JP4833475B2 - 椎間板における髄核置換のための会合性ヒドロゲル - Google Patents
椎間板における髄核置換のための会合性ヒドロゲル Download PDFInfo
- Publication number
- JP4833475B2 JP4833475B2 JP2001534312A JP2001534312A JP4833475B2 JP 4833475 B2 JP4833475 B2 JP 4833475B2 JP 2001534312 A JP2001534312 A JP 2001534312A JP 2001534312 A JP2001534312 A JP 2001534312A JP 4833475 B2 JP4833475 B2 JP 4833475B2
- Authority
- JP
- Japan
- Prior art keywords
- disc
- pva
- nucleus
- associative
- hydrogel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000017 hydrogel Substances 0.000 title claims description 32
- 239000004372 Polyvinyl alcohol Substances 0.000 claims abstract description 43
- 229920002451 polyvinyl alcohol Polymers 0.000 claims abstract description 43
- 208000002193 Pain Diseases 0.000 claims abstract description 15
- 206010061246 Intervertebral disc degeneration Diseases 0.000 claims abstract description 9
- 239000000203 mixture Substances 0.000 claims abstract description 8
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 34
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 34
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 34
- 238000002513 implantation Methods 0.000 claims description 4
- 238000011282 treatment Methods 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000007943 implant Substances 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 abstract description 17
- 238000000034 method Methods 0.000 abstract description 13
- 241000124008 Mammalia Species 0.000 abstract description 3
- 235000019422 polyvinyl alcohol Nutrition 0.000 abstract 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 abstract 1
- 229920002554 vinyl polymer Polymers 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 description 13
- 239000000463 material Substances 0.000 description 11
- 229910052739 hydrogen Inorganic materials 0.000 description 6
- 239000001257 hydrogen Substances 0.000 description 6
- 208000008035 Back Pain Diseases 0.000 description 5
- 238000000338 in vitro Methods 0.000 description 5
- 238000006731 degradation reaction Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000000499 gel Substances 0.000 description 4
- 238000007654 immersion Methods 0.000 description 4
- 210000005036 nerve Anatomy 0.000 description 4
- 229920002125 Sokalan® Polymers 0.000 description 3
- 230000015556 catabolic process Effects 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 238000004132 cross linking Methods 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 230000004927 fusion Effects 0.000 description 3
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 3
- 229920002401 polyacrylamide Polymers 0.000 description 3
- 229920002239 polyacrylonitrile Polymers 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 239000004926 polymethyl methacrylate Substances 0.000 description 3
- 229920001296 polysiloxane Polymers 0.000 description 3
- 238000002791 soaking Methods 0.000 description 3
- 238000002054 transplantation Methods 0.000 description 3
- 206010016654 Fibrosis Diseases 0.000 description 2
- 208000008930 Low Back Pain Diseases 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 208000018180 degenerative disc disease Diseases 0.000 description 2
- 230000018044 dehydration Effects 0.000 description 2
- 238000006297 dehydration reaction Methods 0.000 description 2
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
- 229920001971 elastomer Polymers 0.000 description 2
- 238000010828 elution Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000004761 fibrosis Effects 0.000 description 2
- 229920001519 homopolymer Polymers 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 208000021600 intervertebral disc degenerative disease Diseases 0.000 description 2
- 238000002386 leaching Methods 0.000 description 2
- 210000003141 lower extremity Anatomy 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- 239000002953 phosphate buffered saline Substances 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- -1 polyethylene core Polymers 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- LIKMAJRDDDTEIG-UHFFFAOYSA-N 1-hexene Chemical compound CCCCC=C LIKMAJRDDDTEIG-UHFFFAOYSA-N 0.000 description 1
- 239000004971 Cross linker Substances 0.000 description 1
- 238000005033 Fourier transform infrared spectroscopy Methods 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 238000005411 Van der Waals force Methods 0.000 description 1
- WAIPAZQMEIHHTJ-UHFFFAOYSA-N [Cr].[Co] Chemical class [Cr].[Co] WAIPAZQMEIHHTJ-UHFFFAOYSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 229920000249 biocompatible polymer Polymers 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 239000006229 carbon black Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 239000000599 controlled substance Substances 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000013016 damping Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 238000013399 early diagnosis Methods 0.000 description 1
- 239000013013 elastic material Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 238000001879 gelation Methods 0.000 description 1
- 229920000578 graft copolymer Polymers 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000005226 mechanical processes and functions Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000013081 microcrystal Substances 0.000 description 1
- 238000002324 minimally invasive surgery Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 208000015122 neurodegenerative disease Diseases 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000008560 physiological behavior Effects 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 229920002959 polymer blend Polymers 0.000 description 1
- 229920006124 polyolefin elastomer Polymers 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000011477 surgical intervention Methods 0.000 description 1
- 201000004595 synovitis Diseases 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/26—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/441—Joints for the spine, e.g. vertebrae, spinal discs made of inflatable pockets or chambers filled with fluid, e.g. with hydrogel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/38—Materials or treatment for tissue regeneration for reconstruction of the spine, vertebrae or intervertebral discs
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Paper (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16233899P | 1999-10-29 | 1999-10-29 | |
| US60/162,338 | 1999-10-29 | ||
| PCT/US2000/029874 WO2001032100A2 (en) | 1999-10-29 | 2000-10-27 | Associating hydrogels for nucleus pulposus replacement in intervertebral discs |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003513685A JP2003513685A (ja) | 2003-04-15 |
| JP2003513685A5 JP2003513685A5 (cg-RX-API-DMAC7.html) | 2008-01-31 |
| JP4833475B2 true JP4833475B2 (ja) | 2011-12-07 |
Family
ID=22585202
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001534312A Expired - Lifetime JP4833475B2 (ja) | 1999-10-29 | 2000-10-27 | 椎間板における髄核置換のための会合性ヒドロゲル |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20070106387A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1229873B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP4833475B2 (cg-RX-API-DMAC7.html) |
| AT (1) | ATE257397T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU782208B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2389232C (cg-RX-API-DMAC7.html) |
| DE (1) | DE60007656T2 (cg-RX-API-DMAC7.html) |
| DK (1) | DK1229873T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2213628T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT1229873E (cg-RX-API-DMAC7.html) |
| WO (1) | WO2001032100A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2350638C (en) | 1998-09-11 | 2009-11-24 | Gerhard Schmidmaier | Biologically active implants coated with a biodegradable polymer |
| US6723335B1 (en) * | 2000-04-07 | 2004-04-20 | Jeffrey William Moehlenbruck | Methods and compositions for treating intervertebral disc degeneration |
| ATE415885T1 (de) | 2000-06-09 | 2008-12-15 | Synthes Gmbh | Implantat aus kunststoff für die osteosynthese |
| WO2002002033A1 (de) | 2000-06-30 | 2002-01-10 | Augmentation-Technology Gmbh | Vorrichtung zum injizieren von knochenzement |
| MY133943A (en) | 2000-08-22 | 2007-11-30 | Synthes Gmbh | Bone replacement material |
| TW200400062A (en) | 2002-04-03 | 2004-01-01 | Mathys Medizinaltechnik Ag | Kneadable, pliable bone replacement material |
| US7001433B2 (en) | 2002-05-23 | 2006-02-21 | Pioneer Laboratories, Inc. | Artificial intervertebral disc device |
| US8388684B2 (en) | 2002-05-23 | 2013-03-05 | Pioneer Signal Technology, Inc. | Artificial disc device |
| US7485670B2 (en) | 2002-08-02 | 2009-02-03 | Cambridge Polymer Group, Inc. | Systems and methods for controlling and forming polymer gels |
| US7745532B2 (en) | 2002-08-02 | 2010-06-29 | Cambridge Polymer Group, Inc. | Systems and methods for controlling and forming polymer gels |
| US6951562B2 (en) | 2002-11-13 | 2005-10-04 | Ralph Fritz Zwirnmann | Adjustable length tap and method for drilling and tapping a bore in bone |
| CA2513055A1 (en) * | 2003-01-31 | 2004-08-19 | Zimmer Orthobiologics, Inc. | Hydrogel compositions comprising nucleus pulposus tissue |
| CN1816357B (zh) | 2003-04-30 | 2012-11-28 | 德崇大学 | 用于生物材料应用的热凝胶化的聚合物共混物 |
| KR101050957B1 (ko) | 2003-08-08 | 2011-07-20 | 신세스 게엠바하 | 다공성골대체물을 포화시키는 방법 |
| KR101226811B1 (ko) | 2003-09-05 | 2013-01-28 | 신세스 게엠바하 | 섬유-강화 및/또는 증가된 유동성을 가지는 골 시멘트조성물 |
| US7632294B2 (en) | 2003-09-29 | 2009-12-15 | Promethean Surgical Devices, Llc | Devices and methods for spine repair |
| AU2005213499B2 (en) | 2004-02-06 | 2010-09-02 | Georgia Tech Research Corporation | Surface directed cellular attachment |
| CA2558661C (en) | 2004-02-06 | 2012-09-04 | Georgia Tech Research Corporation | Load bearing biocompatible device |
| US20050209602A1 (en) | 2004-03-22 | 2005-09-22 | Disc Dynamics, Inc. | Multi-stage biomaterial injection system for spinal implants |
| EP1744792B1 (en) | 2004-05-13 | 2018-11-28 | Synthes GmbH | Resorbable polymeric medical goods with improved mechanical properties and method for producing same |
| BRPI0511422A (pt) | 2004-05-21 | 2007-12-11 | Synthes Gmbh | método para suplementar ou substituir um núcleo pulposo localizado em uma região central de um anel fibroso de um disco intervertebral, corpo de hidrogel sólido alongado totalmente hidratado fisiologicamente, instrumento para inserir um corpo de hidrogel alongado em uma região central de um anel fibroso, métodos para hidratar um hidrogel e para preparar uma prótese, e, prótese |
| BRPI0418886A (pt) | 2004-06-03 | 2007-12-11 | Synthes Gmbh | dispositivo para impregnação de um material de substituição de osso poroso |
| TWI374036B (en) | 2004-06-10 | 2012-10-11 | Sean Kerr | Flexible bone composite |
| WO2006010278A1 (en) | 2004-07-26 | 2006-02-02 | Synthes Gmbh | Biocompatible, biodegradable polyurethane materials with controlled hydrophobic to hydrophilic ratio |
| EP1778134A1 (en) * | 2004-07-27 | 2007-05-02 | Synthes USA | Supplementation or replacement of a nucleus pulposus, of an intervertebral disc |
| CN101132741B (zh) | 2005-03-24 | 2010-09-29 | 斯恩蒂斯有限公司 | 用于骨植入物的骨水泥强化的装置 |
| US7914810B2 (en) | 2005-05-06 | 2011-03-29 | Synthes Usa, Llc | Methods for the in situ treatment of bone cancer |
| JP4857437B2 (ja) | 2005-06-13 | 2012-01-18 | 日本メディカルマテリアル株式会社 | 髄核用脊椎椎間板置換材料およびその製造方法 |
| AU2006282883A1 (en) * | 2005-08-26 | 2007-03-01 | Synthes Gmbh | Hydrogel balloon prosthesis for nucleus pulposus |
| KR101377900B1 (ko) | 2005-10-13 | 2014-03-27 | 신세스 게엠바하 | 약물-함침 용기 |
| US8641667B2 (en) | 2005-10-20 | 2014-02-04 | DePuy Synthes Products, LLC | Perfusion device and method |
| GB0523999D0 (en) * | 2005-11-25 | 2006-01-04 | Univ Manchester | Microgel particle |
| WO2008034135A2 (en) | 2006-09-15 | 2008-03-20 | Pioneer Surgical Technology, Inc. | Joint arthroplasty devices having articulating members |
| US8715350B2 (en) | 2006-09-15 | 2014-05-06 | Pioneer Surgical Technology, Inc. | Systems and methods for securing an implant in intervertebral space |
| US8197491B2 (en) | 2006-12-19 | 2012-06-12 | Synthes Usa, Llc | Injectable fastener system and method |
| EA201390099A1 (ru) | 2011-05-26 | 2013-05-30 | Картива, Инк. | Конический суставный имплант и относящиеся к нему инструменты |
| US9241807B2 (en) | 2011-12-23 | 2016-01-26 | Pioneer Surgical Technology, Inc. | Systems and methods for inserting a spinal device |
| TWI590843B (zh) | 2011-12-28 | 2017-07-11 | 信迪思有限公司 | 膜及其製造方法 |
| US10285818B2 (en) | 2012-12-26 | 2019-05-14 | Symbiomedik, Llc | Apparatus, kit, and method for percutaneous intervertebral disc restoration |
| JP6456935B2 (ja) | 2013-06-21 | 2019-01-23 | デピュイ・シンセス・プロダクツ・インコーポレイテッド | フィルム及び製造方法 |
| AU2016243660B2 (en) | 2015-03-31 | 2020-11-12 | Stryker Corporation | Carpometacarpal (CMC) implants and methods |
| US9907663B2 (en) | 2015-03-31 | 2018-03-06 | Cartiva, Inc. | Hydrogel implants with porous materials and methods |
| AU2016248062B2 (en) | 2015-04-14 | 2020-01-23 | Stryker Corporation | Tooling for creating tapered opening in tissue and related methods |
| JP7521152B2 (ja) | 2017-09-08 | 2024-07-24 | エクスタント メディカル ホールディングス，インコーポレイテッド． | 椎間インプラント、器具、及び方法 |
| USD907771S1 (en) | 2017-10-09 | 2021-01-12 | Pioneer Surgical Technology, Inc. | Intervertebral implant |
| US11419733B2 (en) | 2018-01-12 | 2022-08-23 | Percheron Spine, Llc | Spinal disc implant and device and method for percutaneous delivery of the spinal disc implant |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09262279A (ja) * | 1996-03-29 | 1997-10-07 | Japan Atom Energy Res Inst | 粘着性ハイドロゲルの製造方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0286838A (ja) * | 1988-09-22 | 1990-03-27 | Terumo Corp | 水不溶性ヒドロゲルおよびその製造方法 |
| US5143071A (en) * | 1989-03-30 | 1992-09-01 | Nepera, Inc. | Non-stringy adhesive hydrophilic gels |
| US5192326A (en) * | 1990-12-21 | 1993-03-09 | Pfizer Hospital Products Group, Inc. | Hydrogel bead intervertebral disc nucleus |
| JP3007903B2 (ja) * | 1991-03-29 | 2000-02-14 | 京セラ株式会社 | 人工椎間板 |
| US5262475A (en) * | 1992-05-12 | 1993-11-16 | Film Specialties, Inc. | Hydrophilic compositions which are fog-resistant |
| US5534028A (en) * | 1993-04-20 | 1996-07-09 | Howmedica, Inc. | Hydrogel intervertebral disc nucleus with diminished lateral bulging |
| ATE203885T1 (de) * | 1994-09-08 | 2001-08-15 | Stryker Technologies Corp | Bandscheibenkern aus hydrogel |
| US5824093A (en) * | 1994-10-17 | 1998-10-20 | Raymedica, Inc. | Prosthetic spinal disc nucleus |
| US5846214A (en) * | 1996-03-29 | 1998-12-08 | Nichiban Company Limited | PVA hydrogel, hydrogel laminate using the same and hydrogel wound-dressing material using the same |
| US5981826A (en) * | 1997-05-05 | 1999-11-09 | Georgia Tech Research Corporation | Poly(vinyl alcohol) cryogel |
| US6428576B1 (en) * | 1999-04-16 | 2002-08-06 | Endospine, Ltd. | System for repairing inter-vertebral discs |
-
2000
- 2000-10-27 EP EP00976709A patent/EP1229873B1/en not_active Expired - Lifetime
- 2000-10-27 CA CA002389232A patent/CA2389232C/en not_active Expired - Fee Related
- 2000-10-27 PT PT00976709T patent/PT1229873E/pt unknown
- 2000-10-27 ES ES00976709T patent/ES2213628T3/es not_active Expired - Lifetime
- 2000-10-27 WO PCT/US2000/029874 patent/WO2001032100A2/en not_active Ceased
- 2000-10-27 JP JP2001534312A patent/JP4833475B2/ja not_active Expired - Lifetime
- 2000-10-27 AU AU14444/01A patent/AU782208B2/en not_active Ceased
- 2000-10-27 AT AT00976709T patent/ATE257397T1/de active
- 2000-10-27 DE DE60007656T patent/DE60007656T2/de not_active Expired - Lifetime
- 2000-10-27 DK DK00976709T patent/DK1229873T3/da active
-
2006
- 2006-11-22 US US11/562,847 patent/US20070106387A1/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09262279A (ja) * | 1996-03-29 | 1997-10-07 | Japan Atom Energy Res Inst | 粘着性ハイドロゲルの製造方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU1444401A (en) | 2001-05-14 |
| EP1229873B1 (en) | 2004-01-07 |
| CA2389232A1 (en) | 2001-05-10 |
| DE60007656D1 (de) | 2004-02-12 |
| EP1229873A2 (en) | 2002-08-14 |
| AU782208B2 (en) | 2005-07-14 |
| DK1229873T3 (da) | 2004-05-17 |
| WO2001032100A2 (en) | 2001-05-10 |
| JP2003513685A (ja) | 2003-04-15 |
| PT1229873E (pt) | 2004-03-31 |
| ATE257397T1 (de) | 2004-01-15 |
| DE60007656T2 (de) | 2004-06-24 |
| EP1229873A4 (en) | 2003-01-15 |
| WO2001032100A3 (en) | 2001-11-22 |
| CA2389232C (en) | 2008-07-29 |
| ES2213628T3 (es) | 2004-09-01 |
| US20070106387A1 (en) | 2007-05-10 |
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