DK584488A - Isoquinolinderivater - Google Patents
IsoquinolinderivaterInfo
- Publication number
- DK584488A DK584488A DK584488A DK584488A DK584488A DK 584488 A DK584488 A DK 584488A DK 584488 A DK584488 A DK 584488A DK 584488 A DK584488 A DK 584488A DK 584488 A DK584488 A DK 584488A
- Authority
- DK
- Denmark
- Prior art keywords
- aryl
- derivatives
- lower alkyl
- lower alkoxy
- isoquinoline
- Prior art date
Links
- AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical compound C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 title 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000002183 isoquinolinyl group Chemical class C1(=NC=CC2=CC=CC=C12)* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- INAXVFBXDYWQFN-XHSDSOJGSA-N morphinan Chemical class C1C2=CC=CC=C2[C@]23CCCC[C@H]3[C@@H]1NCC2 INAXVFBXDYWQFN-XHSDSOJGSA-N 0.000 abstract 1
- 229940051807 opiod analgesics morphinan derivative Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0046—Ruthenium compounds
- C07F15/0053—Ruthenium compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
- C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP87810651 | 1987-11-11 | ||
EP87810651 | 1987-11-11 |
Publications (3)
Publication Number | Publication Date |
---|---|
DK584488D0 DK584488D0 (da) | 1988-10-20 |
DK584488A true DK584488A (da) | 1989-05-12 |
DK168069B1 DK168069B1 (da) | 1994-01-31 |
Family
ID=8198427
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK584488A DK168069B1 (da) | 1987-11-11 | 1988-10-20 | Isoquinolinderivater og en fremgangsmaade til fremstilling af octahydroisoquinoliner ud fra derivaterne |
Country Status (6)
Country | Link |
---|---|
US (1) | US4857648A (da) |
EP (1) | EP0315886B1 (da) |
JP (1) | JP2579677B2 (da) |
AT (1) | ATE118482T1 (da) |
DE (1) | DE3853043T2 (da) |
DK (1) | DK168069B1 (da) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4791107A (en) * | 1986-07-16 | 1988-12-13 | Hoechst-Roussel Pharmaceuticals, Inc. | Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use |
DE59009525D1 (de) * | 1989-05-10 | 1995-09-21 | Hoffmann La Roche | Herstellung von Isochinolinderivaten. |
JPH0692427B2 (ja) * | 1989-07-11 | 1994-11-16 | 高砂香料工業株式会社 | 2,2’―ビス(ジシクロヘキシルホスフィノ)―6,6’―ジメチル―1,1’―ビフェニルを配位子とする錯体,およびその錯体を用いた有機カルボン酸とそのエステルの製造方法 |
AU685820B2 (en) * | 1990-06-27 | 1998-01-29 | Hoechst-Roussel Pharmaceuticals Incorporated | Tetrahydroisoquinolinylcarbamates of 1,2,3,3A,8,8A-hexahydro-1,3A,8-trimethylpyrrolo(2,3-B)indole |
ATE163183T1 (de) * | 1990-06-27 | 1998-02-15 | Hoechst Marion Roussel Inc | Tetrahydroisochinolinylcarbamate von 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo (2,3-b> indol |
US5084461A (en) * | 1991-03-27 | 1992-01-28 | Merrell Dow Pharmaceuticals Inc. | Azadecalin amides and thioamides as inhibitors of cholesterol biosynthesis |
US5350758A (en) * | 1992-07-08 | 1994-09-27 | Merrell Dow Pharmaceuticals Inc. | Piperidyl sulfonamides and sulfoxamides as inhibitors of cholesterol biosynthesis |
EP0834506B1 (de) * | 1996-10-02 | 2004-01-14 | F. Hoffmann-La Roche Ag | Verfahren zur Herstellung von (9alpha, 13alpha, 14alpha)-1-(3-Methoxymorphinan-17-yl)alkanonen |
EP0834505B1 (de) * | 1996-10-02 | 2004-01-07 | F. Hoffmann-La Roche Ag | Verfahren zur Herstellung von (Z)-1-[1-(4-Methoxybenzyliden)-1,2,3,4,5,6,7,8-octahydro-isochinolin-2-yl]alkanonen |
US5905153A (en) * | 1996-10-02 | 1999-05-18 | Roche Vitamins Inc. | Process for preparing (9α,13α,14α)-1-(3-methoxy-morphinan-17-yl)alkanones |
US5849917A (en) * | 1996-10-02 | 1998-12-15 | Roche Vitamins Inc. | Process for the preparation of isoquinoline compounds |
DE19706396A1 (de) * | 1996-12-09 | 1998-06-10 | Bayer Ag | Verfahren zur Herstellung von 3-(l-Hydroxiphenyl-l-alkoximinomethyl)dioxazinen |
US5880285A (en) * | 1996-12-23 | 1999-03-09 | Roche Vitamins Inc. | Process for manufacture of optically active isochinole compounds |
CN103265489B (zh) * | 2013-06-17 | 2015-03-25 | 苏州立新制药有限公司 | ent-(14S)-3-甲氧基-17-甲基吗喃的制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB685750A (en) * | 1949-10-14 | 1953-01-07 | Hoffmann La Roche | Improvements in or relating to isoquinoline derivatives |
US3634429A (en) * | 1969-09-30 | 1972-01-11 | Hoffmann La Roche | Morphinan derivatives and preparation thereof |
US4247697A (en) * | 1979-09-10 | 1981-01-27 | Hoffmann-La Roche Inc. | 3-Phenoxy morphinans and their derivatives |
US4514569A (en) * | 1982-01-28 | 1985-04-30 | Hendrickson James B | Synthesis of 1-substituted isoquinolines |
DE3436179A1 (de) * | 1984-10-03 | 1986-04-10 | Merck Patent Gmbh, 6100 Darmstadt | Verfahren zur herstellung optisch aktiver amine |
JPS62265266A (ja) * | 1986-05-13 | 1987-11-18 | Takasago Corp | N−アシル−テトラヒドロイソキノリン類の製造法 |
-
1988
- 1988-10-20 DK DK584488A patent/DK168069B1/da not_active IP Right Cessation
- 1988-11-02 EP EP88118220A patent/EP0315886B1/en not_active Expired - Lifetime
- 1988-11-02 DE DE3853043T patent/DE3853043T2/de not_active Expired - Fee Related
- 1988-11-02 AT AT88118220T patent/ATE118482T1/de not_active IP Right Cessation
- 1988-11-08 US US07/268,441 patent/US4857648A/en not_active Expired - Lifetime
- 1988-11-10 JP JP63282634A patent/JP2579677B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE3853043T2 (de) | 1995-06-08 |
JPH01160965A (ja) | 1989-06-23 |
EP0315886A2 (en) | 1989-05-17 |
DE3853043D1 (de) | 1995-03-23 |
EP0315886A3 (en) | 1990-04-25 |
JP2579677B2 (ja) | 1997-02-05 |
ATE118482T1 (de) | 1995-03-15 |
US4857648A (en) | 1989-08-15 |
DK168069B1 (da) | 1994-01-31 |
EP0315886B1 (en) | 1995-02-15 |
DK584488D0 (da) | 1988-10-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B1 | Patent granted (law 1993) | ||
PBP | Patent lapsed |