DE4009117A1 - Neue leukotrien-b(pfeil abwaerts)4(pfeil abwaerts)-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel - Google Patents

Neue leukotrien-b(pfeil abwaerts)4(pfeil abwaerts)-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Info

Publication number
DE4009117A1
DE4009117A1 DE4009117A DE4009117A DE4009117A1 DE 4009117 A1 DE4009117 A1 DE 4009117A1 DE 4009117 A DE4009117 A DE 4009117A DE 4009117 A DE4009117 A DE 4009117A DE 4009117 A1 DE4009117 A1 DE 4009117A1
Authority
DE
Germany
Prior art keywords
solution
mixture
stirred
residue
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE4009117A
Other languages
German (de)
English (en)
Inventor
Josef Dr Heindl
Werner Dr Skuballa
Bernd Dr Buchmann
Wolfgang Dr Froehlich
Roland Dr Ekerdt
Claudia Dr Giesen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Priority to DE4009117A priority Critical patent/DE4009117A1/de
Priority to FI915435A priority patent/FI915435A0/fi
Priority to HU914049A priority patent/HUT60457A/hu
Priority to CA002057042A priority patent/CA2057042A1/en
Priority to PCT/DE1991/000249 priority patent/WO1991014676A1/de
Priority to JP3505661A priority patent/JPH05500227A/ja
Priority to EP97250111A priority patent/EP0801061A2/de
Priority to AU74987/91A priority patent/AU7498791A/en
Priority to EP91905964A priority patent/EP0477311A1/de
Publication of DE4009117A1 publication Critical patent/DE4009117A1/de
Priority to NO914509A priority patent/NO914509D0/no
Priority to US08/161,074 priority patent/US5440044A/en
Priority to US08/464,951 priority patent/US5614634A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/48—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE4009117A 1990-03-19 1990-03-19 Neue leukotrien-b(pfeil abwaerts)4(pfeil abwaerts)-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel Withdrawn DE4009117A1 (de)

Priority Applications (12)

Application Number Priority Date Filing Date Title
DE4009117A DE4009117A1 (de) 1990-03-19 1990-03-19 Neue leukotrien-b(pfeil abwaerts)4(pfeil abwaerts)-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
JP3505661A JPH05500227A (ja) 1990-03-19 1991-03-19 新規ロイコトリエン―ｂ↓４―誘導体、その製法及び医薬品としてのその使用
HU914049A HUT60457A (en) 1990-03-19 1991-03-19 Process for producing leukotriene-beta under 4 derivative
CA002057042A CA2057042A1 (en) 1990-03-19 1991-03-19 Leukotrine-b4 derivatives, a process for the production of these, and their use as medication
PCT/DE1991/000249 WO1991014676A1 (de) 1990-03-19 1991-03-19 Neue leukotrien-b4-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
FI915435A FI915435A0 (fi) 1990-03-19 1991-03-19 Nya leukotrien-b4-derivater, foerfarande foer deras framstaellning och deras anvaendning som laekemedel.
EP97250111A EP0801061A2 (de) 1990-03-19 1991-03-19 Leukotrien-B4-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
AU74987/91A AU7498791A (en) 1990-03-19 1991-03-19 New leucotriene b4 derivatives, methods of preparing them and their use as drugs
EP91905964A EP0477311A1 (de) 1990-03-19 1991-03-19 Neue leukotrien-b 4?-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
NO914509A NO914509D0 (no) 1990-03-19 1991-11-18 Nye leukotrien-b4-derivater, fremgangsmaate for fremstilling derav og anvendelse derav som legemiddel
US08/161,074 US5440044A (en) 1990-03-19 1993-12-03 Leukotriene-B4 derivatives, process for their production and their use as pharmaceutical agents
US08/464,951 US5614634A (en) 1990-03-19 1995-06-05 Leukotriene-B4 derivatives, process for their production and their use as pharmaceutical agents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4009117A DE4009117A1 (de) 1990-03-19 1990-03-19 Neue leukotrien-b(pfeil abwaerts)4(pfeil abwaerts)-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
DE4009117A1 true DE4009117A1 (de) 1991-09-26

Family

ID=6402764

Family Applications (1)

Application Number Title Priority Date Filing Date
DE4009117A Withdrawn DE4009117A1 (de) 1990-03-19 1990-03-19 Neue leukotrien-b(pfeil abwaerts)4(pfeil abwaerts)-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Country Status (9)

Country Link
US (2) US5440044A (https=)
EP (2) EP0477311A1 (https=)
JP (1) JPH05500227A (https=)
AU (1) AU7498791A (https=)
CA (1) CA2057042A1 (https=)
DE (1) DE4009117A1 (https=)
FI (1) FI915435A0 (https=)
HU (1) HUT60457A (https=)
WO (1) WO1991014676A1 (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5599975A (en) * 1993-10-28 1997-02-04 Adir Et Compagnie Cyclised analogues of fatty acid metabolites
WO2002042250A1 (fr) 2000-11-27 2002-05-30 Universite Louis Pasteur (Etablissement Public A Caractere Scientifique, Culturel Et Professionnel) DERIVES DE L'ACIDE 4-HYDROXYBUTANOÏQUE ET DE SON HOMOLOGUE SUPERIEUR COMME LIGANDS DES RECEPTEURS DU η-HYDROXYBUTYRATE (GHB) COMPOSITIONS PHARMACEUTIQUES LES CONTENANT ET UTILISATIONS PHARMACEUTIQUES
EP2520654A1 (en) 2003-08-26 2012-11-07 The Regents of the University of Colorado Inhibitors of serine protease activity and their use in methods and compositions for treatment of bacterial infections
WO2014160768A1 (en) 2013-03-29 2014-10-02 The Regents Of The University Of Colorado Compositions and methods for preparing a subject for organ or non-organ implantation
WO2017117558A1 (en) 2015-12-31 2017-07-06 The Regents Of The University Of Colorado, A Body Corporate Methods and uses for alpha-1 antitrypsin or recombinant forms thereof, on steroid-refractory graft versus host disease involving gastrointestinal complications

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4009117A1 (de) * 1990-03-19 1991-09-26 Schering Ag Neue leukotrien-b(pfeil abwaerts)4(pfeil abwaerts)-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
GB9525828D0 (en) * 1995-12-18 1996-02-21 Bayer Ag Use of hetarylacetic acid derivatives
DE19616133A1 (de) * 1996-04-11 1997-10-16 Schering Ag Neue Leukotrien-B¶4¶-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
PT1228030E (pt) * 1999-11-09 2005-08-31 Alcon Inc Derivados benzenoidicos do acido 15-hidroxieicosatetraenoico e metodos para a sua utilizacao no tratamento das perturbacoes do olho seco
US10780307B2 (en) 2017-11-28 2020-09-22 Lagree Technologies, Inc. Adjustable resistance exercise machine

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988005045A1 (en) * 1986-12-29 1988-07-14 The Upjohn Company Leukotriene b4 analogs
US4855324A (en) * 1987-12-08 1989-08-08 G. D. Searle & Co. Furyl, phenylene, and thienyl leukotriene B4 analogues
DE3817385A1 (de) * 1988-05-19 1989-11-30 Schering Ag Neue leukotrien-b(pfeil abwaerts)4(pfeil abwaerts)-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH089583B2 (ja) * 1987-11-05 1996-01-31 小野薬品工業株式会社 新規なアミド化合物
DE4009117A1 (de) * 1990-03-19 1991-09-26 Schering Ag Neue leukotrien-b(pfeil abwaerts)4(pfeil abwaerts)-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988005045A1 (en) * 1986-12-29 1988-07-14 The Upjohn Company Leukotriene b4 analogs
US4855324A (en) * 1987-12-08 1989-08-08 G. D. Searle & Co. Furyl, phenylene, and thienyl leukotriene B4 analogues
DE3817385A1 (de) * 1988-05-19 1989-11-30 Schering Ag Neue leukotrien-b(pfeil abwaerts)4(pfeil abwaerts)-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Tetrahydron Lett. 92 (1988), S.143-146 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5599975A (en) * 1993-10-28 1997-02-04 Adir Et Compagnie Cyclised analogues of fatty acid metabolites
WO2002042250A1 (fr) 2000-11-27 2002-05-30 Universite Louis Pasteur (Etablissement Public A Caractere Scientifique, Culturel Et Professionnel) DERIVES DE L'ACIDE 4-HYDROXYBUTANOÏQUE ET DE SON HOMOLOGUE SUPERIEUR COMME LIGANDS DES RECEPTEURS DU η-HYDROXYBUTYRATE (GHB) COMPOSITIONS PHARMACEUTIQUES LES CONTENANT ET UTILISATIONS PHARMACEUTIQUES
FR2817256A1 (fr) * 2000-11-27 2002-05-31 Univ Pasteur Derives de l'acides 4-hydroxybutanoique et de son homologue superieur comme ligands des recepteurs du gamma- hydroxybutyrate (ghb), compositions pharmaceutiques les contenant et utilisations pharmaceutiques
EP2520654A1 (en) 2003-08-26 2012-11-07 The Regents of the University of Colorado Inhibitors of serine protease activity and their use in methods and compositions for treatment of bacterial infections
EP3192872A1 (en) 2003-08-26 2017-07-19 The Regents of the University of Colorado, a body corporate Inhibitors of serine protease activity and their use in methods and compositions for treatment of bacterial infections
WO2014160768A1 (en) 2013-03-29 2014-10-02 The Regents Of The University Of Colorado Compositions and methods for preparing a subject for organ or non-organ implantation
WO2017117558A1 (en) 2015-12-31 2017-07-06 The Regents Of The University Of Colorado, A Body Corporate Methods and uses for alpha-1 antitrypsin or recombinant forms thereof, on steroid-refractory graft versus host disease involving gastrointestinal complications

Also Published As

Publication number Publication date
FI915435A7 (fi) 1991-11-18
FI915435A0 (fi) 1991-11-18
EP0801061A3 (https=) 1997-10-22
HU914049D0 (en) 1992-07-28
WO1991014676A1 (de) 1991-10-03
AU7498791A (en) 1991-10-21
HUT60457A (en) 1992-09-28
EP0801061A2 (de) 1997-10-15
JPH05500227A (ja) 1993-01-21
US5440044A (en) 1995-08-08
CA2057042A1 (en) 1991-09-20
US5614634A (en) 1997-03-25
EP0477311A1 (de) 1992-04-01

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