DE3710937A1 - Chromogene verbindungen, ihre herstellung und verwendung als enzymsubstrate - Google Patents

Chromogene verbindungen, ihre herstellung und verwendung als enzymsubstrate

Info

Publication number
DE3710937A1
DE3710937A1 DE19873710937 DE3710937A DE3710937A1 DE 3710937 A1 DE3710937 A1 DE 3710937A1 DE 19873710937 DE19873710937 DE 19873710937 DE 3710937 A DE3710937 A DE 3710937A DE 3710937 A1 DE3710937 A1 DE 3710937A1
Authority
DE
Germany
Prior art keywords
group
lower alkyl
compounds
general formula
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19873710937
Other languages
German (de)
English (en)
Inventor
Hans Dr Phil Wielinger
Gerd Dr Rer Nat Zimmermann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Priority to DE19873710937 priority Critical patent/DE3710937A1/de
Priority to EP88104715A priority patent/EP0285000B1/de
Priority to DE88104715T priority patent/DE3882560D1/de
Priority to AT88104715T priority patent/ATE92076T1/de
Priority to NO881375A priority patent/NO881375L/no
Priority to DK178588A priority patent/DK178588A/da
Priority to AU13876/88A priority patent/AU587931B2/en
Priority to US07/175,858 priority patent/US5108890A/en
Priority to ZA882315A priority patent/ZA882315B/xx
Priority to JP63078297A priority patent/JPS63275551A/ja
Priority to KR1019880003688A priority patent/KR880012639A/ko
Publication of DE3710937A1 publication Critical patent/DE3710937A1/de
Priority to US07/776,590 priority patent/US5190862A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/18—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE19873710937 1987-04-01 1987-04-01 Chromogene verbindungen, ihre herstellung und verwendung als enzymsubstrate Withdrawn DE3710937A1 (de)

Priority Applications (12)

Application Number Priority Date Filing Date Title
DE19873710937 DE3710937A1 (de) 1987-04-01 1987-04-01 Chromogene verbindungen, ihre herstellung und verwendung als enzymsubstrate
EP88104715A EP0285000B1 (de) 1987-04-01 1988-03-24 Chromogene Verbindungen, ihre Herstellung und Verwendung als Enzymsubstrate
DE88104715T DE3882560D1 (enExample) 1987-04-01 1988-03-24
AT88104715T ATE92076T1 (de) 1987-04-01 1988-03-24 Chromogene verbindungen, ihre herstellung und verwendung als enzymsubstrate.
NO881375A NO881375L (no) 1987-04-01 1988-03-28 Kromogene forbindelser, fremgangsmaate for fremstilling derav samt anvendelse derav som enzymsubstrater.
DK178588A DK178588A (da) 1987-04-01 1988-03-30 Chromogene forbindelser, fremstilling deraf og anvendelse som enzymsubstrater
AU13876/88A AU587931B2 (en) 1987-04-01 1988-03-30 Chromogenic compounds, processes for the preparation thereof and the use thereof as enzyme substrates
US07/175,858 US5108890A (en) 1987-04-01 1988-03-31 Chromogenic compounds, processes for the preparation thereof and use thereof as enzyme substrates
ZA882315A ZA882315B (en) 1987-04-01 1988-03-31 Chromogenic compounds,processes for the preparation thereof and the use thereof as enzyme substrates
JP63078297A JPS63275551A (ja) 1987-04-01 1988-04-01 発色性化合物、その製法、該化合物を製造するための中間生成物、該中間生成物の製法、ペプチド結合を開裂する酵素及び血液凝固因子の測定法並びにペプチド結合を開裂する酵素を測定するための診断剤
KR1019880003688A KR880012639A (ko) 1987-04-01 1988-04-01 색원체화합물, 이들의 제법 및 효소기질로서 이들의 사용방법
US07/776,590 US5190862A (en) 1987-04-01 1991-10-11 Chromogenic compounds and the use thereof as enzyme substrates

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873710937 DE3710937A1 (de) 1987-04-01 1987-04-01 Chromogene verbindungen, ihre herstellung und verwendung als enzymsubstrate

Publications (1)

Publication Number Publication Date
DE3710937A1 true DE3710937A1 (de) 1988-10-13

Family

ID=6324611

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19873710937 Withdrawn DE3710937A1 (de) 1987-04-01 1987-04-01 Chromogene verbindungen, ihre herstellung und verwendung als enzymsubstrate
DE88104715T Expired - Fee Related DE3882560D1 (enExample) 1987-04-01 1988-03-24

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE88104715T Expired - Fee Related DE3882560D1 (enExample) 1987-04-01 1988-03-24

Country Status (10)

Country Link
US (1) US5108890A (enExample)
EP (1) EP0285000B1 (enExample)
JP (1) JPS63275551A (enExample)
KR (1) KR880012639A (enExample)
AT (1) ATE92076T1 (enExample)
AU (1) AU587931B2 (enExample)
DE (2) DE3710937A1 (enExample)
DK (1) DK178588A (enExample)
NO (1) NO881375L (enExample)
ZA (1) ZA882315B (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8901423D0 (en) * 1989-01-23 1989-03-15 Fujisawa Pharmaceutical Co Pyrazolopyridine compound and processes for preparation thereof
FR2646853A1 (fr) * 1989-05-09 1990-11-16 Union Pharma Scient Appl Nouveaux derives polypeptidiques d'aminophenylpyridazinones, leurs procedes de preparation, medicaments les contenant, utiles notamment pour le traitement des maladies cardiovasculaires
US5338723A (en) * 1989-10-13 1994-08-16 Merck & Co., Inc. Fibrinogen receptor antagonists
US5208326A (en) * 1991-11-08 1993-05-04 Miles Inc. 8-hydroxy-2h-dibenz(b,f)azepin-2-one dyes
US6011052A (en) * 1996-04-30 2000-01-04 Warner-Lambert Company Pyrazolone derivatives as MCP-1 antagonists
US20030146113A1 (en) * 2000-02-21 2003-08-07 Volker Unkrig Electrochemical sensor for determining blood clotting, corresponding system for measuring blood clotting and method for determining blood clotting
KR100920297B1 (ko) 2004-10-12 2009-10-08 에프. 호프만-라 로슈 아게 고상 펩티드 합성 방법
DE102005003363A1 (de) * 2005-01-25 2006-07-27 Wella Aktiengesellschaft Verwendung kationischer Azacyanin-Farbstoffe zur Färbung von Keratinfasern
DE102005003362A1 (de) 2005-01-25 2006-07-27 Wella Aktiengesellschaft Kationische Azacyanin-Farbstoffe enthaltende Färbemittel
AU2006284751A1 (en) * 2005-09-01 2007-03-08 Array Biopharma Inc. Raf inhibitor compounds and methods of use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH622286A5 (enExample) * 1975-06-23 1981-03-31 Pentapharm Ag
SE407571B (sv) * 1975-07-11 1979-04-02 Kabi Ab Nya kromogena enzymsubstrat for serinproteaser
DE2936543A1 (de) * 1979-09-10 1981-04-09 Behringwerke Ag, 3550 Marburg Chromogene verbindungen
DE3244030A1 (de) * 1982-11-27 1984-05-30 Behringwerke Ag, 3550 Marburg Chromogene verbindungen, verfahren zu ihrer herstellung und ihre verwendung
DE3629175A1 (de) * 1986-08-28 1988-03-17 Behringwerke Ag Chromogene verbindungen, verfahren zu deren herstellung und ihre verwendung

Also Published As

Publication number Publication date
ZA882315B (en) 1988-09-26
KR880012639A (ko) 1988-11-28
ATE92076T1 (de) 1993-08-15
AU1387688A (en) 1988-10-06
JPS63275551A (ja) 1988-11-14
NO881375D0 (no) 1988-03-28
DK178588D0 (da) 1988-03-30
EP0285000A3 (en) 1990-08-29
DK178588A (da) 1988-10-02
EP0285000B1 (de) 1993-07-28
US5108890A (en) 1992-04-28
DE3882560D1 (enExample) 1993-09-02
AU587931B2 (en) 1989-08-31
EP0285000A2 (de) 1988-10-05
JPH0544940B2 (enExample) 1993-07-07
NO881375L (no) 1988-10-03

Similar Documents

Publication Publication Date Title
EP0039880B1 (de) Mittel zum Nachweis esterolytischer und/oder proteolytischer Enzyme und dafür als Substrate geeignete Phenoxy-Aminosäure- und Phenoxy-Peptidester, Verfahren zu deren Herstellung sowie deren Verwendung zur Herstellung der erfindungsgemässen Mittel
EP1157029B1 (de) Oligopeptidderivate zur elektrochemischen messung der aktivität von proteasen
EP0110306B1 (de) Chromogene Verbindungen, Verfahren zu ihrer Herstellung und ihre Verwendung
EP0025190B1 (de) Chromogene Verbindungen und ihre Verwendung als Enzymsubstrate
DE3348172C2 (enExample)
EP0157360B1 (de) Chromogene Aminosäure-und Peptidester, Verfahren zu deren Herstellung, Verwendung dieser Verbindungen in Analysenverfahren sowie Mittel zum Nachweis esterolytischer und/oder proteolytischer Enzyme
EP0285000B1 (de) Chromogene Verbindungen, ihre Herstellung und Verwendung als Enzymsubstrate
EP0157362A2 (de) Chromogene Aminosäure- und Peptidester, Verfahren zu deren Herstellung, Verwendung dieser Verbindungen in Analysenverfahren sowie Mittel zum Nachweis esterolytischer und/oder proteolytischer Enzyme
EP0158225B1 (de) Analysenverfahren und Mittel zum Nachweis esterolytischer und/oder proteolytischer Enzyme
DE2921782C2 (enExample)
US5190862A (en) Chromogenic compounds and the use thereof as enzyme substrates
WO1994020468A1 (de) 4-aminopyridine, ihre herstellung und verwendung als antithrombotisches mittel
DE3045430A1 (de) (alpha)-hydroxy-tripeptid-substrate
WO1994027958A1 (de) 4-amidinophenylsulfonamide zur behandlung von thromboembolischen erkrankungen
DE2943580C2 (de) L-Phenylalanyl-sowie N-Benzoyl-L-phenylalanyl-L-valyl-L-arginin-naphthylester, Verfahren zu deren Herstellung und deren Verwendung
EP1551864A1 (de) Substrate für tafi (a)
WO1986001209A2 (en) NEW p-PHENYLENEDIAMINE PEPTIDES AND REACTANCE CONTAINING THEM FOR THE DETERMINATION OF PROTEASES OF THE BLOOD COAGULATION SYSTEM
US3607859A (en) Furylacryloylgly-clycyl-l-leucinamide and relateo peptides and use thereof in spectrophotometric assay for neutral protease
EP0258784B1 (de) Chromogene Verbindungen, Verfahren zu deren Herstellung und ihre Verwendung
DE3415636A1 (de) Verfahren zur selektiven bestimmung der aktivitaet von kathepsin-b und peptidsubstrate
EP0158224A2 (de) Analysenverfahren und Mittel zum Nachweis esterolytischer und/oder proteolytischer Enzyme
EP0157361B1 (de) Analysenverfahren und Mittel zum Nachweis esterolytischer und/oder proteolytischer Enzyme
DE68928304T2 (de) Substrate für die Bestimmung von Enzymaktivität und Zwischenverbindungen für die Synthese dieser Substrate sowie Prozess der Herstellung der Zwischenverbindungen
DE69515361T2 (de) Trifluormethylketonderivate von Peptiden, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
JPS6037997A (ja) 他の蛋白質分解酵素の存在下でカテプシンｂを測定する方法およびそのために有用な化合物

Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
8139 Disposal/non-payment of the annual fee