DE3722806A1 - 7-(1h-pyrrol-3-yl)-substituierte 3,5-dihydroxy-hept-6-ensaeuren, 7-(1h-pyrrol-3-yl)-substituierte 3,5-dihydroxy-heptansaeuren, ihre entsprechenden (delta)-lactone und salze, verfahren zu ihrer herstellung ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte - Google Patents

7-(1h-pyrrol-3-yl)-substituierte 3,5-dihydroxy-hept-6-ensaeuren, 7-(1h-pyrrol-3-yl)-substituierte 3,5-dihydroxy-heptansaeuren, ihre entsprechenden (delta)-lactone und salze, verfahren zu ihrer herstellung ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte

Info

Publication number
DE3722806A1
DE3722806A1 DE19873722806 DE3722806A DE3722806A1 DE 3722806 A1 DE3722806 A1 DE 3722806A1 DE 19873722806 DE19873722806 DE 19873722806 DE 3722806 A DE3722806 A DE 3722806A DE 3722806 A1 DE3722806 A1 DE 3722806A1
Authority
DE
Germany
Prior art keywords
formula
compound
phenyl
group
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19873722806
Other languages
German (de)
English (en)
Inventor
Heiner Dr Jendralla
Gerhard Dr Beck
Ekkehard Dr Baader
Bela Von Dr Kerekjarto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Priority to DE19873722806 priority Critical patent/DE3722806A1/de
Priority to ES88110533T priority patent/ES2043736T3/es
Priority to AT88110533T priority patent/ATE85324T1/de
Priority to EP88110533A priority patent/EP0300249B1/de
Priority to DE8888110533T priority patent/DE3878067D1/de
Priority to FI883247A priority patent/FI883247A/fi
Priority to PT87927A priority patent/PT87927B/pt
Priority to ZA884918A priority patent/ZA884918B/xx
Priority to US07/216,423 priority patent/US5055484A/en
Priority to AU18880/88A priority patent/AU1888088A/en
Priority to JP63169159A priority patent/JPS6434959A/ja
Priority to DK384288A priority patent/DK384288A/da
Priority to NZ225342A priority patent/NZ225342A/en
Priority to NO88883072A priority patent/NO883072L/no
Priority to HU883600A priority patent/HU208672B/hu
Priority to IL87036A priority patent/IL87036A0/xx
Priority to IE209788A priority patent/IE63205B1/en
Priority to PH37199A priority patent/PH26375A/en
Priority to KR1019880008546A priority patent/KR890002135A/ko
Publication of DE3722806A1 publication Critical patent/DE3722806A1/de
Priority to GR930400426T priority patent/GR3007611T3/el
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE19873722806 1987-07-10 1987-07-10 7-(1h-pyrrol-3-yl)-substituierte 3,5-dihydroxy-hept-6-ensaeuren, 7-(1h-pyrrol-3-yl)-substituierte 3,5-dihydroxy-heptansaeuren, ihre entsprechenden (delta)-lactone und salze, verfahren zu ihrer herstellung ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte Withdrawn DE3722806A1 (de)

Priority Applications (20)

Application Number Priority Date Filing Date Title
DE19873722806 DE3722806A1 (de) 1987-07-10 1987-07-10 7-(1h-pyrrol-3-yl)-substituierte 3,5-dihydroxy-hept-6-ensaeuren, 7-(1h-pyrrol-3-yl)-substituierte 3,5-dihydroxy-heptansaeuren, ihre entsprechenden (delta)-lactone und salze, verfahren zu ihrer herstellung ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte
ES88110533T ES2043736T3 (es) 1987-07-10 1988-07-01 Acidos 3,5-dihidroxi-heptanoicos sustituidos con (1h-pirrol-3-ilo) en posicion 7, sus correspondientes delta-lactonas y sales, procedimientos para su preparacion, su utilizacion como medicamentos, preparados farmaceuticos y productos intermedios.
AT88110533T ATE85324T1 (de) 1987-07-10 1988-07-01 7-(1h-pyrrol-3-yl>-substituierte 3,5-dihydroxyheptans|uren, ihre entsprechenden delta-lactone und salze, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte.
EP88110533A EP0300249B1 (de) 1987-07-10 1988-07-01 7-[1H-Pyrrol-3-yl]-substituierte 3,5-Dihydroxy-heptansäuren, ihre entsprechenden delta-Lactone und Salze, Verfahren zu ihrer Herstellung, ihre Verwendung als Arzneimittel, pharmazeutische Präparate und Zwischenprodukte
DE8888110533T DE3878067D1 (de) 1987-07-10 1988-07-01 7-(1h-pyrrol-3-yl)-substituierte 3,5-dihydroxy-heptansaeuren, ihre entsprechenden delta-lactone und salze, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte.
FI883247A FI883247A (fi) 1987-07-10 1988-07-07 7-/1h-pyrrool-3-yl/-substituerade 3,5-dihydroxihept-6-ensyror, 7-/1h-pyrrol-3-yl/-susbtituerade 3,5 -dihydroxiheptansyror, motsvarande -laktoner och salter av dem, foerfarande foer framstaellning av dessa, deras anvaendning som laekemedel, farmaceutiska preparat och mellanprodukter.
PT87927A PT87927B (pt) 1987-07-10 1988-07-07 Processo para a preparacao de acidos 3,5-dihidroxi-hepta-6-enoicos substituidos por 7-(1h-pirrol-3-ilo), das suas correspondentes delta-lactonas e sais, e de composicoes farmaceuticas que os contem
AU18880/88A AU1888088A (en) 1987-07-10 1988-07-08 7-(1h-pyrrol-3-yl)-substituted 3,5-dihydroxyhept-6-enoic acids, 7-(1h-pyrrol-3-yl)-substituted 3,5-dihydroxyhept-aloic acids, their corresponding delta-lactones and salts, processes for their preparation, their use as medicaments, pfharmaceutical products and int
HU883600A HU208672B (en) 1987-07-10 1988-07-08 Process for producing 7-(1h-pyrrol-3-yl)-substituted 3,5-dihydroxy-hepten acides and 3,5-dihydroxy-heptan acides and pharmaceutical preparations having these compounds as effective substance
ZA884918A ZA884918B (en) 1987-07-10 1988-07-08 7-(1h-pyrrol-3-)-substituted-3,5-dihydroxyhept-6-enoic acids,7-(1h-pyrrol-3-yl)-substituted 3,5-dihydroxyheptanoic acids,their corresponding gamma-lactones and salts,processes for their preparation,their use as medicaments,pharmaceutical products and intermediates
JP63169159A JPS6434959A (en) 1987-07-10 1988-07-08 3,5-dihydroxyhepta acid derivatives, corresponding lactone and salt and manufacture
DK384288A DK384288A (da) 1987-07-10 1988-07-08 7-(1h-pyrrol-3-yl)-substituerede 3,5-dihydroxy-hept-6-en- og -heptansyrer, delta-lactoner og salte deraf, fremgangsmaader og mellemprodukter til deres fremstilling samt deres anvendelse som laegemidler
NZ225342A NZ225342A (en) 1987-07-10 1988-07-08 7-(1h-pyrrol-3-yl)-substituted 3,5-dihydroxyhept-6-enoic or 3,5-dihydroxyheptanoic acid derivatives, their corresponding delta-lactones, pharmaceutical compositions thereof and intermediate compounds
NO88883072A NO883072L (no) 1987-07-10 1988-07-08 Fremgangsmaate til fremstilling av 7-(1h-pyrrol-3-yl)-substituerte 3,5-dihydroksy-hept-6-ensyrer, 7-(1h-pyrrol-3-yl)-substituerte 3,5-dihydroksy-heptansyrer, samt deres mellomprodukter.
US07/216,423 US5055484A (en) 1987-07-10 1988-07-08 7(1h-pyrrol-3-yl)-substituted 3,5-dihydroxyhept-6-enoic acids, 7-(1h-pyrrol-3-yl)-substituted 3,5-dihyroxyhept-anoic acids, their corresponding delta-lactones and salts, their use as medicaments and pharmaceutical products and intermediates
IL87036A IL87036A0 (en) 1987-07-10 1988-07-08 7-(1h-pyrrol-3-yl)-substituted 3,5-dihydroxyhept-6-enoic acids,7-(1h-pyrrol-3-yl)substituted 3,5-dihydroxyheptanoic acids,their corresponding delta-lactones and salts,processes for their preparation and pharmaceutical compositions
IE209788A IE63205B1 (en) 1987-07-10 1988-07-08 7-(1h-pyrrol-3-yl)-substituted 3,5-dihydroxyheptanoic acids, their corresponding Delta-lactones and salts, processes for their preparation, their use as medicaments, pharmaceutical products and intermediates
PH37199A PH26375A (en) 1987-07-10 1988-07-08 7-[1H-pyrrol-3-yl]-substituted 3,5-dihydroxyhept-6-enoic acids-7-[1H-pyrrol-3-YL]-substituted 3,5-dihydroxyheptanoic acids and their pharmaceutical preparation thereof
KR1019880008546A KR890002135A (ko) 1987-07-10 1988-07-09 7-[1H-피롤-3-일]치환된 3,5-디하이드록 시헵트-6-에노산, 7-[1H-피롤-3-일]-치환된 3,5-디하이드록시 헵타노산, 상응하는 이의 δ-락톤 및 염, 이의 제조방법, 이의 약제로서의 용도, 약제학적 생성물 및 중간체
GR930400426T GR3007611T3 (sv) 1987-07-10 1993-04-09

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873722806 DE3722806A1 (de) 1987-07-10 1987-07-10 7-(1h-pyrrol-3-yl)-substituierte 3,5-dihydroxy-hept-6-ensaeuren, 7-(1h-pyrrol-3-yl)-substituierte 3,5-dihydroxy-heptansaeuren, ihre entsprechenden (delta)-lactone und salze, verfahren zu ihrer herstellung ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte

Publications (1)

Publication Number Publication Date
DE3722806A1 true DE3722806A1 (de) 1989-01-19

Family

ID=6331291

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19873722806 Withdrawn DE3722806A1 (de) 1987-07-10 1987-07-10 7-(1h-pyrrol-3-yl)-substituierte 3,5-dihydroxy-hept-6-ensaeuren, 7-(1h-pyrrol-3-yl)-substituierte 3,5-dihydroxy-heptansaeuren, ihre entsprechenden (delta)-lactone und salze, verfahren zu ihrer herstellung ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte
DE8888110533T Expired - Fee Related DE3878067D1 (de) 1987-07-10 1988-07-01 7-(1h-pyrrol-3-yl)-substituierte 3,5-dihydroxy-heptansaeuren, ihre entsprechenden delta-lactone und salze, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE8888110533T Expired - Fee Related DE3878067D1 (de) 1987-07-10 1988-07-01 7-(1h-pyrrol-3-yl)-substituierte 3,5-dihydroxy-heptansaeuren, ihre entsprechenden delta-lactone und salze, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte.

Country Status (19)

Country Link
US (1) US5055484A (sv)
EP (1) EP0300249B1 (sv)
JP (1) JPS6434959A (sv)
KR (1) KR890002135A (sv)
AT (1) ATE85324T1 (sv)
AU (1) AU1888088A (sv)
DE (2) DE3722806A1 (sv)
DK (1) DK384288A (sv)
ES (1) ES2043736T3 (sv)
FI (1) FI883247A (sv)
GR (1) GR3007611T3 (sv)
HU (1) HU208672B (sv)
IE (1) IE63205B1 (sv)
IL (1) IL87036A0 (sv)
NO (1) NO883072L (sv)
NZ (1) NZ225342A (sv)
PH (1) PH26375A (sv)
PT (1) PT87927B (sv)
ZA (1) ZA884918B (sv)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0354418A2 (de) * 1988-08-06 1990-02-14 Hoechst Aktiengesellschaft 6-Fluor-3,5-dihydroxycarbonsäuren und deren Derivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Arzneimittel, pharmazeutische Präparate und Zwischenprodukte

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI94339C (sv) 1989-07-21 1995-08-25 Warner Lambert Co Förfarande för framställning av farmaceutiskt användbar /R-(R*,R*)/-2-(4-fluorfenyl)- , -dihydroxi-5-(1-metyletyl)-3-fenyl-4-/(fenylamino)karbonyl/-1H-pyrrol-1-heptansyra och farmaceutiskt användbara salter därav
IT1237793B (it) * 1989-12-21 1993-06-17 Zambon Spa Composti attivi come inibitori dell'enzima hmg-coa reduttasi
US5128366A (en) * 1990-07-05 1992-07-07 Shinogi & Co., Ltd. Pyrrole derivatives
DE4243279A1 (de) * 1992-12-21 1994-06-23 Bayer Ag Substituierte Triole
US7250444B2 (en) * 2003-08-11 2007-07-31 Pfizer Inc. Pyrrole-based HMG-CoA reductase inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3928380A (en) * 1973-03-29 1975-12-23 Sterling Drug Inc 1,1{40 -Spirobis(cyclopenta-{8 4,5-c{9 pyrroles)
US4647576A (en) * 1984-09-24 1987-03-03 Warner-Lambert Company Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis
US4851427A (en) * 1985-10-25 1989-07-25 Sandoz Pharm. Corp. Pyrrole analogs of mevalonolactone, derivatives thereof and pharmaceutical use
KR900001212B1 (ko) * 1985-10-25 1990-02-28 산도즈 파마슈티칼스 코오포레이숀 메바로노락톤 및 그것의 유도체의 헤테로사이클릭 유사체 및 그것의 생산방법 및 약학적인 그것의 용도
US4681893A (en) * 1986-05-30 1987-07-21 Warner-Lambert Company Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
NO881411L (no) * 1987-04-14 1988-10-17 Bayer Ag Substituerte pyrroler.

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0354418A2 (de) * 1988-08-06 1990-02-14 Hoechst Aktiengesellschaft 6-Fluor-3,5-dihydroxycarbonsäuren und deren Derivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Arzneimittel, pharmazeutische Präparate und Zwischenprodukte
EP0354418A3 (de) * 1988-08-06 1991-07-31 Hoechst Aktiengesellschaft 6-Fluor-3,5-dihydroxycarbonsäuren und deren Derivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Arzneimittel, pharmazeutische Präparate und Zwischenprodukte

Also Published As

Publication number Publication date
DK384288A (da) 1989-01-11
NO883072D0 (no) 1988-07-08
DE3878067D1 (de) 1993-03-18
US5055484A (en) 1991-10-08
HU208672B (en) 1993-12-28
DK384288D0 (da) 1988-07-08
NO883072L (no) 1989-01-11
GR3007611T3 (sv) 1993-08-31
FI883247A (fi) 1989-01-11
EP0300249B1 (de) 1993-02-03
HUT48580A (en) 1989-06-28
PT87927A (pt) 1989-06-30
PT87927B (pt) 1995-03-01
ATE85324T1 (de) 1993-02-15
IE882097L (en) 1989-01-10
ES2043736T3 (es) 1994-01-01
EP0300249A1 (de) 1989-01-25
PH26375A (en) 1992-06-01
FI883247A0 (fi) 1988-07-07
KR890002135A (ko) 1989-04-08
IL87036A0 (en) 1988-12-30
IE63205B1 (en) 1995-04-05
ZA884918B (en) 1989-01-18
JPS6434959A (en) 1989-02-06
AU1888088A (en) 1989-01-12
NZ225342A (en) 1991-03-26

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