624187B1 (en) 2000-06-12 2003-09-23 Health Research, Inc. Long wave length absorbing bacteriochlorin alkyl ether analogs
WO2003061696A2 (en) * 2002-01-23 2003-07-31 Light Sciences Corporation Systems and methods for photodynamic therapy
AU2003248747A1 (en) * 2002-06-27 2004-01-19 Health Research, Inc. Fluorinated chlorin and bacteriochlorin photosensitizers for photodynamic therapy
AU2003249742A1 (en) * 2002-07-02 2004-01-23 Health Research, Inc. Efficient synthesis of pyropheophorbide a and its derivatives
US20040010218A1 (en) * 2002-07-11 2004-01-15 Henderson Barbara W. Photodynamic therapy for the enhancement of vascular permeability to aid in drug delivery to diseased tissues
WO2004067508A2 (en) * 2003-01-24 2004-08-12 The Research Foundation Of State University Of Newyork Use of photodynamic therapy therapeutic agents entrapped in ceramic nanoparticles
CA2589881A1 (en) * 2004-12-03 2006-06-08 University Of Utah Research Foundation Mri guided photodynamic therapy for cancer
EP1833512A1 (en) 2005-01-06 2007-09-19 GE Healthcare AS Optical imaging
US8198432B2 (en) * 2005-02-25 2012-06-12 Health Research, Inc. Porphyrin-based compounds for tumor imaging and photodynamic therapy
US20060198783A1 (en) * 2005-02-25 2006-09-07 Health Research, Inc., Roswell Park Cancer Institute Division Porphyrin-based compounds for tumor imaging and photodynamic therapy
US20090169480A1 (en) * 2007-12-31 2009-07-02 Industrial Technology Research Institute Dendritic polymers and magnetic resonance imaging contrast agent employing the same
US20120034157A1 (en) * 2010-08-03 2012-02-09 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Artificial cells
US9095624B2 (en) * 2011-05-23 2015-08-04 Contango Partners Group, Inc. Modular transport platform for targeted delivery of therapeutic agents
CN104193753A (zh) * 2014-08-26 2014-12-10 江苏红豆杉药业有限公司 一种由红豆杉枝叶提取物制备光敏剂hpph的方法
CN114887055B (zh) * 2022-04-18 2023-06-16 浙江大学 一种糖靶向具有mr/nir显像和光动力治疗功能的诊疗一体化制剂及其制备方法和应用

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Also Published As

Publication number Publication date
CA2329320A1 (en) 2001-06-23
EP1110963A2 (en) 2001-06-27
EP1110963B1 (en) 2004-04-21
CA2329320C (en) 2010-08-24
JP4885354B2 (ja) 2012-02-29
AU7238400A (en) 2001-06-28
US20010046983A1 (en) 2001-11-29
US6534040B2 (en) 2003-03-18
AU779361B2 (en) 2005-01-20
DE60010028D1 (de) 2004-05-27
EP1110963A3 (en) 2001-12-19
ATE264862T1 (de) 2004-05-15
DK1110963T3 (da) 2004-07-05
JP2001335578A (ja) 2001-12-04

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