DE3853043D1 - Isochinolinderivate, ihre Herstellung und Verwendung. - Google Patents

Isochinolinderivate, ihre Herstellung und Verwendung.

Info

Publication number
DE3853043D1
DE3853043D1 DE3853043T DE3853043T DE3853043D1 DE 3853043 D1 DE3853043 D1 DE 3853043D1 DE 3853043 T DE3853043 T DE 3853043T DE 3853043 T DE3853043 T DE 3853043T DE 3853043 D1 DE3853043 D1 DE 3853043D1
Authority
DE
Germany
Prior art keywords
isoquinoline derivatives
production
aryl
derivatives
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3853043T
Other languages
English (en)
Other versions
DE3853043T2 (de
Inventor
Emil Albin Dr Broger
Yvo Dr Crameri
Bernd Dr Heiser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of DE3853043D1 publication Critical patent/DE3853043D1/de
Publication of DE3853043T2 publication Critical patent/DE3853043T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0046—Ruthenium compounds
    • C07F15/0053—Ruthenium compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE3853043T 1987-11-11 1988-11-02 Isochinolinderivate, ihre Herstellung und Verwendung. Expired - Fee Related DE3853043T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP87810651 1987-11-11

Publications (2)

Publication Number Publication Date
DE3853043D1 true DE3853043D1 (de) 1995-03-23
DE3853043T2 DE3853043T2 (de) 1995-06-08

Family

ID=8198427

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3853043T Expired - Fee Related DE3853043T2 (de) 1987-11-11 1988-11-02 Isochinolinderivate, ihre Herstellung und Verwendung.

Country Status (6)

Country Link
US (1) US4857648A (de)
EP (1) EP0315886B1 (de)
JP (1) JP2579677B2 (de)
AT (1) ATE118482T1 (de)
DE (1) DE3853043T2 (de)
DK (1) DK168069B1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4791107A (en) * 1986-07-16 1988-12-13 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use
DK0397042T3 (da) * 1989-05-10 1995-10-02 Hoffmann La Roche Fremstilling af isoquinolinderivater
JPH0692427B2 (ja) * 1989-07-11 1994-11-16 高砂香料工業株式会社 ２，２’―ビス（ジシクロヘキシルホスフィノ）―６，６’―ジメチル―１，１’―ビフェニルを配位子とする錯体，およびその錯体を用いた有機カルボン酸とそのエステルの製造方法
RO110501B1 (ro) * 1990-06-27 1996-01-30 Hoechst Roussel Pharma Derivati de tetrahidroizochinolinil carbamati
AU685820B2 (en) * 1990-06-27 1998-01-29 Hoechst-Roussel Pharmaceuticals Incorporated Tetrahydroisoquinolinylcarbamates of 1,2,3,3A,8,8A-hexahydro-1,3A,8-trimethylpyrrolo(2,3-B)indole
US5084461A (en) * 1991-03-27 1992-01-28 Merrell Dow Pharmaceuticals Inc. Azadecalin amides and thioamides as inhibitors of cholesterol biosynthesis
US5350758A (en) * 1992-07-08 1994-09-27 Merrell Dow Pharmaceuticals Inc. Piperidyl sulfonamides and sulfoxamides as inhibitors of cholesterol biosynthesis
EP0834506B1 (de) * 1996-10-02 2004-01-14 F. Hoffmann-La Roche Ag Verfahren zur Herstellung von (9alpha, 13alpha, 14alpha)-1-(3-Methoxymorphinan-17-yl)alkanonen
EP0834505B1 (de) * 1996-10-02 2004-01-07 F. Hoffmann-La Roche Ag Verfahren zur Herstellung von (Z)-1-[1-(4-Methoxybenzyliden)-1,2,3,4,5,6,7,8-octahydro-isochinolin-2-yl]alkanonen
US5849917A (en) * 1996-10-02 1998-12-15 Roche Vitamins Inc. Process for the preparation of isoquinoline compounds
US5905153A (en) * 1996-10-02 1999-05-18 Roche Vitamins Inc. Process for preparing (9α,13α,14α)-1-(3-methoxy-morphinan-17-yl)alkanones
DE19706396A1 (de) * 1996-12-09 1998-06-10 Bayer Ag Verfahren zur Herstellung von 3-(l-Hydroxiphenyl-l-alkoximinomethyl)dioxazinen
US5880285A (en) * 1996-12-23 1999-03-09 Roche Vitamins Inc. Process for manufacture of optically active isochinole compounds
CN103265489B (zh) * 2013-06-17 2015-03-25 苏州立新制药有限公司 ent-(14S)-3-甲氧基-17-甲基吗喃的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB685750A (en) * 1949-10-14 1953-01-07 Hoffmann La Roche Improvements in or relating to isoquinoline derivatives
US3634429A (en) * 1969-09-30 1972-01-11 Hoffmann La Roche Morphinan derivatives and preparation thereof
US4247697A (en) * 1979-09-10 1981-01-27 Hoffmann-La Roche Inc. 3-Phenoxy morphinans and their derivatives
US4514569A (en) * 1982-01-28 1985-04-30 Hendrickson James B Synthesis of 1-substituted isoquinolines
DE3436179A1 (de) * 1984-10-03 1986-04-10 Merck Patent Gmbh, 6100 Darmstadt Verfahren zur herstellung optisch aktiver amine
JPS62265266A (ja) * 1986-05-13 1987-11-18 Takasago Corp Ｎ−アシル−テトラヒドロイソキノリン類の製造法

Also Published As

Publication number Publication date
JP2579677B2 (ja) 1997-02-05
ATE118482T1 (de) 1995-03-15
DK584488A (da) 1989-05-12
DK584488D0 (da) 1988-10-20
JPH01160965A (ja) 1989-06-23
DE3853043T2 (de) 1995-06-08
US4857648A (en) 1989-08-15
EP0315886B1 (de) 1995-02-15
EP0315886A2 (de) 1989-05-17
DK168069B1 (da) 1994-01-31
EP0315886A3 (en) 1990-04-25

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee