DE3785994T2 - Antikörper gegen Interleukin-1. - Google Patents

Antikörper gegen Interleukin-1.

Info

Publication number
DE3785994T2
DE3785994T2 DE87116724T DE3785994T DE3785994T2 DE 3785994 T2 DE3785994 T2 DE 3785994T2 DE 87116724 T DE87116724 T DE 87116724T DE 3785994 T DE3785994 T DE 3785994T DE 3785994 T2 DE3785994 T2 DE 3785994T2
Authority
DE
Germany
Prior art keywords
antibodies against
against interleukin
interleukin
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE87116724T
Other languages
English (en)
Other versions
DE3785994D1 (de
Inventor
Yasukazu - Ohmoto
Kenji - Nagamura
Hisakazu Aoki
Yoshikatsu - Hirai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of DE3785994D1 publication Critical patent/DE3785994D1/de
Application granted granted Critical
Publication of DE3785994T2 publication Critical patent/DE3785994T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/245—IL-1
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE87116724T 1986-11-13 1987-11-12 Antikörper gegen Interleukin-1. Expired - Fee Related DE3785994T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP27099286 1986-11-13

Publications (2)

Publication Number Publication Date
DE3785994D1 DE3785994D1 (de) 1993-07-01
DE3785994T2 true DE3785994T2 (de) 1993-11-11

Family

ID=17493888

Family Applications (1)

Application Number Title Priority Date Filing Date
DE87116724T Expired - Fee Related DE3785994T2 (de) 1986-11-13 1987-11-12 Antikörper gegen Interleukin-1.

Country Status (5)

Country Link
EP (1) EP0267611B1 (de)
KR (1) KR900004420B1 (de)
DE (1) DE3785994T2 (de)
DK (1) DK590387A (de)
ES (1) ES2054644T3 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0569687B1 (de) * 1984-05-18 2002-08-21 New England Medical Center Hospitals, Inc. Menschliche IL-1 cDNS-Sequenzen die für biologisch aktive menschliche IL-1-Proteine kodieren
US5998578A (en) * 1984-05-18 1999-12-07 New England Medical Center Hospitals, Inc. Biologically active fragments of IL-1β
JPH0681599B2 (ja) * 1988-10-01 1994-10-19 大塚製薬株式会社 インターロイキン―１βに対する抗体
DE68925935T2 (de) * 1988-10-01 1996-08-14 Otsuka Pharma Co Ltd Antikörper gegen Interleukin-1-beta
FR2640146B1 (fr) * 1988-12-08 1993-12-24 Commissariat A Energie Atomique Anticorps monoclonaux anti-interleukines 1(alpha) et 1(beta), leur procede de production et applications desdits anticorps a la detection des interleukines 1(alpha) et 1(beta) et en therapeutique
DK195089A (da) * 1989-04-20 1990-10-21 Morten Bagge Hansen Regulatoriske proteiner
EP0506855A1 (de) * 1989-12-15 1992-10-07 Chiron Corporation Cytokin-antikörper zur behandlung von sepsis
WO1995001997A1 (en) * 1993-07-09 1995-01-19 Smithkline Beecham Corporation RECOMBINANT AND HUMANIZED IL-1β ANTIBODIES FOR TREATMENT OF IL-1 MEDIATED INFLAMMATORY DISORDERS IN MAN
US5959085A (en) * 1993-11-23 1999-09-28 Schering Corporation Human monoclonal antibodies against human cytokines and methods of making and using such antibodies
EP0659766A1 (de) * 1993-11-23 1995-06-28 Schering-Plough Menschliche Monoklonalantikörper gegen menschliche Cytokine und Verfahren zur Herstellung dieser Antikörper
DE4408890A1 (de) * 1994-03-16 1995-09-21 Knoll Ag Verwendung von Il-1-Antagonisten als Arzneimittel zur Behandlung von Erkrankungen mit einem erhöhten Interleukin-6 Serumspiegel
EP0813423B1 (de) * 1995-01-23 2002-07-03 Xenotech Incorporated Zusammensetzung zur verhinderung von osteolyse und metastasen
AU3116697A (en) * 1996-05-20 1997-12-09 Schering Corporation Human interleukin-1j and antagonists thereof
DE69738948D1 (de) 1996-12-06 2008-10-09 Amgen Inc Il-1-inhibitor in kombinationstherapie zur behandlung il-1-vermittelter krankheiten
US6808902B1 (en) 1999-11-12 2004-10-26 Amgen Inc. Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules
GB0020685D0 (en) 2000-08-22 2000-10-11 Novartis Ag Organic compounds
CN1547486A (zh) 2001-06-26 2004-11-17 抗opgl抗体
EA018072B1 (ru) 2002-09-06 2013-05-30 Амджен Инк. Антитело к рецептору интерлейкина-1 типа 1 (il-1r1) и его применение
JP2006517191A (ja) 2002-12-30 2006-07-20 アムジエン・インコーポレーテツド 共刺激因子を用いた併用療法
CA2590164A1 (en) 2005-01-26 2006-08-03 Amgen Fremont Inc. Antibodies against interleukin-1 beta
SI1899378T1 (sl) 2005-06-21 2010-02-26 Xoma Technology Ltd IL-1Beta vezavna protitelesa in njihovi fragmenti
ATE470151T1 (de) 2005-08-02 2010-06-15 Xbiotech Inc Diagnose, behandlung und prävention von gefässerkrankungen mittels il-1alpha- autoantikörpern
TW200736277A (en) 2005-11-14 2007-10-01 Amgen Inc RANKL antibody-PTH/PTHrP chimeric molecules
EP2094306A2 (de) 2006-12-20 2009-09-02 XOMA Technology Ltd. Behandlung von il-1-beta-bedingten erkrankungen
CA2710252C (en) 2007-12-20 2017-03-28 Xoma Technology Ltd. Methods for the treatment of gout
MY154067A (en) 2008-05-30 2015-04-30 Xbiotech Inc IL-1a ABS AND METHODS OF USE
WO2010028275A1 (en) 2008-09-05 2010-03-11 Xoma Technology Ltd. METHODS FOR TREATING OR PREVENTING IL-1ß RELATED DISEASES
JP5976319B2 (ja) 2008-09-12 2016-08-23 エックスバイオテク，インコーポレイテッドＸｂｉｏｔｅｃｈ，Ｉｎｃ． 病原性単球の標的化
MX337586B (es) 2010-05-07 2016-03-11 Xoma Us Llc Anticuerpos anti-interleucina-1beta para usarse en el tratamiento de condiciones relacionadas con interleucina-1beta.
CN107596365A (zh) 2010-06-18 2018-01-19 埃克斯生物科技公司 关节炎治疗
KR101910760B1 (ko) * 2010-08-23 2018-10-22 엑스바이오테크, 인크. 종양성 질병들에 대한 치료
US9724409B2 (en) 2011-04-01 2017-08-08 Xbiotech, Inc. Treatment of inflammatory skin disease
RU2622021C2 (ru) 2011-09-23 2017-06-08 ИксБиотеч, Инк. Лечение кахексии
EP2794657B1 (de) 2011-12-19 2017-10-11 Xoma (Us) Llc Verfahren zur behandlung von akne
US9545441B2 (en) 2012-09-18 2017-01-17 Xbiotech, Inc. Treatment of diabetes
CA3053231A1 (en) 2017-02-16 2018-08-23 Xbiotech Inc. Treatment of hidradenitis suppurativa
US20210236599A1 (en) 2018-08-13 2021-08-05 Iltoo Pharma Combination of interleukin-2 with an interleukin 1 inhibitor, conjugates and therapeutic uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK172052B1 (da) * 1984-12-21 1997-09-29 Otsuka Pharma Co Ltd Antitumor-aktivt stof, fremgangsmåde til dets fremstilling, lægemiddel indeholdende stoffet, gen kodende for stoffet, vektor indeholdende genet samt rekombinant mikroorganisme transformet med en sådan vektor
DE3587605T2 (de) * 1984-12-25 1994-03-17 Dainippon Pharmaceutical Co Interleukin-1 und dessen Derivat.
JPS6291197A (ja) * 1985-10-17 1987-04-25 Dainippon Pharmaceut Co Ltd 抗ヒトインタ−ロイキン１抗体，その製法及びその使用法

Also Published As

Publication number Publication date
DK590387A (da) 1988-05-14
DK590387D0 (da) 1987-11-11
EP0267611B1 (de) 1993-05-26
EP0267611A3 (en) 1988-09-21
ES2054644T3 (es) 1994-08-16
KR880006357A (ko) 1988-07-22
DE3785994D1 (de) 1993-07-01
EP0267611A2 (de) 1988-05-18
KR900004420B1 (ko) 1990-06-25

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee