DE3889638T2 - Substituierte Propanphosphinsäure-Verbindungen. - Google Patents
Substituierte Propanphosphinsäure-Verbindungen.Info
- Publication number
- DE3889638T2 DE3889638T2 DE3889638T DE3889638T DE3889638T2 DE 3889638 T2 DE3889638 T2 DE 3889638T2 DE 3889638 T DE3889638 T DE 3889638T DE 3889638 T DE3889638 T DE 3889638T DE 3889638 T2 DE3889638 T2 DE 3889638T2
- Authority
- DE
- Germany
- Prior art keywords
- hydrogen
- denotes
- group
- cycloaliphatic
- aliphatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids R2P(=O)(OH); Thiophosphinic acids, i.e. R2P(=X)(XH) (X = S, Se)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/48—Phosphonous acids R—P(OH)2; Thiophosphonous acids including RHP(=O)(OH); Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids R2P(=O)(OH); Thiophosphinic acids, i.e. R2P(=X)(XH) (X = S, Se)
- C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB878728483A GB8728483D0 (en) | 1987-12-04 | 1987-12-04 | Chemical compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3889638D1 DE3889638D1 (de) | 1994-06-23 |
DE3889638T2 true DE3889638T2 (de) | 1994-09-15 |
Family
ID=10628049
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3889638T Expired - Lifetime DE3889638T2 (de) | 1987-12-04 | 1988-12-05 | Substituierte Propanphosphinsäure-Verbindungen. |
Country Status (22)
Country | Link |
---|---|
US (3) | US5013863A (de) |
EP (2) | EP0319479A3 (de) |
JP (1) | JP2716761B2 (de) |
KR (1) | KR890009955A (de) |
AT (1) | ATE105840T1 (de) |
AU (1) | AU614316B2 (de) |
CA (1) | CA1337352C (de) |
DD (1) | DD283630A5 (de) |
DE (1) | DE3889638T2 (de) |
DK (1) | DK673588A (de) |
ES (1) | ES2054869T3 (de) |
FI (1) | FI91412C (de) |
GB (1) | GB8728483D0 (de) |
HU (1) | HU202543B (de) |
IE (1) | IE63607B1 (de) |
IL (1) | IL88514A0 (de) |
MX (1) | MX14033A (de) |
NO (1) | NO177674C (de) |
NZ (1) | NZ227182A (de) |
PT (1) | PT89134B (de) |
YU (1) | YU218788A (de) |
ZA (1) | ZA889015B (de) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5457095A (en) * | 1984-10-12 | 1995-10-10 | Ciba-Geigy Corporation | Substituted propane-phosponous acid compounds |
US5243062A (en) * | 1984-10-12 | 1993-09-07 | Ciba-Geigy Corporation | Substituted propane-phosphonous acid compounds |
US5300679A (en) * | 1987-12-04 | 1994-04-05 | Ciba-Geigy Corporation | Substituted propane-phosphinic acid compounds |
US5190933A (en) * | 1987-12-04 | 1993-03-02 | Ciba-Geigy Corporation | Substituted propane-phosphinic acid compounds |
GB8911017D0 (en) * | 1989-05-13 | 1989-06-28 | Ciba Geigy Ag | Substituted aminoalkylphosphinic acids |
US5567840A (en) * | 1989-05-13 | 1996-10-22 | Ciba-Geigy Corporation | Substituted aminoalkylphosphinic acids |
US5281747A (en) * | 1989-05-13 | 1994-01-25 | Ciba-Geigy Corporation | Substituted aminoalkylphosphinic acids |
US5190934A (en) * | 1989-06-03 | 1993-03-02 | Ciba-Geigy Corporation | P-subsituted propane-phosphinic acid compounds |
GB8912814D0 (en) * | 1989-06-03 | 1989-07-19 | Ciba Geigy Ag | P-substituted propane-phospinic acid compounds |
IL98502A (en) * | 1990-06-22 | 1998-04-05 | Ciba Geigy Ag | History of Aminoalkene Phosphine Acid, Process for Their Preparation and Pharmaceutical Preparations Containing Them |
US5179173A (en) * | 1991-04-10 | 1993-01-12 | Nalco Chemical Company | Aminoalkylphosphinates and phosphinic acid-containing polymers therefrom |
EP0543780A3 (en) * | 1991-11-21 | 1993-09-01 | Ciba-Geigy Ag | Novel aminoalkanephosphinic acids and their salts |
GB9125615D0 (en) * | 1991-12-02 | 1992-01-29 | Wyeth John & Brother Ltd | Amines |
AU662404B2 (en) * | 1992-05-08 | 1995-08-31 | Novartis Ag | Novel N-aralkyl- and N-heteroaralkyl-aminoalkanephosphinic acids |
US5298625A (en) * | 1992-12-07 | 1994-03-29 | E. R. Squibb & Sons, Inc. | Process for the preparation of 4-phosphinyl-3-keto-carboxylate and 4-phosphonyl-3-keto-carboxylate intermediates useful in the preparation of phosphorus containing HMG-CoA reductase inhibitors |
GB9304619D0 (en) * | 1993-03-06 | 1993-04-21 | Ciba Geigy Ag | Esters |
US5385939A (en) * | 1993-04-30 | 1995-01-31 | The Trustees Of The University Of Pennsylvania | GABA-ergic modulation of eye growth |
DE19604195C1 (de) * | 1996-02-06 | 1997-04-17 | Hoechst Ag | Verfahren zur Herstellung von Phosphonigsäuremonoalkylestern |
DE19634706A1 (de) * | 1996-08-28 | 1998-03-05 | Hoechst Ag | Verfahren zur Herstellung von 2-Cyanoethyl-phosphinsäureestern |
GB9906882D0 (en) * | 1999-03-25 | 1999-05-19 | Novartis Ag | Organic compounds |
CA2442717A1 (en) * | 2001-03-15 | 2002-09-26 | Saegis Pharmaceuticals, Inc. | Methods for restoring cognitive function following systemic stress |
US20060014801A1 (en) * | 2002-11-22 | 2006-01-19 | The Johns Hopkins University | Prevention and treatment of cognitive impairment using (R)-(-)-5-methyl-1-nicotynoyl-2-pyrazoline (MNP) and analogs |
EP1620437B1 (de) | 2003-04-29 | 2009-06-17 | Pfizer Limited | 5,7-diaminopyrazolo¬4,3-d pyrimidine zur verwendung in der behandlung von bluthochdruck |
AR045794A1 (es) * | 2003-09-23 | 2005-11-16 | Aventis Pharma Inc | Procedimiento para preparar derivados de acido 3- amino-2- hidroxipropilfosfinico |
US20060094782A9 (en) * | 2003-10-31 | 2006-05-04 | Wong Patrick S | Compositions and dosage forms for enhanced absorption |
US7572799B2 (en) | 2003-11-24 | 2009-08-11 | Pfizer Inc | Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors |
DE10356410A1 (de) * | 2003-11-24 | 2005-06-23 | Bioagency Ag | Phosphororganische Verbindungen und deren Verwendung |
DE602005011784D1 (de) | 2004-04-07 | 2009-01-29 | Pfizer | Pyrazoloä4,3-düpyrimidine |
AU2005244867A1 (en) * | 2004-05-14 | 2005-12-01 | The Johns Hopkins University | Method for improving cognitive function by co-administration of a GABAB receptor antagonist and an acetylcholinesterase inhibitor |
SE0402199D0 (sv) * | 2004-09-13 | 2004-09-13 | Astrazeneca Ab | New process I |
WO2006050471A2 (en) * | 2004-11-03 | 2006-05-11 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs of sulfinic acids, methods of synthesis, and use |
US7494985B2 (en) * | 2004-11-03 | 2009-02-24 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs, methods of synthesis, and use |
KR20070101322A (ko) * | 2005-02-11 | 2007-10-16 | 아벤티스 파마슈티칼스 인크. | 치환된 프로판 포스핀산 에스테르 |
GB0608359D0 (en) * | 2006-04-28 | 2006-06-07 | Johnson Matthey Plc | Catalyst additives |
US7585996B2 (en) * | 2006-09-15 | 2009-09-08 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs, methods of synthesis and use |
EP2660266A3 (de) * | 2008-04-03 | 2014-05-21 | Basf Se | Festkörperpolymerisierungsverfahren für Polyester mit Phosphinsäureverbindungen |
DE102008055916A1 (de) | 2008-11-05 | 2010-05-06 | Clariant International Limited | Verfahren zur Herstellung von mono-hydroxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Allylalkoholen und ihre Verwendung |
DE102008055914A1 (de) | 2008-11-05 | 2010-05-06 | Clariant International Limited | Verfahren zur Herstellung von mono-hydroxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Acroleinen und ihre Verwendung |
EP2346885B1 (de) | 2008-11-05 | 2013-08-28 | Clariant International Ltd. | Verfahren zur herstellung von monocarboxyfunktionaslisierten dialkylphosphinsäuren, -estern und -salzen mittels allylalkoholen/acroleinen und ihre verwendung |
DE102008056228A1 (de) * | 2008-11-06 | 2010-05-12 | Clariant International Limited | Verfahren zur Herstellung von monoaminofunktionalisierten Dialkylphosphinsäuren, deren Salze und Ester und ihre Verwendung |
DE102008056339A1 (de) | 2008-11-07 | 2010-05-12 | Clariant International Limited | Verfahren zur Herstellung von mono-aminofunktionalisierten Dialkylphosphinsäuren, -estern und -salzen und ihre Verwendung |
DE102008056341A1 (de) * | 2008-11-07 | 2010-05-12 | Clariant International Limited | Verfahren zur Herstellung von monoaminofunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Acrylnitrilen und ihre Verwendung |
JP5570518B2 (ja) | 2008-11-07 | 2014-08-13 | クラリアント・ファイナンス・(ビーブイアイ)・リミテッド | アクリル酸誘導体を用いたジアルキルホスフィン酸、−エステル及び−塩の製造方法及びそれらの使用 |
DE102008056342A1 (de) | 2008-11-07 | 2010-05-12 | Clariant International Limited | Verfahren zur Herstellung von Dialkylphosphinsäuren, -estern und -salzen mittels Acrylnitrilen und ihre Verwendung |
US8772519B2 (en) | 2008-11-11 | 2014-07-08 | Clariant Finance (Bvi) Limited | Process for preparing mono-allyl-functionalized dialkylphosphinic acids, salts and esters thereof with allylic compounds, and the use thereof |
DE102008060036A1 (de) | 2008-12-02 | 2010-06-10 | Clariant International Limited | Verfahren zur Herstellung von mono-carboxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Vinylester einer Carbonsäure und ihre Verwendung |
DE102008060035A1 (de) * | 2008-12-02 | 2010-06-10 | Clariant International Limited | Verfahren zur Herstellung von mono-hydroxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Vinylester einer Carbonsäure und ihre Verwendung |
DE102008060535A1 (de) | 2008-12-04 | 2010-06-10 | Clariant International Limited | Verfahren zur Herstellung von mono-carboxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Vinylether und ihre Verwendung |
DE102008063668A1 (de) | 2008-12-18 | 2010-07-01 | Clariant International Limited | Verfahren zur Herstellung von Alkylphosponsäuren, -estern und -salzen mittels Oxidation von Alkylphosphonigsäuren und ihre Verwendung |
DE102008063627A1 (de) * | 2008-12-18 | 2010-06-24 | Clariant International Limited | Verfahren zur Herstellung von monohydroxyfunktionalisierten Dialkylphosphinsäuren,-estern und -salzen mittels Ethylenoxid und ihre Verwendung |
DE102008063642A1 (de) | 2008-12-18 | 2010-06-24 | Clariant International Limited | Verfahren zur Herstellung von monocarboxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Alkylenoxiden und ihre Verwendung |
WO2010069545A2 (de) | 2008-12-18 | 2010-06-24 | Clariant International Ltd | Verfahren zur herstellung von ethylendialkylphosphinsäuren, -estern und -salzen mittels acetylen und ihre verwendung |
DE102008063640A1 (de) * | 2008-12-18 | 2010-06-24 | Clariant International Limited | Verfahren zur Herstellung von gemischtsubstituierten Dialkylphosphinsäuren, -estern und -salzen und ihre Verwendung |
DE102008064012A1 (de) | 2008-12-19 | 2010-06-24 | Clariant International Limited | Halogenfreie Addukte von Alkylphosphonigsäurederivaten und diesterbildenden Olefinen, halogenfreie Verfahren zu deren Herstellung und ihre Verwendung |
DE102008064003A1 (de) * | 2008-12-19 | 2010-06-24 | Clariant International Limited | Verfahren zur Herstellung von mono-funktionalisierten Dialkylphosphinsäuren, -estern und -salzen und ihre Verwendung |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3184496A (en) * | 1961-02-27 | 1965-05-18 | Hooker Chemical Corp | Process for the preparation and recovery of triethyl phosphite and derivatives thereof |
DE2032712C3 (de) * | 1970-07-02 | 1978-10-19 | Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung von w-Amino-alkanphosphonsäure bzw.- phosphinsäurederivaten |
DE2440239A1 (de) * | 1974-08-22 | 1976-03-04 | Hoechst Ag | Innere ammoniumsalze von phosphinsaeuren |
US4064163A (en) * | 1976-12-30 | 1977-12-20 | Amchem Products, Inc. | Process for the manufacture of aliphatic phosphonic acids |
EP0014684B1 (de) * | 1979-02-06 | 1982-05-19 | Ciba-Geigy Ag | 2-Substituierte 5-Phenoxy-phenylphosphonsäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Herbizide |
DE3362581D1 (en) * | 1982-04-23 | 1986-04-24 | Ciba Geigy Ag | Herbicide and plant-growth regulator product |
US4536355A (en) * | 1982-10-08 | 1985-08-20 | Zoecon Corporation | Phenoxyphenylaminoalkylphosphinates useful in weed control |
GB8425872D0 (en) * | 1984-10-12 | 1984-11-21 | Ciba Geigy Ag | Chemical compounds |
GB8820266D0 (en) * | 1988-08-26 | 1988-09-28 | Smith Kline French Lab | Compounds |
GB8912814D0 (en) * | 1989-06-03 | 1989-07-19 | Ciba Geigy Ag | P-substituted propane-phospinic acid compounds |
-
1987
- 1987-12-04 GB GB878728483A patent/GB8728483D0/en active Pending
-
1988
- 1988-11-28 IL IL88514A patent/IL88514A0/xx unknown
- 1988-11-28 EP EP88810813A patent/EP0319479A3/de not_active Withdrawn
- 1988-12-01 YU YU02187/88A patent/YU218788A/xx unknown
- 1988-12-01 ZA ZA889015A patent/ZA889015B/xx unknown
- 1988-12-01 NO NO885361A patent/NO177674C/no unknown
- 1988-12-02 DK DK673588A patent/DK673588A/da not_active Application Discontinuation
- 1988-12-02 AU AU26544/88A patent/AU614316B2/en not_active Ceased
- 1988-12-02 MX MX1403388A patent/MX14033A/es unknown
- 1988-12-02 DD DD88322553A patent/DD283630A5/de not_active IP Right Cessation
- 1988-12-02 FI FI885623A patent/FI91412C/fi not_active IP Right Cessation
- 1988-12-02 PT PT89134A patent/PT89134B/pt not_active IP Right Cessation
- 1988-12-02 NZ NZ227182A patent/NZ227182A/en unknown
- 1988-12-02 HU HU886155A patent/HU202543B/hu not_active IP Right Cessation
- 1988-12-02 IE IE361788A patent/IE63607B1/en not_active IP Right Cessation
- 1988-12-02 CA CA000584925A patent/CA1337352C/en not_active Expired - Lifetime
- 1988-12-03 KR KR1019880016196A patent/KR890009955A/ko not_active Application Discontinuation
- 1988-12-05 ES ES88810831T patent/ES2054869T3/es not_active Expired - Lifetime
- 1988-12-05 EP EP88810831A patent/EP0319482B1/de not_active Expired - Lifetime
- 1988-12-05 DE DE3889638T patent/DE3889638T2/de not_active Expired - Lifetime
- 1988-12-05 JP JP63306192A patent/JP2716761B2/ja not_active Expired - Lifetime
- 1988-12-05 AT AT88810831T patent/ATE105840T1/de not_active IP Right Cessation
-
1989
- 1989-07-12 US US07/378,887 patent/US5013863A/en not_active Expired - Lifetime
-
1990
- 1990-02-26 US US07/484,716 patent/US5051524A/en not_active Expired - Lifetime
- 1990-03-30 US US07/502,399 patent/US5064819A/en not_active Expired - Lifetime
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: NOVARTIS AG, BASEL, CH |
|
8328 | Change in the person/name/address of the agent |
Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN |