DE3635864C2 - - Google Patents
Info
- Publication number
- DE3635864C2 DE3635864C2 DE3635864A DE3635864A DE3635864C2 DE 3635864 C2 DE3635864 C2 DE 3635864C2 DE 3635864 A DE3635864 A DE 3635864A DE 3635864 A DE3635864 A DE 3635864A DE 3635864 C2 DE3635864 C2 DE 3635864C2
- Authority
- DE
- Germany
- Prior art keywords
- carnitine
- acid
- reaction
- alkaline earth
- earth metal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims abstract description 23
- 239000008187 granular material Substances 0.000 claims abstract description 16
- 239000013078 crystal Substances 0.000 claims abstract description 14
- 150000007524 organic acids Chemical class 0.000 claims abstract description 9
- 150000003839 salts Chemical class 0.000 claims abstract description 5
- 230000015572 biosynthetic process Effects 0.000 claims abstract description 4
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims abstract 8
- -1 alkaline earth metal carbonate Chemical class 0.000 claims abstract 7
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims abstract 2
- 239000002253 acid Substances 0.000 claims description 13
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 239000000243 solution Substances 0.000 claims description 7
- 238000002360 preparation method Methods 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 2
- 239000007938 effervescent tablet Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000011247 coating layer Substances 0.000 claims 5
- 239000003513 alkali Substances 0.000 claims 3
- 239000008199 coating composition Substances 0.000 claims 3
- 229910052783 alkali metal Inorganic materials 0.000 claims 2
- 150000001340 alkali metals Chemical class 0.000 claims 2
- 239000011248 coating agent Substances 0.000 claims 2
- 238000000576 coating method Methods 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 239000007864 aqueous solution Substances 0.000 claims 1
- 239000010410 layer Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- 229960004203 carnitine Drugs 0.000 abstract description 7
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 10
- 239000003826 tablet Substances 0.000 description 5
- 229910000029 sodium carbonate Inorganic materials 0.000 description 4
- 239000000203 mixture Substances 0.000 description 3
- 235000005985 organic acids Nutrition 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 150000008043 acidic salts Chemical class 0.000 description 2
- 238000007792 addition Methods 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 239000001354 calcium citrate Substances 0.000 description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 238000009434 installation Methods 0.000 description 2
- 235000012663 monocalcium citrate Nutrition 0.000 description 2
- OWFJMGQSOHDIPP-UHFFFAOYSA-L monocalcium citrate Chemical compound [Ca+2].OC(=O)CC(O)(C(O)=O)CC([O-])=O.OC(=O)CC(O)(C(O)=O)CC([O-])=O OWFJMGQSOHDIPP-UHFFFAOYSA-L 0.000 description 2
- 230000009257 reactivity Effects 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical class OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 235000019568 aromas Nutrition 0.000 description 1
- 229960003237 betaine Drugs 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 230000007775 late Effects 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000002161 passivation Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
- A23L2/40—Effervescence-generating compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicinal Preparation (AREA)
- Soy Sauces And Products Related Thereto (AREA)
- Glanulating (AREA)
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19863635864 DE3635864A1 (de) | 1986-06-26 | 1986-10-22 | Verfahren zum herstellen eines brausegranulates, danach hergestelltes brausegranulat sowie dessen verwendung |
| US07/221,788 US4968517A (en) | 1986-10-22 | 1987-10-21 | Method for preparing an effervescent granulate, an effervescent granulate made accordingly |
| DE8787907312T DE3767473D1 (de) | 1986-10-22 | 1987-10-21 | Verfahren zum herstellen eines brausegranulates, danach hergestelltes brausegranulat sowie dessen verwendung. |
| AU81739/87A AU8173987A (en) | 1986-10-22 | 1987-10-21 | Process for producing effervescent granulates, effervescent granulates thus produced and their use |
| PCT/EP1987/000618 WO1988002993A1 (en) | 1986-10-22 | 1987-10-21 | Process for producing effervescent granulates, effervescent granulates thus produced and their use |
| EP87907312A EP0287647B1 (de) | 1986-10-22 | 1987-10-21 | Verfahren zum herstellen eines brausegranulates, danach hergestelltes brausegranulat sowie dessen verwendung |
| AT87907312T ATE59943T1 (de) | 1986-10-22 | 1987-10-21 | Verfahren zum herstellen eines brausegranulates, danach hergestelltes brausegranulat sowie dessen verwendung. |
| PT85972A PT85972B (pt) | 1986-10-22 | 1987-10-22 | Processo para a preparacao de um granulado efervescente contendo uma mistura dum acido organico solido e um carbonato |
| CA000550012A CA1302148C (en) | 1986-10-22 | 1987-10-22 | Method for preparing an effervescent granulate, an effervescent granulate made accordingly, and its utilization |
| ES8703024A ES2008285A6 (es) | 1986-10-22 | 1987-10-22 | Procedimiento para la obtencion de un granulado efervescente. |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3621432 | 1986-06-26 | ||
| DE19863627475 DE3627475A1 (de) | 1986-06-26 | 1986-08-13 | Verfahren zum herstellen eines brausegranulates, danach hergestelltes brausegranulat sowie dessen verwendung |
| DE19863635864 DE3635864A1 (de) | 1986-06-26 | 1986-10-22 | Verfahren zum herstellen eines brausegranulates, danach hergestelltes brausegranulat sowie dessen verwendung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3635864A1 DE3635864A1 (de) | 1988-05-05 |
| DE3635864C2 true DE3635864C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1989-04-06 |
Family
ID=6312198
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19863635864 Granted DE3635864A1 (de) | 1986-06-26 | 1986-10-22 | Verfahren zum herstellen eines brausegranulates, danach hergestelltes brausegranulat sowie dessen verwendung |
| DE8787907312T Expired - Fee Related DE3767473D1 (de) | 1986-10-22 | 1987-10-21 | Verfahren zum herstellen eines brausegranulates, danach hergestelltes brausegranulat sowie dessen verwendung. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8787907312T Expired - Fee Related DE3767473D1 (de) | 1986-10-22 | 1987-10-21 | Verfahren zum herstellen eines brausegranulates, danach hergestelltes brausegranulat sowie dessen verwendung. |
Country Status (9)
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3627475A1 (de) * | 1986-06-26 | 1988-01-14 | Gergely Gerhard | Verfahren zum herstellen eines brausegranulates, danach hergestelltes brausegranulat sowie dessen verwendung |
| DE4027927A1 (de) * | 1990-09-04 | 1992-03-05 | Bayer Ag | Brausekomponente und verfahren zu ihrer herstellung |
| DE69207656T2 (de) * | 1991-01-30 | 1996-10-17 | The Wellcome Foundation Ltd., London | Wasserlösliche tabletten |
| US5629016A (en) * | 1991-01-30 | 1997-05-13 | Glaxo Wellcome Inc. | Water-dispersible tablets |
| GB9215908D0 (en) * | 1992-07-27 | 1992-09-09 | Wellcome Found | Water dispersible tablets |
| US5698226A (en) * | 1993-07-13 | 1997-12-16 | Glaxo Wellcome Inc. | Water-dispersible tablets |
| US5560928A (en) * | 1995-06-23 | 1996-10-01 | Defelice; Stephen L. | Nutritional and/or dietary composition and method of using the same |
| US6974595B1 (en) * | 1996-05-17 | 2005-12-13 | Proethic Pharmaceuticals, Inc. | Pharmaceutical compositions based on Diclofenae |
| US5997901A (en) * | 1998-10-22 | 1999-12-07 | Mills; Robert G. | Method of manufacturing scented molded products |
| AT407111B (de) * | 1998-12-22 | 2000-12-27 | Gergely Dr & Co | Zucker- und/oder zuckeralkoholhältiges matrixmaterial und verfahren zu seiner herstellung |
| WO2008006878A1 (en) | 2006-07-12 | 2008-01-17 | Purac Biochem Bv | Partially neutralized acid coated food-grade particles |
| GR1006148B (el) * | 2007-12-07 | 2008-11-10 | Uni-Pharma Κλεων Τσετης, Φαρμακευτικα Εργαστηρια Αβεε | Αναβραζοντα δισκια και αναβραζοντα κοκκια που περιεχουν τρυγικη καρνιτινη |
| WO2011072320A1 (en) * | 2009-12-14 | 2011-06-23 | Jubilent Global Limited | Effervescent l-carnitine-based composition |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2784100A (en) * | 1955-03-01 | 1957-03-05 | Abbott Lab | Calcium cyclamate tablet and process of making the same |
| US3359119A (en) * | 1964-03-27 | 1967-12-19 | Reynolds Tobacco Co R | Method of preparing an agglomerated food product |
| US3480185A (en) * | 1966-06-20 | 1969-11-25 | Johnson & Johnson | Charged effervescing agent and medicament dispensing metering valve-actuated aerosol container producing a dose of medicament and carbonation in water |
| US3653914A (en) * | 1970-03-20 | 1972-04-04 | Alberto Culver Co | Production of tablets |
| IT1133010B (it) * | 1980-05-15 | 1986-07-09 | Sigma Tau Ind Farmaceuti | Metodo terapuetico per il trattamento del diabete mellito a insorgenza giovanile e composizione farmaceutica per tale metodo |
| AT376147B (de) * | 1980-12-15 | 1984-10-10 | Gergely Gerhard | Verfahren und vorrichtung zum granulieren eines pulvergemisches |
| EP0076340B1 (de) * | 1981-10-06 | 1984-08-15 | Gerhard Dr. Gergely | Verfahren zur Herstellung von gewünschtenfalls zu Brausetabletten verarbeitbaren Brausegranulaten |
| SE462014B (sv) * | 1983-09-28 | 1990-04-30 | Gerhard Gergely | Brusgranulat och foerfarande foer dess framstaellning |
| DE3463261D1 (en) * | 1983-12-28 | 1987-05-27 | Sigma Tau Ind Farmaceuti | Salts of l-carnitine and alkanoyl l-carnitines and process for preparing same |
| US4687782A (en) * | 1984-12-10 | 1987-08-18 | Nutri-Fuels Systems, Inc. | Nutritional composition for enhancing skeletal muscle adaptation to exercise training |
| IT1177384B (it) * | 1984-12-12 | 1987-08-26 | Boeehringer Biochemia Robin Sp | Prodotti dietetici granulari a base di amminoacidi e procedimento per la loro preparazione |
-
1986
- 1986-10-22 DE DE19863635864 patent/DE3635864A1/de active Granted
-
1987
- 1987-10-21 US US07/221,788 patent/US4968517A/en not_active Expired - Lifetime
- 1987-10-21 WO PCT/EP1987/000618 patent/WO1988002993A1/de active IP Right Grant
- 1987-10-21 AT AT87907312T patent/ATE59943T1/de not_active IP Right Cessation
- 1987-10-21 AU AU81739/87A patent/AU8173987A/en not_active Abandoned
- 1987-10-21 DE DE8787907312T patent/DE3767473D1/de not_active Expired - Fee Related
- 1987-10-21 EP EP87907312A patent/EP0287647B1/de not_active Expired - Lifetime
- 1987-10-22 PT PT85972A patent/PT85972B/pt not_active IP Right Cessation
- 1987-10-22 ES ES8703024A patent/ES2008285A6/es not_active Expired
- 1987-10-22 CA CA000550012A patent/CA1302148C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO1988002993A1 (en) | 1988-05-05 |
| CA1302148C (en) | 1992-06-02 |
| ES2008285A6 (es) | 1989-07-16 |
| PT85972B (pt) | 1990-07-31 |
| DE3767473D1 (de) | 1991-02-21 |
| DE3635864A1 (de) | 1988-05-05 |
| ATE59943T1 (de) | 1991-02-15 |
| US4968517A (en) | 1990-11-06 |
| EP0287647B1 (de) | 1991-01-16 |
| PT85972A (de) | 1987-11-01 |
| AU8173987A (en) | 1988-05-25 |
| EP0287647A1 (de) | 1988-10-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AF | Is addition to no. |
Ref country code: DE Ref document number: 3627475 Format of ref document f/p: P |
|
| OP8 | Request for examination as to paragraph 44 patent law | ||
| AF | Is addition to no. |
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| D2 | Grant after examination | ||
| 8364 | No opposition during term of opposition |