DE3786606T2 - Stabilisiertes Benzimidazol-Derivat und Zusammenstellung. - Google Patents

Stabilisiertes Benzimidazol-Derivat und Zusammenstellung.

Info

Publication number
DE3786606T2
DE3786606T2 DE87304860T DE3786606T DE3786606T2 DE 3786606 T2 DE3786606 T2 DE 3786606T2 DE 87304860 T DE87304860 T DE 87304860T DE 3786606 T DE3786606 T DE 3786606T DE 3786606 T2 DE3786606 T2 DE 3786606T2
Authority
DE
Germany
Prior art keywords
composition
benzimidazole derivative
stabilized
stabilized benzimidazole
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE87304860T
Other languages
English (en)
Other versions
DE3786606D1 (de
Inventor
Heinojo Yamasaka
Hiroyasu Uchiyama
Hirotaka Masuda
Yoshiomi Sakamoto
Yoshimi Nakamigawa
Mitsuko Yoshioka
Terumasa Moriga
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Chemiphar Co Ltd
Original Assignee
Nippon Chemiphar Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP61128989A external-priority patent/JPH0791274B2/ja
Priority claimed from JP61128988A external-priority patent/JPH0791273B2/ja
Priority claimed from JP16061286A external-priority patent/JPH0791275B2/ja
Application filed by Nippon Chemiphar Co Ltd filed Critical Nippon Chemiphar Co Ltd
Application granted granted Critical
Publication of DE3786606D1 publication Critical patent/DE3786606D1/de
Publication of DE3786606T2 publication Critical patent/DE3786606T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms
DE87304860T 1986-06-02 1987-06-02 Stabilisiertes Benzimidazol-Derivat und Zusammenstellung. Expired - Fee Related DE3786606T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP61128989A JPH0791274B2 (ja) 1986-06-02 1986-06-02 ベンズイミダゾール誘導体薬剤組成物
JP61128988A JPH0791273B2 (ja) 1986-06-02 1986-06-02 ベンズイミダゾール誘導体薬剤組成物
JP16061286A JPH0791275B2 (ja) 1986-07-08 1986-07-08 ベンズイミダゾール誘導体薬剤組成物

Publications (2)

Publication Number Publication Date
DE3786606D1 DE3786606D1 (de) 1993-08-26
DE3786606T2 true DE3786606T2 (de) 1994-03-17

Family

ID=27315851

Family Applications (1)

Application Number Title Priority Date Filing Date
DE87304860T Expired - Fee Related DE3786606T2 (de) 1986-06-02 1987-06-02 Stabilisiertes Benzimidazol-Derivat und Zusammenstellung.

Country Status (7)

Country Link
US (1) US5294439A (de)
EP (1) EP0248634B1 (de)
KR (1) KR950011414B1 (de)
AR (1) AR246515A1 (de)
AU (1) AU619444B2 (de)
DE (1) DE3786606T2 (de)
ES (1) ES2058114T3 (de)

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JP2614756B2 (ja) * 1988-08-10 1997-05-28 日本ケミファ株式会社 イミダゾール誘導体およびその製造法ならびにこれを含有する抗潰瘍剤
AU4513393A (en) * 1992-07-17 1994-02-14 Astra Aktiebolag Pharmaceutical composition containing antiulcer agent
JPH0656665A (ja) * 1992-08-03 1994-03-01 Nippon Chemiphar Co Ltd イミダゾール誘導体を含有する胃溶性抗潰瘍剤
TW359614B (en) * 1993-08-31 1999-06-01 Takeda Chemical Industries Ltd Composition containing benzimidazole compounds for rectal administration
US20050054682A1 (en) * 1996-01-04 2005-03-10 Phillips Jeffrey O. Pharmaceutical compositions comprising substituted benzimidazoles and methods of using same
US6489346B1 (en) * 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US6645988B2 (en) 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US6699885B2 (en) * 1996-01-04 2004-03-02 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and methods of using same
CN1063971C (zh) * 1997-09-24 2001-04-04 中国兽药监察所 一种动物用冻干活疫苗制造方法
US6326384B1 (en) 1999-08-26 2001-12-04 Robert R. Whittle Dry blend pharmaceutical unit dosage form
US6316020B1 (en) 1999-08-26 2001-11-13 Robert R. Whittle Pharmaceutical formulations
US6780880B1 (en) * 1999-08-26 2004-08-24 Robert R. Whittle FT-Raman spectroscopic measurement
US6262086B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Pharmaceutical unit dosage form
US6268385B1 (en) 1999-08-26 2001-07-31 Robert R. Whittle Dry blend pharmaceutical formulations
US6312723B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Pharmaceutical unit dosage form
US6369087B1 (en) 1999-08-26 2002-04-09 Robert R. Whittle Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6262085B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6312712B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Method of improving bioavailability
DK1222922T3 (da) 1999-10-20 2007-12-03 Eisai R&D Man Co Ltd Fremgangsmåde til stabilisering af benzimidazolforbindelser
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
US20040138180A1 (en) * 2002-10-03 2004-07-15 Barr Laboratories, Inc. Bisphosphonate composition and process for the preparation thereof
JP4749660B2 (ja) * 2002-10-16 2011-08-17 武田薬品工業株式会社 安定な固形製剤
EP1552833B1 (de) * 2002-10-16 2016-12-28 Takeda Pharmaceutical Company Limited Herstellung eines amorphen, optisch aktiven Isomers von Lansoprazol
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US7501426B2 (en) 2004-02-18 2009-03-10 Boehringer Ingelheim International Gmbh 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
US8815916B2 (en) 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8906940B2 (en) 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
DE102005035891A1 (de) 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
EP1852108A1 (de) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG Zusammensetzungen von DPP-IV-Inhibitoren
EA030606B1 (ru) 2006-05-04 2018-08-31 Бёрингер Ингельхайм Интернациональ Гмбх Способы приготовления лекарственного средства, содержащего полиморфы
PE20140960A1 (es) 2008-04-03 2014-08-15 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
BRPI0916997A2 (pt) 2008-08-06 2020-12-15 Boehringer Ingelheim International Gmbh Inibidor de dpp-4 e seu uso
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
EP2344195A2 (de) 2008-09-10 2011-07-20 Boehringer Ingelheim International GmbH Kombinationstherapie zur behandlung von diabetes und zugehörigen leiden
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
BRPI0923121A2 (pt) 2008-12-23 2015-08-11 Boehringer Ingelheim Int Formas salinas de compostos orgânico
TW201036975A (en) 2009-01-07 2010-10-16 Boehringer Ingelheim Int Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy
ES2760917T3 (es) 2009-11-27 2020-05-18 Boehringer Ingelheim Int Tratamiento de pacientes diabéticos genotipificados con inhibidores DPP-IV como la linagliptina
JP6034781B2 (ja) 2010-05-05 2016-11-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 併用療法
EA201991014A1 (ru) 2010-06-24 2019-09-30 Бёрингер Ингельхайм Интернациональ Гмбх Лечение диабета
US9034883B2 (en) 2010-11-15 2015-05-19 Boehringer Ingelheim International Gmbh Vasoprotective and cardioprotective antidiabetic therapy
MX366629B (es) 2011-07-15 2019-07-17 Boehringer Ingelheim Int Quinazolinas sustituidas, su preparación y su uso en composiciones farmacéuticas.
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
EP3685839A1 (de) 2012-05-14 2020-07-29 Boehringer Ingelheim International GmbH Linagliptin zur verwendung in der behandlung von albuminuria und nierenbedingten erkrankungen
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
US9526728B2 (en) 2014-02-28 2016-12-27 Boehringer Ingelheim International Gmbh Medical use of a DPP-4 inhibitor
JP2019517542A (ja) 2016-06-10 2019-06-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング リナグリプチンおよびメトホルミンの組合せ

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2161160B (en) * 1984-07-06 1989-05-24 Fisons Plc Heterocyclic sulphinyl compounds
CA1341314C (en) * 1984-07-06 2001-11-06 David Cox Derivatives of benzimidazole, benzothiazole and benzoxazole
AU4640985A (en) * 1984-08-31 1986-03-06 Nippon Chemiphar Co. Ltd. Benzimidazole derivatives
EP0204215B1 (de) * 1985-05-24 1993-08-11 G.D. Searle & Co. 2-[(1H-Benzimidazol-2-ylsulfonyl)methyl]-benzenamine
US4824856A (en) * 1985-08-14 1989-04-25 Nippon Chemiphar Co., Ltd. Method of protecting gastrointestinal tract
FI864138A (fi) * 1985-10-16 1987-04-17 Fisons Plc Heterocykliska blandningar.

Also Published As

Publication number Publication date
AR246515A1 (es) 1994-08-31
EP0248634A2 (de) 1987-12-09
KR880000405A (ko) 1988-03-25
DE3786606D1 (de) 1993-08-26
ES2058114T3 (es) 1994-11-01
EP0248634A3 (en) 1988-02-24
AU619444B2 (en) 1992-01-30
AU7369987A (en) 1987-12-03
KR950011414B1 (ko) 1995-10-04
US5294439A (en) 1994-03-15
EP0248634B1 (de) 1993-07-21

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee