NO885361D0 - Fremgangsmaate for fremstilling av substituerte propanfosfinsyre-forbindelser. - Google Patents

Fremgangsmaate for fremstilling av substituerte propanfosfinsyre-forbindelser.

Info

Publication number
NO885361D0
NO885361D0 NO885361A NO885361A NO885361D0 NO 885361 D0 NO885361 D0 NO 885361D0 NO 885361 A NO885361 A NO 885361A NO 885361 A NO885361 A NO 885361A NO 885361 D0 NO885361 D0 NO 885361D0
Authority
NO
Norway
Prior art keywords
hydrogen
denotes
group
cycloaliphatic
aliphatic
Prior art date
Application number
NO885361A
Other languages
English (en)
Other versions
NO177674C (no
NO885361L (no
NO177674B (no
Inventor
Eric Keith Baylis
Helmut Bittiger
Wolfgang Froestl
Roger Graham Hall
Ludwig Maier
Stuart John Mickel
Hans-Rudolf Olpe
Original Assignee
Ciba Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy filed Critical Ciba Geigy
Publication of NO885361D0 publication Critical patent/NO885361D0/no
Publication of NO885361L publication Critical patent/NO885361L/no
Publication of NO177674B publication Critical patent/NO177674B/no
Publication of NO177674C publication Critical patent/NO177674C/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/30Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/48Phosphonous acids [RP(OH)2] including [RHP(=O)(OH)]; Thiophosphonous acids including [RP(SH)2], [RHP(=S)(SH)]; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/02Antidotes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/30Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/301Acyclic saturated acids which can have further substituents on alkyl
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NO885361A 1987-12-04 1988-12-01 Analogifremgangsmåte for fremstilling av terapeutisk aktive substituerte propan-fosfinsyre-forbindelser NO177674C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878728483A GB8728483D0 (en) 1987-12-04 1987-12-04 Chemical compounds

Publications (4)

Publication Number Publication Date
NO885361D0 true NO885361D0 (no) 1988-12-01
NO885361L NO885361L (no) 1989-06-05
NO177674B NO177674B (no) 1995-07-24
NO177674C NO177674C (no) 1995-11-01

Family

ID=10628049

Family Applications (1)

Application Number Title Priority Date Filing Date
NO885361A NO177674C (no) 1987-12-04 1988-12-01 Analogifremgangsmåte for fremstilling av terapeutisk aktive substituerte propan-fosfinsyre-forbindelser

Country Status (22)

Country Link
US (3) US5013863A (no)
EP (2) EP0319479A3 (no)
JP (1) JP2716761B2 (no)
KR (1) KR890009955A (no)
AT (1) ATE105840T1 (no)
AU (1) AU614316B2 (no)
CA (1) CA1337352C (no)
DD (1) DD283630A5 (no)
DE (1) DE3889638T2 (no)
DK (1) DK673588A (no)
ES (1) ES2054869T3 (no)
FI (1) FI91412C (no)
GB (1) GB8728483D0 (no)
HU (1) HU202543B (no)
IE (1) IE63607B1 (no)
IL (1) IL88514A0 (no)
MX (1) MX14033A (no)
NO (1) NO177674C (no)
NZ (1) NZ227182A (no)
PT (1) PT89134B (no)
YU (1) YU218788A (no)
ZA (1) ZA889015B (no)

Families Citing this family (55)

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US5457095A (en) * 1984-10-12 1995-10-10 Ciba-Geigy Corporation Substituted propane-phosponous acid compounds
US5243062A (en) * 1984-10-12 1993-09-07 Ciba-Geigy Corporation Substituted propane-phosphonous acid compounds
US5190933A (en) * 1987-12-04 1993-03-02 Ciba-Geigy Corporation Substituted propane-phosphinic acid compounds
US5300679A (en) * 1987-12-04 1994-04-05 Ciba-Geigy Corporation Substituted propane-phosphinic acid compounds
GB8911017D0 (en) * 1989-05-13 1989-06-28 Ciba Geigy Ag Substituted aminoalkylphosphinic acids
US5281747A (en) * 1989-05-13 1994-01-25 Ciba-Geigy Corporation Substituted aminoalkylphosphinic acids
US5567840A (en) * 1989-05-13 1996-10-22 Ciba-Geigy Corporation Substituted aminoalkylphosphinic acids
GB8912814D0 (en) * 1989-06-03 1989-07-19 Ciba Geigy Ag P-substituted propane-phospinic acid compounds
US5190934A (en) * 1989-06-03 1993-03-02 Ciba-Geigy Corporation P-subsituted propane-phosphinic acid compounds
IL114631A (en) * 1990-06-22 1998-12-06 Novartis Ag Anti-epileptic preparations containing antagonists of BABAG
US5179173A (en) * 1991-04-10 1993-01-12 Nalco Chemical Company Aminoalkylphosphinates and phosphinic acid-containing polymers therefrom
EP0767174A1 (de) * 1991-11-21 1997-04-09 Ciba-Geigy Ag Neue Aminoalkanphosphinsäuren und ihre Salze
GB9125615D0 (en) * 1991-12-02 1992-01-29 Wyeth John & Brother Ltd Amines
AU662404B2 (en) * 1992-05-08 1995-08-31 Novartis Ag Novel N-aralkyl- and N-heteroaralkyl-aminoalkanephosphinic acids
US5298625A (en) * 1992-12-07 1994-03-29 E. R. Squibb & Sons, Inc. Process for the preparation of 4-phosphinyl-3-keto-carboxylate and 4-phosphonyl-3-keto-carboxylate intermediates useful in the preparation of phosphorus containing HMG-CoA reductase inhibitors
GB9304619D0 (en) * 1993-03-06 1993-04-21 Ciba Geigy Ag Esters
US5385939A (en) * 1993-04-30 1995-01-31 The Trustees Of The University Of Pennsylvania GABA-ergic modulation of eye growth
DE19604195C1 (de) * 1996-02-06 1997-04-17 Hoechst Ag Verfahren zur Herstellung von Phosphonigsäuremonoalkylestern
DE19634706A1 (de) * 1996-08-28 1998-03-05 Hoechst Ag Verfahren zur Herstellung von 2-Cyanoethyl-phosphinsäureestern
GB9906882D0 (en) * 1999-03-25 1999-05-19 Novartis Ag Organic compounds
CA2442717A1 (en) * 2001-03-15 2002-09-26 Saegis Pharmaceuticals, Inc. Methods for restoring cognitive function following systemic stress
US20060014801A1 (en) * 2002-11-22 2006-01-19 The Johns Hopkins University Prevention and treatment of cognitive impairment using (R)-(-)-5-methyl-1-nicotynoyl-2-pyrazoline (MNP) and analogs
RS20050810A (en) 2003-04-29 2007-08-03 Pfizer Inc., 5,7-diaminopyrazolo(4,3-d)pyrimidines useful in the treatment of hypertension
AR045794A1 (es) * 2003-09-23 2005-11-16 Aventis Pharma Inc Procedimiento para preparar derivados de acido 3- amino-2- hidroxipropilfosfinico
KR20060109922A (ko) * 2003-10-31 2006-10-23 알자 코포레이션 가바펜틴 및 프리가발린의 개선된 흡수를 위한 조성물 및제형
DE10356410A1 (de) * 2003-11-24 2005-06-23 Bioagency Ag Phosphororganische Verbindungen und deren Verwendung
US7572799B2 (en) 2003-11-24 2009-08-11 Pfizer Inc Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
WO2005097799A1 (en) 2004-04-07 2005-10-20 Pfizer Limited Pyrazolo`4,3-d! pyrimidines
WO2005112908A1 (en) * 2004-05-14 2005-12-01 The Johns Hopkins University Method for improving cognitive function
SE0402199D0 (sv) * 2004-09-13 2004-09-13 Astrazeneca Ab New process I
WO2006050471A2 (en) * 2004-11-03 2006-05-11 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of sulfinic acids, methods of synthesis, and use
WO2006050472A2 (en) * 2004-11-03 2006-05-11 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphonous and -phosphinic acids
AU2006213663A1 (en) * 2005-02-11 2006-08-17 Aventis Pharmaceuticals Inc. Substituted propane phosphinic acid esters
GB0608359D0 (en) * 2006-04-28 2006-06-07 Johnson Matthey Plc Catalyst additives
WO2008033572A1 (en) * 2006-09-15 2008-03-20 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
ES2370977T3 (es) * 2008-04-03 2011-12-26 Basf Se Procedimiento de polimerización en estado sólido para poliéster con compuestos de ácido fosfínico.
DE102008055916A1 (de) 2008-11-05 2010-05-06 Clariant International Limited Verfahren zur Herstellung von mono-hydroxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Allylalkoholen und ihre Verwendung
WO2010051883A1 (de) 2008-11-05 2010-05-14 Clariant International Ltd Verfahren zur herstellung von dialkylphosphinsäuren, -estern und -salzen mittels allylalkoholen/acroleinen und ihre verwendung
DE102008055914A1 (de) 2008-11-05 2010-05-06 Clariant International Limited Verfahren zur Herstellung von mono-hydroxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Acroleinen und ihre Verwendung
DE102008056228A1 (de) * 2008-11-06 2010-05-12 Clariant International Limited Verfahren zur Herstellung von monoaminofunktionalisierten Dialkylphosphinsäuren, deren Salze und Ester und ihre Verwendung
DE102008056341A1 (de) 2008-11-07 2010-05-12 Clariant International Limited Verfahren zur Herstellung von monoaminofunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Acrylnitrilen und ihre Verwendung
DE102008056342A1 (de) * 2008-11-07 2010-05-12 Clariant International Limited Verfahren zur Herstellung von Dialkylphosphinsäuren, -estern und -salzen mittels Acrylnitrilen und ihre Verwendung
DE102008056339A1 (de) 2008-11-07 2010-05-12 Clariant International Limited Verfahren zur Herstellung von mono-aminofunktionalisierten Dialkylphosphinsäuren, -estern und -salzen und ihre Verwendung
CN102186864A (zh) 2008-11-07 2011-09-14 科莱恩金融(Bvi)有限公司 利用丙烯酸衍生物制备二烷基次膦酸、二烷基次膦酸酯和二烷基次膦酸盐的方法,以及它们的用途
CN102171226B (zh) 2008-11-11 2015-02-11 科莱恩金融(Bvi)有限公司 利用烯丙基化合物制备单烯丙基官能化的二烷基次膦酸、其盐或酯的方法以及它们的用途
DE102008060036A1 (de) 2008-12-02 2010-06-10 Clariant International Limited Verfahren zur Herstellung von mono-carboxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Vinylester einer Carbonsäure und ihre Verwendung
DE102008060035A1 (de) * 2008-12-02 2010-06-10 Clariant International Limited Verfahren zur Herstellung von mono-hydroxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Vinylester einer Carbonsäure und ihre Verwendung
DE102008060535A1 (de) 2008-12-04 2010-06-10 Clariant International Limited Verfahren zur Herstellung von mono-carboxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Vinylether und ihre Verwendung
DE102008063627A1 (de) * 2008-12-18 2010-06-24 Clariant International Limited Verfahren zur Herstellung von monohydroxyfunktionalisierten Dialkylphosphinsäuren,-estern und -salzen mittels Ethylenoxid und ihre Verwendung
DE102008063640A1 (de) * 2008-12-18 2010-06-24 Clariant International Limited Verfahren zur Herstellung von gemischtsubstituierten Dialkylphosphinsäuren, -estern und -salzen und ihre Verwendung
WO2010069545A2 (de) 2008-12-18 2010-06-24 Clariant International Ltd Verfahren zur herstellung von ethylendialkylphosphinsäuren, -estern und -salzen mittels acetylen und ihre verwendung
DE102008063642A1 (de) 2008-12-18 2010-06-24 Clariant International Limited Verfahren zur Herstellung von monocarboxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Alkylenoxiden und ihre Verwendung
DE102008063668A1 (de) 2008-12-18 2010-07-01 Clariant International Limited Verfahren zur Herstellung von Alkylphosponsäuren, -estern und -salzen mittels Oxidation von Alkylphosphonigsäuren und ihre Verwendung
DE102008064012A1 (de) 2008-12-19 2010-06-24 Clariant International Limited Halogenfreie Addukte von Alkylphosphonigsäurederivaten und diesterbildenden Olefinen, halogenfreie Verfahren zu deren Herstellung und ihre Verwendung
DE102008064003A1 (de) * 2008-12-19 2010-06-24 Clariant International Limited Verfahren zur Herstellung von mono-funktionalisierten Dialkylphosphinsäuren, -estern und -salzen und ihre Verwendung

