DE3678498D1 - Cytidine-diphosphocholine salze, besonders geeignet fuer oralen gebrauch. - Google Patents

Cytidine-diphosphocholine salze, besonders geeignet fuer oralen gebrauch.

Info

Publication number
DE3678498D1
DE3678498D1 DE8686108677T DE3678498T DE3678498D1 DE 3678498 D1 DE3678498 D1 DE 3678498D1 DE 8686108677 T DE8686108677 T DE 8686108677T DE 3678498 T DE3678498 T DE 3678498T DE 3678498 D1 DE3678498 D1 DE 3678498D1
Authority
DE
Germany
Prior art keywords
salts
diphosphocholine
cytidine
especially suitable
oral use
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8686108677T
Other languages
German (de)
English (en)
Inventor
Federico Gennari
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioresearch SRL
Original Assignee
Bioresearch SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioresearch SRL filed Critical Bioresearch SRL
Application granted granted Critical
Publication of DE3678498D1 publication Critical patent/DE3678498D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Cosmetics (AREA)
DE8686108677T 1985-07-05 1986-06-25 Cytidine-diphosphocholine salze, besonders geeignet fuer oralen gebrauch. Expired - Fee Related DE3678498D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT21447/85A IT1188178B (it) 1985-07-05 1985-07-05 Sali della citidin-difospocolina particolarmente idonei per uso orale

Publications (1)

Publication Number Publication Date
DE3678498D1 true DE3678498D1 (de) 1991-05-08

Family

ID=11181915

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686108677T Expired - Fee Related DE3678498D1 (de) 1985-07-05 1986-06-25 Cytidine-diphosphocholine salze, besonders geeignet fuer oralen gebrauch.

Country Status (6)

Country Link
US (1) US4789666A (enExample)
EP (1) EP0207436B1 (enExample)
JP (1) JPS6212794A (enExample)
AT (1) ATE62250T1 (enExample)
DE (1) DE3678498D1 (enExample)
IT (1) IT1188178B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990004400A1 (en) * 1988-10-27 1990-05-03 Massachusetts Institute Of Technology PROCESS FOR INCREASING PHOSPHATIDYLCHOLINE $i(IN VIVO)
KR0177841B1 (ko) * 1992-01-30 1999-04-01 나까무라 간노스께 시티딘 디인산 콜린의 제조방법
CA2094217A1 (en) * 1992-04-17 1993-10-18 Yasutaka Igari Transmucosal therapeutic composition
EP1041992A4 (en) * 1997-12-24 2007-05-09 Ferrer Int HYPERHYDRATED CITICOLIN, THE PRODUCTION THEREOF AND ITS USE
US7915233B1 (en) 1998-08-31 2011-03-29 Wellstat Therapeutics Corporation Compositions and methods for treatment of mitochondrial diseases
US6472378B2 (en) * 1998-08-31 2002-10-29 Pro-Neuron, Inc. Compositions and methods for treatment of mitochondrial diseases
US7807654B2 (en) * 1998-08-31 2010-10-05 Wellstat Therapeutics Corporation Compositions and methods for treatment of mitochondrial diseases
MXPA04002099A (es) * 2001-09-05 2004-06-07 Yamasa Corp Composiciones medicinales para neuropatia diabetica.
EA008179B1 (ru) * 2002-07-11 2007-04-27 Ямаса Корпорейшн Цитидин-5'-дифосфохолин для профилактики или лечения токсической (лекарственно-индуцированной) периферической невропатии
CA2566612C (en) * 2004-05-13 2015-06-30 Massachusetts Institute Of Technology Uridine effects on dopamine release
JP2026020428A (ja) * 2024-04-08 2026-02-09 協和発酵バイオ株式会社 シチジンジリン酸コリン配糖体、組成物、シチジン残基含有化合物の配糖体の製造方法、遺伝子組換え微生物、シチジン残基含有化合物の製造方法、及びシチジン残基含有化合物の配糖体の生成の抑制方法
JPWO2025216249A1 (enExample) * 2024-04-08 2025-10-16

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3666748A (en) * 1967-12-18 1972-05-30 Takeda Chemical Industries Ltd Method for production of cytidine (or deoxycytidine)-5{40 -diphosphate choline and intermediates therefor
NL149812B (nl) * 1969-04-24 1976-06-15 Takeda Chemical Industries Ltd Werkwijze ter bereiding van farmaceutische preparaten, alsmede werkwijze ter bereiding van kristallijn cytidine-5'-difosfaat-choline-monohydraat.
JPS5517769B2 (enExample) * 1972-01-10 1980-05-14
JPS6043078B2 (ja) * 1980-10-31 1985-09-26 株式会社興人 シチジンジリン酸コリンの製法
CA1188998A (en) * 1980-11-12 1985-06-18 Stephen R. Ash System and method for controlling and monitoring blood or biologic fluid flow
JPS6043079B2 (ja) * 1980-12-25 1985-09-26 株式会社興人 シチジン二リン酸コリンの製造方法
IT1177373B (it) * 1984-12-06 1987-08-26 Bioresearch Spa Sali della 5'-metiltio-5'-deossiadenosina con acidi solfonici a lunga catena alchilica

Also Published As

Publication number Publication date
JPH0217559B2 (enExample) 1990-04-20
EP0207436A3 (en) 1988-01-27
IT1188178B (it) 1988-01-07
EP0207436A2 (en) 1987-01-07
US4789666A (en) 1988-12-06
ATE62250T1 (de) 1991-04-15
JPS6212794A (ja) 1987-01-21
IT8521447A0 (it) 1985-07-05
EP0207436B1 (en) 1991-04-03

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: BIORESEARCH S.P.A., LISCATE, MAILAND/MILANO, IT

8339 Ceased/non-payment of the annual fee