DE60009904D1 - Bakteriochlorine und bakteriopurpurine und deren verwendung zur photodynamischen therapie von tumoren sowie ein verfahren zu deren herstellung - Google Patents

Bakteriochlorine und bakteriopurpurine und deren verwendung zur photodynamischen therapie von tumoren sowie ein verfahren zu deren herstellung

Info

Publication number
DE60009904D1
DE60009904D1 DE60009904T DE60009904T DE60009904D1 DE 60009904 D1 DE60009904 D1 DE 60009904D1 DE 60009904 T DE60009904 T DE 60009904T DE 60009904 T DE60009904 T DE 60009904T DE 60009904 D1 DE60009904 D1 DE 60009904D1
Authority
DE
Germany
Prior art keywords
bacteriochlorins
bacteriopurpurins
photodynamic therapy
methods
bacteriopurpurine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60009904T
Other languages
English (en)
Other versions
DE60009904T2 (de
Inventor
C Robinson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Miravant Pharmaceuticals Inc
Original Assignee
Miravant Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miravant Pharmaceuticals Inc filed Critical Miravant Pharmaceuticals Inc
Publication of DE60009904D1 publication Critical patent/DE60009904D1/de
Application granted granted Critical
Publication of DE60009904T2 publication Critical patent/DE60009904T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE60009904T 1999-05-27 2000-05-23 Bakteriochlorine und bakteriopurpurine und deren verwendung zur photodynamischen therapie von tumoren sowie ein verfahren zu deren herstellung Expired - Fee Related DE60009904T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/320,731 US6376483B1 (en) 1999-05-27 1999-05-27 Bacteriochlorins and bacteriopurpurins useful as photoselective compounds for photodynamic therapy and a process for their production
US320731 1999-05-27
PCT/US2000/013999 WO2000073308A2 (en) 1999-05-27 2000-05-23 Bacteriochlorins and bacteriopurpurins useful as photoselective compounds for photodynamic therapy and a process for their production

Publications (2)

Publication Number Publication Date
DE60009904D1 true DE60009904D1 (de) 2004-05-19
DE60009904T2 DE60009904T2 (de) 2005-04-07

Family

ID=23247659

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60009904T Expired - Fee Related DE60009904T2 (de) 1999-05-27 2000-05-23 Bakteriochlorine und bakteriopurpurine und deren verwendung zur photodynamischen therapie von tumoren sowie ein verfahren zu deren herstellung

Country Status (7)

Country Link
US (1) US6376483B1 (de)
EP (1) EP1189906B1 (de)
AT (1) ATE264331T1 (de)
AU (1) AU5151900A (de)
CA (1) CA2372239A1 (de)
DE (1) DE60009904T2 (de)
WO (1) WO2000073308A2 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5648485A (en) * 1994-10-26 1997-07-15 University Of British Columbia β, β-dihydroxy meso-substituted chlorins, isobacteriochlorins, and bacteriochlorins
US6559374B2 (en) * 2000-07-21 2003-05-06 North Carolina State University Trans beta substituted chlorins and methods of making and using the same
WO2003086460A2 (en) * 2002-04-05 2003-10-23 Candela Corporation High fluence rate activation of photosensitizers for dermatological applications
US20050008687A1 (en) * 2003-07-07 2005-01-13 Makoto Yuasa Metal-porphyrin-complex-embedded liposomes, production process thereof, and medicines making use of the same
CA2437638A1 (en) * 2003-08-20 2005-02-20 John Robert North Photodynamic therapy
US7501507B2 (en) * 2004-06-14 2009-03-10 North Carolina State University Route to formyl-porphyrins
US7534807B2 (en) * 2005-02-18 2009-05-19 North Carolina State University De novo synthesis of bacteriochlorins
GB0819594D0 (en) 2008-10-24 2008-12-03 Univ Coimbrra Process
US9186349B2 (en) 2009-05-12 2015-11-17 Mallinckrodt Llc Diaza heterocyclic compounds for phototherapy
WO2010132515A1 (en) 2009-05-12 2010-11-18 Mallinckrodt Inc. Compounds containing acyclic n-n bonds for phototherapy
JP7034148B2 (ja) 2016-06-10 2022-03-11 ニルバナ サイエンシーズ インク． 波長範囲が狭い蛍光発光のヒドロポルフィリンビーズ
US10919904B2 (en) 2016-08-17 2021-02-16 North Carolina State University Northern-southern route to synthesis of bacteriochlorins
EP3565818A4 (de) 2017-02-03 2021-03-10 NIRvana Sciences Inc. Hydroporphyrine zur photoakustischen bildgebung
US11904026B2 (en) 2017-02-03 2024-02-20 Nirvana Sciences Inc. Metallohydroporphyrins for photoacoustic imaging
CA3203821A1 (en) * 2021-01-04 2022-07-07 James Bruce PITNER Metallohydroporphyrins for photoacoustic imaging

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4649151A (en) 1982-09-27 1987-03-10 Health Research, Inc. Drugs comprising porphyrins
US5534506A (en) 1986-01-02 1996-07-09 University Of Toledo Use of purpurins, chlorins and purpurin- and chlorin-containing compositions
US5051415A (en) 1986-01-02 1991-09-24 The University Of Toledo Production and use of purpurins, chlorins and purpurin- and chlorin-containing compositions
US5216012A (en) 1986-01-02 1993-06-01 University Of Toledo Production and use of purpurins, chlorins and purpurin- and chlorin-containing compositions
US5049557A (en) 1986-05-13 1991-09-17 Chai-Tech Corporation Metallo-organic salt compounds and pharmaceutical uses thereof
US4877872A (en) 1986-06-24 1989-10-31 The University Of Toledo Production and use of dimers of hematoporophyrin, purpurins, chlorines and purpurin- and chlorin-complexes
US5171749A (en) 1987-01-20 1992-12-15 University Of British Columbia Wavelength-specific cytotoxic agents
US5283255A (en) 1987-01-20 1994-02-01 The University Of British Columbia Wavelength-specific cytotoxic agents
US5109129A (en) 1989-09-29 1992-04-28 The University Of Toledo, Medical College Of Ohio Porphyrin derivatives
US5002962A (en) 1988-07-20 1991-03-26 Health Research, Inc. Photosensitizing agents
US5198460A (en) 1988-07-20 1993-03-30 Health Research Inc. Pyropheophorbides and their use in photodynamic therapy
US5177073A (en) 1988-09-30 1993-01-05 Baylor Research Institute Therapeutic compositions derived from photoactive compounds
US5236915A (en) 1990-05-31 1993-08-17 Health Research, Inc. Meso poly(4-sulfonatophenyl) porphines as MRI image enhancing agents
US5272056A (en) 1991-01-03 1993-12-21 The Research Foundation Of State University Of New York Modification of DNA and oligonucleotides using metal complexes of polyaza ligands
US5563262A (en) 1991-03-28 1996-10-08 University Of Toledo Diels alder adducts of vinyl porphyrins
US5212300A (en) 1991-09-12 1993-05-18 Sun Company, Inc. (R&M) Cyano- and polycyanometallo-porphyrins as catalysts for alkane oxidation
PT660712E (pt) 1992-09-21 2001-11-30 Quadra Logic Tech Inc Activacao in vivo transdermal de agentes fotossensiveis no sangue
US5405957A (en) 1992-10-30 1995-04-11 The University Of British Columbia Wavelength-specific photosensitive compounds and expanded porphyrin-like compounds and methods of use
US5368841A (en) 1993-02-11 1994-11-29 The General Hospital Corporation Photodynamic therapy for the destruction of the synovium in the treatment of rheumatoid arthritis and the inflammatory arthritides
US5591847A (en) 1994-05-23 1997-01-07 Health Research, Inc. Long wavelength absorbing photosensitizers related to purpurin-18, bacteriopurpurin-18 and related compounds with imide linkages
US5563132A (en) 1994-06-21 1996-10-08 Bodaness; Richard S. Two-step cancer treatment method
US5648485A (en) 1994-10-26 1997-07-15 University Of British Columbia β, β-dihydroxy meso-substituted chlorins, isobacteriochlorins, and bacteriochlorins
US5770730A (en) 1996-03-08 1998-06-23 Health Research, Inc. Synthesis of carbodimide analogs of chlorins and bacteriochlorins and their use for diagnosis and treatment of cancer

Also Published As

Publication number Publication date
ATE264331T1 (de) 2004-04-15
EP1189906A2 (de) 2002-03-27
EP1189906B1 (de) 2004-04-14
AU5151900A (en) 2000-12-18
WO2000073308A3 (en) 2001-04-19
US6376483B1 (en) 2002-04-23
WO2000073308A2 (en) 2000-12-07
CA2372239A1 (en) 2000-12-07
DE60009904T2 (de) 2005-04-07

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee