DE3686041D1 - Herstellung eines vitamin-c-vorlaeufers mittels genetisch modifizierter organismen. - Google Patents

Herstellung eines vitamin-c-vorlaeufers mittels genetisch modifizierter organismen.

Info

Publication number
DE3686041D1
DE3686041D1 DE8686905045T DE3686041T DE3686041D1 DE 3686041 D1 DE3686041 D1 DE 3686041D1 DE 8686905045 T DE8686905045 T DE 8686905045T DE 3686041 T DE3686041 T DE 3686041T DE 3686041 D1 DE3686041 D1 DE 3686041D1
Authority
DE
Germany
Prior art keywords
dkg
klg
expresses
fermentation
precursor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8686905045T
Other languages
English (en)
Other versions
DE3686041T2 (de
Inventor
Kimber Hardy
De Pol Hendrick Van
June Grindley
A Payton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Danisco US Inc
Original Assignee
Biogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858519536A external-priority patent/GB8519536D0/en
Application filed by Biogen Inc filed Critical Biogen Inc
Publication of DE3686041D1 publication Critical patent/DE3686041D1/de
Application granted granted Critical
Publication of DE3686041T2 publication Critical patent/DE3686041T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01274—2,5-Didehydrogluconate reductase (1.1.1.274), i.e. 2,5-diketo-D-gluconic acid reductase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/58—Aldonic, ketoaldonic or saccharic acids
    • C12P7/60—2-Ketogulonic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Vessels, Lead-In Wires, Accessory Apparatuses For Cathode-Ray Tubes (AREA)
  • Investigating Strength Of Materials By Application Of Mechanical Stress (AREA)
  • Joining Of Building Structures In Genera (AREA)
DE8686905045T 1985-08-02 1986-08-01 Herstellung eines vitamin-c-vorlaeufers mittels genetisch modifizierter organismen. Expired - Lifetime DE3686041T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB858519536A GB8519536D0 (en) 1985-08-02 1985-08-02 Vitamin c precursor
US79243285A 1985-10-29 1985-10-29
PCT/US1986/001571 WO1987000863A1 (en) 1985-08-02 1986-08-01 Production of a vitamin c precursor using genetically modified organisms

Publications (2)

Publication Number Publication Date
DE3686041D1 true DE3686041D1 (de) 1992-08-20
DE3686041T2 DE3686041T2 (de) 1993-01-28

Family

ID=26289601

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686905045T Expired - Lifetime DE3686041T2 (de) 1985-08-02 1986-08-01 Herstellung eines vitamin-c-vorlaeufers mittels genetisch modifizierter organismen.

Country Status (7)

Country Link
EP (1) EP0231354B1 (de)
JP (4) JPH0817706B2 (de)
AT (1) ATE78297T1 (de)
AU (1) AU594080B2 (de)
DE (1) DE3686041T2 (de)
DK (1) DK175120B1 (de)
WO (1) WO1987000863A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5008193A (en) * 1984-06-14 1991-04-16 Genentech, Inc. Ascorbic acid intermediates and process enzymes
US5032514A (en) * 1988-08-08 1991-07-16 Genentech, Inc. Metabolic pathway engineering to increase production of ascorbic acid intermediates
US5376544A (en) * 1992-09-08 1994-12-27 Rutgers The State University Of New Jersey Enzymes for the production of 2-keto-L-gulonic acid
US5795761A (en) * 1996-01-11 1998-08-18 Rutgers, The State University Of New Jersey Mutants of 2,5-diketo-D-gluconic acid (2,5-DKG) reductase A
US6916646B1 (en) * 1997-06-23 2005-07-12 Genencor International, Inc. Enterobacteriaceae fermentation strains
US6407046B1 (en) 1998-09-03 2002-06-18 Genencor International, Inc. Mutant EGIII cellulase, DNA encoding such EGIII compositions and methods for obtaining same
US6187732B1 (en) 1998-09-03 2001-02-13 Genencor International, Inc. Mutant EGIII cellulase, DNA encoding such EGIII compositions and methods for obtaining same
US6358715B1 (en) 1998-12-04 2002-03-19 Genencor International, Inc. Production of ascorbic acid
US6576452B1 (en) 2000-10-04 2003-06-10 Genencor International, Inc. 2,5-diketo-L-gluconic acid reductases and methods of use
CN112430560B (zh) * 2019-08-26 2024-01-05 中国科学院分子植物科学卓越创新中心 一种2-酮基-l-古龙酸生产菌株及其构建方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57186496A (en) * 1981-05-11 1982-11-16 Ajinomoto Co Inc Preparation of l-threonine by fermentation
IL72225A (en) * 1983-06-28 1990-08-31 Genentech Inc 2,5-diketogluconic acid reductase,its preparation and use in converting 2,5-diketogluconic acid into 2-keto-l-gluconic acid
JPS60118186A (ja) * 1983-11-17 1985-06-25 Shionogi & Co Ltd ２・５−ジケト−ｄ−グルコン酸リダクタ−ゼ

Also Published As

Publication number Publication date
EP0231354B1 (de) 1992-07-15
DK175120B1 (da) 2004-06-07
ATE78297T1 (de) 1992-08-15
DK169487A (da) 1987-04-02
EP0231354A4 (de) 1988-10-06
AU6221086A (en) 1987-03-05
JP2577876B2 (ja) 1997-02-05
JPH06319564A (ja) 1994-11-22
DK169487D0 (da) 1987-04-02
WO1987000863A1 (en) 1987-02-12
AU594080B2 (en) 1990-03-01
JPH0838185A (ja) 1996-02-13
DE3686041T2 (de) 1993-01-28
JP2526021B2 (ja) 1996-08-21
JP2577877B2 (ja) 1997-02-05
JPH0817706B2 (ja) 1996-02-28
EP0231354A1 (de) 1987-08-12
JPH0838189A (ja) 1996-02-13
JPS63500493A (ja) 1988-02-25

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: GENENCOR INTERNATIONAL, INC., ROCHESTER, N.Y., US

8328 Change in the person/name/address of the agent

Free format text: ULLRICH & NAUMANN, 69115 HEIDELBERG