ES521041A0 - Procedimiento para la preparacion de nuevos derivados de aminoacidos biciclicos. - Google Patents
Procedimiento para la preparacion de nuevos derivados de aminoacidos biciclicos.Info
- Publication number
- ES521041A0 ES521041A0 ES521041A ES521041A ES521041A0 ES 521041 A0 ES521041 A0 ES 521041A0 ES 521041 A ES521041 A ES 521041A ES 521041 A ES521041 A ES 521041A ES 521041 A0 ES521041 A0 ES 521041A0
- Authority
- ES
- Spain
- Prior art keywords
- procedure
- preparation
- amino acid
- acid derivatives
- new bicycle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Indole Compounds (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19823211676 DE3211676A1 (de) | 1982-03-30 | 1982-03-30 | Neue derivate von cycloalka (c) pyrrol-carbonsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue cycloalka (c) pyrrol-carbonsaeuren als zwischenstufen und verfahren zu deren herstellung |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8401937A1 ES8401937A1 (es) | 1984-01-01 |
ES521041A0 true ES521041A0 (es) | 1984-01-01 |
Family
ID=6159702
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES521041A Granted ES521041A0 (es) | 1982-03-30 | 1983-03-28 | Procedimiento para la preparacion de nuevos derivados de aminoacidos biciclicos. |
ES521741A Expired ES8402570A1 (es) | 1982-03-30 | 1983-04-22 | Procedimiento para la preparacion de nuevos aminoacidos biciclicos. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES521741A Expired ES8402570A1 (es) | 1982-03-30 | 1983-04-22 | Procedimiento para la preparacion de nuevos aminoacidos biciclicos. |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP0090362A3 (es) |
JP (1) | JPS58177967A (es) |
KR (1) | KR840004069A (es) |
AU (1) | AU560124B2 (es) |
CA (1) | CA1198118A (es) |
DE (1) | DE3211676A1 (es) |
DK (1) | DK144783A (es) |
ES (2) | ES521041A0 (es) |
FI (1) | FI831049L (es) |
GR (1) | GR78157B (es) |
HU (1) | HU193876B (es) |
IL (1) | IL68267A (es) |
NO (2) | NO831168L (es) |
NZ (1) | NZ203719A (es) |
PH (1) | PH19003A (es) |
PT (1) | PT76472B (es) |
ZA (1) | ZA832229B (es) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3226768A1 (de) * | 1981-11-05 | 1983-05-26 | Hoechst Ag, 6230 Frankfurt | Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung |
IE55867B1 (en) * | 1981-12-29 | 1991-02-14 | Hoechst Ag | New derivatives of bicyclic aminoacids,processes for their preparation,agents containing these compounds and their use,and new bicyclic aminoacids as intermediates and processes for their preparation |
DE3246503A1 (de) * | 1982-12-16 | 1984-06-20 | Hoechst Ag, 6230 Frankfurt | Derivate der cis, endo-2-azabicyclo-(5.3.0)-decan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung |
US5175306A (en) * | 1983-01-31 | 1992-12-29 | Hoechst Aktiengesellschaft | Process for the resolution of racemates of optically active bicyclic imino-α-carboxylic esters |
DE3303344A1 (de) | 1983-02-02 | 1984-08-02 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von n-alkylierten aminosaeuren und deren estern |
FI841052A (fi) * | 1983-03-16 | 1984-09-17 | Usv Pharma Corp | Foereningar foer behandling av blodtryckssjukdomar. |
FR2546886B2 (fr) * | 1983-06-06 | 1986-05-16 | Adir | Derives d'acides isoindoledicarboxyliques, leur preparation et compositions pharmaceutiques les contenant |
DE3333455A1 (de) * | 1983-09-16 | 1985-04-11 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung n-alkylierter dipeptide und deren estern |
DE3333454A1 (de) * | 1983-09-16 | 1985-04-11 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von n-alkylierten dipeptiden und deren estern |
DE3410732A1 (de) * | 1984-03-23 | 1985-09-26 | Hoechst Ag, 6230 Frankfurt | Methode zur behandlung des glaukoms |
DE3413710A1 (de) * | 1984-04-12 | 1985-10-24 | Hoechst Ag, 6230 Frankfurt | Verfahren zur behandlung der herzinsuffizienz |
US5684016A (en) * | 1984-04-12 | 1997-11-04 | Hoechst Aktiengesellschaft | Method of treating cardiac insufficiency |
CA1244041A (en) * | 1984-07-30 | 1988-11-01 | Elijah H. Gold | Process for the preparation of cis, endo- octahydrocyclopenta¬b|pyrrole-2-carboxylate |
DE3431541A1 (de) * | 1984-08-28 | 1986-03-06 | Hoechst Ag, 6230 Frankfurt | Cis,endo-2-azabicycloalkan-3-carbonsaeure-derivate, verfahren zu deren herstellung, deren verwendung sowie zwischenprodukte bei deren herstellung |
US5231080A (en) * | 1985-10-15 | 1993-07-27 | Hoechst Aktiengesellschaft | Method for the treatment of atherosclerosis, thrombosis, and peripheral vessel disease |
US5231084A (en) * | 1986-03-27 | 1993-07-27 | Hoechst Aktiengesellschaft | Compounds having a cognition adjuvant action, agents containing them, and the use thereof for the treatment and prophylaxis of cognitive dysfuncitons |
DE3633496A1 (de) * | 1986-10-02 | 1988-04-14 | Hoechst Ag | Kombination von angiotensin-converting-enzyme-hemmern mit calciumantagonisten sowie deren verwendung in arzneimitteln |
DE3639879A1 (de) * | 1986-11-21 | 1988-06-01 | Hoechst Ag | Verfahren zur herstellung von mono-, bi- und tricyclischen aminosaeuren, zwischenprodukte dieses verfahrens sowie ein verfahren zu deren herstellung |
DE3722007A1 (de) * | 1987-07-03 | 1989-01-12 | Hoechst Ag | Verfahren zur herstellung bicyclischer aminocarbonsaeuren, zwischenprodukte dieses verfahrens und deren verwendung |
JPH0278659A (ja) * | 1988-09-12 | 1990-03-19 | Shionogi & Co Ltd | アザビシクロアルカン類化合物 |
DE3839127A1 (de) * | 1988-11-19 | 1990-05-23 | Hoechst Ag | Pyrrolidon-2-carbonsaeure-derivate mit psychotroper wirkung |
DD284030A5 (de) | 1988-11-24 | 1990-10-31 | Hoechst Ag,De | Verfahren zur herstellung von peptiden mit bradykinin-antagonistischer wirkung |
LT3872B (en) | 1993-12-06 | 1996-04-25 | Hoechst Ag | Novel peptides and pharmaceutical compositions containing them |
DK0796855T3 (da) | 1996-03-20 | 2002-05-27 | Hoechst Ag | Hæmmere af knogleresorption og vitronectin-receptorantagonister |
FR2746394B1 (fr) | 1996-03-20 | 1998-05-29 | Roussel Uclaf | Nouveaux composes tricycliques, leur procede de preparation, et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant |
IN183120B (es) | 1996-10-18 | 1999-09-11 | Vertex Pharma | |
DE19653647A1 (de) | 1996-12-20 | 1998-06-25 | Hoechst Ag | Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung |
DE19741235A1 (de) | 1997-09-18 | 1999-03-25 | Hoechst Marion Roussel De Gmbh | Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
DE19741873A1 (de) * | 1997-09-23 | 1999-03-25 | Hoechst Marion Roussel De Gmbh | Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
DE19751251A1 (de) | 1997-11-19 | 1999-05-20 | Hoechst Marion Roussel De Gmbh | Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate |
DE19821483A1 (de) | 1998-05-14 | 1999-11-18 | Hoechst Marion Roussel De Gmbh | Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
SV2003000617A (es) | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
TW201127828A (en) | 2003-09-05 | 2011-08-16 | Vertex Pharma | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease |
AU2006279357B2 (en) | 2005-08-19 | 2012-05-31 | Janssen Pharmaceutica Nv | Processes and intermediates |
US8399615B2 (en) | 2005-08-19 | 2013-03-19 | Vertex Pharmaceuticals Incorporated | Processes and intermediates |
AR055395A1 (es) | 2005-08-26 | 2007-08-22 | Vertex Pharma | Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c |
US7964624B1 (en) | 2005-08-26 | 2011-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
CA2643688A1 (en) | 2006-02-27 | 2007-08-30 | Vertex Pharmaceuticals Incorporated | Co-crystals and pharmaceutical compositions comprising the same |
EP1993994A2 (en) | 2006-03-16 | 2008-11-26 | Vertex Pharmceuticals Incorporated | Deuterated hepatitis c protease inhibitors |
CA2679426A1 (en) | 2007-02-27 | 2008-09-04 | Luc Farmer | Inhibitors of serine proteases |
EA200970806A1 (ru) | 2007-02-27 | 2010-08-30 | Вертекс Фармасьютикалз Инкорпорейтед | Сокристаллы и содержащие их фармацевтические композиции |
EP2436682A1 (en) | 2007-08-30 | 2012-04-04 | Vertex Pharmceuticals Incorporated | Co-crystals and pharmaceutical compositions comprising the same |
US8178333B2 (en) | 2008-06-24 | 2012-05-15 | Codexis, Inc. | Biocatalytic processes for the preparation of substantially stereomerically pure fused bicyclic proline compounds |
JP5829529B2 (ja) * | 2011-08-29 | 2015-12-09 | 日本曹達株式会社 | 光学活性4級アンモニウム塩、および光学活性化合物の製造方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL58849A (en) * | 1978-12-11 | 1983-03-31 | Merck & Co Inc | Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them |
FR2487829A2 (fr) * | 1979-12-07 | 1982-02-05 | Science Union & Cie | Nouveaux imino acides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme |
EP0050800B2 (en) * | 1980-10-23 | 1995-06-07 | Schering Corporation | Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them |
DE3260423D1 (en) * | 1981-02-17 | 1984-08-30 | Warner Lambert Co | Substituted acyl derivatives of octahydro-1h-isoindole-1-carboxylic acids and esters |
ZA826022B (en) * | 1981-08-21 | 1983-08-31 | Univ Miami | Novel complex amido and imido derivatives of carboxyalkyl peptides and thioethers and ethers of peptides |
EP0081094A1 (en) * | 1981-11-12 | 1983-06-15 | Merck & Co. Inc. | Substituted omega-amino-carboxymethyldipeptide antihypertensive agents |
DE3360065D1 (en) * | 1982-03-08 | 1985-03-28 | Schering Corp | Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them |
-
1982
- 1982-03-30 DE DE19823211676 patent/DE3211676A1/de not_active Withdrawn
-
1983
- 1983-03-24 EP EP83102961A patent/EP0090362A3/de not_active Withdrawn
- 1983-03-28 ES ES521041A patent/ES521041A0/es active Granted
- 1983-03-28 FI FI831049A patent/FI831049L/fi not_active Application Discontinuation
- 1983-03-28 GR GR70912A patent/GR78157B/el unknown
- 1983-03-28 NZ NZ203719A patent/NZ203719A/en unknown
- 1983-03-28 KR KR1019830001244A patent/KR840004069A/ko not_active Application Discontinuation
- 1983-03-29 JP JP58051780A patent/JPS58177967A/ja active Pending
- 1983-03-29 NO NO831168A patent/NO831168L/no unknown
- 1983-03-29 AU AU12970/83A patent/AU560124B2/en not_active Ceased
- 1983-03-29 CA CA000424770A patent/CA1198118A/en not_active Expired
- 1983-03-29 HU HU831064A patent/HU193876B/hu unknown
- 1983-03-29 PT PT76472A patent/PT76472B/pt unknown
- 1983-03-29 PH PH28723A patent/PH19003A/en unknown
- 1983-03-29 DK DK144783A patent/DK144783A/da not_active Application Discontinuation
- 1983-03-29 ZA ZA832229A patent/ZA832229B/xx unknown
- 1983-03-30 IL IL68267A patent/IL68267A/xx unknown
- 1983-04-22 ES ES521741A patent/ES8402570A1/es not_active Expired
- 1983-11-25 NO NO834352A patent/NO834352L/no unknown
Also Published As
Publication number | Publication date |
---|---|
ES521741A0 (es) | 1984-02-01 |
NO831168L (no) | 1983-10-03 |
ES8401937A1 (es) | 1984-01-01 |
PT76472B (de) | 1986-01-24 |
NO834352L (no) | 1983-10-03 |
ES8402570A1 (es) | 1984-02-01 |
AU1297083A (en) | 1983-10-06 |
CA1198118A (en) | 1985-12-17 |
PH19003A (en) | 1985-12-03 |
KR840004069A (ko) | 1984-10-06 |
DE3211676A1 (de) | 1983-10-06 |
JPS58177967A (ja) | 1983-10-18 |
FI831049A0 (fi) | 1983-03-28 |
ZA832229B (en) | 1983-12-28 |
EP0090362A2 (de) | 1983-10-05 |
IL68267A0 (en) | 1983-06-15 |
IL68267A (en) | 1987-03-31 |
DK144783D0 (da) | 1983-03-29 |
NZ203719A (en) | 1986-02-21 |
DK144783A (da) | 1983-10-01 |
HU193876B (en) | 1987-12-28 |
EP0090362A3 (de) | 1985-09-18 |
AU560124B2 (en) | 1987-04-02 |
PT76472A (de) | 1983-04-01 |
GR78157B (es) | 1984-09-26 |
FI831049L (fi) | 1983-10-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20000601 |