IT1188178B - Sali della citidin-difospocolina particolarmente idonei per uso orale - Google Patents

Sali della citidin-difospocolina particolarmente idonei per uso orale

Info

Publication number
IT1188178B
IT1188178B IT21447/85A IT2144785A IT1188178B IT 1188178 B IT1188178 B IT 1188178B IT 21447/85 A IT21447/85 A IT 21447/85A IT 2144785 A IT2144785 A IT 2144785A IT 1188178 B IT1188178 B IT 1188178B
Authority
IT
Italy
Prior art keywords
salts
diphospocoline
citidin
particularly suitable
oral use
Prior art date
Application number
IT21447/85A
Other languages
English (en)
Italian (it)
Other versions
IT8521447A0 (it
Inventor
Federico Gennari
Original Assignee
Bioresearch Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioresearch Spa filed Critical Bioresearch Spa
Priority to IT21447/85A priority Critical patent/IT1188178B/it
Publication of IT8521447A0 publication Critical patent/IT8521447A0/it
Priority to DE8686108677T priority patent/DE3678498D1/de
Priority to AT86108677T priority patent/ATE62250T1/de
Priority to EP86108677A priority patent/EP0207436B1/en
Priority to US06/878,697 priority patent/US4789666A/en
Priority to JP61156325A priority patent/JPS6212794A/ja
Application granted granted Critical
Publication of IT1188178B publication Critical patent/IT1188178B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Cosmetics (AREA)
IT21447/85A 1985-07-05 1985-07-05 Sali della citidin-difospocolina particolarmente idonei per uso orale IT1188178B (it)

Priority Applications (6)

Application Number Priority Date Filing Date Title
IT21447/85A IT1188178B (it) 1985-07-05 1985-07-05 Sali della citidin-difospocolina particolarmente idonei per uso orale
DE8686108677T DE3678498D1 (de) 1985-07-05 1986-06-25 Cytidine-diphosphocholine salze, besonders geeignet fuer oralen gebrauch.
AT86108677T ATE62250T1 (de) 1985-07-05 1986-06-25 Cytidine-diphosphocholine salze, besonders geeignet fuer oralen gebrauch.
EP86108677A EP0207436B1 (en) 1985-07-05 1986-06-25 New cytidine-diphosphocholine salts, particularly suitable for oral use
US06/878,697 US4789666A (en) 1985-07-05 1986-06-26 Cytidine-diphosphocholine salts, particularly suitable for oral use
JP61156325A JPS6212794A (ja) 1985-07-05 1986-07-04 特に経口使用に適する新シチジンジホスホコリン塩、その製造方法及びそれからなる治療薬

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT21447/85A IT1188178B (it) 1985-07-05 1985-07-05 Sali della citidin-difospocolina particolarmente idonei per uso orale

Publications (2)

Publication Number Publication Date
IT8521447A0 IT8521447A0 (it) 1985-07-05
IT1188178B true IT1188178B (it) 1988-01-07

Family

ID=11181915

Family Applications (1)

Application Number Title Priority Date Filing Date
IT21447/85A IT1188178B (it) 1985-07-05 1985-07-05 Sali della citidin-difospocolina particolarmente idonei per uso orale

Country Status (6)

Country Link
US (1) US4789666A (enExample)
EP (1) EP0207436B1 (enExample)
JP (1) JPS6212794A (enExample)
AT (1) ATE62250T1 (enExample)
DE (1) DE3678498D1 (enExample)
IT (1) IT1188178B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0408668B1 (en) * 1988-10-27 1994-05-11 Massachusetts Institute Of Technology Process for increasing phosphatidylcholine in vivo
KR0177841B1 (ko) * 1992-01-30 1999-04-01 나까무라 간노스께 시티딘 디인산 콜린의 제조방법
EP0566135A1 (en) * 1992-04-17 1993-10-20 Takeda Chemical Industries, Ltd. Transmucosal composition comprising a peptide and a cytidine derivative
JP4530534B2 (ja) * 1997-12-24 2010-08-25 フエルレル インターナショナル、ソシエダッド アノニマ 超水和シチコリン、プロセスおよび使用
US6472378B2 (en) * 1998-08-31 2002-10-29 Pro-Neuron, Inc. Compositions and methods for treatment of mitochondrial diseases
US7915233B1 (en) 1998-08-31 2011-03-29 Wellstat Therapeutics Corporation Compositions and methods for treatment of mitochondrial diseases
US7807654B2 (en) * 1998-08-31 2010-10-05 Wellstat Therapeutics Corporation Compositions and methods for treatment of mitochondrial diseases
CN1551778A (zh) * 2001-09-05 2004-12-01 ɽ����ʽ���� 用于糖尿病神经病变的药物组合物
CN100358533C (zh) * 2002-07-11 2008-01-02 雅玛山酱油株式会社 用于药物诱导的神经病的药物组合物
CA2566612C (en) * 2004-05-13 2015-06-30 Massachusetts Institute Of Technology Uridine effects on dopamine release
WO2025216249A1 (ja) * 2024-04-08 2025-10-16 協和発酵バイオ株式会社 シチジンジリン酸コリン配糖体、組成物、シチジン残基含有化合物の配糖体の製造方法、遺伝子組換え微生物、シチジン残基含有化合物の製造方法、及びシチジン残基含有化合物の配糖体の生成の抑制方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1189549A (en) * 1967-12-18 1970-04-29 Takeda Chemical Industries Ltd A Method for Production of Cytidine (Deoxycytidine)-5'-Diphosphate Choline and Intermediates therefor
NL149812B (nl) * 1969-04-24 1976-06-15 Takeda Chemical Industries Ltd Werkwijze ter bereiding van farmaceutische preparaten, alsmede werkwijze ter bereiding van kristallijn cytidine-5'-difosfaat-choline-monohydraat.
JPS5517769B2 (enExample) * 1972-01-10 1980-05-14
JPS6043078B2 (ja) * 1980-10-31 1985-09-26 株式会社興人 シチジンジリン酸コリンの製法
CA1188998A (en) * 1980-11-12 1985-06-18 Stephen R. Ash System and method for controlling and monitoring blood or biologic fluid flow
JPS6043079B2 (ja) * 1980-12-25 1985-09-26 株式会社興人 シチジン二リン酸コリンの製造方法
IT1177373B (it) * 1984-12-06 1987-08-26 Bioresearch Spa Sali della 5'-metiltio-5'-deossiadenosina con acidi solfonici a lunga catena alchilica

Also Published As

Publication number Publication date
EP0207436A2 (en) 1987-01-07
US4789666A (en) 1988-12-06
EP0207436A3 (en) 1988-01-27
IT8521447A0 (it) 1985-07-05
JPH0217559B2 (enExample) 1990-04-20
ATE62250T1 (de) 1991-04-15
EP0207436B1 (en) 1991-04-03
JPS6212794A (ja) 1987-01-21
DE3678498D1 (de) 1991-05-08

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