DE3855802T2 - Von Makrophagen abstammender Entzündungsvermittler(MIP-1-alpha et MIP-1-beta) - Google Patents
Von Makrophagen abstammender Entzündungsvermittler(MIP-1-alpha et MIP-1-beta)Info
- Publication number
- DE3855802T2 DE3855802T2 DE3855802T DE3855802T DE3855802T2 DE 3855802 T2 DE3855802 T2 DE 3855802T2 DE 3855802 T DE3855802 T DE 3855802T DE 3855802 T DE3855802 T DE 3855802T DE 3855802 T2 DE3855802 T2 DE 3855802T2
- Authority
- DE
- Germany
- Prior art keywords
- mip
- inflammatory cytokine
- beta
- alpha
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 210000002540 macrophage Anatomy 0.000 title abstract 2
- 102100031092 C-C motif chemokine 3 Human genes 0.000 title 1
- 101710155856 C-C motif chemokine 3 Proteins 0.000 title 1
- 102100031102 C-C motif chemokine 4 Human genes 0.000 title 1
- 101710155855 C-C motif chemokine 4 Proteins 0.000 title 1
- 239000005550 inflammation mediator Substances 0.000 title 1
- 102100040247 Tumor necrosis factor Human genes 0.000 abstract 4
- 210000004027 cell Anatomy 0.000 abstract 4
- 102000004127 Cytokines Human genes 0.000 abstract 3
- 108090000695 Cytokines Proteins 0.000 abstract 3
- 101710151805 Mitochondrial intermediate peptidase 1 Proteins 0.000 abstract 3
- 230000002757 inflammatory effect Effects 0.000 abstract 3
- 108060008682 Tumor Necrosis Factor Proteins 0.000 abstract 2
- 230000001939 inductive effect Effects 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 108010013563 Lipoprotein Lipase Proteins 0.000 abstract 1
- 102100022119 Lipoprotein lipase Human genes 0.000 abstract 1
- 230000001195 anabolic effect Effects 0.000 abstract 1
- 230000035584 blastogenesis Effects 0.000 abstract 1
- 230000010002 chemokinesis Effects 0.000 abstract 1
- 239000002299 complementary DNA Substances 0.000 abstract 1
- 230000003013 cytotoxicity Effects 0.000 abstract 1
- 231100000135 cytotoxicity Toxicity 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000002158 endotoxin Substances 0.000 abstract 1
- 229960002897 heparin Drugs 0.000 abstract 1
- 229920000669 heparin Polymers 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 230000008595 infiltration Effects 0.000 abstract 1
- 238000001764 infiltration Methods 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- CWERGRDVMFNCDR-UHFFFAOYSA-M thioglycolate(1-) Chemical compound [O-]C(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-M 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/521—Chemokines
- C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/21—Chemokines, e.g. MIP-1, MIP-2, RANTES, MCP, PF-4
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
- G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- G01N2400/38—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence, e.g. gluco- or galactomannans, e.g. Konjac gum, Locust bean gum, Guar gum
- G01N2400/40—Glycosaminoglycans, i.e. GAG or mucopolysaccharides, e.g. chondroitin sulfate, dermatan sulfate, hyaluronic acid, heparin, heparan sulfate, and related sulfated polysaccharides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Cell Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Pain & Pain Management (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10482787A | 1987-10-02 | 1987-10-02 | |
| US23893788A | 1988-09-02 | 1988-09-02 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3855802D1 DE3855802D1 (de) | 1997-04-03 |
| DE3855802T2 true DE3855802T2 (de) | 1997-06-12 |
Family
ID=26801988
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE3855802T Expired - Fee Related DE3855802T2 (de) | 1987-10-02 | 1988-10-03 | Von Makrophagen abstammender Entzündungsvermittler(MIP-1-alpha et MIP-1-beta) |
Country Status (7)
| Country | Link |
|---|---|
| EP (2) | EP0310136B1 (de) |
| JP (2) | JP3022566B2 (de) |
| AT (1) | ATE149176T1 (de) |
| AU (1) | AU626800B2 (de) |
| DE (1) | DE3855802T2 (de) |
| ES (1) | ES2100839T3 (de) |
| GR (1) | GR3022689T3 (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5145676A (en) * | 1981-09-08 | 1992-09-08 | The Rockefeller University | Method and agents for promoting wound healing |
| JPS6490199A (en) * | 1987-09-30 | 1989-04-06 | Hiromi Fujiwara | T cell growth factor derived from thymic interstitial cell and production thereof |
| WO1990002762A1 (en) * | 1988-09-02 | 1990-03-22 | The Rockefeller University | Macrophage-derived inflammatory mediator (mip-2) |
| GB8915414D0 (en) * | 1989-07-05 | 1989-08-23 | Ciba Geigy | Novel cytokines |
| ES2088925T3 (es) * | 1989-07-10 | 1996-10-01 | Univ Rockefeller | Promotores de la actividad del factor estimulador de colonias. |
| CA2091266A1 (en) * | 1990-09-14 | 1992-03-15 | Patricia Tekamp-Olson | Expression of macrophage inducible proteins (mips) in yeast cells |
| US6420374B1 (en) | 1990-11-30 | 2002-07-16 | Fred Hutchinson Cancer Research Center | Use of xanthines as immunosuppressants and to inhibit allograft reactions |
| EP0548376A1 (de) * | 1991-07-19 | 1993-06-30 | Otsuka Pharmaceutical Co., Ltd. | Antitumorheilmittel |
| US6495129B1 (en) | 1994-03-08 | 2002-12-17 | Human Genome Sciences, Inc. | Methods of inhibiting hematopoietic stem cells using human myeloid progenitor inhibitory factor-1 (MPIF-1) (Ckbeta-8/MIP-3) |
| US6623942B2 (en) | 1994-03-08 | 2003-09-23 | Human Genome Sciences, Inc. | Macrophage inflammatory protein-4 (MIP-4) polynucleotides |
| US6790947B1 (en) | 1995-06-07 | 2004-09-14 | Icos Corporation | Polynucleotides encoding macrophage derived chemokine |
| US5688927A (en) * | 1995-06-07 | 1997-11-18 | Icos Corporation | Macrophage derived chemokine |
| US7018627B1 (en) | 1995-06-07 | 2006-03-28 | Icos Corporation | Macrophage derived chemokine (MDC), MDC analogs, MDC inhibitor substances, and uses thereof |
| US6320023B1 (en) | 1995-06-07 | 2001-11-20 | Icos Corporation | Macrophage derived chemokine |
| US6737513B1 (en) | 1996-06-07 | 2004-05-18 | Icos Corporation | Macrophage derived chemokine (MDC) and chemokine analogs and assay to identify modulators of MDC activity, and therapeutic uses for same |
| US6498015B1 (en) | 1995-06-07 | 2002-12-24 | Icos Corporation | Methods of identifying agents that modulate the binding between MDC and an MDC receptor |
| HUP9701282A3 (en) * | 1995-06-07 | 1999-09-28 | Icos Corp Bothell | Macrophage derived chemokine and chemokine analogs |
| GB9600559D0 (en) * | 1996-01-11 | 1996-03-13 | British Biotech Pharm | Use of chemokines |
| US5840544A (en) * | 1996-04-17 | 1998-11-24 | Incyte Pharmaceuticals, Inc. | DNA encoding rantes homolog from prostate |
| WO1997045543A2 (en) * | 1996-05-28 | 1997-12-04 | The Government Of The United States Of America, As Represented By The Secretary Of Health And Human Services, National Institutes Of Health | Cc chemokine receptor 5, antibodies thereto, transgenic animals |
| US6399078B1 (en) | 1998-06-01 | 2002-06-04 | University Of Maryland Biotechnology Institute | Chemokine—glycosaminoglycan complexes and their use in treating or preventing receptor mediated diseases |
| FR2783528A1 (fr) * | 1998-08-28 | 2000-03-24 | Commissariat Energie Atomique | Procede de synthese d'une chimiokine marquee, chimiokine marquee et trousse d'analyse |
| WO2000012554A1 (fr) * | 1998-08-28 | 2000-03-09 | Commissariat A L'energie Atomique | Procede de synthese d'une chimiokine marquee, chimiokine marquee et trousse d'analyse |
| US7041302B2 (en) * | 2001-01-09 | 2006-05-09 | Biother Corporation | Therapeutic modulation of the tumor inflammatory response |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1983000930A1 (en) * | 1981-09-08 | 1983-03-17 | Univ Rockefeller | Lipoprotein lipase suppression by endotoxin-induce mediator (shock assay) |
-
1988
- 1988-10-03 ES ES88116329T patent/ES2100839T3/es not_active Expired - Lifetime
- 1988-10-03 EP EP88116329A patent/EP0310136B1/de not_active Expired - Lifetime
- 1988-10-03 JP JP63249724A patent/JP3022566B2/ja not_active Expired - Lifetime
- 1988-10-03 AU AU23336/88A patent/AU626800B2/en not_active Ceased
- 1988-10-03 EP EP96113024A patent/EP0761685A3/de not_active Withdrawn
- 1988-10-03 DE DE3855802T patent/DE3855802T2/de not_active Expired - Fee Related
- 1988-10-03 AT AT88116329T patent/ATE149176T1/de active
-
1997
- 1997-02-27 GR GR970400370T patent/GR3022689T3/el unknown
- 1997-11-06 JP JP09304526A patent/JP3051834B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP3051834B2 (ja) | 2000-06-12 |
| EP0310136B1 (de) | 1997-02-26 |
| ATE149176T1 (de) | 1997-03-15 |
| EP0761685A3 (de) | 1998-01-28 |
| DE3855802D1 (de) | 1997-04-03 |
| EP0761685A2 (de) | 1997-03-12 |
| EP0310136A3 (de) | 1990-03-07 |
| AU2333688A (en) | 1989-07-27 |
| ES2100839T3 (es) | 1997-07-01 |
| JPH029391A (ja) | 1990-01-12 |
| JPH10185899A (ja) | 1998-07-14 |
| AU626800B2 (en) | 1992-08-13 |
| GR3022689T3 (en) | 1997-05-31 |
| JP3022566B2 (ja) | 2000-03-21 |
| EP0310136A2 (de) | 1989-04-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |