DE3853711D1 - Zwischenverbindungen für die Synthese von 5,6,7,8-Tetrahydro-L-erythro-biopterin und seiner Derivate. - Google Patents

Zwischenverbindungen für die Synthese von 5,6,7,8-Tetrahydro-L-erythro-biopterin und seiner Derivate.

Info

Publication number
DE3853711D1
DE3853711D1 DE3853711T DE3853711T DE3853711D1 DE 3853711 D1 DE3853711 D1 DE 3853711D1 DE 3853711 T DE3853711 T DE 3853711T DE 3853711 T DE3853711 T DE 3853711T DE 3853711 D1 DE3853711 D1 DE 3853711D1
Authority
DE
Germany
Prior art keywords
biopterin
erythro
tetrahydro
intermediates
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3853711T
Other languages
English (en)
Other versions
DE3853711T2 (de
Inventor
Masayasu Kurono
Takehiko Suzuki
Tomio Ogasawara
Nobuko Ohishi
Kunio Yagi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
VITAMIN KENKYUSHO KK
Original Assignee
VITAMIN KENKYUSHO KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP62299977A external-priority patent/JP2611790B2/ja
Priority claimed from JP62299978A external-priority patent/JP2567637B2/ja
Priority claimed from JP62299979A external-priority patent/JP2567638B2/ja
Priority claimed from JP62299980A external-priority patent/JP2567639B2/ja
Priority claimed from JP15221788A external-priority patent/JP2674707B2/ja
Application filed by VITAMIN KENKYUSHO KK filed Critical VITAMIN KENKYUSHO KK
Publication of DE3853711D1 publication Critical patent/DE3853711D1/de
Application granted granted Critical
Publication of DE3853711T2 publication Critical patent/DE3853711T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P25/00—Preparation of compounds containing alloxazine or isoalloxazine nucleus, e.g. riboflavin

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE3853711T 1987-11-30 1988-11-29 Zwischenverbindungen für die Synthese von 5,6,7,8-Tetrahydro-L-erythro-biopterin und seiner Derivate. Expired - Fee Related DE3853711T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP62299977A JP2611790B2 (ja) 1987-11-30 1987-11-30 テトラヒドロフラニルピリミジン誘導体
JP62299978A JP2567637B2 (ja) 1987-11-30 1987-11-30 ジヒドロプテリジン誘導体
JP62299979A JP2567638B2 (ja) 1987-11-30 1987-11-30 テトラヒドロプテリジン誘導体
JP62299980A JP2567639B2 (ja) 1987-11-30 1987-11-30 プテリジン誘導体
JP15221788A JP2674707B2 (ja) 1988-06-22 1988-06-22 Ｌ‐ビオプテリンの製法

Publications (2)

Publication Number Publication Date
DE3853711D1 true DE3853711D1 (de) 1995-06-08
DE3853711T2 DE3853711T2 (de) 1996-01-11

Family

ID=27527977

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3853711T Expired - Fee Related DE3853711T2 (de) 1987-11-30 1988-11-29 Zwischenverbindungen für die Synthese von 5,6,7,8-Tetrahydro-L-erythro-biopterin und seiner Derivate.

Country Status (4)

Country Link
US (2) US4937342A (de)
EP (1) EP0318926B1 (de)
CA (1) CA1334654C (de)
DE (1) DE3853711T2 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5196533A (en) * 1983-04-11 1993-03-23 South Alabama Medical Science Foundation, Usa Cyclization of 5 amino-pyrimidines to quinoid 6,6 disubstituted dihydropteridines
JP2843592B2 (ja) * 1989-02-28 1999-01-06 日清製粉株式会社 Ｌ−リボース誘導体
US5198547A (en) * 1992-03-16 1993-03-30 South Alabama Medical Science Foundation, Usa Process for N5-formylating tetrahydropteridines
DE4418097A1 (de) 1994-05-24 1995-11-30 Cassella Ag Verwendung von Tetrahydropteridin-Derivaten als Hemmstoffe der NO-Synthase
DE60138029D1 (de) 2000-08-31 2009-04-30 Asubio Pharma Co Ltd Verfahren zur herstellung von biopterinen
US7442372B2 (en) 2003-08-29 2008-10-28 Biomarin Pharmaceutical Inc. Delivery of therapeutic compounds to the brain and other tissues
AU2004291149C1 (en) 2003-11-17 2021-01-21 Biomarin Pharmaceutical Inc. Methods and Compositions for the Treatment of Metabolic Disorders
US8003126B2 (en) 2004-11-17 2011-08-23 Biomarin Pharmaceutical Inc. Stable tablet formulation
CA2588994A1 (en) * 2004-12-08 2006-06-15 Biomarin Pharmaceutical Inc. Methods and compositions for the treatment of pulmonary hypertension of the newborn
EP1965803A1 (de) * 2005-12-05 2008-09-10 Biomarin Pharmaceutical Inc. Verfahren und zusammensetzungen zur behandlung von krankheiten
WO2008089148A1 (en) * 2007-01-12 2008-07-24 Biomarin Pharmaceutical Inc. Method of treating a metabolic or neuropsychiatry disorder with a bh4 derivative prodrug
EP2114944A2 (de) * 2007-01-12 2009-11-11 BioMarin Pharmaceutical Inc. Tetrahydrobiopterin-prodrugs
PT2545939T (pt) 2007-04-11 2021-02-17 Biomarin Pharm Inc Métodos de administração de tetra-hidrobiopterina, composições associadas, e métodos de medição
CN101969953B (zh) 2008-01-03 2013-01-09 生物马林药物股份有限公司 用于治疗bh4反应性疾病的喋呤类似物
CN101959891A (zh) * 2008-01-07 2011-01-26 生物马林药物股份有限公司 合成四氢生物蝶呤的方法
US9216178B2 (en) 2011-11-02 2015-12-22 Biomarin Pharmaceutical Inc. Dry blend formulation of tetrahydrobiopterin
CN102627644B (zh) * 2012-04-10 2014-04-16 凯莱英医药集团（天津）股份有限公司 一种通过直接手性合成方法制备二盐酸沙丙蝶呤的方法
CN104592175B (zh) * 2014-12-29 2017-01-25 江苏清泉化学股份有限公司 一种 2,5‑二烷氧基二氢呋喃类化合物的制备方法
WO2016189542A1 (en) 2015-05-28 2016-12-01 Natco Pharma Ltd Novel process for the preparation of sapropterin dihydrochloride and its key intermediate, l-biopterin
WO2019175328A1 (en) 2018-03-14 2019-09-19 Imba - Institut Für Molekulare Biotechnologie Gmbh Bh4pathwayactivationandusethereoffortreatingcancer
WO2019175332A1 (en) 2018-03-14 2019-09-19 Imba - Institut Für Molekulare Biotechnologie Gmbh Bh4 pathway inhibition and use thereof for treating t-cell mediated autoimmune diseases or hypersensitivity

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA582950A (en) * 1959-09-08 California Institute Research Foundation Pteridine derivatives
US2955110A (en) * 1955-01-13 1960-10-04 American Cyanamid Co Substituted pteridines and method of preparing the same
US2940966A (en) * 1958-05-15 1960-06-14 Daniel R Bullard Glucoside of 2-amino-4-hydroxy-6-(1', 2'-dihydroxypropyl)-pteridine
DE2831600A1 (de) * 1978-07-19 1980-01-31 Boehringer Sohn Ingelheim Neue substituierte 2-phenylamino-1, 3-tetrahydropyrimidine-(2), deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben
JPS5883691A (ja) * 1981-11-13 1983-05-19 Kanegafuchi Chem Ind Co Ltd １′，２′−ジアシル−（６ｒ，ｓ）−５，６，７，８−テトラヒドロ−ｌ−ビオプテリンおよびその製法
JPS5925323A (ja) * 1982-03-03 1984-02-09 鐘淵化学工業株式会社 プテリン誘導体からなる脳内神経伝達物質の関わる疾病の治療剤
JPS5921685A (ja) * 1982-07-28 1984-02-03 Suntory Ltd Ｌ―エリスロ―バイオプテリンの製造法
JPS5982091A (ja) * 1982-10-29 1984-05-11 Suntory Ltd バイオプテリンの製法
JPS60178887A (ja) * 1984-02-23 1985-09-12 Kanegafuchi Chem Ind Co Ltd ５，６，７，８−テトラヒドロ−ｌ−ビオプテリンの製造法
JPS60199889A (ja) * 1984-03-24 1985-10-09 Kanegafuchi Chem Ind Co Ltd ５，６，７，８−テトラヒドロ−ｌ−エリスロ−ビオプテリンの硫酸塩およびその製法
JPS60204786A (ja) * 1984-03-29 1985-10-16 Univ Nagoya （６ｒ）―テトラヒドロビオプテリンの合成法
US4550109A (en) * 1984-05-31 1985-10-29 The Board Of Regents, The University Of Texas System Lipoidal biopterin compounds
CA1262347A (en) * 1985-01-28 1989-10-17 Suntory Limited Preparation process of (6r)-tetrahydro-l-biopterin
JPS61277618A (ja) * 1985-06-04 1986-12-08 Suntory Ltd 自閉症治療剤
US4939252A (en) * 1989-04-20 1990-07-03 Hoffmann-La Roche Inc. Novel intermediates for the preparation of Carbovir

Also Published As

Publication number Publication date
EP0318926A2 (de) 1989-06-07
EP0318926A3 (de) 1991-01-09
US5037981A (en) 1991-08-06
DE3853711T2 (de) 1996-01-11
EP0318926B1 (de) 1995-05-03
US4937342A (en) 1990-06-26
CA1334654C (en) 1995-03-07

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee