DE3853711D1 - Zwischenverbindungen für die Synthese von 5,6,7,8-Tetrahydro-L-erythro-biopterin und seiner Derivate. - Google Patents
Zwischenverbindungen für die Synthese von 5,6,7,8-Tetrahydro-L-erythro-biopterin und seiner Derivate.Info
- Publication number
- DE3853711D1 DE3853711D1 DE3853711T DE3853711T DE3853711D1 DE 3853711 D1 DE3853711 D1 DE 3853711D1 DE 3853711 T DE3853711 T DE 3853711T DE 3853711 T DE3853711 T DE 3853711T DE 3853711 D1 DE3853711 D1 DE 3853711D1
- Authority
- DE
- Germany
- Prior art keywords
- biopterin
- erythro
- tetrahydro
- intermediates
- synthesis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P25/00—Preparation of compounds containing alloxazine or isoalloxazine nucleus, e.g. riboflavin
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP62299977A JP2611790B2 (ja) | 1987-11-30 | 1987-11-30 | テトラヒドロフラニルピリミジン誘導体 |
JP62299980A JP2567639B2 (ja) | 1987-11-30 | 1987-11-30 | プテリジン誘導体 |
JP62299978A JP2567637B2 (ja) | 1987-11-30 | 1987-11-30 | ジヒドロプテリジン誘導体 |
JP62299979A JP2567638B2 (ja) | 1987-11-30 | 1987-11-30 | テトラヒドロプテリジン誘導体 |
JP15221788A JP2674707B2 (ja) | 1988-06-22 | 1988-06-22 | L‐ビオプテリンの製法 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3853711D1 true DE3853711D1 (de) | 1995-06-08 |
DE3853711T2 DE3853711T2 (de) | 1996-01-11 |
Family
ID=27527977
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3853711T Expired - Fee Related DE3853711T2 (de) | 1987-11-30 | 1988-11-29 | Zwischenverbindungen für die Synthese von 5,6,7,8-Tetrahydro-L-erythro-biopterin und seiner Derivate. |
Country Status (4)
Country | Link |
---|---|
US (2) | US4937342A (de) |
EP (1) | EP0318926B1 (de) |
CA (1) | CA1334654C (de) |
DE (1) | DE3853711T2 (de) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5196533A (en) * | 1983-04-11 | 1993-03-23 | South Alabama Medical Science Foundation, Usa | Cyclization of 5 amino-pyrimidines to quinoid 6,6 disubstituted dihydropteridines |
JP2843592B2 (ja) * | 1989-02-28 | 1999-01-06 | 日清製粉株式会社 | L−リボース誘導体 |
US5198547A (en) * | 1992-03-16 | 1993-03-30 | South Alabama Medical Science Foundation, Usa | Process for N5-formylating tetrahydropteridines |
DE4418097A1 (de) | 1994-05-24 | 1995-11-30 | Cassella Ag | Verwendung von Tetrahydropteridin-Derivaten als Hemmstoffe der NO-Synthase |
EP1314782B1 (de) | 2000-08-31 | 2009-03-18 | Asubio Pharma Co., Ltd. | Verfahren zur herstellung von biopterinen |
US7442372B2 (en) | 2003-08-29 | 2008-10-28 | Biomarin Pharmaceutical Inc. | Delivery of therapeutic compounds to the brain and other tissues |
EP3138566B1 (de) * | 2003-11-17 | 2022-01-26 | BioMarin Pharmaceutical Inc. | Behandlung von phenylketonurie mit bh4 |
WO2006055511A2 (en) | 2004-11-17 | 2006-05-26 | Biomarin Pharmaceutical Inc. | Stable tablet formulation of tetrahydrobiopterin |
CA2588994A1 (en) * | 2004-12-08 | 2006-06-15 | Biomarin Pharmaceutical Inc. | Methods and compositions for the treatment of pulmonary hypertension of the newborn |
WO2007067570A1 (en) * | 2005-12-05 | 2007-06-14 | Biomarin Pharmaceutical Inc. | Methods and compositions for the treatment of disease |
WO2008089148A1 (en) * | 2007-01-12 | 2008-07-24 | Biomarin Pharmaceutical Inc. | Method of treating a metabolic or neuropsychiatry disorder with a bh4 derivative prodrug |
AU2008206486C1 (en) * | 2007-01-12 | 2013-09-26 | Biomarin Pharmaceutical Inc. | Tetrahydrobiopterin prodrugs |
ES2851177T3 (es) | 2007-04-11 | 2021-09-03 | Biomarin Pharm Inc | Tetrahidrobiopterina para el tratamiento de afecciones asociadas con niveles elevados de fenilalanina |
CA2711160A1 (en) | 2008-01-03 | 2009-07-16 | Biomarin Pharmaceutical Inc. | Pterin analog for treating bh4 responsive condition |
CN101959891A (zh) * | 2008-01-07 | 2011-01-26 | 生物马林药物股份有限公司 | 合成四氢生物蝶呤的方法 |
US9216178B2 (en) | 2011-11-02 | 2015-12-22 | Biomarin Pharmaceutical Inc. | Dry blend formulation of tetrahydrobiopterin |
CN102627644B (zh) * | 2012-04-10 | 2014-04-16 | 凯莱英医药集团(天津)股份有限公司 | 一种通过直接手性合成方法制备二盐酸沙丙蝶呤的方法 |
CN104592175B (zh) * | 2014-12-29 | 2017-01-25 | 江苏清泉化学股份有限公司 | 一种 2,5‑二烷氧基二氢呋喃类化合物的制备方法 |
WO2016189542A1 (en) | 2015-05-28 | 2016-12-01 | Natco Pharma Ltd | Novel process for the preparation of sapropterin dihydrochloride and its key intermediate, l-biopterin |
WO2019175328A1 (en) | 2018-03-14 | 2019-09-19 | Imba - Institut Für Molekulare Biotechnologie Gmbh | Bh4pathwayactivationandusethereoffortreatingcancer |
WO2019175332A1 (en) | 2018-03-14 | 2019-09-19 | Imba - Institut Für Molekulare Biotechnologie Gmbh | Bh4 pathway inhibition and use thereof for treating t-cell mediated autoimmune diseases or hypersensitivity |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA582950A (en) * | 1959-09-08 | California Institute Research Foundation | Pteridine derivatives | |
US2955110A (en) * | 1955-01-13 | 1960-10-04 | American Cyanamid Co | Substituted pteridines and method of preparing the same |
US2940966A (en) * | 1958-05-15 | 1960-06-14 | Daniel R Bullard | Glucoside of 2-amino-4-hydroxy-6-(1', 2'-dihydroxypropyl)-pteridine |
DE2831600A1 (de) * | 1978-07-19 | 1980-01-31 | Boehringer Sohn Ingelheim | Neue substituierte 2-phenylamino-1, 3-tetrahydropyrimidine-(2), deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben |
JPS5883691A (ja) * | 1981-11-13 | 1983-05-19 | Kanegafuchi Chem Ind Co Ltd | 1′,2′−ジアシル−(6r,s)−5,6,7,8−テトラヒドロ−l−ビオプテリンおよびその製法 |
JPS5925323A (ja) * | 1982-03-03 | 1984-02-09 | 鐘淵化学工業株式会社 | プテリン誘導体からなる脳内神経伝達物質の関わる疾病の治療剤 |
JPS5921685A (ja) * | 1982-07-28 | 1984-02-03 | Suntory Ltd | L―エリスロ―バイオプテリンの製造法 |
JPS5982091A (ja) * | 1982-10-29 | 1984-05-11 | Suntory Ltd | バイオプテリンの製法 |
JPS60178887A (ja) * | 1984-02-23 | 1985-09-12 | Kanegafuchi Chem Ind Co Ltd | 5,6,7,8−テトラヒドロ−l−ビオプテリンの製造法 |
JPS60199889A (ja) * | 1984-03-24 | 1985-10-09 | Kanegafuchi Chem Ind Co Ltd | 5,6,7,8−テトラヒドロ−l−エリスロ−ビオプテリンの硫酸塩およびその製法 |
JPS60204786A (ja) * | 1984-03-29 | 1985-10-16 | Univ Nagoya | (6r)―テトラヒドロビオプテリンの合成法 |
US4550109A (en) * | 1984-05-31 | 1985-10-29 | The Board Of Regents, The University Of Texas System | Lipoidal biopterin compounds |
US4713454A (en) * | 1985-01-28 | 1987-12-15 | Shiratori Pharmaceutical Co., Ltd. | Preparation process of (6R)-tetrahydro-L-biopterin |
JPS61277618A (ja) * | 1985-06-04 | 1986-12-08 | Suntory Ltd | 自閉症治療剤 |
US4939252A (en) * | 1989-04-20 | 1990-07-03 | Hoffmann-La Roche Inc. | Novel intermediates for the preparation of Carbovir |
-
1988
- 1988-11-29 EP EP88119891A patent/EP0318926B1/de not_active Expired - Lifetime
- 1988-11-29 CA CA000584504A patent/CA1334654C/en not_active Expired - Fee Related
- 1988-11-29 US US07/277,109 patent/US4937342A/en not_active Expired - Fee Related
- 1988-11-29 DE DE3853711T patent/DE3853711T2/de not_active Expired - Fee Related
-
1990
- 1990-04-27 US US07/515,962 patent/US5037981A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US4937342A (en) | 1990-06-26 |
EP0318926A3 (de) | 1991-01-09 |
EP0318926B1 (de) | 1995-05-03 |
EP0318926A2 (de) | 1989-06-07 |
DE3853711T2 (de) | 1996-01-11 |
CA1334654C (en) | 1995-03-07 |
US5037981A (en) | 1991-08-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |