DE60000826T2 - 14.beta.,17-alpha-hydroxymethylandrostan derivate als androgene - Google Patents

14.beta.,17-alpha-hydroxymethylandrostan derivate als androgene

Info

Publication number
DE60000826T2
DE60000826T2 DE60000826T DE60000826T DE60000826T2 DE 60000826 T2 DE60000826 T2 DE 60000826T2 DE 60000826 T DE60000826 T DE 60000826T DE 60000826 T DE60000826 T DE 60000826T DE 60000826 T2 DE60000826 T2 DE 60000826T2
Authority
DE
Germany
Prior art keywords
alkyl
halogen
hydrogen
cyano
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60000826T
Other languages
German (de)
English (en)
Other versions
DE60000826D1 (de
Inventor
Dirk Leysen
Jan Loozen
Jaap Van Der Louw
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon NV
Original Assignee
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel NV filed Critical Akzo Nobel NV
Application granted granted Critical
Publication of DE60000826D1 publication Critical patent/DE60000826D1/de
Publication of DE60000826T2 publication Critical patent/DE60000826T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J15/00—Stereochemically pure steroids containing carbon, hydrogen, halogen or oxygen having a partially or totally inverted skeleton, e.g. retrosteroids, L-isomers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE60000826T 1999-03-08 2000-03-02 14.beta.,17-alpha-hydroxymethylandrostan derivate als androgene Expired - Lifetime DE60000826T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99200665 1999-03-08
PCT/EP2000/001755 WO2000053619A1 (en) 1999-03-08 2000-03-02 14.beta., 17-alpha-hydroxymethylandrostane derivatives as androgens

Publications (2)

Publication Number Publication Date
DE60000826D1 DE60000826D1 (de) 2003-01-02
DE60000826T2 true DE60000826T2 (de) 2003-04-10

Family

ID=8239953

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60000826T Expired - Lifetime DE60000826T2 (de) 1999-03-08 2000-03-02 14.beta.,17-alpha-hydroxymethylandrostan derivate als androgene

Country Status (11)

Country Link
US (1) US6881728B1 (https=)
EP (1) EP1163259B1 (https=)
JP (1) JP4749550B2 (https=)
AR (1) AR022852A1 (https=)
AT (1) ATE228143T1 (https=)
AU (1) AU3162200A (https=)
CA (1) CA2359218A1 (https=)
CO (1) CO5150195A1 (https=)
DE (1) DE60000826T2 (https=)
PE (1) PE20001489A1 (https=)
WO (1) WO2000053619A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU778017B2 (en) * 1999-12-02 2004-11-11 N.V. Organon 14,15-beta-methylene substituted androgens
DK1343806T3 (da) * 2000-12-11 2008-09-22 Organon Nv Methylensteroider som nye androgener
DE10104327A1 (de) * 2001-01-24 2002-07-25 Schering Ag 11beta-Halogensteroide, deren Herstellung und Verwendung zur Herstellung von Arzneimitteln sowie 11beta-Halogensteroide enthaltende pharmazeutische Präparate
TWI221154B (en) * 2001-09-12 2004-09-21 Akzo Nobel Nv 17alpha-hydroxy-14beta-steroids with hormonal effect
PE20050677A1 (es) 2003-12-22 2005-10-04 Akzo Nobel Nv Esteroides con perfil androgenico y progestagenico mixto

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USB337823I5 (https=) * 1959-09-25 1976-03-23
US3086027A (en) * 1960-01-22 1963-04-16 Lilly Co Eli 19-nor-4, 9(10)-steroids and process
IE60780B1 (en) * 1987-01-23 1994-08-10 Akzo Nv New 11-aryl steroid derivatives
US5264427A (en) * 1992-01-29 1993-11-23 Research Corporation Technologies, Inc. 20-substituted pregnene derivatives and their use as androgen synthesis inhibitors
US6180682B1 (en) * 1999-01-26 2001-01-30 Virgil A. Place Buccal drug delivery system for use in male contraception

Also Published As

Publication number Publication date
JP4749550B2 (ja) 2011-08-17
ATE228143T1 (de) 2002-12-15
EP1163259A1 (en) 2001-12-19
CA2359218A1 (en) 2000-09-14
AU3162200A (en) 2000-09-28
US6881728B1 (en) 2005-04-19
JP2002539135A (ja) 2002-11-19
DE60000826D1 (de) 2003-01-02
CO5150195A1 (es) 2002-04-29
PE20001489A1 (es) 2000-12-29
AR022852A1 (es) 2002-09-04
WO2000053619A1 (en) 2000-09-14
EP1163259B1 (en) 2002-11-20

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Legal Events

Date Code Title Description
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8327 Change in the person/name/address of the patent owner

Owner name: N.V. ORGANON, OSS, NL

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Representative=s name: WUESTHOFF & WUESTHOFF PATENT- UND RECHTSANWAEL, DE