DE60007656T2 - Bindende hydrogele zum ersatz des nukleus pulposus - Google Patents

Bindende hydrogele zum ersatz des nukleus pulposus Download PDF

Info

Publication number
DE60007656T2
DE60007656T2 DE60007656T DE60007656T DE60007656T2 DE 60007656 T2 DE60007656 T2 DE 60007656T2 DE 60007656 T DE60007656 T DE 60007656T DE 60007656 T DE60007656 T DE 60007656T DE 60007656 T2 DE60007656 T2 DE 60007656T2
Authority
DE
Germany
Prior art keywords
pva
core
hydrogel
pvp
disc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60007656T
Other languages
German (de)
English (en)
Other versions
DE60007656D1 (de
Inventor
Staud Michele MARCOLONGO
Michael Anthony LOWMAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Drexel University
Original Assignee
Drexel University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Drexel University filed Critical Drexel University
Publication of DE60007656D1 publication Critical patent/DE60007656D1/de
Application granted granted Critical
Publication of DE60007656T2 publication Critical patent/DE60007656T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/441—Joints for the spine, e.g. vertebrae, spinal discs made of inflatable pockets or chambers filled with fluid, e.g. with hydrogel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/38—Materials or treatment for tissue regeneration for reconstruction of the spine, vertebrae or intervertebral discs

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Paper (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DE60007656T 1999-10-29 2000-10-27 Bindende hydrogele zum ersatz des nukleus pulposus Expired - Lifetime DE60007656T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16233899P 1999-10-29 1999-10-29
US162338P 1999-10-29
PCT/US2000/029874 WO2001032100A2 (en) 1999-10-29 2000-10-27 Associating hydrogels for nucleus pulposus replacement in intervertebral discs

Publications (2)

Publication Number Publication Date
DE60007656D1 DE60007656D1 (de) 2004-02-12
DE60007656T2 true DE60007656T2 (de) 2004-06-24

Family

ID=22585202

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60007656T Expired - Lifetime DE60007656T2 (de) 1999-10-29 2000-10-27 Bindende hydrogele zum ersatz des nukleus pulposus

Country Status (11)

Country Link
US (1) US20070106387A1 (cg-RX-API-DMAC7.html)
EP (1) EP1229873B1 (cg-RX-API-DMAC7.html)
JP (1) JP4833475B2 (cg-RX-API-DMAC7.html)
AT (1) ATE257397T1 (cg-RX-API-DMAC7.html)
AU (1) AU782208B2 (cg-RX-API-DMAC7.html)
CA (1) CA2389232C (cg-RX-API-DMAC7.html)
DE (1) DE60007656T2 (cg-RX-API-DMAC7.html)
DK (1) DK1229873T3 (cg-RX-API-DMAC7.html)
ES (1) ES2213628T3 (cg-RX-API-DMAC7.html)
PT (1) PT1229873E (cg-RX-API-DMAC7.html)
WO (1) WO2001032100A2 (cg-RX-API-DMAC7.html)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2350638C (en) 1998-09-11 2009-11-24 Gerhard Schmidmaier Biologically active implants coated with a biodegradable polymer
US6723335B1 (en) * 2000-04-07 2004-04-20 Jeffrey William Moehlenbruck Methods and compositions for treating intervertebral disc degeneration
ATE415885T1 (de) 2000-06-09 2008-12-15 Synthes Gmbh Implantat aus kunststoff für die osteosynthese
WO2002002033A1 (de) 2000-06-30 2002-01-10 Augmentation-Technology Gmbh Vorrichtung zum injizieren von knochenzement
MY133943A (en) 2000-08-22 2007-11-30 Synthes Gmbh Bone replacement material
TW200400062A (en) 2002-04-03 2004-01-01 Mathys Medizinaltechnik Ag Kneadable, pliable bone replacement material
US7001433B2 (en) 2002-05-23 2006-02-21 Pioneer Laboratories, Inc. Artificial intervertebral disc device
US8388684B2 (en) 2002-05-23 2013-03-05 Pioneer Signal Technology, Inc. Artificial disc device
US7485670B2 (en) 2002-08-02 2009-02-03 Cambridge Polymer Group, Inc. Systems and methods for controlling and forming polymer gels
US7745532B2 (en) 2002-08-02 2010-06-29 Cambridge Polymer Group, Inc. Systems and methods for controlling and forming polymer gels
US6951562B2 (en) 2002-11-13 2005-10-04 Ralph Fritz Zwirnmann Adjustable length tap and method for drilling and tapping a bore in bone
CA2513055A1 (en) * 2003-01-31 2004-08-19 Zimmer Orthobiologics, Inc. Hydrogel compositions comprising nucleus pulposus tissue
CN1816357B (zh) 2003-04-30 2012-11-28 德崇大学 用于生物材料应用的热凝胶化的聚合物共混物
KR101050957B1 (ko) 2003-08-08 2011-07-20 신세스 게엠바하 다공성골대체물을 포화시키는 방법
KR101226811B1 (ko) 2003-09-05 2013-01-28 신세스 게엠바하 섬유-강화 및/또는 증가된 유동성을 가지는 골 시멘트조성물
US7632294B2 (en) 2003-09-29 2009-12-15 Promethean Surgical Devices, Llc Devices and methods for spine repair
AU2005213499B2 (en) 2004-02-06 2010-09-02 Georgia Tech Research Corporation Surface directed cellular attachment
CA2558661C (en) 2004-02-06 2012-09-04 Georgia Tech Research Corporation Load bearing biocompatible device
US20050209602A1 (en) 2004-03-22 2005-09-22 Disc Dynamics, Inc. Multi-stage biomaterial injection system for spinal implants
EP1744792B1 (en) 2004-05-13 2018-11-28 Synthes GmbH Resorbable polymeric medical goods with improved mechanical properties and method for producing same
BRPI0511422A (pt) 2004-05-21 2007-12-11 Synthes Gmbh método para suplementar ou substituir um núcleo pulposo localizado em uma região central de um anel fibroso de um disco intervertebral, corpo de hidrogel sólido alongado totalmente hidratado fisiologicamente, instrumento para inserir um corpo de hidrogel alongado em uma região central de um anel fibroso, métodos para hidratar um hidrogel e para preparar uma prótese, e, prótese
BRPI0418886A (pt) 2004-06-03 2007-12-11 Synthes Gmbh dispositivo para impregnação de um material de substituição de osso poroso
TWI374036B (en) 2004-06-10 2012-10-11 Sean Kerr Flexible bone composite
WO2006010278A1 (en) 2004-07-26 2006-02-02 Synthes Gmbh Biocompatible, biodegradable polyurethane materials with controlled hydrophobic to hydrophilic ratio
EP1778134A1 (en) * 2004-07-27 2007-05-02 Synthes USA Supplementation or replacement of a nucleus pulposus, of an intervertebral disc
CN101132741B (zh) 2005-03-24 2010-09-29 斯恩蒂斯有限公司 用于骨植入物的骨水泥强化的装置
US7914810B2 (en) 2005-05-06 2011-03-29 Synthes Usa, Llc Methods for the in situ treatment of bone cancer
JP4857437B2 (ja) 2005-06-13 2012-01-18 日本メディカルマテリアル株式会社 髄核用脊椎椎間板置換材料およびその製造方法
AU2006282883A1 (en) * 2005-08-26 2007-03-01 Synthes Gmbh Hydrogel balloon prosthesis for nucleus pulposus
KR101377900B1 (ko) 2005-10-13 2014-03-27 신세스 게엠바하 약물-함침 용기
US8641667B2 (en) 2005-10-20 2014-02-04 DePuy Synthes Products, LLC Perfusion device and method
GB0523999D0 (en) * 2005-11-25 2006-01-04 Univ Manchester Microgel particle
WO2008034135A2 (en) 2006-09-15 2008-03-20 Pioneer Surgical Technology, Inc. Joint arthroplasty devices having articulating members
US8715350B2 (en) 2006-09-15 2014-05-06 Pioneer Surgical Technology, Inc. Systems and methods for securing an implant in intervertebral space
US8197491B2 (en) 2006-12-19 2012-06-12 Synthes Usa, Llc Injectable fastener system and method
EA201390099A1 (ru) 2011-05-26 2013-05-30 Картива, Инк. Конический суставный имплант и относящиеся к нему инструменты
US9241807B2 (en) 2011-12-23 2016-01-26 Pioneer Surgical Technology, Inc. Systems and methods for inserting a spinal device
TWI590843B (zh) 2011-12-28 2017-07-11 信迪思有限公司 膜及其製造方法
US10285818B2 (en) 2012-12-26 2019-05-14 Symbiomedik, Llc Apparatus, kit, and method for percutaneous intervertebral disc restoration
JP6456935B2 (ja) 2013-06-21 2019-01-23 デピュイ・シンセス・プロダクツ・インコーポレイテッド フィルム及び製造方法
AU2016243660B2 (en) 2015-03-31 2020-11-12 Stryker Corporation Carpometacarpal (CMC) implants and methods
US9907663B2 (en) 2015-03-31 2018-03-06 Cartiva, Inc. Hydrogel implants with porous materials and methods
AU2016248062B2 (en) 2015-04-14 2020-01-23 Stryker Corporation Tooling for creating tapered opening in tissue and related methods
JP7521152B2 (ja) 2017-09-08 2024-07-24 エクスタント メディカル ホールディングス，インコーポレイテッド． 椎間インプラント、器具、及び方法
USD907771S1 (en) 2017-10-09 2021-01-12 Pioneer Surgical Technology, Inc. Intervertebral implant
US11419733B2 (en) 2018-01-12 2022-08-23 Percheron Spine, Llc Spinal disc implant and device and method for percutaneous delivery of the spinal disc implant

