DE515995T1 - N-(5-thioxo-l-propyl)-l-cystein und derivate, deren herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzungen. - Google Patents
N-(5-thioxo-l-propyl)-l-cystein und derivate, deren herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzungen.Info
- Publication number
- DE515995T1 DE515995T1 DE199292108659T DE92108659T DE515995T1 DE 515995 T1 DE515995 T1 DE 515995T1 DE 199292108659 T DE199292108659 T DE 199292108659T DE 92108659 T DE92108659 T DE 92108659T DE 515995 T1 DE515995 T1 DE 515995T1
- Authority
- DE
- Germany
- Prior art keywords
- compounds
- formula
- alkyl
- compounds according
- prolyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 title claims 12
- 238000004519 manufacturing process Methods 0.000 title claims 3
- 239000008194 pharmaceutical composition Substances 0.000 title claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- -1 methoxycarbonylmethyl Chemical group 0.000 claims 3
- GRRYKTAZNOFTOA-WHFBIAKZSA-N (2r)-3-sulfanyl-2-[[(2s)-5-sulfanylidenepyrrolidine-2-carbonyl]amino]propanoic acid Chemical compound OC(=O)[C@H](CS)NC(=O)[C@@H]1CCC(=S)N1 GRRYKTAZNOFTOA-WHFBIAKZSA-N 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 2
- 108010084118 N-(5-thioxo-L-prolyl)-L-cysteine Proteins 0.000 claims 2
- 241000208125 Nicotiana Species 0.000 claims 2
- 235000002637 Nicotiana tabacum Nutrition 0.000 claims 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 2
- 238000003915 air pollution Methods 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 230000007812 deficiency Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 150000002431 hydrogen Chemical group 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 208000019423 liver disease Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 239000000779 smoke Substances 0.000 claims 2
- 239000011593 sulfur Substances 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 1
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000005862 (C1-C6)alkanoyl group Chemical group 0.000 claims 1
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 1
- 125000006719 (C6-C10) aryl (C1-C6) alkyl group Chemical group 0.000 claims 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- 125000000041 C6-C10 aryl group Chemical group 0.000 claims 1
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 239000004201 L-cysteine Substances 0.000 claims 1
- MZVQCMJNVPIDEA-UHFFFAOYSA-N [CH2]CN(CC)CC Chemical group [CH2]CN(CC)CC MZVQCMJNVPIDEA-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 238000005917 acylation reaction Methods 0.000 claims 1
- 230000029936 alkylation Effects 0.000 claims 1
- 238000005804 alkylation reaction Methods 0.000 claims 1
- 125000003435 aroyl group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 125000004663 dialkyl amino group Chemical group 0.000 claims 1
- 125000002228 disulfide group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000004185 ester group Chemical group 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 238000006460 hydrolysis reaction Methods 0.000 claims 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
- CFHGBZLNZZVTAY-UHFFFAOYSA-N lawesson's reagent Chemical group C1=CC(OC)=CC=C1P1(=S)SP(=S)(C=2C=CC(OC)=CC=2)S1 CFHGBZLNZZVTAY-UHFFFAOYSA-N 0.000 claims 1
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Natural products C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 238000006722 reduction reaction Methods 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 230000009466 transformation Effects 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06173—Dipeptides with the first amino acid being heterocyclic and Glp-amino acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI911470A IT1249650B (it) | 1991-05-29 | 1991-05-29 | N-(5-tioxo-l-prolil)-l-cisteina e suoi derivati, loro preparazione ed impiego terapeutico |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE515995T1 true DE515995T1 (de) | 1993-04-08 |
Family
ID=11360007
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE199292108659T Pending DE515995T1 (de) | 1991-05-29 | 1992-05-22 | N-(5-thioxo-l-propyl)-l-cystein und derivate, deren herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzungen. |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5254579A (OSRAM) |
| EP (1) | EP0515995A3 (OSRAM) |
| DE (1) | DE515995T1 (OSRAM) |
| ES (1) | ES2052484T1 (OSRAM) |
| GR (1) | GR930300007T1 (OSRAM) |
| IT (1) | IT1249650B (OSRAM) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL98310A (en) * | 1990-06-08 | 1996-08-04 | Astra Ab | Pharmaceutical compositions comprising cystine derivatives |
| IT1256178B (it) * | 1992-11-30 | 1995-11-29 | Lorenzo Ferrari | Composti ad attivita' terapeutica utili per il trattamento di malattieconnesse ad una carenza di glutatione, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono. |
| SE9500897D0 (sv) * | 1995-03-14 | 1995-03-14 | Astra Ab | The pharmacological use of certain cystine derivatives |
| JP2000501385A (ja) * | 1995-11-13 | 2000-02-08 | スミスクライン・ビーチャム・コーポレイション | 血液調節化合物 |
| EP0861030A4 (en) * | 1995-11-13 | 1999-03-03 | Smithkline Beecham Corp | HEMOREGULATORY COMPOUNDS |
| AR023819A1 (es) | 1999-05-03 | 2002-09-04 | Astrazeneca Ab | FORMULACIoN FARMACEUTICA, KIT DE PARTES Y UTILIZACION DE DICHA FORMULACION |
| SE9901573D0 (sv) | 1999-05-03 | 1999-05-03 | Astra Ab | New compounds |
| KR100986225B1 (ko) | 2001-02-16 | 2010-10-07 | 아스비오파마 가부시키가이샤 | Ａｏｐ－１ 유전자 또는 ａｏｐ－１의 발현 감소를수반하는 질환의 치료 방법 및 상기 질환의 치료약 |
| US6644012B2 (en) | 2001-11-02 | 2003-11-11 | Alston (Switzerland) Ltd | Gas turbine set |
| US6523346B1 (en) | 2001-11-02 | 2003-02-25 | Alstom (Switzerland) Ltd | Process for controlling the cooling air mass flow of a gas turbine set |
| US6640550B2 (en) | 2001-11-02 | 2003-11-04 | Alstom (Switzerland) Ltd | Gas turbo-group with cooling air system |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL8500847A (nl) * | 1984-03-29 | 1985-10-16 | Sandoz Ag | Gesubstitueerde alfa-aminozuren, hun bereiding en farmaceutische preparaten die ze bevatten. |
| IT1216096B (it) * | 1988-03-15 | 1990-02-22 | Farmaceutica Italiana S P A S | L_piroglutamil_l_cisteina, dipeptide ad elevata attivita'anticatarattogena e composizioni farmaceutiche che lo contengono. |
-
1991
- 1991-05-29 IT ITMI911470A patent/IT1249650B/it active IP Right Grant
-
1992
- 1992-05-08 US US07/879,907 patent/US5254579A/en not_active Expired - Lifetime
- 1992-05-22 DE DE199292108659T patent/DE515995T1/de active Pending
- 1992-05-22 ES ES92108659T patent/ES2052484T1/es active Pending
- 1992-05-22 EP EP19920108659 patent/EP0515995A3/en not_active Withdrawn
-
1993
- 1993-04-28 GR GR930300007T patent/GR930300007T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GR930300007T1 (OSRAM) | 1993-04-28 |
| ITMI911470A1 (it) | 1992-11-29 |
| IT1249650B (it) | 1995-03-09 |
| ITMI911470A0 (it) | 1991-05-29 |
| EP0515995A2 (en) | 1992-12-02 |
| EP0515995A3 (en) | 1993-07-21 |
| ES2052484T1 (es) | 1994-07-16 |
| US5254579A (en) | 1993-10-19 |
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