DE3925135A1 - Verfahren und vorrichtung zur automatisierten durchfuehrung und auswertung von agglutinationsreaktionen, insbesondere zur bestimmung leichter agglutination - Google Patents
Verfahren und vorrichtung zur automatisierten durchfuehrung und auswertung von agglutinationsreaktionen, insbesondere zur bestimmung leichter agglutinationInfo
- Publication number
- DE3925135A1 DE3925135A1 DE3925135A DE3925135A DE3925135A1 DE 3925135 A1 DE3925135 A1 DE 3925135A1 DE 3925135 A DE3925135 A DE 3925135A DE 3925135 A DE3925135 A DE 3925135A DE 3925135 A1 DE3925135 A1 DE 3925135A1
- Authority
- DE
- Germany
- Prior art keywords
- agglutination
- tube
- separation
- measured value
- determined
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 230000004520 agglutination Effects 0.000 title claims abstract description 66
- 230000003287 optical effect Effects 0.000 title claims abstract description 14
- 238000009792 diffusion process Methods 0.000 title abstract 2
- 238000012360 testing method Methods 0.000 title description 12
- 238000000034 method Methods 0.000 claims abstract description 26
- 238000006243 chemical reaction Methods 0.000 claims abstract description 16
- 238000011156 evaluation Methods 0.000 claims abstract description 11
- 210000002966 serum Anatomy 0.000 claims abstract description 11
- 239000000725 suspension Substances 0.000 claims abstract description 10
- 238000000926 separation method Methods 0.000 claims description 51
- 239000007788 liquid Substances 0.000 claims description 50
- 238000005406 washing Methods 0.000 claims description 32
- 239000011541 reaction mixture Substances 0.000 claims description 21
- 239000000203 mixture Substances 0.000 claims description 19
- 230000035699 permeability Effects 0.000 claims description 18
- 239000003153 chemical reaction reagent Substances 0.000 claims description 12
- 230000005499 meniscus Effects 0.000 claims description 11
- 238000004062 sedimentation Methods 0.000 claims description 9
- 230000008859 change Effects 0.000 claims description 5
- 238000007654 immersion Methods 0.000 claims description 5
- 230000007246 mechanism Effects 0.000 claims description 5
- 238000006073 displacement reaction Methods 0.000 claims description 4
- 239000011521 glass Substances 0.000 claims description 3
- 238000012545 processing Methods 0.000 claims description 3
- 238000002834 transmittance Methods 0.000 claims description 3
- 230000005855 radiation Effects 0.000 claims 1
- 239000004575 stone Substances 0.000 claims 1
- 230000008569 process Effects 0.000 abstract description 3
- 238000011109 contamination Methods 0.000 abstract description 2
- 210000003743 erythrocyte Anatomy 0.000 description 11
- 210000004369 blood Anatomy 0.000 description 6
- 239000008280 blood Substances 0.000 description 6
- 239000002245 particle Substances 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 238000011835 investigation Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000005192 partition Methods 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 2
- 241000237074 Centris Species 0.000 description 1
- 102000006395 Globulins Human genes 0.000 description 1
- 108010044091 Globulins Proteins 0.000 description 1
- 206010018910 Haemolysis Diseases 0.000 description 1
- 244000089486 Phragmites australis subsp australis Species 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/04—Investigating sedimentation of particle suspensions
- G01N15/042—Investigating sedimentation of particle suspensions by centrifuging and investigating centrifugates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/04—Investigating sedimentation of particle suspensions
- G01N15/05—Investigating sedimentation of particle suspensions in blood
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/04—Investigating sedimentation of particle suspensions
- G01N15/042—Investigating sedimentation of particle suspensions by centrifuging and investigating centrifugates
- G01N2015/045—Investigating sedimentation of particle suspensions by centrifuging and investigating centrifugates by optical analysis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
Landscapes
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU884032A HUT52250A (en) | 1988-07-29 | 1988-07-29 | Method and device for performing and evaluating agglutination reactions in first of all detecting weak agglutination |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3925135A1 true DE3925135A1 (de) | 1990-02-01 |
Family
ID=10966617
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE3925135A Withdrawn DE3925135A1 (de) | 1988-07-29 | 1989-07-28 | Verfahren und vorrichtung zur automatisierten durchfuehrung und auswertung von agglutinationsreaktionen, insbesondere zur bestimmung leichter agglutination |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JPH0299865A (it) |
| DE (1) | DE3925135A1 (it) |
| FR (1) | FR2634886A1 (it) |
| HU (1) | HUT52250A (it) |
| IT (1) | IT8921372A0 (it) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4016885A1 (de) * | 1990-05-25 | 1991-11-28 | Behringwerke Ag | Methode zur bestimmung des von-willebrand-faktors |
| DE4041554A1 (de) * | 1990-12-22 | 1991-05-02 | Komanns Aribert | Verfahren und vorrichtung zur messung der sedimentationskinetik von blutzellen, haemagglutinaten und antigen-antikoerper-komplexen unter einwirkung von zentrifugalkraeften |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3605829A (en) * | 1970-04-29 | 1971-09-20 | Becton Dickinson Co | Blood handling machine |
| JPS5933856B2 (ja) * | 1979-10-09 | 1984-08-18 | オリンパス光学工業株式会社 | 凝集反応測定方法およびそれに用いる反応容器 |
| AU554009B2 (en) * | 1981-11-04 | 1986-08-07 | Unisearch Limited | Whole blood clotting timer |
| HU192531B (en) * | 1984-01-26 | 1987-06-29 | Mueszeripari Muevek Lab | Multifunctional centrifuge |
| IT1209604B (it) * | 1984-11-27 | 1989-08-30 | Instrumentation Lab Spa | Metodo ed apparecchiatura per la misura di parametri di coagulazione. |
| US4720465A (en) * | 1985-05-14 | 1988-01-19 | Fisher Scientific Company | Centrifugal kinetic agglutination assay |
-
1988
- 1988-07-29 HU HU884032A patent/HUT52250A/hu unknown
-
1989
- 1989-07-28 JP JP1196425A patent/JPH0299865A/ja active Pending
- 1989-07-28 FR FR8910397A patent/FR2634886A1/fr not_active Withdrawn
- 1989-07-28 IT IT8921372A patent/IT8921372A0/it unknown
- 1989-07-28 DE DE3925135A patent/DE3925135A1/de not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0299865A (ja) | 1990-04-11 |
| FR2634886A1 (fr) | 1990-02-02 |
| HUT52250A (en) | 1990-06-28 |
| IT8921372A0 (it) | 1989-07-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8139 | Disposal/non-payment of the annual fee |