DE3725137A1 - Neue peptide und peptidderivate, deren herstellung und sie enthaltende pharmazeutische zusammensetzungen - Google Patents
Neue peptide und peptidderivate, deren herstellung und sie enthaltende pharmazeutische zusammensetzungenInfo
- Publication number
- DE3725137A1 DE3725137A1 DE19873725137 DE3725137A DE3725137A1 DE 3725137 A1 DE3725137 A1 DE 3725137A1 DE 19873725137 DE19873725137 DE 19873725137 DE 3725137 A DE3725137 A DE 3725137A DE 3725137 A1 DE3725137 A1 DE 3725137A1
- Authority
- DE
- Germany
- Prior art keywords
- phe
- boc
- isobutyl
- homostatin
- tetrafluoro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 210000001913 submandibular gland Anatomy 0.000 description 1
- RQSBRFZHUKLKNO-VIFPVBQESA-N tert-butyl n-[(2s)-4-methyl-1-oxopentan-2-yl]carbamate Chemical compound CC(C)C[C@@H](C=O)NC(=O)OC(C)(C)C RQSBRFZHUKLKNO-VIFPVBQESA-N 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 229960004441 tyrosine Drugs 0.000 description 1
- 229960004295 valine Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB868619182A GB8619182D0 (en) | 1986-08-06 | 1986-08-06 | Peptides & derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3725137A1 true DE3725137A1 (de) | 1988-02-11 |
Family
ID=10602311
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19873725137 Withdrawn DE3725137A1 (de) | 1986-08-06 | 1987-07-29 | Neue peptide und peptidderivate, deren herstellung und sie enthaltende pharmazeutische zusammensetzungen |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPS6348295A (enExample) |
| BE (1) | BE1001618A4 (enExample) |
| CH (1) | CH673655A5 (enExample) |
| DE (1) | DE3725137A1 (enExample) |
| FR (1) | FR2602511A1 (enExample) |
| GB (2) | GB8619182D0 (enExample) |
| IT (1) | IT1211681B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5071837A (en) * | 1990-11-28 | 1991-12-10 | Warner-Lambert Company | Novel renin inhibiting peptides |
| CA2098020C (en) * | 1991-01-02 | 2003-10-21 | Daniel Schirlin | Anti-viral compounds |
| EP0707564B1 (en) * | 1993-07-08 | 2000-09-20 | Merrell Pharmaceuticals Inc. | Difluoro statone analogs |
| DE69418050T2 (de) * | 1993-09-09 | 1999-11-25 | Merrell Pharmaceuticals Inc., Cincinnati | Antivirale analoge von difluorostaton |
| US6114380A (en) * | 1995-12-18 | 2000-09-05 | Merrell Pharmaceuticals Inc. | Difluoro statone analogs |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK356085A (da) * | 1984-08-06 | 1986-02-07 | Upjohn Co | Reninhaemmende peptid eller et farmaceutisk acceptabelt syreadditionssalt deraf |
| ZA86746B (en) * | 1985-02-04 | 1986-09-24 | Merrell Dow Pharma | Novel peptidase inhibitors |
| CH672792A5 (enExample) * | 1985-02-19 | 1989-12-29 | Sandoz Ag | |
| WO1986006379A1 (en) * | 1985-04-19 | 1986-11-06 | The Upjohn Company | Dihalo-statine substituted renin inhibitors |
| HU200473B (en) * | 1985-11-01 | 1990-06-28 | Pfizer | Process for producing polypeptides containing difluorocyclostatine and pharmaceutical compositions comprising same |
| ATE109157T1 (de) * | 1987-07-01 | 1994-08-15 | Pfizer | Fluor enthaltende renin-inhibitoren. |
| JPH10183253A (ja) * | 1996-12-24 | 1998-07-14 | Nisshin Steel Co Ltd | 表面性状及び加工性に優れた冷延鋼板又は溶融めっき鋼板の製造方法 |
-
1986
- 1986-08-06 GB GB868619182A patent/GB8619182D0/en active Pending
-
1987
- 1987-07-27 BE BE8700830A patent/BE1001618A4/fr not_active IP Right Cessation
- 1987-07-27 FR FR8710662A patent/FR2602511A1/fr not_active Withdrawn
- 1987-07-28 IT IT8748235A patent/IT1211681B/it active
- 1987-07-29 DE DE19873725137 patent/DE3725137A1/de not_active Withdrawn
- 1987-07-31 CH CH2936/87A patent/CH673655A5/de not_active IP Right Cessation
- 1987-08-03 GB GB8718325A patent/GB2196958B/en not_active Expired - Lifetime
- 1987-08-05 JP JP62196151A patent/JPS6348295A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| GB8718325D0 (en) | 1987-09-09 |
| IT8748235A0 (it) | 1987-07-28 |
| JPS6348295A (ja) | 1988-02-29 |
| BE1001618A4 (fr) | 1989-12-19 |
| GB8619182D0 (en) | 1986-09-17 |
| GB2196958B (en) | 1990-07-04 |
| GB2196958A (en) | 1988-05-11 |
| FR2602511A1 (fr) | 1988-02-12 |
| CH673655A5 (enExample) | 1990-03-30 |
| IT1211681B (it) | 1989-11-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8139 | Disposal/non-payment of the annual fee |