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0286838A (ja) * 1988-09-22 1990-03-27 Terumo Corp 水不溶性ヒドロゲルおよびその製造方法
US5143071A (en) * 1989-03-30 1992-09-01 Nepera, Inc. Non-stringy adhesive hydrophilic gels
US5192326A (en) * 1990-12-21 1993-03-09 Pfizer Hospital Products Group, Inc. Hydrogel bead intervertebral disc nucleus
JP3007903B2 (ja) * 1991-03-29 2000-02-14 京セラ株式会社 人工椎間板
US5262475A (en) * 1992-05-12 1993-11-16 Film Specialties, Inc. Hydrophilic compositions which are fog-resistant
US5534028A (en) * 1993-04-20 1996-07-09 Howmedica, Inc. Hydrogel intervertebral disc nucleus with diminished lateral bulging
ATE203885T1 (de) * 1994-09-08 2001-08-15 Stryker Technologies Corp Bandscheibenkern aus hydrogel
US5824093A (en) * 1994-10-17 1998-10-20 Raymedica, Inc. Prosthetic spinal disc nucleus
US5846214A (en) * 1996-03-29 1998-12-08 Nichiban Company Limited PVA hydrogel, hydrogel laminate using the same and hydrogel wound-dressing material using the same
JPH09262279A (ja) * 1996-03-29 1997-10-07 Japan Atom Energy Res Inst 粘着性ハイドロゲルの製造方法
US5981826A (en) * 1997-05-05 1999-11-09 Georgia Tech Research Corporation Poly(vinyl alcohol) cryogel
US6428576B1 (en) * 1999-04-16 2002-08-06 Endospine, Ltd. System for repairing inter-vertebral discs

Also Published As

Publication number Publication date
AU1444401A (en) 2001-05-14
EP1229873B1 (en) 2004-01-07
CA2389232A1 (en) 2001-05-10
DE60007656D1 (de) 2004-02-12
EP1229873A2 (en) 2002-08-14
AU782208B2 (en) 2005-07-14
DK1229873T3 (da) 2004-05-17
WO2001032100A2 (en) 2001-05-10
JP2003513685A (ja) 2003-04-15
PT1229873E (pt) 2004-03-31
JP4833475B2 (ja) 2011-12-07
ATE257397T1 (de) 2004-01-15
EP1229873A4 (en) 2003-01-15
WO2001032100A3 (en) 2001-11-22
CA2389232C (en) 2008-07-29
ES2213628T3 (es) 2004-09-01
US20070106387A1 (en) 2007-05-10

Similar Documents

Publication Publication Date Title
DE60007656T2 (de) Bindende hydrogele zum ersatz des nukleus pulposus
DE69333556T2 (de) Injizierbare keramische Zusammensetzungen sowie Verfahren für ihre Herstellung und Verwendung
DE69324909T2 (de) Anwendung von injizierbaren biomaterialien auf kollagen-basis zur reparatur und verstärkung des afterschliessmuskels
DE3879921T2 (de) Prothese für meniscus.
DE69522060T2 (de) Bandscheibenkern aus Hydrogel
DE69818373T2 (de) Füllmaterial für implantierbare Prothesen aus Weichgewebe und Implantate daraus
DE60302412T2 (de) Röntgensichtbarer Bandscheibenkern aus Hydrogel
DE69005031T2 (de) Injizierbare polymere Körper.
DE69531779T2 (de) Herstllung von autogenen körperersatzteilen
DE69423520T2 (de) Biologisch kompatibles hydrogel
DE60023284T2 (de) Zwischenwirbel-discuspulposus-prothese mit formveränderungseigenschaften
DE69935425T2 (de) Perkutane Bandscheiben-Prothese und Herstellverfahren
DE69318835T2 (de) Behandlung einer refluxstörung durch injektion von mikropartikeln
US7214245B1 (en) Associating hydrogels for nucleus pulposus replacement in intervertebral discs
DE69630253T2 (de) Füllmaterial für implantierbare Prothesen aus Weichgewebe und Implantate daraus
DE69528834T2 (de) Injizierbare nicht immunogenische knorpel- und knochenzubereitung
EP1227851B1 (de) Resorbierbares knochen-implantatmaterial sowie verfahren zur herstellung desselben
DE60305227T2 (de) Bandscheibenbehandlung mit einem Vernetzer und einem Inaktivator oder Stabilisator
DE69112425T2 (de) Hydrogel-zwischenwirbel-discus-pulposus.
DE69306114T2 (de) Verwendung von in situ modifikation von alginat zur vorbeugung von gewebeadhäsion
DE69127354T2 (de) Prothese
DE60006356T2 (de) Hochmineralisierte osteogene schwammzusammensetzungen und ihre verwendung
DE69021204T2 (de) Meniskus-prothese.
DE60105884T2 (de) Mittel und Verfahren zum Verformen von Weichgewebe
DE69020254T2 (de) Knochenkollagenmatrix für implantate.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition