DE3751576D1 - Virale Inaktivierung und Reinigung von aktiven Proteinen. - Google Patents

Virale Inaktivierung und Reinigung von aktiven Proteinen.

Info

Publication number
DE3751576D1
DE3751576D1 DE3751576T DE3751576T DE3751576D1 DE 3751576 D1 DE3751576 D1 DE 3751576D1 DE 3751576 T DE3751576 T DE 3751576T DE 3751576 T DE3751576 T DE 3751576T DE 3751576 D1 DE3751576 D1 DE 3751576D1
Authority
DE
Germany
Prior art keywords
purification
active proteins
viral inactivation
inactivation
viral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3751576T
Other languages
English (en)
Other versions
DE3751576T2 (de
Inventor
Robert E Jordan
Jaleh Kilpatrick
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Bayer Corp
Original Assignee
Bayer AG
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25384645&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3751576(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer AG, Bayer Corp filed Critical Bayer AG
Application granted granted Critical
Publication of DE3751576D1 publication Critical patent/DE3751576D1/de
Publication of DE3751576T2 publication Critical patent/DE3751576T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8128—Antithrombin III
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE3751576T 1986-07-11 1987-06-27 Virale Inaktivierung und Reinigung von aktiven Proteinen. Expired - Fee Related DE3751576T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/884,446 US4749783A (en) 1986-07-11 1986-07-11 Viral inactivation and purification of active proteins

Publications (2)

Publication Number Publication Date
DE3751576D1 true DE3751576D1 (de) 1995-12-07
DE3751576T2 DE3751576T2 (de) 1996-04-04

Family

ID=25384645

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3751576T Expired - Fee Related DE3751576T2 (de) 1986-07-11 1987-06-27 Virale Inaktivierung und Reinigung von aktiven Proteinen.

Country Status (6)

Country Link
US (1) US4749783A (de)
EP (1) EP0252392B1 (de)
JP (3) JPH0768275B2 (de)
AU (1) AU589868B2 (de)
CA (1) CA1341269C (de)
DE (1) DE3751576T2 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1341379C (en) 1988-04-28 2002-07-23 Welfide Corporation Purified antithrombin-iii and methods of producing the same
JP2678249B2 (ja) * 1988-06-22 1997-11-17 株式会社ミドリ十字 アンチトロンビン−▲ｉｉｉ▼製剤
JPH03215430A (ja) * 1990-01-19 1991-09-20 Kita Kiyoshi 関節腔抗凝固剤
WO1991001367A1 (en) * 1989-07-20 1991-02-07 Bioeng, Inc. Supercritical fluid disruption of and extraction from microbial cells
FR2679251B1 (fr) * 1991-07-18 1993-11-12 Nord Assoc Essor Transfusion San Procede de preparation d'un concentre de thrombine humaine destine a un usage therapeutique.
US5610285A (en) 1994-08-24 1997-03-11 Bayer Corporation Purification of α-1 proteinase inhibitor using novel chromatographic separation conditions
ES2094701B1 (es) * 1995-07-12 1997-09-01 Grifols Grupo Sa Procedimiento para la produccion de antitrombina iii
US6632648B1 (en) 1996-05-14 2003-10-14 Elan Drug Delivery Limited Methods of terminal sterilization of fibrinogen
AT405739B (de) 1997-09-19 1999-11-25 Immuno Ag Verfahren zur reinigung von antithrombin iii
US6093804A (en) * 1998-09-24 2000-07-25 American National Red Cross Method for purification of alpha-1 proteinase inhibitor
DE19923027C2 (de) * 1999-05-19 2002-09-19 Aventis Behring Gmbh Verfahren zur Inaktivierung von Viren
WO2002048176A1 (en) 2000-12-14 2002-06-20 Bayer Corporation Method of preparing alpha-1 proteinase inhibitor
US7777006B2 (en) 2002-12-31 2010-08-17 Csl Behring L.L.C. Method for purification of alpha-1-antitrypsin
EP1664123B2 (de) * 2003-09-22 2011-11-30 Kamada Ltd. Herstellung eines alpha-1-proteinaseinhibitors im grossmassstab und dessen verwendung
CN102924565A (zh) * 2004-06-07 2013-02-13 厄普弗朗特色谱公司 血浆或者血清蛋白的分离
ES2294976B1 (es) * 2007-11-12 2008-12-16 Grifols, S.A. "procedimiento de obtencion de albumina humana de alta eficacia para su uso en terapia de detoxificacion".
EP3446710A1 (de) 2017-08-25 2019-02-27 Glenmark Pharmaceuticals S.A. Verfahren zur inaktivierung von viralen verunreinigungen
WO2023052556A1 (en) 2021-09-30 2023-04-06 Ichnos Sciences SA Methods of inactivating viral contaminants with a mixture of solvent and detergent

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE392038B (sv) * 1971-09-08 1977-03-14 Kabi Ab Forfarande for isolering av antitrombin ur blod eller blodprodukter
JPS5359018A (en) * 1976-11-10 1978-05-27 Green Cross Corp:The Concentrated xiii-th blood coagulating factor derived from human placentaand its preparation
CH630243A5 (fr) * 1978-05-11 1982-06-15 Nestle Sa Procede de recuperation des proteines du lactoserum.
DE2916711A1 (de) * 1979-04-25 1980-11-06 Behringwerke Ag Blutgerinnungsfaktoren und verfahren zu ihrer herstellung
US4305871A (en) * 1980-09-02 1981-12-15 Edward Shanbrom Method of selectively increasing yield and purity of certain cryoprecipitate proteins by heating
DE3037600C2 (de) * 1980-10-04 1982-07-22 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Faktor zur Stimulation der Proliferationsrate von Leberzellen
JPS5874617A (ja) * 1981-10-28 1983-05-06 Green Cross Corp:The 人由来血液凝固第７因子含有水溶液の加熱処理方法
US4481189A (en) * 1982-04-14 1984-11-06 New York Blood Center Inc. Process for preparing sterilized plasma and plasma derivatives
JPS6048930A (ja) * 1983-08-24 1985-03-16 Nippon Sekijiyuujishiya アンチトロンビン３の精製法
JPS6122022A (ja) * 1983-12-28 1986-01-30 Green Cross Corp:The 血漿蛋白の加熱処理方法
JPS61189228A (ja) * 1985-02-19 1986-08-22 Nippon Sekijiyuujishiya 血液凝固第８因子製剤の製法
US4673733A (en) * 1985-04-11 1987-06-16 Sudhish Chandra Treatment of biological and pharmaceutical products adsorbed on a solid phase with virus and pyrogen inactivating agents
US4656254A (en) * 1985-12-02 1987-04-07 Miles Laboratories, Inc. Method of preparing alpha-1-proteinase inhibitor and antithrombin III
ATE84041T1 (de) * 1987-04-27 1993-01-15 Miles Inc Verfahren zur herstellung von hochgereinigtem alpha-1-proteinase-inhibitor.

Also Published As

Publication number Publication date
JPH0768275B2 (ja) 1995-07-26
CA1341269C (en) 2001-07-10
AU7497587A (en) 1988-01-14
DE3751576T2 (de) 1996-04-04
JPS6323896A (ja) 1988-02-01
EP0252392A2 (de) 1988-01-13
EP0252392A3 (en) 1989-06-07
JPH07116236B2 (ja) 1995-12-13
EP0252392B1 (de) 1995-11-02
US4749783A (en) 1988-06-07
JPH083197A (ja) 1996-01-09
JPH06321994A (ja) 1994-11-22
AU589868B2 (en) 1989-10-19

Similar Documents

Publication Publication Date Title
DE3751576T2 (de) Virale Inaktivierung und Reinigung von aktiven Proteinen.
DE68917729T2 (de) Reinigung und verabreichung von dns-reparatur-enzymen.
NO874357D0 (no) Rensing av pichia-produserte lipofile proteiner.
DE68910713D1 (de) Isolierung, Reinigung, Charakterisierung, Klonierung und Sequenzierung von N-alpha-Acetyltransferase.
DE3783573T2 (de) Komplex von pullulan und polyaethylenglykol.
DE3854738D1 (de) Katheter zur zerstörung von steinen.
DE3785388D1 (de) Antivirale peptide und mittel zur behandlung von herpes.
DE3784459T2 (de) Arithmetische und logische einheit fuer elemente von galois-feldern.
DE3780091D1 (de) Behandlung von pilzinfektionen.
DE69206580T2 (de) Silikontetrahydrazide und Reinigung von DNS.
DE3788691D1 (de) Verhütung von Fusariumkrankheiten und Mikroorganismen dafür.
DE3777861D1 (de) Behandlung von gasen.
DE68912685D1 (de) Reinigung von Glucosaminoglucan abbauenden Enzymen.
DE3770184D1 (de) Behandlung von gasstroemen.
DE3670310D1 (de) Elektrochemische behandlung von ligninen.
DE3680000D1 (de) Stabilisierte aktive formen von vitamin-d3.
DE3670956D1 (de) Behandlung von fluessigkeiten.
DE3885913D1 (de) Aufbereitung von Alkoxysilanen.
DE68923219D1 (de) Behandlung von Abfällen.
DE3685413D1 (de) Insektizide und viren.
IT8719420A0 (it) Purificazione di interleuchina-1umana ricombinante.
ATE74537T1 (de) Behandlung von gebrauchten antimonhalidkatalysatoren.
ATE81454T1 (de) Acyl-carnitin zur behandlung und zur verhuetung von virusinfektionen.
DE3883754D1 (de) Mittel zur prophylaxe und behandlung von viralen infektionskrankheiten.
ATE74334T1 (de) Behandlung von gasen.

Legal Events

Date Code Title Description
8363 Opposition against the patent
8339 Ceased/non-payment of the annual fee