ES8401937A1 - Procedimiento para la preparacion de nuevos derivados de aminoacidos biciclicos. - Google Patents
Procedimiento para la preparacion de nuevos derivados de aminoacidos biciclicos.Info
- Publication number
- ES8401937A1 ES8401937A1 ES521041A ES521041A ES8401937A1 ES 8401937 A1 ES8401937 A1 ES 8401937A1 ES 521041 A ES521041 A ES 521041A ES 521041 A ES521041 A ES 521041A ES 8401937 A1 ES8401937 A1 ES 8401937A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- cycloalka
- pyrrole
- alkyl
- carboxylic acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS DERIVADOS DE AMINOACIDOS BICICLICOS.CONSISTE EN A) HACER REACCIONAR COMPUESTOS DE FORMULA GENERAL (II) CON COMPUESTOS DE FORMULA GENERAL (III), B) HACER REACCIONAR COMPUESTOS DE FORMULA GENERAL (IV) CON COMPUESTOS DE FORMULA GENERAL (V), C) HACER REACCIONAR COMPUESTOS DE FORMULA (IV) CON COMPUESTOS DE FORMULA OHC-CO2R2 Y CON COMPUESTOS DE FORMULA X-CO-CH3, D) HACER REACCIONAR COMPUESTOS DE FORMULA GENERAL (IV) CON COMPUESTOS DE FORMULA GENERAL (VI) PARA LA OBTENCION DE DERIVADOS DE AMINOACIDOS BICICLICOS DE FORMULAGENERAL (I), DONDE LOS ATOMOS DE CARBONO DE CABEZA DE PUENTE ESTAN CONFIGURADOS CIS O TRANS UNO RESPECTO DE OTRO.TIENE APLICACIONES FARMACOLOGICAS POR SU EFECTO HIPOTENSOR SANGUINEO INTENSO Y LARGA PERSISTENCIA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19823211676 DE3211676A1 (de) | 1982-03-30 | 1982-03-30 | Neue derivate von cycloalka (c) pyrrol-carbonsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue cycloalka (c) pyrrol-carbonsaeuren als zwischenstufen und verfahren zu deren herstellung |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8401937A1 true ES8401937A1 (es) | 1984-01-01 |
ES521041A0 ES521041A0 (es) | 1984-01-01 |
Family
ID=6159702
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES521041A Granted ES521041A0 (es) | 1982-03-30 | 1983-03-28 | Procedimiento para la preparacion de nuevos derivados de aminoacidos biciclicos. |
ES521741A Expired ES8402570A1 (es) | 1982-03-30 | 1983-04-22 | Procedimiento para la preparacion de nuevos aminoacidos biciclicos. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES521741A Expired ES8402570A1 (es) | 1982-03-30 | 1983-04-22 | Procedimiento para la preparacion de nuevos aminoacidos biciclicos. |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP0090362A3 (es) |
JP (1) | JPS58177967A (es) |
KR (1) | KR840004069A (es) |
AU (1) | AU560124B2 (es) |
CA (1) | CA1198118A (es) |
DE (1) | DE3211676A1 (es) |
DK (1) | DK144783A (es) |
ES (2) | ES521041A0 (es) |
FI (1) | FI831049L (es) |
GR (1) | GR78157B (es) |
HU (1) | HU193876B (es) |
IL (1) | IL68267A (es) |
NO (2) | NO831168L (es) |
NZ (1) | NZ203719A (es) |
PH (1) | PH19003A (es) |
PT (1) | PT76472B (es) |
ZA (1) | ZA832229B (es) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3226768A1 (de) * | 1981-11-05 | 1983-05-26 | Hoechst Ag, 6230 Frankfurt | Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung |
GR78413B (es) * | 1981-12-29 | 1984-09-27 | Hoechst Ag | |
DE3246503A1 (de) * | 1982-12-16 | 1984-06-20 | Hoechst Ag, 6230 Frankfurt | Derivate der cis, endo-2-azabicyclo-(5.3.0)-decan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung |
US5175306A (en) * | 1983-01-31 | 1992-12-29 | Hoechst Aktiengesellschaft | Process for the resolution of racemates of optically active bicyclic imino-α-carboxylic esters |
DE3303344A1 (de) | 1983-02-02 | 1984-08-02 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von n-alkylierten aminosaeuren und deren estern |
DK156484A (da) * | 1983-03-16 | 1984-09-17 | Usv Pharma Corp | Aminosyrederivater |
FR2546886B2 (fr) * | 1983-06-06 | 1986-05-16 | Adir | Derives d'acides isoindoledicarboxyliques, leur preparation et compositions pharmaceutiques les contenant |
DE3333454A1 (de) * | 1983-09-16 | 1985-04-11 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von n-alkylierten dipeptiden und deren estern |
DE3333455A1 (de) * | 1983-09-16 | 1985-04-11 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung n-alkylierter dipeptide und deren estern |
DE3410732A1 (de) * | 1984-03-23 | 1985-09-26 | Hoechst Ag, 6230 Frankfurt | Methode zur behandlung des glaukoms |
US5684016A (en) * | 1984-04-12 | 1997-11-04 | Hoechst Aktiengesellschaft | Method of treating cardiac insufficiency |
DE3413710A1 (de) * | 1984-04-12 | 1985-10-24 | Hoechst Ag, 6230 Frankfurt | Verfahren zur behandlung der herzinsuffizienz |
EP0190224A1 (en) * | 1984-07-30 | 1986-08-13 | Schering Corporation | PROCESS FOR THE PREPARATION OF CIS, ENDOOCTAHYDROCYCLOPENTA [b] PYRROLE-2-CARBOXYLATE |
DE3431541A1 (de) * | 1984-08-28 | 1986-03-06 | Hoechst Ag, 6230 Frankfurt | Cis,endo-2-azabicycloalkan-3-carbonsaeure-derivate, verfahren zu deren herstellung, deren verwendung sowie zwischenprodukte bei deren herstellung |
US5231080A (en) * | 1985-10-15 | 1993-07-27 | Hoechst Aktiengesellschaft | Method for the treatment of atherosclerosis, thrombosis, and peripheral vessel disease |
US5231084A (en) * | 1986-03-27 | 1993-07-27 | Hoechst Aktiengesellschaft | Compounds having a cognition adjuvant action, agents containing them, and the use thereof for the treatment and prophylaxis of cognitive dysfuncitons |
DE3633496A1 (de) * | 1986-10-02 | 1988-04-14 | Hoechst Ag | Kombination von angiotensin-converting-enzyme-hemmern mit calciumantagonisten sowie deren verwendung in arzneimitteln |
DE3639879A1 (de) * | 1986-11-21 | 1988-06-01 | Hoechst Ag | Verfahren zur herstellung von mono-, bi- und tricyclischen aminosaeuren, zwischenprodukte dieses verfahrens sowie ein verfahren zu deren herstellung |
DE3722007A1 (de) * | 1987-07-03 | 1989-01-12 | Hoechst Ag | Verfahren zur herstellung bicyclischer aminocarbonsaeuren, zwischenprodukte dieses verfahrens und deren verwendung |
JPH0278659A (ja) * | 1988-09-12 | 1990-03-19 | Shionogi & Co Ltd | アザビシクロアルカン類化合物 |
DE3839127A1 (de) * | 1988-11-19 | 1990-05-23 | Hoechst Ag | Pyrrolidon-2-carbonsaeure-derivate mit psychotroper wirkung |
DD284030A5 (de) | 1988-11-24 | 1990-10-31 | Hoechst Ag,De | Verfahren zur herstellung von peptiden mit bradykinin-antagonistischer wirkung |
LT3872B (en) | 1993-12-06 | 1996-04-25 | Hoechst Ag | Novel peptides and pharmaceutical compositions containing them |
FR2746394B1 (fr) | 1996-03-20 | 1998-05-29 | Roussel Uclaf | Nouveaux composes tricycliques, leur procede de preparation, et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant |
EP0796855B1 (de) | 1996-03-20 | 2002-02-06 | Hoechst Aktiengesellschaft | Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten |
PL194025B1 (pl) | 1996-10-18 | 2007-04-30 | Vertex Pharma | Inhibitory proteaz serynowych, a zwłaszcza proteazy wirusa NS3 zapalenia wątroby C, kompozycja farmaceutyczna i zastosowanie inhibitorów proteaz serynowych |
DE19653647A1 (de) | 1996-12-20 | 1998-06-25 | Hoechst Ag | Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung |
DE19741235A1 (de) | 1997-09-18 | 1999-03-25 | Hoechst Marion Roussel De Gmbh | Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
DE19741873A1 (de) * | 1997-09-23 | 1999-03-25 | Hoechst Marion Roussel De Gmbh | Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
DE19751251A1 (de) | 1997-11-19 | 1999-05-20 | Hoechst Marion Roussel De Gmbh | Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate |
DE19821483A1 (de) | 1998-05-14 | 1999-11-18 | Hoechst Marion Roussel De Gmbh | Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
SV2003000617A (es) | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
TWI359147B (en) | 2003-09-05 | 2012-03-01 | Vertex Pharma | Inhibitors of serine proteases, particularly hcv n |
US8399615B2 (en) | 2005-08-19 | 2013-03-19 | Vertex Pharmaceuticals Incorporated | Processes and intermediates |
KR20130038947A (ko) * | 2005-08-19 | 2013-04-18 | 버텍스 파마슈티칼스 인코포레이티드 | 방법 및 중간체 |
AR055395A1 (es) | 2005-08-26 | 2007-08-22 | Vertex Pharma | Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c |
US7964624B1 (en) | 2005-08-26 | 2011-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
CA2643688A1 (en) | 2006-02-27 | 2007-08-30 | Vertex Pharmaceuticals Incorporated | Co-crystals and pharmaceutical compositions comprising the same |
KR20080112303A (ko) | 2006-03-16 | 2008-12-24 | 버텍스 파마슈티칼스 인코포레이티드 | 중수소화 c형 간염 프로테아제 억제제 |
CN101903392A (zh) | 2007-02-27 | 2010-12-01 | 弗特克斯药品有限公司 | 丝氨酸蛋白酶的抑制剂 |
ATE542815T1 (de) | 2007-02-27 | 2012-02-15 | Vertex Pharma | Kokristalle und pharmazeutische zusammensetzungen damit |
CN101835774B (zh) | 2007-08-30 | 2014-09-17 | 弗特克斯药品有限公司 | 共晶体和包含该共晶体的药物组合物 |
CN102816106A (zh) | 2008-06-24 | 2012-12-12 | 默沙东公司 | 用于制备基本上立体异构纯的稠合二环脯氨酸化合物的生物催化方法 |
JP5829529B2 (ja) * | 2011-08-29 | 2015-12-09 | 日本曹達株式会社 | 光学活性4級アンモニウム塩、および光学活性化合物の製造方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL58849A (en) * | 1978-12-11 | 1983-03-31 | Merck & Co Inc | Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them |
FR2487829A2 (fr) * | 1979-12-07 | 1982-02-05 | Science Union & Cie | Nouveaux imino acides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme |
DE19575012I2 (de) * | 1980-10-23 | 2002-01-24 | Schering Corp | Carboxyalkyl-Dipeptide Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
DE3260423D1 (en) * | 1981-02-17 | 1984-08-30 | Warner Lambert Co | Substituted acyl derivatives of octahydro-1h-isoindole-1-carboxylic acids and esters |
ZA826022B (en) * | 1981-08-21 | 1983-08-31 | Univ Miami | Novel complex amido and imido derivatives of carboxyalkyl peptides and thioethers and ethers of peptides |
EP0081094A1 (en) * | 1981-11-12 | 1983-06-15 | Merck & Co. Inc. | Substituted omega-amino-carboxymethyldipeptide antihypertensive agents |
DE3360065D1 (en) * | 1982-03-08 | 1985-03-28 | Schering Corp | Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them |
-
1982
- 1982-03-30 DE DE19823211676 patent/DE3211676A1/de not_active Withdrawn
-
1983
- 1983-03-24 EP EP83102961A patent/EP0090362A3/de not_active Withdrawn
- 1983-03-28 KR KR1019830001244A patent/KR840004069A/ko not_active Application Discontinuation
- 1983-03-28 FI FI831049A patent/FI831049L/fi not_active Application Discontinuation
- 1983-03-28 NZ NZ203719A patent/NZ203719A/en unknown
- 1983-03-28 GR GR70912A patent/GR78157B/el unknown
- 1983-03-28 ES ES521041A patent/ES521041A0/es active Granted
- 1983-03-29 CA CA000424770A patent/CA1198118A/en not_active Expired
- 1983-03-29 DK DK144783A patent/DK144783A/da not_active Application Discontinuation
- 1983-03-29 AU AU12970/83A patent/AU560124B2/en not_active Ceased
- 1983-03-29 PH PH28723A patent/PH19003A/en unknown
- 1983-03-29 JP JP58051780A patent/JPS58177967A/ja active Pending
- 1983-03-29 ZA ZA832229A patent/ZA832229B/xx unknown
- 1983-03-29 HU HU831064A patent/HU193876B/hu unknown
- 1983-03-29 NO NO831168A patent/NO831168L/no unknown
- 1983-03-29 PT PT76472A patent/PT76472B/pt unknown
- 1983-03-30 IL IL68267A patent/IL68267A/xx unknown
- 1983-04-22 ES ES521741A patent/ES8402570A1/es not_active Expired
- 1983-11-25 NO NO834352A patent/NO834352L/no unknown
Also Published As
Publication number | Publication date |
---|---|
NZ203719A (en) | 1986-02-21 |
NO834352L (no) | 1983-10-03 |
PH19003A (en) | 1985-12-03 |
EP0090362A2 (de) | 1983-10-05 |
HU193876B (en) | 1987-12-28 |
PT76472A (de) | 1983-04-01 |
FI831049L (fi) | 1983-10-01 |
DK144783D0 (da) | 1983-03-29 |
DE3211676A1 (de) | 1983-10-06 |
ES521741A0 (es) | 1984-02-01 |
AU1297083A (en) | 1983-10-06 |
KR840004069A (ko) | 1984-10-06 |
IL68267A0 (en) | 1983-06-15 |
ES521041A0 (es) | 1984-01-01 |
JPS58177967A (ja) | 1983-10-18 |
ES8402570A1 (es) | 1984-02-01 |
PT76472B (de) | 1986-01-24 |
DK144783A (da) | 1983-10-01 |
CA1198118A (en) | 1985-12-17 |
IL68267A (en) | 1987-03-31 |
FI831049A0 (fi) | 1983-03-28 |
NO831168L (no) | 1983-10-03 |
EP0090362A3 (de) | 1985-09-18 |
ZA832229B (en) | 1983-12-28 |
AU560124B2 (en) | 1987-04-02 |
GR78157B (es) | 1984-09-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20000601 |