ES2058114T3 - Derivado de bencimidazol estabilizado y composicion. - Google Patents

Derivado de bencimidazol estabilizado y composicion.

Info

Publication number
ES2058114T3
ES2058114T3 ES87304860T ES87304860T ES2058114T3 ES 2058114 T3 ES2058114 T3 ES 2058114T3 ES 87304860 T ES87304860 T ES 87304860T ES 87304860 T ES87304860 T ES 87304860T ES 2058114 T3 ES2058114 T3 ES 2058114T3
Authority
ES
Spain
Prior art keywords
group
derivative
bencimidazole
stabilized
atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87304860T
Other languages
English (en)
Inventor
Heinojo Yamasaka
Hiroyasu Uchiyama
Hirotaka Masuda
Yoshiomi Sakamoto
Yoshimi Nakamigawa
Mitsuko Yoshioka
Terumasa Moriga
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Chemiphar Co Ltd
Original Assignee
Nippon Chemiphar Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP61128989A external-priority patent/JPH0791274B2/ja
Priority claimed from JP61128988A external-priority patent/JPH0791273B2/ja
Priority claimed from JP16061286A external-priority patent/JPH0791275B2/ja
Application filed by Nippon Chemiphar Co Ltd filed Critical Nippon Chemiphar Co Ltd
Application granted granted Critical
Publication of ES2058114T3 publication Critical patent/ES2058114T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A UN DERIVADO DE BENCIMIDAZOL FISIOLOGICAMENTE ACTIVO DE FORMULA (I) EN LA QUE R1 ES UN ATOMO DE HIDROGENO, UN GRUPO ALQUILO DE 1 A 8 C, UN GRUPO FLUOROALQUILO DE 1 A 6 C, UN GRUPO CICLOALQUILO, UN GRUPO FENILO O UN GRUPO ARALQUILO; R2 ES UN H O UN GRUPO ALQUILO DE CADENA CORTA; O BIEN R1 Y R2 JUNTO CON EL ATOMO DE N ADYACENTE FORMAN UN ANILLO; R3A, R3B, R4A, R4B Y R4C SON INDEPENDIENTEMENTE CADA UNO UN ATOMO DE H O DE UN HALOGENO O UN GRUPO FLUOROALQUILO DE 1 A 6 C, ALQUILO, ALCOXI O ALCOXICARBONILO DE CADENA CORTA O UN GRUPO AMINO. EL DERIVADO DE BENCIMIDAZOL ESTABILIZADO ESTA EN FORMA AMORFA O EN CONTACTO CON UN MATERIAL BASICO.
ES87304860T 1986-06-02 1987-06-02 Derivado de bencimidazol estabilizado y composicion. Expired - Lifetime ES2058114T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP61128989A JPH0791274B2 (ja) 1986-06-02 1986-06-02 ベンズイミダゾール誘導体薬剤組成物
JP61128988A JPH0791273B2 (ja) 1986-06-02 1986-06-02 ベンズイミダゾール誘導体薬剤組成物
JP16061286A JPH0791275B2 (ja) 1986-07-08 1986-07-08 ベンズイミダゾール誘導体薬剤組成物

Publications (1)

Publication Number Publication Date
ES2058114T3 true ES2058114T3 (es) 1994-11-01

Family

ID=27315851

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87304860T Expired - Lifetime ES2058114T3 (es) 1986-06-02 1987-06-02 Derivado de bencimidazol estabilizado y composicion.

Country Status (7)

Country Link
US (1) US5294439A (es)
EP (1) EP0248634B1 (es)
KR (1) KR950011414B1 (es)
AR (1) AR246515A1 (es)
AU (1) AU619444B2 (es)
DE (1) DE3786606T2 (es)
ES (1) ES2058114T3 (es)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2614756B2 (ja) * 1988-08-10 1997-05-28 日本ケミファ株式会社 イミダゾール誘導体およびその製造法ならびにこれを含有する抗潰瘍剤
WO1994002140A1 (en) * 1992-07-17 1994-02-03 Astra Aktiebolag Pharmaceutical composition containing antiulcer agent
JPH0656665A (ja) * 1992-08-03 1994-03-01 Nippon Chemiphar Co Ltd イミダゾール誘導体を含有する胃溶性抗潰瘍剤
TW359614B (en) * 1993-08-31 1999-06-01 Takeda Chemical Industries Ltd Composition containing benzimidazole compounds for rectal administration
US6645988B2 (en) * 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US6699885B2 (en) * 1996-01-04 2004-03-02 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and methods of using same
US6489346B1 (en) 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US20050054682A1 (en) * 1996-01-04 2005-03-10 Phillips Jeffrey O. Pharmaceutical compositions comprising substituted benzimidazoles and methods of using same
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
CN1063971C (zh) * 1997-09-24 2001-04-04 中国兽药监察所 一种动物用冻干活疫苗制造方法
US6262085B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6780880B1 (en) 1999-08-26 2004-08-24 Robert R. Whittle FT-Raman spectroscopic measurement
US6262086B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Pharmaceutical unit dosage form
US6268385B1 (en) 1999-08-26 2001-07-31 Robert R. Whittle Dry blend pharmaceutical formulations
US6369087B1 (en) * 1999-08-26 2002-04-09 Robert R. Whittle Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6312723B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Pharmaceutical unit dosage form
US6326384B1 (en) 1999-08-26 2001-12-04 Robert R. Whittle Dry blend pharmaceutical unit dosage form
US6316020B1 (en) 1999-08-26 2001-11-13 Robert R. Whittle Pharmaceutical formulations
US6312712B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Method of improving bioavailability
RU2259828C2 (ru) 1999-10-20 2005-09-10 Эйсай Ко., Лтд. Способы стабилизации соединений на основе бензимидазола
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
US20040138180A1 (en) * 2002-10-03 2004-07-15 Barr Laboratories, Inc. Bisphosphonate composition and process for the preparation thereof
ES2534713T3 (es) 2002-10-16 2015-04-27 Takeda Pharmaceutical Company Limited Preparaciones sólidas estables
JP4749660B2 (ja) * 2002-10-16 2011-08-17 武田薬品工業株式会社 安定な固形製剤
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US7501426B2 (en) 2004-02-18 2009-03-10 Boehringer Ingelheim International Gmbh 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
US8906940B2 (en) 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8815916B2 (en) 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
DE102005035891A1 (de) 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
NZ619413A (en) 2006-05-04 2015-08-28 Boehringer Ingelheim Int Polymorphs of a dpp-iv enzyme inhibitor
EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
PE20110235A1 (es) 2006-05-04 2011-04-14 Boehringer Ingelheim Int Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
AR071175A1 (es) 2008-04-03 2010-06-02 Boehringer Ingelheim Int Composicion farmaceutica que comprende un inhibidor de la dipeptidil-peptidasa-4 (dpp4) y un farmaco acompanante
BRPI0916997A2 (pt) 2008-08-06 2020-12-15 Boehringer Ingelheim International Gmbh Inibidor de dpp-4 e seu uso
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
BRPI0919288A2 (pt) 2008-09-10 2015-12-15 Boehring Ingelheim Internat Gmbh teriapia de combinação para tratamento de diabetes e condições relacionadas.
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
CN102256976A (zh) 2008-12-23 2011-11-23 贝林格尔.英格海姆国际有限公司 有机化合物的盐形式
AR074990A1 (es) 2009-01-07 2011-03-02 Boehringer Ingelheim Int Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina
KR20210033559A (ko) 2009-11-27 2021-03-26 베링거 인겔하임 인터내셔날 게엠베하 리나글립틴과 같은 ｄｐｐ－ｉｖ 억제제를 사용한 유전자형 검사된 당뇨병 환자의 치료
CN102946875A (zh) 2010-05-05 2013-02-27 贝林格尔.英格海姆国际有限公司 组合疗法
EP3124041A1 (en) 2010-06-24 2017-02-01 Boehringer Ingelheim International GmbH Diabetes therapy
AR083878A1 (es) 2010-11-15 2013-03-27 Boehringer Ingelheim Int Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento
AU2012285904C1 (en) 2011-07-15 2017-08-31 Boehringer Ingelheim International Gmbh Substituted quinazolines, the preparation thereof and the use thereof in pharmaceutical compositions
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
EP2849755A1 (en) 2012-05-14 2015-03-25 Boehringer Ingelheim International GmbH A xanthine derivative as dpp -4 inhibitor for use in the treatment of podocytes related disorders and/or nephrotic syndrome
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
US9526728B2 (en) 2014-02-28 2016-12-27 Boehringer Ingelheim International Gmbh Medical use of a DPP-4 inhibitor
WO2017211979A1 (en) 2016-06-10 2017-12-14 Boehringer Ingelheim International Gmbh Combinations of linagliptin and metformin

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2161160B (en) * 1984-07-06 1989-05-24 Fisons Plc Heterocyclic sulphinyl compounds
CA1341314C (en) * 1984-07-06 2001-11-06 David Cox Derivatives of benzimidazole, benzothiazole and benzoxazole
AU4640985A (en) * 1984-08-31 1986-03-06 Nippon Chemiphar Co. Ltd. Benzimidazole derivatives
AU5768886A (en) * 1985-05-24 1986-11-27 G.D. Searle & Co. 2-((1-h-benzimidazol-2-ylsulfinyl)methyl)benzenamines
US4824856A (en) * 1985-08-14 1989-04-25 Nippon Chemiphar Co., Ltd. Method of protecting gastrointestinal tract
US4851419A (en) * 1985-10-16 1989-07-25 Fisons Plc Certain 2-pyridinyl-phenylsulfinyl-benzoxazoles, the corresponding benzothiazoles or benzimidazoles having anti-inflammatory or gastric acid secretion inhibition activity

Also Published As

Publication number Publication date
EP0248634A3 (en) 1988-02-24
DE3786606D1 (de) 1993-08-26
US5294439A (en) 1994-03-15
KR880000405A (ko) 1988-03-25
EP0248634B1 (en) 1993-07-21
AR246515A1 (es) 1994-08-31
EP0248634A2 (en) 1987-12-09
KR950011414B1 (ko) 1995-10-04
AU7369987A (en) 1987-12-03
DE3786606T2 (de) 1994-03-17
AU619444B2 (en) 1992-01-30

Similar Documents

Publication Publication Date Title
ES2058114T3 (es) Derivado de bencimidazol estabilizado y composicion.
DE69127463D1 (de) Schuhwerk
PT1088823E (pt) Material acrilico
AR240794A2 (es) Derivados de 2-(2'-nitrobenzoil)-1,3-ciclohexanodiona composicion herbicida que los comprende y procedimiento para prepararlos.
DK2143420T3 (da) Formulering, der omfatter mutant(er) af lysosomal alfa-galactosidase A, til behandling af Fabrys sygdom
ES2053738T3 (es) Sulfonamidas aromaticas sustituidas como agentes antiglaucoma.
GB1509367A (en) Ginglymus joint implant
ES2054725T3 (es) Heteroaromatos anulares de cinco miembros de p-fenoxi-fenoximetilo.
IL81356A (en) Stable emissions of highly fluorinated organic compounds
ES2123287T3 (es) Derivados 3-benzoil benzofuranicos como antagonistas de la hormona tiroidea.
JPS57188513A (en) Cysteine release system
ES2028857T3 (es) Procedimiento para la preparacion de derivados de amino-tiazol y amino-oxazol.
ES2055115T3 (es) Derivados de fenil-amidina y fenil-guanidina sustituidos en posicion orto y agentes antidiabeticos y hipoglicemicos que los contienen.
AR017885A1 (es) Derivados de 3-(benzazol-4-il)pirimidindiona, herbicidas preparados con dichos derivados, procedimiento para controlar el crecimiento de plantasindeseables, mediante la aplicacion de dichos herbicidas y compuestos intermediarios utilizables en la preparacion de dichos derivados.
PT90504A (pt) Processo para a preparacao de alcoois peptidicos com actividade anticoagulante
DK162839C (da) N,3-diacyl-2-oxindol-1-carboxamid-forbindelser og 3-acyl-2-oxindol-forbindelser til anvendelse som mellemprodukter ved deres fremstilling
SE9701681D0 (sv) New compounds
GT199900120A (es) Formulaciones que contienen tensoactivo de acido sulfonico aromatico neutralizado con amina alcoxilada.
DK207086D0 (da) Anvendelse af dopaminagonister
PT1140200E (pt) Medicamentos anticancerosos a base de antraquinona
DK360789D0 (da) Plasmider til fremstilling af alfa-amylase i bacillus
MX9102192A (es) Mejoras en compuestos de piperazinoalquilbenzoxazina y piperazinoalquilbenzotiazin sustituidos con un heterociclo, asi como procedimiento para su preparacion.
FR2592049B1 (fr) Nouveaux analogues de composes polypeptidiques hypocalcemiants epargnant le calcium de l'organisme, leur preparation et les medicaments contenant ces principes actifs
DK265385A (da) Formstofslidliste til understaetning af transportkaeder, navnlig kaeder med formstofkaedeled
DK0878195T3 (da) Anvendelse af en 2-aroyl-3-arylbenzo(b)thiophenforbindelse til reduktion af fibrinogenniveauerne

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 248634

Country of ref document: ES