DE3780504D1 - Verfahren zur herstellung von pyrimidinderivaten. - Google Patents
Verfahren zur herstellung von pyrimidinderivaten.Info
- Publication number
- DE3780504D1 DE3780504D1 DE8787810260T DE3780504T DE3780504D1 DE 3780504 D1 DE3780504 D1 DE 3780504D1 DE 8787810260 T DE8787810260 T DE 8787810260T DE 3780504 T DE3780504 T DE 3780504T DE 3780504 D1 DE3780504 D1 DE 3780504D1
- Authority
- DE
- Germany
- Prior art keywords
- mercapto
- formula
- image
- fluoroalkoxypyrimidine
- halo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 3
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 3
- 229910052794 bromium Inorganic materials 0.000 abstract 3
- 229910052801 chlorine Inorganic materials 0.000 abstract 3
- 239000000460 chlorine Substances 0.000 abstract 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 2
- VOPWNXZWBYDODV-UHFFFAOYSA-N Chlorodifluoromethane Chemical compound FC(F)Cl VOPWNXZWBYDODV-UHFFFAOYSA-N 0.000 abstract 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 2
- -1 alkali metal nitrite Chemical class 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 239000011737 fluorine Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 229940100389 Sulfonylurea Drugs 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
- 239000002585 base Substances 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/38—One sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/858,636 US4692524A (en) | 1986-05-02 | 1986-05-02 | Process for the preparation of pyrimidine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3780504D1 true DE3780504D1 (de) | 1992-08-27 |
Family
ID=25328782
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8787810260T Expired - Lifetime DE3780504D1 (de) | 1986-05-02 | 1987-04-24 | Verfahren zur herstellung von pyrimidinderivaten. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4692524A (enExample) |
| EP (1) | EP0244359B1 (enExample) |
| JP (1) | JPH0629265B2 (enExample) |
| KR (2) | KR900006837B1 (enExample) |
| AT (1) | ATE78474T1 (enExample) |
| DE (1) | DE3780504D1 (enExample) |
| ES (1) | ES2042600T3 (enExample) |
| GR (1) | GR3005854T3 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4900827A (en) * | 1988-12-22 | 1990-02-13 | Ciba-Geigy Corporation | Process for the preparation of pyrimidine derivatives |
| JPH0662588B2 (ja) * | 1989-01-24 | 1994-08-17 | 川口化学工業株式会社 | ４，６―ビス（ジフルオロメトキシ）―２―メチルチオピリミジンの製造法 |
| DE3914714A1 (de) * | 1989-05-04 | 1990-11-22 | Bayer Ag | Pyrimidinyl (thiono) (thiol)-phosphor(phosphon)saeure(amid)ester |
| CA2076690C (en) * | 1991-08-30 | 2003-01-07 | Jean-Paul Roduit | Process for the production of 2-(methylthio)-disodium barbiturate |
| US5780202A (en) * | 1994-04-08 | 1998-07-14 | Toyo Boseki Kabushiki Kaisha | Antistatic photosensitive multilayered structure and method for producing the same |
| CA2208734C (en) * | 1996-07-24 | 2006-05-30 | Lonza Ag | Process for preparing 4,6-bis(difluoro-methoxy)pyrimidine derivatives |
| CN101456845B (zh) * | 2008-06-24 | 2010-11-03 | 陕西师范大学 | 4,5-二芳基-2-巯基嘧啶类化合物及其合成方法和药物用途 |
| KR101713184B1 (ko) * | 2015-07-20 | 2017-03-22 | 솔로몬 시스테크 리미티드 | 자기 정전용량방식 터치 센서의 쇼트 불량 감지방법 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4480101A (en) * | 1981-07-16 | 1984-10-30 | Ciba-Geigy Corporation | Fluoroalkoxy-aminopyrimidines |
| US4545811A (en) * | 1981-08-06 | 1985-10-08 | Ciba-Geigy Corporation | N-Phenylsulfonyl-N'-triazinyl-ureas |
| US4478635A (en) * | 1982-01-11 | 1984-10-23 | Ciba-Geigy Corporation | N-Arylsulfonyl-N'-pyrimidinylureas |
| MA19680A1 (fr) * | 1982-01-11 | 1983-10-01 | Novartis Ag | N- arylsulfonyl - n' - pyrimidinylurees. |
| BR8302396A (pt) * | 1982-05-12 | 1984-01-10 | Du Pont | Composto;composicao e processo adequados para controlar o crescimento de vegetacao indesejada |
| US4542216A (en) * | 1984-03-27 | 1985-09-17 | Ciba Geigy Corporation | Process for producing fluoroalkoxyaminopyrimidines |
-
1986
- 1986-05-02 US US06/858,636 patent/US4692524A/en not_active Expired - Lifetime
-
1987
- 1987-04-24 ES ES87810260T patent/ES2042600T3/es not_active Expired - Lifetime
- 1987-04-24 DE DE8787810260T patent/DE3780504D1/de not_active Expired - Lifetime
- 1987-04-24 AT AT87810260T patent/ATE78474T1/de not_active IP Right Cessation
- 1987-04-24 EP EP87810260A patent/EP0244359B1/de not_active Expired - Lifetime
- 1987-05-01 JP JP62108748A patent/JPH0629265B2/ja not_active Expired - Lifetime
- 1987-05-02 KR KR1019870004309A patent/KR900006837B1/ko not_active Expired
-
1990
- 1990-06-19 KR KR1019900009271A patent/KR920006782B1/ko not_active Expired
-
1992
- 1992-10-01 GR GR920401480T patent/GR3005854T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0244359A3 (en) | 1987-12-23 |
| US4692524A (en) | 1987-09-08 |
| EP0244359B1 (de) | 1992-07-22 |
| ES2042600T3 (es) | 1993-12-16 |
| KR900006837B1 (ko) | 1990-09-22 |
| EP0244359A2 (de) | 1987-11-04 |
| JPH0629265B2 (ja) | 1994-04-20 |
| KR870011106A (ko) | 1987-12-21 |
| KR920006782B1 (ko) | 1992-08-17 |
| KR920002007A (ko) | 1992-01-30 |
| GR3005854T3 (enExample) | 1993-06-07 |
| ATE78474T1 (de) | 1992-08-15 |
| JPS62281869A (ja) | 1987-12-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA200100457A1 (ru) | Способ получения циталопрама | |
| DE3780504D1 (de) | Verfahren zur herstellung von pyrimidinderivaten. | |
| ZA822582B (en) | Chemical process | |
| ATE243685T1 (de) | Verfahren zur herstellung von 2-chlor-5- chlormethylthiazol | |
| ATE217869T1 (de) | Verfahren zur herstellung von fluoralkenylthio heterozyclische derivate | |
| DK0565558T3 (da) | Fremgangsmåde og mellemprodukter til fremstilling af azabicyclo(2.2.2)octan-3-iminer | |
| IT1172346B (it) | Procedimento per produrre eteri 3-fenossibenzil-2-(4-alcossifenil)-2-metilpropilici | |
| DE3767564D1 (de) | 7-(phenylacetamido)-4-alkylcumarine, verfahren zu ihrer herstellung sowie ihre verwendung in verfahren zur fluorometrischen bestimmung der aktivitaet von hydrolasen, insbesondere von penicillin-g-acylase. | |
| DK0435824T3 (da) | Fremgangsmåde til fremstilling af isothiocyanater | |
| ATE92049T1 (de) | Herbizide sulfonylharnstoffe, verfahren zu ihrer herstellung und ihre verwendung zur beeinflussung des pflanzenwachstums. | |
| DE59309966D1 (de) | Verfahren zur Herstellung von 2-Chlor-5-aminomethylpyridin | |
| DE59206660D1 (de) | Verfahren zur Herstellung von Halogenanthranilsäuren | |
| ATA83990A (de) | Verfahren zur herstellung von n-succinimidylcarbonaten | |
| DK0662475T3 (da) | Fremgangsmåde til fremstilling af 2-perfluoralkyl-3-oxazolin-5-on. | |
| YU147179A (en) | Process for preparing new imidazo (1,2-a) imidazoles | |
| SE8005127L (sv) | Sett att framstella 15-hydroxiimino-e-homoeburnanderivat | |
| TNSN88070A1 (fr) | Procede de preparation de l'acide (pyridyl-3)-3-1h, 3h-pyrrolo (1,2-c) thiazolecarboxylique-7dextrogyre | |
| DE59001648D1 (de) | Verfahren zur herstellung von aliphatischen substituierten fluorbenzolen. | |
| ATE16802T1 (de) | Cyclopropanderivate, verfahren zu ihrer herstellung und ihre verwendung bei der herstellung von dihalovinylcyclopropancarbons|uren. | |
| ATE4198T1 (de) | Fluorierte azomethine, verfahren zu ihrer herstellung und ihre verwendung als zwischenprodukte. | |
| DE59001382D1 (de) | Verfahren zur herstellung von 1-alkylthio- und 1-benzylthio-1-formylcyclopropanen. | |
| Okazaki et al. | “Selenium Polonovski Reaction” Using Benzeneselenenyl Triflate | |
| ATE292T1 (de) | Spiro-derivate von 3-(3,5 -dihalogenphenyl)-oxazolidin-2-thion-4-onen, verfahren zu ihrer herstellung sowie ihre verwendung als fungizide. | |
| ATE8883T1 (de) | Verfahren zur herstellung von nbenzylsubstituierten imiden. | |
| DK0609254T3 (da) | Fremgangsmåde til fremstilling af 2,5-dihydroxyphenyleddikesyre |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: NOVARTIS AG, BASEL, CH |
|
| 8339 | Ceased/non-payment of the annual fee |