DE50310038D1 - Hemmstoffe der urokinase, ihre herstellung und verwendung - Google Patents

Hemmstoffe der urokinase, ihre herstellung und verwendung

Info

Publication number
DE50310038D1
DE50310038D1 DE50310038T DE50310038T DE50310038D1 DE 50310038 D1 DE50310038 D1 DE 50310038D1 DE 50310038 T DE50310038 T DE 50310038T DE 50310038 T DE50310038 T DE 50310038T DE 50310038 D1 DE50310038 D1 DE 50310038D1
Authority
DE
Germany
Prior art keywords
urokinase
preparation
ingredients
tumor
prophylaxis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE50310038T
Other languages
German (de)
English (en)
Inventor
Joerg Stuerzebecher
Torsten Steinmetzer
Andrea Schweinitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medicines Company Leipzig GmbH
Original Assignee
Curacyte AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2002110592 external-priority patent/DE10210592A1/de
Application filed by Curacyte AG filed Critical Curacyte AG
Application granted granted Critical
Publication of DE50310038D1 publication Critical patent/DE50310038D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • C07K5/06069—Ser-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epidemiology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE50310038T 2002-03-11 2003-03-11 Hemmstoffe der urokinase, ihre herstellung und verwendung Expired - Lifetime DE50310038D1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE2002110592 DE10210592A1 (de) 2002-03-11 2002-03-11 Hemmstoffe der Urokinase, ihre Herstellung und Verwendung
DE10245059 2002-09-26
DE10261435 2002-12-28
PCT/EP2003/002489 WO2003076391A2 (de) 2002-03-11 2003-03-11 Hemmstoffe der urokinase, ihre herstellung und verwendung

Publications (1)

Publication Number Publication Date
DE50310038D1 true DE50310038D1 (de) 2008-08-07

Family

ID=27808239

Family Applications (1)

Application Number Title Priority Date Filing Date
DE50310038T Expired - Lifetime DE50310038D1 (de) 2002-03-11 2003-03-11 Hemmstoffe der urokinase, ihre herstellung und verwendung

Country Status (9)

Country Link
US (2) US7838560B2 (https=)
EP (1) EP1485345B1 (https=)
JP (1) JP4898091B2 (https=)
AT (1) ATE399175T1 (https=)
AU (1) AU2003219039A1 (https=)
CA (1) CA2478409C (https=)
DE (1) DE50310038D1 (https=)
DK (1) DK1485345T3 (https=)
WO (1) WO2003076391A2 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10301300B4 (de) * 2003-01-15 2009-07-16 Curacyte Chemistry Gmbh Verwendung von acylierten 4-Amidino- und 4-Guanidinobenzylaminen zur Inhibierung von Plasmakallikrein
DE10342108A1 (de) 2003-09-11 2005-04-14 Curacyte Chemistry Gmbh Basisch-substituierte Benzylaminanaloga als Inhibitoren des Gerinnungsfaktors Xa, ihre Herstellung und Verwendung
AU2005204428A1 (en) * 2004-01-07 2005-07-28 Ambit Biosciences Corporation Conjugated small molecules
DE102004045720A1 (de) * 2004-09-21 2006-03-23 Wilex Ag Stabile Dosierungsform von Phenylalanin-Derivaten
MX2007016439A (es) 2005-06-24 2008-03-04 Wilex Ag Uso de inhibidores de urocinasa para el tratamiento y/o prevencion de enfermedades neuropatologicas.
DE102005044319A1 (de) * 2005-09-16 2007-03-22 Curacyte Chemistry Gmbh 2-(Aminomethyl)-5-Chlor-Benzylamid-Derivate und ihre Verwendung als Hemmstoffe des Gerinnungsfaktors Xa
DE102006050672A1 (de) 2006-10-24 2008-04-30 Curacyte Discovery Gmbh Hemmstoffe des Plasmins und des Plasmakallikreins
CN101835449A (zh) * 2007-08-31 2010-09-15 Dsmip资产有限公司 4-脒基苄胺用于美容和/或皮肤病学的用途
DE102009022794A1 (de) * 2009-05-27 2010-12-02 Philipps-Universität Marburg Verwendung von Hemmstoffen der HAT und TMPRSS2 als Arzneimittel
WO2012004678A2 (en) 2010-07-07 2012-01-12 The Medicines Company (Leipzig) Gmbh Serine protease inhibitors
ES2654440T3 (es) 2010-12-21 2018-02-13 The Medicines Company (Leipzig) Gmbh Inhibidores de serina proteasa de tipo tripsina, su preparación y uso como inhibidores selectivos de los factores de coagulación IIa y Xa
EP2872110A2 (en) 2012-07-12 2015-05-20 DSM IP Assets B.V. Cosmetic composition comprising benzylsulfonyl-d-ser-homophe-(4-amidino-benzylamide) and a polyalcohol
JPWO2014168197A1 (ja) * 2013-04-12 2017-02-16 東レ株式会社 抗血栓性を有する人工血管
EP2960232A1 (en) 2014-06-25 2015-12-30 DSM IP Assets B.V. Process for the production of a dipeptide derivative

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3577700D1 (de) 1984-11-30 1990-06-21 Shosuke Okamoto Lysinderivat und proteinase-inhibitor.
AU8868991A (en) 1990-11-15 1992-06-11 Pentapharm Ag Meta-substituted phenyl alanine derivatives
DE4243858A1 (de) 1992-12-23 1994-06-30 Thomae Gmbh Dr K Aminosäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
JPH07509731A (ja) 1993-02-10 1995-10-26 ペンタファルム　アクチェンゲゼルシャフト トロンビン阻害剤としての置換されたフェニルアラニン誘導体のピペラジド
SE9301916D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
US5550213A (en) 1993-12-27 1996-08-27 Rutgers, The State University Of New Jersey Inhibitors of urokinase plasminogen activator
AU1025795A (en) 1994-01-27 1995-08-03 Mitsubishi Chemical Corporation Prolineamide derivatives
IL112795A (en) 1994-03-04 2001-01-28 Astrazeneca Ab Peptide derivatives as antithrombic agents their preparation and pharmaceutical compositions containing them
US5726159A (en) * 1994-03-04 1998-03-10 Eli Lilly And Company Antithrombotic agents
US5707966A (en) * 1994-03-04 1998-01-13 Eli Lilly And Company Antithrombotic agents
US5705487A (en) * 1994-03-04 1998-01-06 Eli Lilly And Company Antithrombotic agents
EP1384725A3 (en) 1994-04-26 2007-02-21 Aventis Pharmaceuticals Inc. Factor Xa inhibitors
US6030972A (en) 1995-02-17 2000-02-29 Basf Aktiengesellschaft Dipeptide amidines as thrombin inhibitors
US5914319A (en) * 1995-02-27 1999-06-22 Eli Lilly And Company Antithrombotic agents
US5710130A (en) * 1995-02-27 1998-01-20 Eli Lilly And Company Antithrombotic agents
CH689611A5 (de) 1995-03-01 1999-07-15 Pentapharm Ag Urokinase-Inhibitoren.
US5786328A (en) * 1995-06-05 1998-07-28 Genentech, Inc. Use of kunitz type plasma kallikrein inhibitors
TWI238827B (en) 1995-12-21 2005-09-01 Astrazeneca Ab Prodrugs of thrombin inhibitors
JP2000514788A (ja) * 1996-06-25 2000-11-07 イーライ・リリー・アンド・カンパニー 抗凝固剤
ZA986594B (en) 1997-07-25 1999-01-27 Abbott Lab Urokinase inhibitors
WO1999040088A1 (en) * 1998-02-09 1999-08-12 3-Dimensional Pharmaceuticals, Inc. Heteroaryl amidines, methylamidines and guanidines as protease inhibitors, in particular as urokinase inhibitors
US6624169B1 (en) * 1998-07-20 2003-09-23 Wilex Biotechnology Gmbh Urokinase inhibitors
US7342018B2 (en) * 1998-07-20 2008-03-11 Wilex Ag Urokinase inhibitors and uses thereof
GB9816228D0 (en) * 1998-07-24 1998-09-23 Pfizer Ltd Isoquinolines
US6576613B1 (en) 1998-07-24 2003-06-10 Corvas International, Inc. Title inhibitors of urokinase
SE9802974D0 (sv) 1998-09-03 1998-09-03 Astra Ab New crystalline forms
AU9059798A (en) 1998-09-18 2000-04-10 Pentapharm Ag Urokinase inhibitors
EP1144373B1 (en) * 1999-01-13 2005-10-19 Genentech, Inc. Serine protease inhibitors
FR2791683A1 (fr) 1999-03-30 2000-10-06 Synthelabo Derives de n-sulfonyl-dipeptides, leur preparation et leur application en therapeutique
GB9908410D0 (en) * 1999-04-13 1999-06-09 Pfizer Ltd Pyridines
AR023510A1 (es) 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
DE19940389A1 (de) * 1999-08-25 2001-03-01 Wilex Biotechnology Gmbh Selektive Inhibitoren des Urokinase-Plasminogen Aktivators
US6797504B1 (en) 2000-09-08 2004-09-28 Dendreon San Diego Llc Inhibitors of serine protease activity of matriptase or MTSP1
DE10005631A1 (de) * 2000-02-09 2001-08-23 Max Planck Gesellschaft Arginin-Mimetika als Faktor X¶a¶-Inhibitoren
DE10013715A1 (de) * 2000-03-20 2001-09-27 Wilex Biotechnology Gmbh Hochselektive Inhibitoren des Urokinase-Plasminogenaktivators
DE60117783T2 (de) 2000-04-25 2006-11-30 Abbott Laboratories, Abbott Park Naphthamidin-urokinaseinhibitoren
DE10029015A1 (de) 2000-06-15 2001-12-20 Curacyte Ag Hemmstoffe für den Gerinnungsfaktor Xa
DE10029014A1 (de) * 2000-06-15 2001-12-20 Univ Schiller Jena Urokinase-Hemmstoffe
WO2001097794A2 (en) 2000-06-21 2001-12-27 Georgetown University Inhibitors of matriptase for the treatment of cancer
WO2002006280A2 (en) 2000-07-13 2002-01-24 Millennium Pharamaceuticals, Inc. INHIBITORS OF FACTOR Xa
AU785260B2 (en) * 2000-08-11 2006-12-07 Wilex Ag Non-covalent inhibitors of urokinase and blood vessel formation
DE60034447T2 (de) * 2000-08-11 2008-02-14 Wilex Ag Nicht-kovalente Urokinase-und Angiogenese-Inhibitoren
AU2002230836A1 (en) 2000-12-18 2002-07-01 Merck & Co., Inc. Benzylamine derivatives and their use as thrombin inhibitors
DE10102878A1 (de) * 2001-01-23 2002-08-01 Haemosys Gmbh Oligo- oder Polyalkylengekoppelte Thrombininhibitoren
JP4179878B2 (ja) * 2001-02-02 2008-11-12 中外製薬株式会社 ペプチド誘導体
SI1453852T1 (sl) * 2001-12-12 2007-06-30 Wilex Ag Selektivni arilgvanidinpeptidi kot inhibitorji urokinaze
AU2003206945A1 (en) 2002-02-22 2003-09-09 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Use of proteinase inhibitors in the treatment of autoimmune diseases
DE10210590A1 (de) * 2002-03-11 2003-10-02 Curacyte Ag Hemmstoffe des Gerinnungsfaktors Xa, ihre Herstellung und Verwendung
DE10212555A1 (de) 2002-03-15 2003-09-25 Univ Schiller Jena Verwendung von Hemmstoffen des Gerinnungsfaktors Xa als Wirkstoffe zur Erkennung und Unterdrückung des Wachstums maligner Tumore sowie der von diesen ausgehenden Metastasierung
DE10225876A1 (de) * 2002-06-11 2003-12-24 Wilex Ag Guanidinophenylalaninverbindungen als Urokinase-Inhibitoren
AU2002349247A1 (en) * 2002-10-04 2004-04-23 Pentapharm Ag Substrate for tafi (a)
DE10301300B4 (de) * 2003-01-15 2009-07-16 Curacyte Chemistry Gmbh Verwendung von acylierten 4-Amidino- und 4-Guanidinobenzylaminen zur Inhibierung von Plasmakallikrein
DE10322191B4 (de) * 2003-05-16 2014-02-27 The Medicines Company (Leipzig) Gmbh N-sulfonylierte Aminosäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung
DE10323898A1 (de) * 2003-05-26 2004-12-23 Wilex Ag Hydroxyamidin- und Hydroxyguanidin-Verbindungen als Urokinase-Hemmstoffe
DE10342108A1 (de) * 2003-09-11 2005-04-14 Curacyte Chemistry Gmbh Basisch-substituierte Benzylaminanaloga als Inhibitoren des Gerinnungsfaktors Xa, ihre Herstellung und Verwendung
DE102005044319A1 (de) * 2005-09-16 2007-03-22 Curacyte Chemistry Gmbh 2-(Aminomethyl)-5-Chlor-Benzylamid-Derivate und ihre Verwendung als Hemmstoffe des Gerinnungsfaktors Xa
DE102006050672A1 (de) * 2006-10-24 2008-04-30 Curacyte Discovery Gmbh Hemmstoffe des Plasmins und des Plasmakallikreins

Also Published As

Publication number Publication date
DK1485345T3 (da) 2008-11-03
JP4898091B2 (ja) 2012-03-14
CA2478409C (en) 2012-07-31
WO2003076391A3 (de) 2004-01-22
JP2005526762A (ja) 2005-09-08
ATE399175T1 (de) 2008-07-15
EP1485345A2 (de) 2004-12-15
AU2003219039A1 (en) 2003-09-22
WO2003076391A2 (de) 2003-09-18
US20110065799A1 (en) 2011-03-17
CA2478409A1 (en) 2003-09-18
US20050176993A1 (en) 2005-08-11
US8476306B2 (en) 2013-07-02
US7838560B2 (en) 2010-11-23
EP1485345B1 (de) 2008-06-25

Similar Documents

Publication Publication Date Title
DE50310516D1 (de) Fredericamycin-derivate
BG108181A (bg) Нови спиротрициклични производни и тяхното използване като инхибитори на фосфодиестераза-7
TW200510325A (en) 2-acylamino-4-phenylthiazole derivatives, preparation thereof and therapeutic application thereof
DK1809280T3 (da) Mitotiske kinesininhibitorer og fremgangsmåder til anvendelse deraf
CY1113306T1 (el) Παραγωγα της κινολινης και η χρηση τους ως προσδεματων 5-ht6
NO20061736L (no) Krystallform av epotilon B
WO2003084539A3 (en) New pharmaceutical compositions based on anticholinergics and p38 kinase inhibitors
CY1116768T1 (el) Συνθεσεις οι οποιες περιεχουν βλαστοκυτταρα θηλυκης γαμετικης σειρας και μεθοδοι χρησης αυτων
MXPA05005223A (es) Diaminotriazoles utiles como inhibidores de proteinas cinasas.
ATE433973T1 (de) Azolylaminoazine als inhibitoren von proteinkinasen
AU2003218215A1 (en) Azolylaminoazines as inhibitors of protein kinases
AU2003220300A1 (en) Compositions useful as inhibitors of protein kinases
DE50310038D1 (de) Hemmstoffe der urokinase, ihre herstellung und verwendung
TW200634012A (en) 3-amino-pyrazolo[3,4b]pyridines as inhibitors of protein tyrosine kinases, their production and use as pharmaceutical agents
MX2007000505A (es) Derivados de oxindol sustituidos y medicamentos que contienen los mismos.
PL376324A1 (en) Piperazinyl and diazapanyl benzamides and benzthioamides
AU2000233235A1 (en) Use of interleukin-6 antagonists for the treatment of diseases characterised by high levels of aromatase
ATE291024T1 (de) Neue 4-aminofuropyrimidine und ihre verwendung
PT1390371E (pt) Oxazolo- e furopirimidinas e sua utilizacao em medicamentos contra tumores
IL163026A (en) Benzofuran and benzothiophene derivatives useful in the treatment of hyper-proliferative disorders
NO20054371L (no) Somatostatin-dopamin kimaere analoger
TNSN06138A1 (fr) Inhibitors of the mutant form of kit
BR0209541A (pt) Uso das imidazotriazinonas 2-fenil-substituìdas
ATE549024T1 (de) Chinazolin-kaliumkanalhemmer
UA83821C2 (ru) Производные бензолсульфонамидов, способ их получения и их применение для лечения воспалительных заболеваний и утоления боли

Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: THE MEDICINES COMPANY (LEIPZIG) GMBH, 04103 LE, DE

8364 No opposition during term of opposition