DE3604510A1 - Neue peptide und peptidderivate, ihre herstellung und verwendung und sie enthaltende pharmazeutische zubereitungen - Google Patents

Neue peptide und peptidderivate, ihre herstellung und verwendung und sie enthaltende pharmazeutische zubereitungen

Info

Publication number
DE3604510A1
DE3604510A1 DE19863604510 DE3604510A DE3604510A1 DE 3604510 A1 DE3604510 A1 DE 3604510A1 DE 19863604510 DE19863604510 DE 19863604510 DE 3604510 A DE3604510 A DE 3604510A DE 3604510 A1 DE3604510 A1 DE 3604510A1
Authority
DE
Germany
Prior art keywords
compound
peptide
formula
group
phe
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19863604510
Other languages
German (de)
English (en)
Inventor
Robert H. Newton Centre Mass. Abeles
Michael H. Seattle Wash. Gelb
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Sandoz Patent GmbH
Original Assignee
Sandoz AG
Sandoz Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG, Sandoz Patent GmbH filed Critical Sandoz AG
Publication of DE3604510A1 publication Critical patent/DE3604510A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DE19863604510 1985-02-19 1986-02-13 Neue peptide und peptidderivate, ihre herstellung und verwendung und sie enthaltende pharmazeutische zubereitungen Withdrawn DE3604510A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70265185A 1985-02-19 1985-02-19

Publications (1)

Publication Number Publication Date
DE3604510A1 true DE3604510A1 (de) 1986-08-21

Family

ID=24822094

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19863604510 Withdrawn DE3604510A1 (de) 1985-02-19 1986-02-13 Neue peptide und peptidderivate, ihre herstellung und verwendung und sie enthaltende pharmazeutische zubereitungen

Country Status (7)

Country Link
JP (1) JPS61194097A ( )
BE (1) BE904233A ( )
CH (1) CH672792A5 ( )
DE (1) DE3604510A1 ( )
FR (1) FR2577557B1 ( )
GB (1) GB2171103B ( )
IT (1) IT1203743B ( )

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4873221A (en) * 1986-06-05 1989-10-10 Ici Americas Inc. Difluoro peptide compounds
US4882420A (en) * 1985-04-19 1989-11-21 The Upjohn Company Dihalo-statine substituted renin inhibitors

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5194588A (en) * 1985-01-22 1993-03-16 Ici Americas Inc. Aminoalcohol intermediates for peptide derivatives
US5055450A (en) * 1985-01-22 1991-10-08 Ici Americas Inc. Peptide derivatives
GB8600263D0 (en) * 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives
US5496927A (en) * 1985-02-04 1996-03-05 Merrell Pharmaceuticals Inc. Peptidase inhibitors
GB8613704D0 (en) * 1986-06-05 1986-07-09 Ici America Inc Difluoro keto compounds
GB8619182D0 (en) * 1986-08-06 1986-09-17 Sandoz Ltd Peptides & derivatives
NZ223148A (en) * 1987-01-16 1989-10-27 Merrell Dow Pharma Peptide derivatives having peptidase inhibition activity
US4855303A (en) * 1987-07-01 1989-08-08 Pfizer Inc. Fluorine containing renin inhibitors
US5071837A (en) * 1990-11-28 1991-12-10 Warner-Lambert Company Novel renin inhibiting peptides
CA2098020C (en) * 1991-01-02 2003-10-21 Daniel Schirlin Anti-viral compounds
KR100220876B1 (ko) * 1991-01-02 1999-10-01 슈테펜엘.네스비트 항 바이러스 화합물
IL108031A0 (en) * 1992-12-22 1994-04-12 Procter & Gamble Difluoro pentapeptide derivatives and pharmaceutical compositions containing them
AU667995B2 (en) * 1993-02-15 1996-04-18 Bayer Aktiengesellschaft New pseudopeptides having an antiviral action
DE69425971T2 (de) * 1993-07-08 2001-05-23 Merrell Dow Pharma Analoge von difluoro-staton
KR100308839B1 (ko) * 1993-09-09 2002-10-04 메렐 파마슈티칼스 인크. 디플루오로 스타톤 항바이러스성 유사체
JP3574455B2 (ja) * 1994-02-04 2004-10-06 メレルファーマスーティカルズ インコーポレイテッド 抗ウイルス剤として有用なマクロ環式ジフルオロスタトン誘導体類
GB9502152D0 (en) * 1995-02-03 1995-03-29 Zeneca Ltd Proline derivatives
US6114380A (en) * 1995-12-18 2000-09-05 Merrell Pharmaceuticals Inc. Difluoro statone analogs
US8324347B2 (en) * 2009-02-24 2012-12-04 Institute For Systems Biology Methods of using halogenated peptides as internal standards for liquid chromatography-mass spectrometry

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2424253A1 (fr) * 1978-04-27 1979-11-23 Brun Lab Sa Le Nouveaux derives de peptides analogues des enkephalines, leur procede de preparation et leur application therapeutique
GR75019B ( ) * 1980-09-17 1984-07-12 Univ Miami
WO1986006379A1 (en) * 1985-04-19 1986-11-06 The Upjohn Company Dihalo-statine substituted renin inhibitors

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4882420A (en) * 1985-04-19 1989-11-21 The Upjohn Company Dihalo-statine substituted renin inhibitors
US4873221A (en) * 1986-06-05 1989-10-10 Ici Americas Inc. Difluoro peptide compounds

Also Published As

Publication number Publication date
IT8647666A0 (it) 1986-02-18
FR2577557B1 (fr) 1990-05-11
GB8603835D0 (en) 1986-03-26
BE904233A (fr) 1986-08-18
JPS61194097A (ja) 1986-08-28
FR2577557A1 (fr) 1986-08-22
GB2171103A (en) 1986-08-20
GB2171103B (en) 1989-01-25
IT1203743B (it) 1989-02-23
CH672792A5 ( ) 1989-12-29

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Legal Events

Date Code Title Description
8141 Disposal/no request for examination