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US3184496A (en) * 1961-02-27 1965-05-18 Hooker Chemical Corp Process for the preparation and recovery of triethyl phosphite and derivatives thereof
DE2032712C3 (de) * 1970-07-02 1978-10-19 Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von w-Amino-alkanphosphonsäure bzw.- phosphinsäurederivaten
DE2440239A1 (de) * 1974-08-22 1976-03-04 Hoechst Ag Innere ammoniumsalze von phosphinsaeuren
US4064163A (en) * 1976-12-30 1977-12-20 Amchem Products, Inc. Process for the manufacture of aliphatic phosphonic acids
ATE1069T1 (de) * 1979-02-06 1982-06-15 Ciba-Geigy Ag 2-substituierte 5-phenoxy -phenylphosphonsaeurederivate, verfahren zu ihrer herstellung und ihre verwendung als herbizide.
DE3362581D1 (en) * 1982-04-23 1986-04-24 Ciba Geigy Ag Herbicide and plant-growth regulator product
US4536355A (en) * 1982-10-08 1985-08-20 Zoecon Corporation Phenoxyphenylaminoalkylphosphinates useful in weed control
GB8425872D0 (en) * 1984-10-12 1984-11-21 Ciba Geigy Ag Chemical compounds
GB8820266D0 (en) * 1988-08-26 1988-09-28 Smith Kline French Lab Compounds
GB8912814D0 (en) * 1989-06-03 1989-07-19 Ciba Geigy Ag P-substituted propane-phospinic acid compounds

Also Published As

Publication number Publication date
EP0319482B1 (en) 1994-05-18
HU202543B (en) 1991-03-28
DK673588D0 (da) 1988-12-02
EP0319479A3 (en) 1990-07-04
EP0319482A2 (en) 1989-06-07
JPH01301687A (ja) 1989-12-05
JP2716761B2 (ja) 1998-02-18
MX14033A (es) 1994-02-28
NO177674C (no) 1995-11-01
IL88514A0 (en) 1989-06-30
DD283630A5 (de) 1990-10-17
DK673588A (da) 1989-06-05
PT89134B (pt) 1993-12-31
FI885623A (fi) 1989-06-05
KR890009955A (ko) 1989-08-05
CA1337352C (en) 1995-10-17
DE3889638D1 (de) 1994-06-23
US5013863A (en) 1991-05-07
EP0319482A3 (en) 1990-07-11
IE883617L (en) 1989-06-04
FI91412B (fi) 1994-03-15
US5064819A (en) 1991-11-12
NO885361L (no) 1989-06-05
GB8728483D0 (en) 1988-01-13
ATE105840T1 (de) 1994-06-15
FI91412C (fi) 1994-06-27
DE3889638T2 (de) 1994-09-15
NO177674B (no) 1995-07-24
US5051524A (en) 1991-09-24
NZ227182A (en) 1991-03-26
FI885623A0 (fi) 1988-12-02
YU218788A (en) 1990-12-31
AU2654488A (en) 1989-06-08
HUT48897A (en) 1989-07-28
ZA889015B (en) 1989-08-30
ES2054869T3 (es) 1994-08-16
IE63607B1 (en) 1995-05-17
EP0319479A2 (en) 1989-06-07
PT89134A (pt) 1989-12-29
AU614316B2 (en) 1991-08-29

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