DE3851865D1 - Verfahren zur Umwandlung des niedrigschmelzenden Polymorphs von Buspirone hydrochlorid in das höherschmelzende. - Google Patents

Verfahren zur Umwandlung des niedrigschmelzenden Polymorphs von Buspirone hydrochlorid in das höherschmelzende.

Info

Publication number
DE3851865D1
DE3851865D1 DE3851865T DE3851865T DE3851865D1 DE 3851865 D1 DE3851865 D1 DE 3851865D1 DE 3851865 T DE3851865 T DE 3851865T DE 3851865 T DE3851865 T DE 3851865T DE 3851865 D1 DE3851865 D1 DE 3851865D1
Authority
DE
Germany
Prior art keywords
melting
converting
low
polymorph
buspirone hydrochloride
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3851865T
Other languages
English (en)
Other versions
DE3851865T2 (de
Inventor
Robert J Behme
Terry T Kensler
Douglas G Mikolasek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of DE3851865D1 publication Critical patent/DE3851865D1/de
Publication of DE3851865T2 publication Critical patent/DE3851865T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Glass Compositions (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Gears, Cams (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Arrangement Or Mounting Of Propulsion Units For Vehicles (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Body Structure For Vehicles (AREA)
DE3851865T 1987-08-28 1988-08-26 Verfahren zur Umwandlung des niedrigschmelzenden Polymorphs von Buspirone hydrochlorid in das höherschmelzende. Expired - Fee Related DE3851865T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/090,302 US4810789A (en) 1987-08-28 1987-08-28 Process for buspirone hydrochloride polymorphic crystalline form conversion

Publications (2)

Publication Number Publication Date
DE3851865D1 true DE3851865D1 (de) 1994-11-24
DE3851865T2 DE3851865T2 (de) 1995-02-23

Family

ID=22222189

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3851865T Expired - Fee Related DE3851865T2 (de) 1987-08-28 1988-08-26 Verfahren zur Umwandlung des niedrigschmelzenden Polymorphs von Buspirone hydrochlorid in das höherschmelzende.

Country Status (23)

Country Link
US (1) US4810789A (de)
EP (1) EP0304940B1 (de)
JP (1) JP2702519B2 (de)
KR (1) KR970011294B1 (de)
AT (1) ATE113044T1 (de)
AU (1) AU618746B2 (de)
CY (1) CY1839A (de)
DE (1) DE3851865T2 (de)
DK (1) DK478688A (de)
ES (1) ES2060632T3 (de)
FI (1) FI91066C (de)
HK (1) HK71495A (de)
HU (1) HU199831B (de)
IE (1) IE65988B1 (de)
IL (1) IL87292A (de)
MY (1) MY100863A (de)
NO (1) NO169284C (de)
NZ (1) NZ225895A (de)
OA (1) OA08907A (de)
PT (1) PT88355B (de)
SU (1) SU1731056A3 (de)
YU (1) YU46961B (de)
ZA (1) ZA885867B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5631017A (en) * 1993-03-26 1997-05-20 Beth Israel Deaconess Medical Center, Inc. Topical application of buspirone for treatment of pathological conditions associated with immune responses
US5484788A (en) * 1993-03-26 1996-01-16 Beth Israel Hospital Association Buspirone as a systemic immunosuppressant
HU217129B (hu) * 1993-07-16 1999-11-29 EGIS Gyógyszergyár Rt. Eljárás nagy tisztaságú buspiron gyógyászati hatóanyag előállítására
US5637314A (en) * 1995-06-07 1997-06-10 Beth Israel Deaconess Medical Center, Inc. Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis
KR100322018B1 (ko) * 1999-01-23 2002-02-04 윤종용 음성대역 잡음 보상장치
US6465255B1 (en) * 1999-01-29 2002-10-15 The Regents Of The University Of California Method for identifying and probing phase transitions in materials
US7612095B2 (en) * 2002-04-19 2009-11-03 Faes Farma, S.A. Polymorph of 4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazole-2-yl]-1-piperidinyl]ethyl]-αα-dimethyl-benzeneacetic acid
JP2010013472A (ja) * 2009-09-09 2010-01-21 Faes Farma Sa ４−［２−［１−（２−エトキシエチル）−１Ｈ−ベンズイミダゾール−２−イル］−１−ピペリジニル］エチル］−α，α−ジメチルベンゼノ酢酸の多形体

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation
US3976776A (en) * 1972-12-06 1976-08-24 Mead Johnson & Company Tranquilizer process employing N-(heteroarcyclic)piperazinylalkylazaspiroalkanediones
US4351939A (en) * 1980-10-16 1982-09-28 Mead Johnson & Company Spiro-quaternary ammonium halides and N-(2-pyrimidinyl)piperazinylalkylazaspiroalkanedione process
US4476248A (en) * 1983-02-28 1984-10-09 The Upjohn Company Crystallization of ibuprofen
DD263531A5 (de) * 1986-10-21 1989-01-04 ������@���Kk�� Verfahren zur herstellung von verbrueckten bicyclischen imidverbindungen
US5015646A (en) * 1987-08-28 1991-05-14 Bristol-Myers Squibb Co. Pharmaceutically useful polymorphic modification of buspirone

Also Published As

Publication number Publication date
ZA885867B (en) 1989-05-30
HU199831B (en) 1990-03-28
DE3851865T2 (de) 1995-02-23
SU1731056A3 (ru) 1992-04-30
AU2048088A (en) 1989-03-02
HK71495A (en) 1995-05-19
YU46961B (sh) 1994-09-09
JP2702519B2 (ja) 1998-01-21
IL87292A (en) 1992-07-15
US4810789A (en) 1989-03-07
KR890003739A (ko) 1989-04-17
NO883806L (no) 1989-03-01
OA08907A (en) 1989-10-31
AU618746B2 (en) 1992-01-09
NO169284C (no) 1992-06-03
DK478688A (da) 1989-03-01
IE882362L (en) 1989-02-28
NO169284B (no) 1992-02-24
FI91066C (fi) 1994-05-10
IE65988B1 (en) 1995-11-29
ES2060632T3 (es) 1994-12-01
DK478688D0 (da) 1988-08-26
EP0304940A1 (de) 1989-03-01
PT88355A (pt) 1989-06-30
KR970011294B1 (ko) 1997-07-09
YU160488A (en) 1990-04-30
PT88355B (pt) 1995-12-29
MY100863A (en) 1991-03-15
NO883806D0 (no) 1988-08-25
CY1839A (en) 1995-12-01
FI91066B (fi) 1994-01-31
EP0304940B1 (de) 1994-10-19
FI883960A0 (fi) 1988-08-26
IL87292A0 (en) 1989-01-31
ATE113044T1 (de) 1994-11-15
JPS6471872A (en) 1989-03-16
FI883960A (fi) 1989-03-01
HUT47563A (en) 1989-03-28
NZ225895A (en) 1991-04-26

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee